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Cisplatin-induced therapy-related myelodysplastic syndrome during avelumab maintenance therapy for metastatic urothelial carcinoma
Cisplatin-induced therapy-related myelodysplastic syndrome during avelumab maintenance therapy for metastatic urothelial carcinoma
A 64 year-old man underwent a radical cystectomy for muscle-invasive bladder cancer. Five years later, lung and m...
Primary adenocarcinoma of the lacrimal sac with 5-year recurrence-free survival after radiation therapy alone: a case report
Primary adenocarcinoma of the lacrimal sac with 5-year recurrence-free survival after radiation therapy alone: a case report
Lacrimal sac tumors are rare, with approximately 800 cases reported worldwide; primary adenocarcinoma of the lacrimal sac ...
Gastrectomy after neoadjuvant chemotherapy in five cases of locally advanced gastric cancer with pancreatic head invasion
Gastrectomy after neoadjuvant chemotherapy in five cases of locally advanced gastric cancer with pancreatic head invasion
Locally advanced gastric cancer (LAGC) with pancreatic head invasion (T4b) carries a poor prognosis despite radical surger...
Laparoscopically resected appendiceal dual tumor composed of goblet cell carcinoma and low-grade mucinous neoplasm: a case report and literature review
Laparoscopically resected appendiceal dual tumor composed of goblet cell carcinoma and low-grade mucinous neoplasm: a case report and literature review
Dual tumors, comprising two different types of tumor, are uncommon pathologic findings. Appendiceal goblet cell carcinoid ...
Exceptional response to brigatinib following alectinib failure in a patient with fusion-positive duodenal carcinoma
Exceptional response to brigatinib following alectinib failure in a patient with fusion-positive duodenal carcinoma
Patients with advanced duodenal carcinoma typically have a poor prognosis due to limited practical chemotherapy options. W...
Immune checkpoint inhibitor restores daily function in patient with microsatellite instability (MSI)-high advanced endometrial cancer and poor performance status
Immune checkpoint inhibitor restores daily function in patient with microsatellite instability (MSI)-high advanced endometrial cancer and poor performance status
The immune checkpoint system suppresses T-cell activity. Unlike cytotoxic anticancer drugs that directly kill cells, immun...
Coexistence of plasmablastic lymphoma and adenocarcinoma in the stomach: a case report and literature review
Coexistence of plasmablastic lymphoma and adenocarcinoma in the stomach: a case report and literature review
Plasmablastic lymphoma (PBL) is a rare B-cell lymphoma. Reports on primary gastric PBL are limited, and its endoscopic fea...
Co-occurrence of breast cancer and malignant peripheral nerve sheath tumor in a patient with neurofibromatosis type 1
Co-occurrence of breast cancer and malignant peripheral nerve sheath tumor in a patient with neurofibromatosis type 1
Patients with neurofibromatosis type 1 (NF1) have an increased risk of developing breast cancer and other malignancies. Du...
A case of triple-negative breast cancer with thalassemia manifested by anemia progression during neoadjuvant chemotherapy
A case of triple-negative breast cancer with thalassemia manifested by anemia progression during neoadjuvant chemotherapy
Thalassemia is an inherited hemoglobinopathy characterized by anemia. In Japan, beta-thalassemia occurs in only 1 in 1000 ...
Coexisting germline variants of and in a patient with Lynch syndrome who had uterine and ovarian cancer
Coexisting germline variants of and in a patient with Lynch syndrome who had uterine and ovarian cancer
Lynch syndrome is an autosomal dominant disorder caused by a heterozygous pathogenic germline variant in mismatch repair (...
A case of autoimmune hemolytic anemia with cold agglutinin disease post-operation for recurrent ovarian cancer
A case of autoimmune hemolytic anemia with cold agglutinin disease post-operation for recurrent ovarian cancer
Autoimmune hemolytic anemia is a rare complication following surgery for recurrent ovarian cancer, with no previously repo...
Complete recovery from pseudocirrhosis caused by chemotherapy for diffuse liver metastases of breast cancer
Complete recovery from pseudocirrhosis caused by chemotherapy for diffuse liver metastases of breast cancer
Pseudocirrhosis refers to morphologic changes of the liver seen radiographically that mimic cirrhosis and arise in the set...
A case of primary malignant melanoma of the ureter
A case of primary malignant melanoma of the ureter
We performed a laparoscopic left nephroureterectomy for a patient with primary malignant melanoma of the left ureter. Four...
Simultaneous malignant peripheral nerve sheath tumour and malignant melanoma of the anorectal region
Simultaneous malignant peripheral nerve sheath tumour and malignant melanoma of the anorectal region
A 69-year-old male presented to our clinic with bloody faecal matter. Examination revealed a 60-mm type 1 tumour on the po...
Continuous measurement of radioactivity for a patient with chronic kidney disease during radioactive iodine therapy and hemodialysis: a case report
Continuous measurement of radioactivity for a patient with chronic kidney disease during radioactive iodine therapy and hemodialysis: a case report
The half-life of radioactive iodine (RAI) is prolonged in patients with chronic kidney disease (CKD) because RAI is mainly...
