SCI Abstract

search
+
Correlative studies reveal factors contributing to successful CAR-T cell therapies in cancer
Correlative studies reveal factors contributing to successful CAR-T cell therapies in cancer
Cellular and targeted immunotherapies have revolutionized cancer treatments in the last several decades. Successful cellul...
CAR T-cell therapy to treat multiple myeloma: current state and future directions
CAR T-cell therapy to treat multiple myeloma: current state and future directions
Chimeric antigen receptor (CAR) T-cell therapy represents a transformative advancement in treating relapsed or refractory ...
TRIM-endous functional network of tripartite motif 29 (TRIM29) in cancer progression and beyond
TRIM-endous functional network of tripartite motif 29 (TRIM29) in cancer progression and beyond
While most Tripartite motif (TRIM) family proteins are E3 ubiquitin ligases, some members have functions beyond the regula...
Evolving strategies for addressing CAR T-cell toxicities
Evolving strategies for addressing CAR T-cell toxicities
The field of chimeric antigen receptor (CAR) T-cell therapy has grown from a fully experimental concept to now boasting a ...
Influence of antibody–drug conjugate cleavability, drug-to-antibody ratio, and free payload concentration on systemic toxicities: A systematic review and meta-analysis
Influence of antibody–drug conjugate cleavability, drug-to-antibody ratio, and free payload concentration on systemic toxicities: A systematic review and meta-analysis
While in theory antibody drug conjugates (ADCs) deliver high-dose chemotherapy directly to target cells, numerous side eff...
Homologous recombination deficiency (HRD) diagnostics: underlying mechanisms and new perspectives
Homologous recombination deficiency (HRD) diagnostics: underlying mechanisms and new perspectives
Homologous recombination deficiency (HRD) is considered a universal and effective sign of a tumor’s sensitivity to p...
Recapitulating the potential contribution of protein S-palmitoylation in cancer
Recapitulating the potential contribution of protein S-palmitoylation in cancer
Protein S-palmitoylation is a reversible form of protein lipidation in which the formation of a thioester bond occurs betw...
Neuropeptide Y in cancer—biological functions and potential clinical implications
Neuropeptide Y in cancer—biological functions and potential clinical implications
Neuropeptide Y (NPY) is a sympathetic neurotransmitter widely distributed in the peripheral and central nervous system, af...
LGR5: An emerging therapeutic target for cancer metastasis and chemotherapy resistance
LGR5: An emerging therapeutic target for cancer metastasis and chemotherapy resistance
Cancer stem cells play an important role in tumor progression and chemotherapy resistance. Leucine-rich G repeat-containin...
The diversity of natural killer cell functional and phenotypic states in cancer
The diversity of natural killer cell functional and phenotypic states in cancer
The role of natural killer (NK) cells as immune effectors is well established, as is their utility as immunotherapeutic ag...
Cellular plasticity and non-small cell lung cancer: role of T and NK cell immune evasion and acquisition of resistance to immunotherapies
Cellular plasticity and non-small cell lung cancer: role of T and NK cell immune evasion and acquisition of resistance to immunotherapies
Lung cancer is a leading global cause of mortality, with non-small cell lung cancer (NSCLC) accounting for a significant p...
Efficacy of innovative systemic treatments in combination with radiotherapy for bone metastases: a GEMO (the European Study Group of Bone Metastases) state of the art
Efficacy of innovative systemic treatments in combination with radiotherapy for bone metastases: a GEMO (the European Study Group of Bone Metastases) state of the art
The management of bone metastases (BoM) requires a multidisciplinary approach to prevent complications, necessitating upda...
Minimally invasive biomarkers for triaging lung nodules—challenges and future perspectives
Minimally invasive biomarkers for triaging lung nodules—challenges and future perspectives
CT chest scans are commonly performed worldwide, either in routine clinical practice for a wide range of indications&n...
Immunomodulatory role of oncogenic alterations in non-small cell lung cancer: a review of implications for immunotherapy
Immunomodulatory role of oncogenic alterations in non-small cell lung cancer: a review of implications for immunotherapy
Immune checkpoint inhibitors (ICIs) have improved clinical outcomes in patients with non-small cell lung cancer (NSCLC) la...
