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Retraction Note: Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma
Department of Urology, The Third Medical Center, Chinese PLA General Hospital, 100853, Beijing, ChinaShengpan Wu, Baojun W...
Identification of RAPGEF3 as the therapeutic vulnerability of basal-subtype lung squamous cell carcinoma
Identification of RAPGEF3 as the therapeutic vulnerability of basal-subtype lung squamous cell carcinoma
Lung squamous cell carcinoma (LUSC), particularly the basal-subtype, remains a leading cause of cancer-related mortality, ...
ALDH1A3 promotes aggressive basal-like pancreatic cancer through an AP-1/RUNX2 enhancer network
ALDH1A3 promotes aggressive basal-like pancreatic cancer through an AP-1/RUNX2 enhancer network
The basal-like transcriptional subtype of pancreatic ductal adenocarcinoma (PDAC) is linked to therapy resistance and poor...
Retraction Note to: KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling
The Editors-in-Chief have retracted this article. After publication, concerns were raised regarding high image similaritie...
Coexistence of P53 and KRAS mutations enhances ERK1/2 signaling by inducing EGR1 expression through mutp53 and c-JUN interaction
Coexistence of P53 and KRAS mutations enhances ERK1/2 signaling by inducing EGR1 expression through mutp53 and c-JUN interaction
The ERK1/2 signaling pathway, one of the most frequently dysregulated oncogenic pathways, can be initiated by diverse muta...
Activated MAFB in ovarian cancer promotes cytoskeletal remodeling and immune microenvironment suppression by interfering with m6A modifications through WTAP competition
Activated MAFB in ovarian cancer promotes cytoskeletal remodeling and immune microenvironment suppression by interfering with m6A modifications through WTAP competition
The tumor microenvironment (TME) coordinates cancer progression through complex transcriptional networks, but the molecula...
Immune evasion from macrophages by NEAT1-induced CD24 in liver cancer
Immune evasion from macrophages by NEAT1-induced CD24 in liver cancer
The limited efficacy of immune checkpoint inhibitors in hepatocellular carcinoma (HCC) can arise from the involvement of i...
Chromosomal abnormalities of mesenchymal stromal cells in hematological malignancies
Chromosomal abnormalities of mesenchymal stromal cells in hematological malignancies
Historically, hematological malignancies (HMs) and solid cancers were primarily attributed to cell-intrinsic mechanisms. H...
Editorial Expression of Concern: DCAF12 promotes apoptosis and inhibits NF-κB activation by acting as an endogenous antagonist of IAPs
The Editors-in-Chief are issuing this Editorial Expression of Concern to alert readers that concerns have been raised abou...
Lack of dominant-negative activity for tumor-related ZNRF3 missense mutations at endogenous levels
Lack of dominant-negative activity for tumor-related ZNRF3 missense mutations at endogenous levels
ZNRF3, a negative regulator of β-catenin signaling, removes Wnt receptors from the membrane. Currently, it is unknown...
Identification of novel germline mutations in FUT7 and EXT1 linked with hereditary multiple exostoses
Identification of novel germline mutations in FUT7 and EXT1 linked with hereditary multiple exostoses
Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder primarily linked with mutations in Exostosi...
Mitochondrial unfolded protein response-dependent β-catenin signaling promotes neuroendocrine prostate cancer
Mitochondrial unfolded protein response-dependent β-catenin signaling promotes neuroendocrine prostate cancer
The mitochondrial unfolded protein response (UPRmt) maintains mitochondrial quality control and proteostasis under stress ...
PRMT5-regulated splicing of DNA repair genes drives chemoresistance in breast cancer stem cells
PRMT5-regulated splicing of DNA repair genes drives chemoresistance in breast cancer stem cells
Breast cancer stem cells (BCSCs) are a rare cell population that is responsible for tumour initiation, metastasis and chem...
A TBX2-driven signaling switch from androgen receptor to glucocorticoid receptor confers therapeutic resistance in prostate cancer
A TBX2-driven signaling switch from androgen receptor to glucocorticoid receptor confers therapeutic resistance in prostate cancer
Recent studies suggest that glucocorticoid receptor (GR) activation can cause enzalutamide resistance in advanced prostate...
CBL0137 and NKG2A blockade: a novel immuno-oncology combination therapy for Myc-overexpressing triple-negative breast cancers
CBL0137 and NKG2A blockade: a novel immuno-oncology combination therapy for Myc-overexpressing triple-negative breast cancers
The MYC proto-oncogene is upregulated in >60% of triple-negative breast cancers (TNBCs), it can directly promote tu...
