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Personalized oncology in pheochromocytomas and paragangliomas: integrating genetic analysis with machine learning
Personalized oncology in pheochromocytomas and paragangliomas: integrating genetic analysis with machine learning
Pheochromocytomas and paragangliomas (PCCs/PGLs) are uncommon neuroendocrine tumors with a significant genetic tendency. A...
Current evidence on patient precautions for reducing breast cancer-related lymphedema manifestation and progression risks
Current evidence on patient precautions for reducing breast cancer-related lymphedema manifestation and progression risks
Risk management and self-management strategies for breast cancer-related lymphedema (BCRL) must balance best-evidence guid...
Essential components of the maintenance phase of complex decongestive therapy
Essential components of the maintenance phase of complex decongestive therapy
Complex decongestive therapy is the current gold standard for non-surgical clinical lymphedema management and consists of ...
The effect of compression therapies and therapeutic modalities on lymphedema secondary to cancer: a rapid review and evidence map
The effect of compression therapies and therapeutic modalities on lymphedema secondary to cancer: a rapid review and evidence map
The identification of effective therapeutic modalities to manage lymphedema secondary to cancer is a high priority among p...
Recent advancements in cGAS-STING activation, tumor immune evasion, and therapeutic implications
Recent advancements in cGAS-STING activation, tumor immune evasion, and therapeutic implications
The cGAS-STING signaling pathway is indeed a pivotal component of the immune system and serve as a crucial link between in...
Advancements in long non-coding RNA-based therapies for cancer: targeting, delivery, and clinical implications
Advancements in long non-coding RNA-based therapies for cancer: targeting, delivery, and clinical implications
Long non-coding RNAs (lncRNAs) have been in the spotlight for the past two decades due to their extensive role in regulati...
Introducing the ELPIS scale: a novel tool for measuring emotional empathy toward cancer patients
Introducing the ELPIS scale: a novel tool for measuring emotional empathy toward cancer patients
Empathy, defined as the ability to understand and share another person’s feelings, is crucial in the healthcare sett...
siRNA-based strategies to combat drug resistance in gastric cancer
siRNA-based strategies to combat drug resistance in gastric cancer
Chemotherapy is a key treatment option for gastric cancer, but over 50% of patients develop either inherent or acquired re...
Transforming cancer detection and treatment with nanoflowers
Transforming cancer detection and treatment with nanoflowers
Nanoflowers, an innovative class of nanoparticles with a distinctive flower-like structure, have garnered significant inte...
Inhibition of STAT3-NF-κB pathway facilitates SSPH I-induced ferroptosis in HepG2 cells
Inhibition of STAT3-NF-κB pathway facilitates SSPH I-induced ferroptosis in HepG2 cells
Hepatocellular carcinoma (HCC), a highly lethal solid tumor, has shown responsiveness to ferroptosis inducers, presenting ...
A study with cancer stem cells and three-dimensional tumoroids: investigation of the combined effects of 5-fluorouracil and doxorubicin in breast cancer
A study with cancer stem cells and three-dimensional tumoroids: investigation of the combined effects of 5-fluorouracil and doxorubicin in breast cancer
The purpose of the present study was in vitro determination of the combined effects of doxorubucin and 5-fluorouracil by 2...
Genipin’s potential as an anti-cancer agent: from phytochemical origins to clinical prospects
Genipin’s potential as an anti-cancer agent: from phytochemical origins to clinical prospects
This comprehensive review delves into the multifaceted aspects of genipin, a bioactive compound derived from medicinal pla...
A drug repurposing study identifies novel FOXM1 inhibitors with in vitro activity against breast cancer cells
A drug repurposing study identifies novel FOXM1 inhibitors with in vitro activity against breast cancer cells
FOXM1, a proto-oncogenic transcription factor, plays a critical role in cancer development and treatment resistance in can...
The role of IL-17 in the pathogenesis and treatment of glioblastoma—an update on the state of the art and future perspectives
The role of IL-17 in the pathogenesis and treatment of glioblastoma—an update on the state of the art and future perspectives
Glioblastoma (GBM) is the most common malignant brain tumor, which, despite significant progress made in the last years in...
The role of histamine and its receptors in breast cancer: from pathology to therapeutic targets
The role of histamine and its receptors in breast cancer: from pathology to therapeutic targets
Breast cancer is the most common malignancy in women, and despite the development of new treatment methods and the decreas...
CTLA-4 silencing could promote anti-tumor effects in hepatocellular
CTLA-4 silencing could promote anti-tumor effects in hepatocellular
Preclinical and clinical research showed that immune checkpoint blockade provides beneficial effects for many patients wit...
