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Sleep disturbances, shift work, and epigenetic ageing in working-age adults: findings from the Young Finns study
Sleep disturbances, shift work, and epigenetic ageing in working-age adults: findings from the Young Finns study
Sleep disturbances are known to have adverse effects on health, but knowledge on the effect of sleep disturbances on epige...
Comparative performance evaluation of bisulfite- and enzyme-based DNA conversion methods
Comparative performance evaluation of bisulfite- and enzyme-based DNA conversion methods
Bisulfite conversion (BC) has been the gold standard in DNA methylation profiling for decades. During this chemical proces...
Targeting the epigenetic regulation of ferroptosis: a potential therapeutic approach for sepsis-associated acute kidney injury
Targeting the epigenetic regulation of ferroptosis: a potential therapeutic approach for sepsis-associated acute kidney injury
Sepsis is a syndrome of organ dysfunction caused by the invasion of pathogenic microorganisms. In clinical practice, patie...
Association analysis between an epigenetic alcohol risk score and blood pressure
Association analysis between an epigenetic alcohol risk score and blood pressure
Epigenome‐wide association studies have identified multiple DNA methylation sites (CpGs) associated with alcohol con...
A multi-trait epigenome-wide association study identified DNA methylation signature of inflammation among men with HIV
A multi-trait epigenome-wide association study identified DNA methylation signature of inflammation among men with HIV
Inflammation underlies many conditions causing excess morbidity and mortality among people with HIV (PWH). A handful of si...
Epigenetic signatures of asthma: a comprehensive study of DNA methylation and clinical markers
Epigenetic signatures of asthma: a comprehensive study of DNA methylation and clinical markers
Asthma, a complex respiratory disease, presents with inflammatory symptoms in the lungs, blood, and other tissues. We inve...
DNA methylation biomarker panels for differentiating various liver adenocarcinomas, including hepatocellular carcinoma, cholangiocarcinoma, colorectal liver metastases and pancreatic adenocarcinoma liver metastases
DNA methylation biomarker panels for differentiating various liver adenocarcinomas, including hepatocellular carcinoma, cholangiocarcinoma, colorectal liver metastases and pancreatic adenocarcinoma liver metastases
DNA methylation biomarkers are one of the most promising tools for the diagnosis and differentiation of adenocarcinomas of...
Integrative analysis based on ATAC-seq and RNA-seq reveals a novel oncogene PRPF3 in hepatocellular carcinoma
Integrative analysis based on ATAC-seq and RNA-seq reveals a novel oncogene PRPF3 in hepatocellular carcinoma
Assay of Transposase Accessible Chromatin Sequencing (ATAC-seq) is a high-throughput sequencing technique that detects ope...
A validated restriction enzyme ddPCR cg05575921 (AHRR) assay to accurately assess smoking exposure
A validated restriction enzyme ddPCR cg05575921 (AHRR) assay to accurately assess smoking exposure
In this study, a novel restriction enzyme (RE) digestion-based droplet digital polymerase chain reaction (ddPCR) assay was...
Low expression of miR-182 caused by DNA hypermethylation accelerates acute lymphocyte leukemia development by targeting PBX3 and BCL2: miR-182 promoter methylation is a predictive marker for hypomethylation agents + BCL2 inhibitor venetoclax
Low expression of miR-182 caused by DNA hypermethylation accelerates acute lymphocyte leukemia development by targeting PBX3 and BCL2: miR-182 promoter methylation is a predictive marker for hypomethylation agents + BCL2 inhibitor venetoclax
miR-182 promoter hypermethylation frequently occurs in various tumors, including acute myeloid leukemia, and leads to low ...
Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
Acute lymphoblastic leukemia (ALL) is the most prevalent cancer in children, and despite considerable progress in treatmen...
Nucleosome reorganisation in breast cancer tissues
Nucleosome reorganisation in breast cancer tissues
Nucleosome repositioning in cancer is believed to cause many changes in genome organisation and gene expression. Understan...