Mevalonate kinase inhibits anti-tumor immunity by impairing the tumor cell-intrinsic interferon response in microsatellite instability colorectal cancer
Mevalonate kinase inhibits anti-tumor immunity by impairing the tumor cell-intrinsic interferon response in microsatellite instability colorectal cancer
Insufficient tumor cell-intrinsic interferon response represents a major obstacle in immune checkpoint blockade (ICB) ther...
MYC upstream region orchestrates resistance to PI3K inhibitors in cancer cells through FOXO3a-mediated autophagic adaptation
MYC upstream region orchestrates resistance to PI3K inhibitors in cancer cells through FOXO3a-mediated autophagic adaptation
The MYC oncogene is frequently overexpressed in tumors and inhibition of its translation is considered an attractive thera...
Enhanced anti-cancer efficacy of arginine deaminase expressed by tumor-seeking Salmonella Gallinarum
Enhanced anti-cancer efficacy of arginine deaminase expressed by tumor-seeking Salmonella Gallinarum
Amino acid deprivation, particularly of nonessential amino acids that can be synthesized by normal cells but not by cancer...
Characterisation of APOBEC3B-Mediated RNA editing in breast cancer cells reveals regulatory roles of NEAT1 and MALAT1 lncRNAs
Characterisation of APOBEC3B-Mediated RNA editing in breast cancer cells reveals regulatory roles of NEAT1 and MALAT1 lncRNAs
RNA editing is a crucial post-transcriptional process that influences gene expression and increases the diversity of the p...
Correction: Targeting MERTK on tumour cells and macrophages: a potential intervention for sporadic and NF2-related meningioma and schwannoma tumours
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 ...
Insight into mammary gland development and tumor progression in an E2F5 conditional knockout mouse model
Insight into mammary gland development and tumor progression in an E2F5 conditional knockout mouse model
Development of breast cancer is linked to altered regulation of mammary gland developmental processes. A better understand...
Hypoxic stabilization of RIPOR3 mRNA via METTL3-mediated m6A methylation drives breast cancer progression and metastasis
Hypoxic stabilization of RIPOR3 mRNA via METTL3-mediated m6A methylation drives breast cancer progression and metastasis
Dysregulated N6-methyladenosine (m6A) modification has been associated with breast cancer pathogenesis. Hypoxia which char...
Targeting CircAURKA prevents colorectal cancer progression via enhancing CTNNB1 protein degradation
Targeting CircAURKA prevents colorectal cancer progression via enhancing CTNNB1 protein degradation
Tumor progression of colorectal cancer (CRC) seriously affects patient prognosis. For CRC patients with advanced-stage dis...
USP36 promotes colorectal cancer progression through inhibition of p53 signaling pathway via stabilizing RBM28
USP36 promotes colorectal cancer progression through inhibition of p53 signaling pathway via stabilizing RBM28
Colorectal cancer (CRC) stands as the second most common cause of cancer-related mortality globally and p53, a widely reco...
E7-mediated repression of miR-203 promotes LASP1-dependent proliferation in HPV-positive cervical cancer
E7-mediated repression of miR-203 promotes LASP1-dependent proliferation in HPV-positive cervical cancer
Human papillomaviruses (HPV) are a major cause of malignancy, contributing to ~5% of all human cancers worldwide, includin...
Molecular mechanisms of non-genetic aberrant peptide production in cancer
Molecular mechanisms of non-genetic aberrant peptide production in cancer
The cancer peptidome has long been known to be altered by genetic mutations. However, more recently, non-genetic polypepti...
Bone-metastatic lung adenocarcinoma cells bearing CD74-ROS1 fusion interact with macrophages to promote their dissemination
Bone-metastatic lung adenocarcinoma cells bearing CD74-ROS1 fusion interact with macrophages to promote their dissemination
Approximately 40% of patients with lung adenocarcinoma (LUAD) often develop bone metastases during the course of their dis...
MUC1-C regulates NEAT1 lncRNA expression and paraspeckle formation in cancer progression
MUC1-C regulates NEAT1 lncRNA expression and paraspeckle formation in cancer progression
The MUC1 gene evolved in mammals for adaptation of barrier tissues in response to infections and damage. Paraspeckles are ...
Trans-activating mutations of the pseudokinase ERBB3
Trans-activating mutations of the pseudokinase ERBB3
Genetic changes in the ERBB family of receptor tyrosine kinases serve as oncogenic driver events and predictive biomarkers...
Antitumor activity of Z15-0-2, a bispecific nanobody targeting PD-1 and CTLA-4
Antitumor activity of Z15-0-2, a bispecific nanobody targeting PD-1 and CTLA-4
The combination of programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) antibodies has pot...
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