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Neurocognitive function in lower grade glioma patients selected for proton radiotherapy: real-world data from a prospective cohort study
Neurocognitive function in lower grade glioma patients selected for proton radiotherapy: real-world data from a prospective cohort study
To determine neurocognitive function (NCF) profiles of patients with lower grade glioma (LGG) eligible to undergo proton r...
Prognostic revalidation of RANO categories for extent of resection in glioblastoma: a reconstruction of individual patient data
Prognostic revalidation of RANO categories for extent of resection in glioblastoma: a reconstruction of individual patient data
The RANO classification for glioblastoma defines resection categories based on volumetric tumor assessments, aiming to sta...
RAPID, a multicenter collaboration for the study of craniopharyngiomas: challenges, opportunities, and future directions
RAPID, a multicenter collaboration for the study of craniopharyngiomas: challenges, opportunities, and future directions
Competing interests Dr. Little was an investor in Kogent Surgical a...
Comparison of adjuvant radiation versus observation and salvage radiation after subtotal resection of a WHO grade I skull base meningioma: a propensity score-adjusted analysis
Comparison of adjuvant radiation versus observation and salvage radiation after subtotal resection of a WHO grade I skull base meningioma: a propensity score-adjusted analysis
In patients with subtotal resection (STR) of WHO grade I skull base meningiomas, treatment strategies of adjuvant radiatio...
The association between postoperative photon radiotherapy dose and disease control and salvage treatment in pediatric and adolescent ependymoma: a multi-institutional investigation
The association between postoperative photon radiotherapy dose and disease control and salvage treatment in pediatric and adolescent ependymoma: a multi-institutional investigation
We characterized the association between photon radiation dose (< 59.4 versus ≥ 59.4 Gy)...
Establishment and transcriptomic characteristics of radio-resistant meningioma cell lines
Establishment and transcriptomic characteristics of radio-resistant meningioma cell lines
Radio-resistance poses a significant challenge in meningioma treatment. This study aimed to establish radio-resistant meni...
Clinical predictors of overall survival in very elderly meningioma patients: a surveillance, epidemiology, and end results (SEER) database analysis
Clinical predictors of overall survival in very elderly meningioma patients: a surveillance, epidemiology, and end results (SEER) database analysis
Surgical resection is the gold standard of management for symptomatic intracranial meningiomas. However, surgical interven...
Ciprofol reduces postoperative glioma recurrence by promoting MAPK11-PML phosphorylation: insights from transcriptomic and proteomic analysis
Ciprofol reduces postoperative glioma recurrence by promoting MAPK11-PML phosphorylation: insights from transcriptomic and proteomic analysis
Glioma, the most common malignant tumor of the central nervous system, has a high postoperative recurrence rate. While Cip...
Improving IL12 immunotherapy in glioblastoma by targeting the long noncoding RNA
Improving IL12 immunotherapy in glioblastoma by targeting the long noncoding RNA
The potent antitumor effects of interleukin 12 (IL12) gene therapy in glioblastoma (GBM) are significantly attenuated by t...
Current clinical trials for craniopharyngiomas: what’s on the horizon?
Current clinical trials for craniopharyngiomas: what’s on the horizon?
Craniopharyngiomas are histologically low-grade tumors in the sellar/suprasellar region that grow close to critical struct...
Extra-central nervous system metastasis from high-grade glioma: a single-institution experience
Extra-central nervous system metastasis from high-grade glioma: a single-institution experience
Extra-central nervous system metastasis (ECM) from glioblastoma and other high-grade gliomas (HGGs) is exceedingly rare, l...
Peritumoral edema resolves infrequently in surgically treated patients with intracranial meningioma– a retrospective study of 279 meningioma patients
Peritumoral edema resolves infrequently in surgically treated patients with intracranial meningioma– a retrospective study of 279 meningioma patients
The resolution of peritumoral brain edema (PTBE) following surgery for intracranial meningioma (IM) is poorly understood. ...
Characterizing the molecular and spatial heterogeneity of midline gliomas in adults: a single institution analysis
Characterizing the molecular and spatial heterogeneity of midline gliomas in adults: a single institution analysis
Primary gliomas arising within midline structures of the central nervous system are associated with a worse prognosis comp...
Gene therapy and genome-editing for schwannoma in -related schwannomatosis: current understanding and future directions
Gene therapy and genome-editing for schwannoma in -related schwannomatosis: current understanding and future directions
NF2-related schwannomatosis (NF2-SWN) is a rare genetic disorder characterized by bilateral vestibular schwannomas. NF2-SW...
The 4S of spinal astrocytoma: specific location, syrinx, spasticity and score on Modified Mccormick Scale (MMS) predict long term outcomes in patients undergoing surgical resection of intramedullary spinal astrocytomas
The 4S of spinal astrocytoma: specific location, syrinx, spasticity and score on Modified Mccormick Scale (MMS) predict long term outcomes in patients undergoing surgical resection of intramedullary spinal astrocytomas
The aim of this study was to explore the factors that could predict long term clinical outcomes in SA. A retrospective stu...
