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Immunosenescence and cancer: molecular hallmarks, tumor microenvironment remodeling, and age-specific immunotherapy challenges
Immunosenescence and cancer: molecular hallmarks, tumor microenvironment remodeling, and age-specific immunotherapy challenges
Immunosenescence, the age-related decline in immune function, profoundly impacts cancer progression and therapeutic outcom...
Clinical applications of circulating tumor cells in metastasis and therapy
Clinical applications of circulating tumor cells in metastasis and therapy
Circulating tumor cells (CTCs), which serve as an early indicator of tumors in peripheral blood, are closely associated wi...
Recent advances in universal chimeric antigen receptor T cell therapy
Recent advances in universal chimeric antigen receptor T cell therapy
While chimeric antigen receptor (CAR) T cell therapy is highly effective for hematological malignancies, its widespread us...
The role of neoantigens and tumor mutational burden in cancer immunotherapy: advances, mechanisms, and perspectives
The role of neoantigens and tumor mutational burden in cancer immunotherapy: advances, mechanisms, and perspectives
Cancer immunotherapy has revolutionized oncology by leveraging the immune system to combat tumors. Among various biomarker...
WT1-mRNA dendritic cell vaccination of patients with glioblastoma multiforme, malignant pleural mesothelioma, metastatic breast cancer, and other solid tumors: type 1 T-lymphocyte responses are associated with clinical outcome
WT1-mRNA dendritic cell vaccination of patients with glioblastoma multiforme, malignant pleural mesothelioma, metastatic breast cancer, and other solid tumors: type 1 T-lymphocyte responses are associated with clinical outcome
Cell therapies, including tumor antigen-loaded dendritic cells used as therapeutic cancer vaccines, offer treatment option...
N7-methylguanosine modification in cancers: from mechanisms to therapeutic potential
N7-methylguanosine modification in cancers: from mechanisms to therapeutic potential
N7-methylguanosine (m7G) is an important RNA modification involved in epigenetic regulation that is commonly observed in b...
Transcriptional regulatory network analysis identifies GRN as a key regulator bridging chemotherapy and immunotherapy response in small cell lung cancer
Transcriptional regulatory network analysis identifies GRN as a key regulator bridging chemotherapy and immunotherapy response in small cell lung cancer
Small cell lung cancer (SCLC) is an aggressive and heterogeneous subtype, representing 15% of lung cancer cases. Although ...
Unraveling the roles and mechanisms of mitochondrial translation in normal and malignant hematopoiesis
Unraveling the roles and mechanisms of mitochondrial translation in normal and malignant hematopoiesis
Due to spatial and genomic independence, mitochondria possess a translational mechanism distinct from that of cytoplasmic ...
Increased Epstein‒Barr virus reactivation following prophylaxis for cytomegalovirus infection after haploidentical haematopoietic stem cell transplantation
Increased Epstein‒Barr virus reactivation following prophylaxis for cytomegalovirus infection after haploidentical haematopoietic stem cell transplantation
Letermovir (LTV) prophylaxis is effective in reducing the incidence of clinically significant cytomegalovirus (CMV) infect...
NPM1 inhibits tumoral antigen presentation to promote immune evasion and tumor progression
NPM1 inhibits tumoral antigen presentation to promote immune evasion and tumor progression
Tumor cells develop multiple mechanisms to facilitate their immune evasion. Identifying tumor-intrinsic factors that suppo...
Mapping the cell therapy landscape: insights into clinical trials and regulatory advances in China
Mapping the cell therapy landscape: insights into clinical trials and regulatory advances in China
In recent years, cell therapy research and commercialization have significantly accelerated, especially after the US FDA a...
Neutrophil-specific expression of JAK2-V617F or CALRmut induces distinct inflammatory profiles in myeloproliferative neoplasia
Neutrophil-specific expression of JAK2-V617F or CALRmut induces distinct inflammatory profiles in myeloproliferative neoplasia
Neutrophils play a crucial role in inflammation and in the increased thrombotic risk in myeloproliferative neoplasms (MPNs...
Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy
Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy
Macrophages infiltrating tumour tissues or residing in the microenvironment of solid tumours are known as tumour-associate...
Non-invasive diagnosis of esophageal cancer by a simplified circulating cell-free DNA methylation assay targeting OTOP2 and KCNA3: a double-blinded, multicenter, prospective study
Non-invasive diagnosis of esophageal cancer by a simplified circulating cell-free DNA methylation assay targeting OTOP2 and KCNA3: a double-blinded, multicenter, prospective study
Esophageal cancer (EC) is a highly lethal disease lacking early detection approaches. We previously identified that OTOP2 ...
