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Evaluation of the Prognostic Role of Leptin and Cyclin D1 Expression in Colorectal Cancer
Background: Colorectal cancer (CRC) is one of the most malignancies worldwide. This study aimed to determine the role of l...
Comparison of Interleukin-18 Serum Levels in Patients with Breast Cancer and Idiopathic Granulomatous Mastitis
Background: Breast cancer (BC), as a global challenge, is one of the most prevalent malignant diseases among women. Idiopa...
Urothelial Carcinoma Stage and Grade Association with the Expression Levels of Eukaryotic Initiation Factor 4E and 4E Binding Protein 1
Background: Bladder cancer (BCa) accounts for the fourth most common cancer among men. Eukaryote translation initiation fa...
Flaxseed Extract Can Modulates Apoptotic Genes to Promote Cell Death in Breast Cancer Cells
Background: Breast cancer is a multifactorial malignancy with uncertain treatment outcomes that make its challenging treat...
Evaluation of Potential miR-221, miR-93, miR-21, and miR-24 as Molecular Markers for Laryngeal Squamous Cell Carcinoma
Background: Laryngeal cancer, the most prevalent head and neck malignancy, represents 2.4% of all tumors and is the 11th m...
Feature Selection Algorithms Combined with Experimental Validation Reveal COL10A1 and TMPRSS4 Genes as Potential Diagnostic Biomarkers in Pancreatic Ductal Adenocarcinoma
Background: Pancreatic adenocarcinoma (PAAD) is often diagnosed at a late stage, preventing curative surgery. Early detect...
Prevalence and Clinicopathologic Features of HER2 Overexpression in Endocervical Adenocarcinoma
Background: Endocervical adenocarcinoma (ENCA) has poor prognosis and is increasing in developing countries. Human epiderm...
Nettle (Urtica Dioica L.) Modulates Angiogenesis by Targeting the PI3K/AKT/eNOS Pathway in Prostate Cancer
Background: Medicinal plants, predominantly those rich in polyphenolic mixtures, have been recommended to have chemopreven...
The Safety and Efficacy of Cold Atmospheric Plasma as a Novel Therapy: An in vivo Study
Background: Cold atmospheric plasma (CAP) may reduce bacteria and aid wound healing through reactive oxygen species. Recen...
Pediatric Pituitary Pituicytoma: A Case Report of Comprehensive Management
Pituicytoma, originated from pituicyte cells, is a rare pituitary tumor, especially in children. In 2007, this tumor was c...
Stromal Cell-Derived Factor1 Genetic Variation at Locus 801 in Patients with Endometrial Cancer
Background: The gene's 3′ untranslated region of stromal cell-derived factor1 (SDF-1/ CXC chemokine ligand 12 (CXCL12...
The Effect of Proton Pump Inhibitors on Metastatic Breast Cancer in Patients Treated with CDK4/6i
Background: This study aimed to assess the effect of proton pump inhibitors (PPIs) on hormone receptor-positive (HR+) and ...
Efficacy of Combined Bevacizumab and Angiotensin-Converting Enzyme Inhibitors or Angiotensin II type 1 Receptor Blockers in Metastatic Colorectal Cancer Patients
Background: Bevacizumab, used in the treatment of metastatic colorectal cancer (mCRC), has an angiogenesis inhibitory effe...
N-Nornuciferine Promotes Human Non-Small Cell Lung Cancer A549 Cells Apoptosis via miR-361-3p/TRAF2/JNK Axis
Background: N-Nornuciferine (N-NF) is an aporphine alkaloid in lotus leaf with a good resource for obtaining the biologica...
Exploring miR-30b Methylation and MALAT-1 Expression as Diagnostic Biomarkers for Non-Small Cell Lung Cancer
Background: Aberrant methylation and expression of various noncoding RNAs, including microRNAs (miRNAs) and long noncoding...
Management of HER2-Low Metastatic Breast Cancer: A Comprehensive Statement by an Expert Group from the Middle East and Africa Region
Approximately 50 to 67% of breast cancers (BCs), traditionally categorized as human epidermal growth factor receptor 2 (HE...
MLH1 Methylation-Based Testing in Peripheral Blood Mononuclear Cells is a Promising Biomarker for Colorectal Cancer Diagnosis and Prognosis
Background: Recent evidence has shown that peripheral blood mononuclear cells (PBMCs) can reflect the epigenetic profile o...
High Expression of Myosin ⅩⅥ Predicts Poor Prognosis in Head and Neck Squamous Cell Carcinoma
Background: Myosins, a superfamily of actin-dependent molecular motors, have emerged as crucial players in tumorigenesis. ...
Ozonated Aloe Vera Oil Accelerates Radiation Dermatitis Healing in Sprague Dawley Rats
Background: Radiation dermatitis is the most common side-effect of radiation therapy. The current daily therapy uses topic...
Clinical Benefits of Metronomic Chemotherapy in Platinum-Refractory, Recurrent, and Metastatic Head and Neck Squamous Cell Carcinoma
Background: Patients with platinum-refractory disease who experience early treatment failure of head and neck squamous cel...
Lysophosphatidylcholine Acyltransferase 1 (LPCAT1): A Predictor of Acute Leukemia Prognosis
Background: Lysophosphatidylcholine acyltransferases 1 (LPCAT1) overexpression and prognostic significance have been shown...
Positive Expression of IGFBP2 as a Novel Prognostic Biomarker for Patients with Lower-Grade Gliomas
Background: Previous studies have identified insulin-like growth factor-binding protein 2 (IGFBP2) as a target gene associ...
Aberrant DNA Methylation of FTH-1 and SHOX2 Contributes to Lung Cancer Progression
Background: Lung cancer is the most lethal malignancy in the world due to its poor prognosis. DNA methylation change has b...
Cytogenetics and Molecular Abnormalities in Pediatric Patients with Acute Myeloid Leukemia in a Referral Center in Tehran, Iran
Background: Acute myeloid leukemia (AML) accounts for 15%-20% of childhood leukemia. A variety of cytogenetic abnormalitie...
Identification of Breast Cancer Biomarkers by Constructing Protein-Protein Interaction and miRNAs-mRNAs Networks
Background: In cancer-related diseases, early detection and control of disease progression are very important for successf...
Endometriosis-associated Ovarian Cancer, from Risk Factors to Survival Rate: A Systematic Review and Meta-Analysis
Background: Endometriosis experts recommend monitoring patients until menopause before considering surgery, with concerns ...
Stereotactic Body Radiotherapy in Bulky Hepatocellular Carcinoma with Portal Vein Thrombosis: A Feasibility Review in an Egyptian Cohort
Background: Hepatocellular carcinoma (HCC) complicated by portal vein thrombosis presents significant clinical challenges....
Anticancer Activity of Holothuria Leucospilota-Derived Saponin on MNK45 Gastric Cancer Cell via Upregulation of CDH1 Hub Gene
Background: The treatment of gastric cancer (GC) is still quite challenging. Yet, marine invertebrates have been found to ...
Deciphering the Genetic Alterations in PIK3CA Gene Interacting Network and Their Putative Association with Breast Cancer: A Computational Approach
Background: Cancer is a polygenic complex disorder involving a network of genes. The phosphatidylinositol 3-kinase (PIK3CA...
The Implication of Chuang's Prognostic Scale in Metastatic Gastric Cancer
Background: Patients with metastatic gastric cancer (mGC) endure a significant symptom burden following subsequent lines o...
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