Clinical trial design for novel targeted agents in neuro-oncology
Clinical trial design for novel targeted agents in neuro-oncology
Biomarker-based clinical trials investigating targeted treatments for brain tumors have surged due to better access to bio...
Impact of upfront adjuvant chemoradiation on survival in patients with molecularly defined oligodendroglioma: the benefits of PCV over TMZ
Impact of upfront adjuvant chemoradiation on survival in patients with molecularly defined oligodendroglioma: the benefits of PCV over TMZ
Oligodendroglioma is an adult-type diffuse glioma defined by 1p/19q codeletion and IDH1/2 mutation. Treatment includes sur...
Advanced imaging reveals enhanced malignancy in glioblastomas involving the subventricular zone: evidence of increased infiltrative growth and perfusion
Advanced imaging reveals enhanced malignancy in glioblastomas involving the subventricular zone: evidence of increased infiltrative growth and perfusion
Glioblastoma’s infiltrative growth and heterogeneity are influenced by neural, molecular, genetic, and immunological...
In-patient neurosurgical tumor treatments for malignant glioma patients in Germany
In-patient neurosurgical tumor treatments for malignant glioma patients in Germany
Treatment for malignant gliomas involves multiple disciplines, including neurosurgery, radiation therapy, medical and neur...
Development and application of explainable artificial intelligence using machine learning classification for long-term facial nerve function after vestibular schwannoma surgery
Development and application of explainable artificial intelligence using machine learning classification for long-term facial nerve function after vestibular schwannoma surgery
Vestibular schwannomas (VSs) represent the most common cerebellopontine angle tumors, posing a challenge in preserving fac...
Brain volume loss after cranial irradiation: a controlled comparison study between photon vs proton radiotherapy for WHO grade 2–3 gliomas
Brain volume loss after cranial irradiation: a controlled comparison study between photon vs proton radiotherapy for WHO grade 2–3 gliomas
Radiation therapy (RT) is an integral treatment component in patients with glioma but associated with neurotoxicity. Proto...
Social media “SoMe” in neuro-oncology: a review of the literature
Social media “SoMe” in neuro-oncology: a review of the literature
This article examines the current state of social media (SoMe) in neuro-oncology and neurosurgical oncology. The goal of t...
Congress of Neurological Surgeons systematic review and evidence‑based guidelines on the management of recurrent diffuse low-grade glioma: update
Congress of Neurological Surgeons systematic review and evidence‑based guidelines on the management of recurrent diffuse low-grade glioma: update
Target population These recommendations apply to adult patients with recurrent WHO grade 2 infiltrative diffuse glioma (ol...
Comparative analysis of hypofractionated short-course versus standard radiation therapy in elderly patients with glioblastoma: analysis of nationwide database
Comparative analysis of hypofractionated short-course versus standard radiation therapy in elderly patients with glioblastoma: analysis of nationwide database
Hypofractionated short-course radiation therapy (SCRT) is an alternative treatment option for elderly or frail patients wi...
Quality of life after stereotactic radiosurgery for brain metastasis: an assessment from a prospective national registry
Quality of life after stereotactic radiosurgery for brain metastasis: an assessment from a prospective national registry
Stereotactic radiosurgery (SRS) is frequently used in the management of brain metastasis patients. However, there is an ur...
A multi-center, clinical analysis of IDH-mutant gliomas, WHO Grade 4: implications for prognosis and clinical trial design
A multi-center, clinical analysis of IDH-mutant gliomas, WHO Grade 4: implications for prognosis and clinical trial design
Mutations in the Isocitrate Dehydrogenase (IDH) genes, IDH1 or IDH2, define a group of adult diffuse gliomas associated wi...
Targeting the RAS/MAPK pathway in children with glioma
Targeting the RAS/MAPK pathway in children with glioma
Pediatric gliomas are the most common brain tumor in children, encompassing both low-grade glioma (pLGG) and high-grade gl...
Intraoperative radiotherapy combined with spinal stabilization surgery—a novel treatment strategy for spinal metastases based on a first single-center experiences
Intraoperative radiotherapy combined with spinal stabilization surgery—a novel treatment strategy for spinal metastases based on a first single-center experiences
Current treatment of spinal metastases (SM) aims on preserving spinal stability, neurological status, and functional statu...
Suberanilohydroxamic acid (SAHA), a HDAC inhibitor, suppresses the effect of Treg cells by targeting the c-Myc/CCL1 pathway in glioma stem cells and improves PD-L1 blockade therapy
Suberanilohydroxamic acid (SAHA), a HDAC inhibitor, suppresses the effect of Treg cells by targeting the c-Myc/CCL1 pathway in glioma stem cells and improves PD-L1 blockade therapy
A strong immunosuppressive tumor microenvironment (TME) represents the major barrier responsible for the failure of curren...
Neuroradiological features of patients with bilateral macronodular adrenocortical disease and meningiomas associated or not with genetic variants of ARMC5– a case series
Neuroradiological features of patients with bilateral macronodular adrenocortical disease and meningiomas associated or not with genetic variants of ARMC5– a case series
Meningiomas are the most common primary brain and central nervous system tumors, accounting for approximately 40% of these...
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