CTGF (CCN2): a multifaceted mediator in breast cancer progression and therapeutic targeting
CTGF (CCN2): a multifaceted mediator in breast cancer progression and therapeutic targeting
Breast cancer, with its diverse subtypes like ER-positive, HER-2-positive, and triple-negative, presents complex challenge...
The fibro-adipogenic progenitor APOD+DCN+LUM+ cell population in aggressive carcinomas
The fibro-adipogenic progenitor APOD+DCN+LUM+ cell population in aggressive carcinomas
We identified a progenitor cell population highly enriched in samples from invasive and chemo-resistant carcinomas, charac...
The role of circular RNA during the urological cancer metastasis: exploring regulatory mechanisms and potential therapeutic targets
The role of circular RNA during the urological cancer metastasis: exploring regulatory mechanisms and potential therapeutic targets
Metastasis is a major contributor to treatment failure and death in urological cancers, representing an important biomedic...
Survival mechanisms of circulating tumor cells and their implications for cancer treatment
Survival mechanisms of circulating tumor cells and their implications for cancer treatment
Metastasis remains the principal trigger for relapse and mortality across diverse cancer types. Circulating tumor cells (C...
In vivo manufacture and manipulation of CAR-T cells for better druggability
In vivo manufacture and manipulation of CAR-T cells for better druggability
The current CAR-T cell therapy products have been hampered in their druggability due to the personalized preparation requi...
Tumor-associated fibrosis: a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination
Tumor-associated fibrosis: a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination
Epithelial ovarian cancer (EOC) is often diagnosed in advanced stage with peritoneal dissemination. Recent studies indicat...
Glioblastoma stem cell metabolism and immunity
Glioblastoma stem cell metabolism and immunity
Despite enormous efforts being invested in the development of novel therapies for brain malignancies, there remains a dire...
Epidemiology of nasopharyngeal carcinoma: current insights and future outlook
Epidemiology of nasopharyngeal carcinoma: current insights and future outlook
Nasopharyngeal carcinoma (NPC) is characterised by its remarkable geographical and ethnic distribution. The interplay betw...
Multifaceted role of the DNA replication protein MCM10 in maintaining genome stability and its implication in human diseases
Multifaceted role of the DNA replication protein MCM10 in maintaining genome stability and its implication in human diseases
MCM10 plays a vital role in genome duplication and is crucial for DNA replication initiation, elongation, and termination....
Natural killer cells in neuroblastoma: immunological insights and therapeutic perspectives
Natural killer cells in neuroblastoma: immunological insights and therapeutic perspectives
Natural killer (NK) cells have multifaceted roles within the complex tumor milieu. They are pivotal components of innate i...
The role of mitochondria in tumor metastasis and advances in mitochondria-targeted cancer therapy
The role of mitochondria in tumor metastasis and advances in mitochondria-targeted cancer therapy
Mitochondria are central actors in diverse physiological phenomena ranging from energy metabolism to stress signaling and ...
The biological function of extracellular vesicles in prostate cancer and their clinical application as diagnostic and prognostic biomarkers
The biological function of extracellular vesicles in prostate cancer and their clinical application as diagnostic and prognostic biomarkers
Prostate cancer (PCa) is one of the most commonly diagnosed malignancies and main causes of cancer-related deaths worldwid...
CAR T cells in solid tumors and metastasis: paving the way forward
CAR T cells in solid tumors and metastasis: paving the way forward
CAR T cell therapy, hailed as a breakthrough in cancer treatment due to its remarkable outcomes in hematological malignanc...
Functional links between the microbiome and the molecular pathways of colorectal carcinogenesis
Functional links between the microbiome and the molecular pathways of colorectal carcinogenesis
Colorectal cancer (CRC) is a common cancer, with a concerning rise in early-onset CRC cases, signalling a shift in disease...
Mitochondrial ribosomal proteins in metastasis and their potential use as prognostic and therapeutic targets
Mitochondrial ribosomal proteins in metastasis and their potential use as prognostic and therapeutic targets
The mitochondrion is an essential cell organelle known as the powerhouse of the cell. Mitochondrial ribosomal proteins (MR...
Tumor necrosis factor superfamily signaling: life and death in cancer
Tumor necrosis factor superfamily signaling: life and death in cancer
Immune checkpoint inhibitors have shaped the landscape of cancer treatment. However, many patients either do not respond o...
Load More
format_indent_increase