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Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime
Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime
Duchenne muscular dystrophy (DMD) is associated with distinct mitochondrial stress responses. Here, we aimed to determine ...
Ion dynamics and the regulation of circadian cellular physiology
Ion dynamics and the regulation of circadian cellular physiology
Circadian rhythms in physiology and behaviour allow organisms to anticipate the daily environmental changes imposed by the...
The role of intracellular calcium and Rho kinase pathways in G protein-coupled receptor-mediated contractions of urinary bladder urothelium and lamina propria.
The role of intracellular calcium and Rho kinase pathways in G protein-coupled receptor-mediated contractions of urinary bladder urothelium and lamina propria.
The influence of extracellular and intracellular calcium (Ca2+) on smooth muscle contractile activity varies between organ...
Editorial: Special section on inward rectifier potassium channels
Editorial: Special section on inward rectifier potassium channels
* Corresponding Author; email: [email protected]1Anesthesiology, Department of Pharmacology, Vanderbilt University, Nashvi...
Circulating microRNAs associated with non-alcoholic fatty liver disease
Circulating microRNAs associated with non-alcoholic fatty liver disease
MicroRNAs (miRNAs) are secreted from cells as either protein bound or enclosed in extracellular vesicles. Circulating live...
Glycolytic side pathways regulating macrophage inflammatory phenotypes and functions
Glycolytic side pathways regulating macrophage inflammatory phenotypes and functions
Macrophages are crucial effector cells of the innate immune system and have important roles in the initiation and resoluti...
Molecular and cellular basis of praziquantel action in the cardiovascular system
Molecular and cellular basis of praziquantel action in the cardiovascular system
The anthelmintic drug praziquantel (PZQ) causes contraction of parasitic schistosomes, as well as constriction of blood ve...
Resident muscle stem myogenic characteristics in postnatal muscle growth impairments in children with cerebral palsy
Resident muscle stem myogenic characteristics in postnatal muscle growth impairments in children with cerebral palsy
Children with cerebral palsy (CP), have impaired postnatal muscle growth, with some muscles developing contractures. Funct...
The lactate receptor GPR81 is predominantly expressed in type II human skeletal muscle fibers: potential for lactate autocrine signaling
The lactate receptor GPR81 is predominantly expressed in type II human skeletal muscle fibers: potential for lactate autocrine signaling
GPR81 was first identified in adipocytes as a receptor for L-lactate, which upon binding inhibits cAMP-PKA-CREB signaling....
MicroRNA-30e-3p reduces coronary microembolism-induced cardiomyocyte pyroptosis and inflammation by sequestering HDAC2 from the SMAD7 promoter
MicroRNA-30e-3p reduces coronary microembolism-induced cardiomyocyte pyroptosis and inflammation by sequestering HDAC2 from the SMAD7 promoter
Objective: This study investigates the mechanism by which microRNA (miR)-30e-3p reduces coronary microembolism (CME)-induc...
Cellularity in bone marrow autografts for bone and fracture healing
Cellularity in bone marrow autografts for bone and fracture healing
The use of autografts, as primary cell and tissue source is the current gold standard approach to treat critical size bone...
Non-steroidal anti-inflammatory drugs and implications for the cyclooxygenase pathway in embryonic development
Non-steroidal anti-inflammatory drugs and implications for the cyclooxygenase pathway in embryonic development
Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of analgesics that inhibit the activity of cyclooxygenase isoen...
Succinate-SUCNR1 induces renal tubular cell apoptosis
Succinate-SUCNR1 induces renal tubular cell apoptosis
Succinate has long been known to be only an intermediate product of the tricarboxylic acid cycle until identified as a nat...
Evolving roles of activins and inhibins in ovarian cancer pathophysiology
Evolving roles of activins and inhibins in ovarian cancer pathophysiology
Activins and Inhibins are unique members of the Transforming Growth Factor-b (TGFb) family of growth factors, with the abi...
Gender Differences in GRK2 in Cardiovascular Diseases and its Interactions with Estrogen
Gender Differences in GRK2 in Cardiovascular Diseases and its Interactions with Estrogen
G protein-coupled receptor kinase 2 (GRK2) is a multifunctional protein involved in regulating G protein-coupled receptor ...
miR-542-5p Targets c-myc and Negates the Cell Proliferation Effect of SphK1 in Intestinal Epithelial Cells
miR-542-5p Targets c-myc and Negates the Cell Proliferation Effect of SphK1 in Intestinal Epithelial Cells
Intestinal epithelial barrier defects occur commonly during a variety of pathological conditions, though their underlying ...
Physiology of chemokines in the cancer microenvironment
Physiology of chemokines in the cancer microenvironment
Chemokines are chemotactic cytokines whose canonical functions govern movement of receptor-expressing cells along chemical...
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