Role of ZNF334 in cervical cancer: implications for EMT reversal and tumor suppression
Role of ZNF334 in cervical cancer: implications for EMT reversal and tumor suppression
Zinc-finger proteins are involved in many biological processes. However, the role of Zinc-finger protein 334 (ZNF334) in c...
Molecular pathway of anticancer effect of next-generation HSP90 inhibitors XL-888 and Debio0932 in neuroblastoma cell line
Molecular pathway of anticancer effect of next-generation HSP90 inhibitors XL-888 and Debio0932 in neuroblastoma cell line
Neuroblastoma is a common nervous system tumor in childhood, and current treatments are not adequate. HSP90 is a molecular...
A phase-I study of second-line S-IROX for unresectable pancreatic cancer after gemcitabine plus nab-paclitaxel failure
A phase-I study of second-line S-IROX for unresectable pancreatic cancer after gemcitabine plus nab-paclitaxel failure
Gemcitabine plus nab-paclitaxel (GnP) and FOLFIRINOX are widely used as first-line regimens for unresectable pancreatic ca...
Possible protective effect of rosuvastatin in chemotherapy-induced cardiotoxicity in HER2 positive breast cancer patients: a randomized controlled trial
Possible protective effect of rosuvastatin in chemotherapy-induced cardiotoxicity in HER2 positive breast cancer patients: a randomized controlled trial
Cardiotoxicity is a side effect of chemotherapy in human epidermal growth factor receptor 2 (HER2) positive breast cancer ...
Molecular docking aided machine learning for the identification of potential VEGFR inhibitors against renal cell carcinoma
Molecular docking aided machine learning for the identification of potential VEGFR inhibitors against renal cell carcinoma
Renal cell carcinoma is a highly vascular tumor associated with vascular endothelial growth factor (VEGF) expression. The ...
Utilization of neoadjuvant chemotherapy for muscle-invasive bladder cancer in elderly patients: a retrospective cohort study
Utilization of neoadjuvant chemotherapy for muscle-invasive bladder cancer in elderly patients: a retrospective cohort study
Neoadjuvant chemotherapy (NAC) improves overall survival in muscle-invasive bladder cancer (MIBC). Older patients often do...
Small molecule inhibitors of the VEGF and tyrosine kinase for the treatment of cervical cancer
Small molecule inhibitors of the VEGF and tyrosine kinase for the treatment of cervical cancer
Cervical cancer accounts for most deaths due to cancer in women, majorly in developing nations. The culprit behind this di...
Anti-cancer potential of casein and its derivatives: novel strategies for cancer treatment
Anti-cancer potential of casein and its derivatives: novel strategies for cancer treatment
Cancer is one of the leading causes of death worldwide, with over 10 million fatalities annually. While tumors ca...
Targeting the pancreatic tumor microenvironment by plant-derived products and their nanoformulations
Targeting the pancreatic tumor microenvironment by plant-derived products and their nanoformulations
Pancreatic cancer remains a significant health issue with limited treatment options. The tumor stroma, a complex environme...
The multifaceted role of PCSK9 in cancer pathogenesis, tumor immunity, and immunotherapy
The multifaceted role of PCSK9 in cancer pathogenesis, tumor immunity, and immunotherapy
Proprotein convertase subtilisin/kexin type 9 (PCSK9), a well-known regulator of cholesterol metabolism and cardiovascular...
The combined anti-tumor effects of 5-fluorouracil and neurokinin receptor inhibitor, aprepitant, against colorectal cancer: In vitro and in vivo study
The combined anti-tumor effects of 5-fluorouracil and neurokinin receptor inhibitor, aprepitant, against colorectal cancer: In vitro and in vivo study
Colorectal cancer (CRC) is one of the world’s largest health concerns with growing global incidence and mortality. T...
CRP inhibits the osteoblastic differentiation of OPCs via the up-regulation of primary cilia and repression of the Hedgehog signaling pathway
CRP inhibits the osteoblastic differentiation of OPCs via the up-regulation of primary cilia and repression of the Hedgehog signaling pathway
Inflammation disrupts bone metabolism and leads to bone damage. C-reactive protein (CRP) is a typical inflammation marker....
Advancements in biosensors for cancer detection: revolutionizing diagnostics
Advancements in biosensors for cancer detection: revolutionizing diagnostics
Cancer stands as the reigning champion of life-threatening diseases, casting a shadow with the highest global mortality ra...
Clinical significance of blocking novel immune checkpoint B7-H4 in urothelial carcinoma of bladder as a potential therapeutic target
Clinical significance of blocking novel immune checkpoint B7-H4 in urothelial carcinoma of bladder as a potential therapeutic target
Urothelial Carcinoma of Bladder is complex disease with high mortality and recurrence rates. Current standard regimes have...
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