Remodeling of anti-tumor immunity with antibodies targeting a p53 mutant
Remodeling of anti-tumor immunity with antibodies targeting a p53 mutant
p53, the most frequently mutated gene in cancer, lacks effective targeted drugs. We developed monoclonal antibodies (mAbs)...
Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy
Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy
The Wnt/β-catenin signaling pathway plays a crucial role in various physiological processes, encompassing development...
Bone marrow graft versus peripheral blood graft in haploidentical hematopoietic stem cells transplantation: a retrospective analysis in1344 patients of SFGM-TC registry
Bone marrow graft versus peripheral blood graft in haploidentical hematopoietic stem cells transplantation: a retrospective analysis in1344 patients of SFGM-TC registry
The use of peripheral blood (PB) or bone marrow (BM) stem cells graft in haploidentical hematopoietic stem cell transplant...
Vaccines: a promising therapy for myelodysplastic syndrome
Vaccines: a promising therapy for myelodysplastic syndrome
Myelodysplastic neoplasms (MDS) define clonal hematopoietic malignancies characterized by heterogeneous mutational and cli...
cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment
cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment
Cancer is a complex disease resulting from abnormal cell growth that is induced by a number of genetic and environmental f...
Metabolic reprogramming in the tumor microenvironment of liver cancer
Metabolic reprogramming in the tumor microenvironment of liver cancer
The liver is essential for metabolic homeostasis. The onset of liver cancer is often accompanied by dysregulated liver fun...
Nanobody-based trispecific T cell engager (Nb-TriTE) enhances therapeutic efficacy by overcoming tumor-mediated immunosuppression
Nanobody-based trispecific T cell engager (Nb-TriTE) enhances therapeutic efficacy by overcoming tumor-mediated immunosuppression
T cell engagers (TCEs) have been established as an emerging modality for hematologic malignancies, but solid tumo...
Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy
Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy
Inflammation is a fundamental defensive response to harmful stimuli, but the overactivation of inflammatory responses is a...
Novel research and future prospects of artificial intelligence in cancer diagnosis and treatment
Novel research and future prospects of artificial intelligence in cancer diagnosis and treatment
Research into the potential benefits of artificial intelligence for comprehending the intricate biology of cancer has grow...
Genitourinary cancers updates: highlights from ASCO 2023
Genitourinary cancers updates: highlights from ASCO 2023
Significant scientific advances in immunotherapy and targeted therapy approaches have improved clinical outcomes and incre...
Direct inhibition of dioxygenases TET1 by the rheumatoid arthritis drug auranofin selectively induces cancer cell death in T-ALL
Direct inhibition of dioxygenases TET1 by the rheumatoid arthritis drug auranofin selectively induces cancer cell death in T-ALL
T-cell acute lymphoblastic leukemia (T-ALL) is a type of hematologic tumor with malignant proliferation of hematopoietic p...
Retraction Note: The LINC00623/NAT10 signaling axis promotes pancreatic cancer progression by remodeling ac4C modification of mRNA
Retraction Note: The LINC00623/NAT10 signaling axis promotes pancreatic cancer progression by remodeling ac4C modification of mRNA
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Correction: Acylglycerol kinase promotes tumour growth and metastasis via activating the PI3K/AKT/GSK3β signalling pathway in renal cell carcinoma
Correction: Acylglycerol kinase promotes tumour growth and metastasis via activating the PI3K/AKT/GSK3β signalling pathway in renal cell carcinoma
Qian Zhu, Ai-Lin Zhong and Hao Hu have contributed equally to this work.State Key Laboratory of Oncology in Southern China...
Outcomes of patients with secondary central nervous system lymphoma following CAR T-cell therapy: a multicenter cohort study
Outcomes of patients with secondary central nervous system lymphoma following CAR T-cell therapy: a multicenter cohort study
Chimeric antigen receptor T-cell therapy (CAR-T) has been successful in treating relapsed/refractory B-cell lymphomas. How...
Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy
Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy
T cell differentiation is a highly regulated, multi-step process necessary for the progressive establishment of effector f...
CRISPR screening in hematology research: from bulk to single-cell level
CRISPR screening in hematology research: from bulk to single-cell level
The CRISPR genome editing technology has revolutionized the way gene function is studied. Genome editing can be achieved i...
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