Two Japanese patients with metastatic castration-resistant prostate cancer with somatic biallelic loss and splice site variant or loss who responded to Poly-ADP-ribose polymerase inhibitor: A case report
Two Japanese patients with metastatic castration-resistant prostate cancer with somatic biallelic loss and splice site variant or loss who responded to Poly-ADP-ribose polymerase inhibitor: A case report
We treated two patients with metastatic castration-resistant prostate cancer (mCRPC) who achieved a response duration of m...
A case of zolbetuximab-induced protein-losing gastroenteropathy in a patient with advanced gastric cancer
A case of zolbetuximab-induced protein-losing gastroenteropathy in a patient with advanced gastric cancer
Zolbetuximab is a monoclonal antibody targeting Claudin 18.2 that has been approved for the treatment of advanced gastric ...
Delayed-onset immune-related colitis more than three years after nivolumab therapy for metastatic renal cell carcinoma: A case report
Delayed-onset immune-related colitis more than three years after nivolumab therapy for metastatic renal cell carcinoma: A case report
Nivolumab, a PD-1 inhibitor, enhances anti-tumor immunity but can cause immune-related adverse events (irAEs). Although ir...
Conversion surgery of stage 4 gastric cancer with peritoneal dissemination after overcoming immune-related liver injury: a case report and literature review
Conversion surgery of stage 4 gastric cancer with peritoneal dissemination after overcoming immune-related liver injury: a case report and literature review
The prognosis for unresectable advanced gastric cancer remains poor. Chemotherapy is the primary treatment, and the recent...
Hydrogel spacer infection during prostate cancer radiotherapy: a case report of successful abscess management through radical prostatectomy
Hydrogel spacer infection during prostate cancer radiotherapy: a case report of successful abscess management through radical prostatectomy
Hydrogel spacers can be inserted to create a gap between the prostate and rectum prior to radiotherapy for prostate cancer...
Immune checkpoint inhibitor-associated sick sinus syndrome and cardiogenic shock
Immune checkpoint inhibitor-associated sick sinus syndrome and cardiogenic shock
Immune checkpoint inhibitors (ICI) represent a major advance in the treatment of cancer. Most studies of ICI have underest...
Reduction of bleeding by cabozantinib in metastatic renal cell carcinoma with hereditary hemorrhagic telangiectasia
Reduction of bleeding by cabozantinib in metastatic renal cell carcinoma with hereditary hemorrhagic telangiectasia
Hereditary hemorrhagic telangiectasia (HHT) is a rare genetic disorder characterized by refractory recurrent epistaxis and...
Ileal perforation at the site of peritoneal metastasis with intestinal infiltration by dual EGFR-VEGF pathway inhibition in an EGFR-mutant non-small cell lung cancer patient
Ileal perforation at the site of peritoneal metastasis with intestinal infiltration by dual EGFR-VEGF pathway inhibition in an EGFR-mutant non-small cell lung cancer patient
Gastrointestinal (GI) perforation including ileal perforation is a rare complication of antivascular endothelial growth fa...
A case of selpercatinib treatment for anaplastic thyroid carcinoma resulting in abscess formation
A case of selpercatinib treatment for anaplastic thyroid carcinoma resulting in abscess formation
Rearranged during transfection (RET) gene abnormality is a driver gene mutation that causes thyroid cancer, and selpercati...
A case of pagetoid spread of urothelial carcinoma with notable reduction achieved through enfortumab vedotin, resulting in complete surgical resection
A case of pagetoid spread of urothelial carcinoma with notable reduction achieved through enfortumab vedotin, resulting in complete surgical resection
Secondary extramammary Paget’s disease is a rare condition associated with the contiguous extension of tumor cells f...
Fertility preservation in men with hypogonadotropic hypogonadism secondary to germinoma: two cases of gonadotropin replacement therapy before induction of anticancer chemotherapy
Fertility preservation in men with hypogonadotropic hypogonadism secondary to germinoma: two cases of gonadotropin replacement therapy before induction of anticancer chemotherapy
Hypogonadotropic hypogonadism can be caused by brain tumors. For a malignancy such as a germ cell tumor, chemotherapy comb...
Dermatofibrosarcoma protuberance with a unique appearance mimicking neurofibroma arising from a conventional area
Dermatofibrosarcoma protuberance with a unique appearance mimicking neurofibroma arising from a conventional area
A 21 year-old Japanese man had a rapidly growing pedunculated soft tumor in the abdomen within the past year, the...
SMARCA4-deficient epithelioid sarcoma revealed by comprehensive genomic profiling, leading to a notable response by nivolumab treatment
SMARCA4-deficient epithelioid sarcoma revealed by comprehensive genomic profiling, leading to a notable response by nivolumab treatment
A 50-year-old man presented with a bulky mass in the left thigh and was referred to our department. He showed an impaired ...
Prophylactic use of duloxetine hydrochloride in oxaliplatin-induced first-bite syndrome
Prophylactic use of duloxetine hydrochloride in oxaliplatin-induced first-bite syndrome
First-bite syndrome (FBS) is manifested as acute and severe pain in the parotid region occurring at the first bite of a me...
Prostate ductal adenocarcinoma with MLH1 copy number loss, microsatellite instability high and BRCA2 mutation
Prostate ductal adenocarcinoma with MLH1 copy number loss, microsatellite instability high and BRCA2 mutation
Mismatch repair deficiency (MMRd) or microsatellite instability high (MSI-H) is rare in prostate cancer and more frequentl...
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