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Personalized neoantigen vaccines in urologic malignancies
Personalized neoantigen vaccines in urologic malignancies
Personalized neoantigen vaccines utilize mutation-driven neoantigens to induce tumor-specific immune responses. This strat...
CHD1 status drives divergent metabolic pathways in SPOP-mutant prostate cancer
CHD1 status drives divergent metabolic pathways in SPOP-mutant prostate cancer
CHD1 loss is common in SPOP-mutant prostate cancer; however, this combined phenotype has not yet been clearly defined. Gen...
CHD1 loss reprograms SREBP2-driven cholesterol synthesis to fuel androgen-responsive growth and castration resistance in SPOP-mutated prostate tumors
CHD1 loss reprograms SREBP2-driven cholesterol synthesis to fuel androgen-responsive growth and castration resistance in SPOP-mutated prostate tumors
Despite undergoing castration, most individuals with prostate cancer (PCa) experience progression to castration-resistant ...
Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of esophageal adenocarcinoma
Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of esophageal adenocarcinoma
Locally advanced esophageal adenocarcinoma remains difficult to treat and the ecological and evolutionary dynamics respons...
Fishing for melanoma metastasis-initiating cells in lymph nodes
Fishing for melanoma metastasis-initiating cells in lymph nodes
The complex nature of metastasis-initiating cells (MICs) has long hindered our understanding of how cancer spreads and how...
MCSP+ metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization
MCSP+ metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization
To investigate the early, poorly understood events driving metastatic progression, we searched for the earliest detectable...
Sensitizing solid tumors to CAR-mediated cytotoxicity by lipid nanoparticle delivery of synthetic antigens
Sensitizing solid tumors to CAR-mediated cytotoxicity by lipid nanoparticle delivery of synthetic antigens
Chimeric antigen receptor (CAR) T cell immunotherapy relies on CAR targeting of tumor-associated antigens; however, hetero...
Age-associated nicotinamide adenine dinucleotide decline drives CAR-T cell failure
Age-associated nicotinamide adenine dinucleotide decline drives CAR-T cell failure
Chimeric antigen receptor (CAR) T cell therapy is one of the most promising cancer treatments. However, different hurdles ...
Defining the transcriptional lineages of breast cancer subtypes
Defining the transcriptional lineages of breast cancer subtypes
In this work, we demonstrate the transcriptional networks that link breast cancer subtypes and their cells of origin, and ...
A 3D genome view of colon cancer initiation
A 3D genome view of colon cancer initiation
The early molecular events driving cancer initiation remain elusive, hampering prognostic accuracy. A comparative analysis...
Global loss of promoter–enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis
Global loss of promoter–enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis
Although three-dimensional (3D) genome architecture is crucial for gene regulation, its role in disease remains elusive. W...
Recapitulating the adenoma–carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids
Recapitulating the adenoma–carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids
Carcinogenesis results from the sequential acquisition of oncogenic mutations that convert normal cells into invasive, met...
Modeling adenoma–carcinoma progression from a single MLH1-knockout cell via colon organoids
Modeling adenoma–carcinoma progression from a single MLH1-knockout cell via colon organoids
Starting from a single MLH1-knockout human colon cell, we modeled the transition of daughter cells and resultant organoids...
The pro-oncogenic noncanonical activity of a RAS•GTP:RanGAP1 complex facilitates nuclear protein export
The pro-oncogenic noncanonical activity of a RAS•GTP:RanGAP1 complex facilitates nuclear protein export
Canonical RAS signaling, including PI3K/AKT- and RAF/MEK-dependent activities, results mainly from RAS•GTP interacti...
Single-cell transcriptomic landscape deciphers olfactory neuroblastoma subtypes and intra-tumoral heterogeneity
Single-cell transcriptomic landscape deciphers olfactory neuroblastoma subtypes and intra-tumoral heterogeneity
Olfactory neuroblastoma (ONB) is a rare malignancy known to originate from the olfactory epithelium. The complex tumor eco...
Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer
Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer
Despite the abundance of somatic structural variations (SVs) in cancer, the underlying molecular mechanisms of their forma...
Enhanced precision in immunotherapy
Enhanced precision in immunotherapy
Recent advancements in targeted immune checkpoint blockade (ICB) therapy have reshaped cancer treatment paradigms. However...
Integrative single-cell analysis of human colorectal cancer reveals patient stratification with distinct immune evasion mechanisms
Integrative single-cell analysis of human colorectal cancer reveals patient stratification with distinct immune evasion mechanisms
The tumor microenvironment (TME) considerably influences colorectal cancer (CRC) progression, therapeutic response and cli...
How tumors hijack macrophages for immune evasion
How tumors hijack macrophages for immune evasion
Resistance of cancers to immune checkpoint blockades is frequently observed. Pancreatic cancer cells are now shown to crea...
Dual inhibition of EGFR and PI3K with a single drug
Dual inhibition of EGFR and PI3K with a single drug
Precision medicine holds immense promise for treating individuals with cancer. A new study unveils MTX-531 — a drug ...
Single-cell atlas defines distinct immune escape mechanisms in colorectal cancer
Single-cell atlas defines distinct immune escape mechanisms in colorectal cancer
An integrative single-cell analysis of the human colorectum reveals tumor-associated cellular alterations and regulatory p...
BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models
BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models
The MCL1 gene is frequently amplified in cancer and codes for the antiapoptotic protein myeloid cell leukemia 1 (MCL1), wh...
A comeback for checkpoint inhibition in multiple myeloma
A comeback for checkpoint inhibition in multiple myeloma
Early trials of immune checkpoint inhibitors (ICIs) in multiple myeloma (MM) showed increased mortality, halting their dev...
Clinical response and pathway-specific correlates following TIGIT–LAG3 blockade in myeloma: the MyCheckpoint randomized clinical trial
Clinical response and pathway-specific correlates following TIGIT–LAG3 blockade in myeloma: the MyCheckpoint randomized clinical trial
Persons with myeloma were randomized to receive an anti-TIGIT (T cell immunoreceptor) or anti-LAG3 (lymphocyte activation ...
Single-cell multiomic dissection of response and resistance to chimeric antigen receptor T cells against BCMA in relapsed multiple myeloma
Single-cell multiomic dissection of response and resistance to chimeric antigen receptor T cells against BCMA in relapsed multiple myeloma
Markers that predict response and resistance to chimeric antigen receptor (CAR) T cells in relapsed/refractory multiple my...
Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis
Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis
The circadian clock regulates daily rhythms of numerous physiological activities through tightly coordinated modulation of...
Autologous HER2-specific CAR T cells after lymphodepletion for advanced sarcoma: a phase 1 trial
Autologous HER2-specific CAR T cells after lymphodepletion for advanced sarcoma: a phase 1 trial
In this prospective, interventional phase 1 study for individuals with advanced sarcoma, we infused autologous HER2-specif...
Using single-cell transcriptomics to predict which tumors will respond to targeted therapy
Using single-cell transcriptomics to predict which tumors will respond to targeted therapy
We performed a proof-of-concept study showing that single-cell RNA sequencing, a method for capturing rich tumor informati...
Sarcoma ecotypes determine immunotherapy benefit
Sarcoma ecotypes determine immunotherapy benefit
Sarcomas are heterogeneous connective tissue tumors that occur at various anatomic sites and are generally difficult to tr...
PRMT9 inhibition sparks immune responses in AML
PRMT9 inhibition sparks immune responses in AML
Arginine methylation is crucial for tumor maintenance. PRMT9 levels are elevated in acute myeloid leukemia, and its inhibi...
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