Targeting histone demethylases JMJD3 and UTX: selenium as a potential therapeutic agent for cervical cancer
Targeting histone demethylases JMJD3 and UTX: selenium as a potential therapeutic agent for cervical cancer
The intriguing connection between selenium and cancer resembles a captivating puzzle that keeps researchers engaged and cu...
Epigenetics of the far northern Yakutian population
Epigenetics of the far northern Yakutian population
Yakuts are one of the indigenous populations of the subarctic and arctic territories of Siberia characterized by a contine...
DNA methylation profiles reveal sex-specific associations between gestational exposure to ambient air pollution and placenta cell-type composition in the PRISM cohort study
DNA methylation profiles reveal sex-specific associations between gestational exposure to ambient air pollution and placenta cell-type composition in the PRISM cohort study
Gestational exposure to ambient air pollution has been associated with adverse health outcomes for mothers and newborns. T...
Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization
Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization
Aging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecu...
Long-term decitabine/retinoic acid maintenance treatment in an elderly sAML patient with high-risk genetics
Long-term decitabine/retinoic acid maintenance treatment in an elderly sAML patient with high-risk genetics
Elderly patients with AML ineligible for induction have a dismal prognosis; hence disease stabilization is a primary treat...
EZH2 K63-polyubiquitination affecting migration in extranodal natural killer/T-cell lymphoma
EZH2 K63-polyubiquitination affecting migration in extranodal natural killer/T-cell lymphoma
Overexpressed EZH2 is oncogenically involved in the pathogenesis of different cancerous contexts including extranodal natu...
Targeting oncogenic TERT promoter variants by allele-specific epigenome editing
Targeting oncogenic TERT promoter variants by allele-specific epigenome editing
Activation of dominant oncogenes by small or structural genomic alterations is a common driver mechanism in many cancers. ...
A 2-decade bibliometric analysis of epigenetics of cardiovascular disease: from past to present
A 2-decade bibliometric analysis of epigenetics of cardiovascular disease: from past to present
Cardiovascular disease (CVD) remains a major health killer worldwide, and the role of epigenetic regulation in CVD has bee...
Retraction Note: Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelialmesenchymal transition, migration, and on the pro-inflammatory phenotype
Retraction Note: Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelialmesenchymal transition, migration, and on the pro-inflammatory phenotype
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma
Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma
Cholangiocarcinoma (CCA) refers to a collection of malignant tumors that develop from the biliary epithelium. Extensive cl...
Tazemetostat decreases β-catenin and CD13 protein expression in HEPG-2 and Hepatitis B virus-transfected HEPG-2 with decreased cell viability
Tazemetostat decreases β-catenin and CD13 protein expression in HEPG-2 and Hepatitis B virus-transfected HEPG-2 with decreased cell viability
Hepatocellular carcinoma (HCC) is one of the global health concerns. Hepatitis B virus (HBV) is one of the major causes of...
DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study
DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study
Puberty is a highly heritable and variable trait, with environmental factors having a role in its eventual timing and deve...
Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis
Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis
Epithelial mesenchymal transformation (EMT) in alveolar type 2 epithelial cells (AT2) is closely associated with pulmonary...
Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen
Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen
Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. Dysregulation of the epigenetic machinery i...
Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome
Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome
B vitamins such as folate (B9), B6, and B12 are key in one carbon metabolism, which generates methyl donors for DNA methyl...
N6-methyladenosine methylation in kidney injury
N6-methyladenosine methylation in kidney injury
Multiple mechanisms are involved in kidney damage, among which the role of epigenetic modifications in the occurrence and ...
Unlocking the secrets: the power of methylation-based cfDNA detection of tissue damage in organ systems
Unlocking the secrets: the power of methylation-based cfDNA detection of tissue damage in organ systems
Detecting organ and tissue damage is essential for early diagnosis, treatment decisions, and monitoring disease progressio...
Pharmacological EZH2 inhibition combined with retinoic acid treatment promotes differentiation and apoptosis in rhabdomyosarcoma cells
Pharmacological EZH2 inhibition combined with retinoic acid treatment promotes differentiation and apoptosis in rhabdomyosarcoma cells
Rhabdomyosarcomas (RMS) are predominantly paediatric sarcomas thought to originate from muscle precursor cells due to impa...
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