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Growth hormone-releasing hormone signaling and manifestations within the cardiovascular system
Growth hormone-releasing hormone signaling and manifestations within the cardiovascular system
Growth hormone (GH)-releasing hormone (GHRH), a hypothalamic peptide initially characterized for its role in GH regulation...
The differential diagnosis of adrenocortical tumors: systematic review of Ki-67 and IGF2 and meta-analysis of Ki-67
The differential diagnosis of adrenocortical tumors: systematic review of Ki-67 and IGF2 and meta-analysis of Ki-67
Distinguishing benign from malignant adrenocortical tumors (ACT) is not always easy, particularly for tumors with unclear ...
Complexity in the interpretation and application of multiple guidelines for thyroid nodules: the need for coordinated recommendations for “small” lesions
Complexity in the interpretation and application of multiple guidelines for thyroid nodules: the need for coordinated recommendations for “small” lesions
Multiple guidelines for thyroid nodule management have been developed by endocrinologists, often in collaboration with sur...
From pituitary cells to prostate gland in health and disease: direct and indirect endocrine connections
From pituitary cells to prostate gland in health and disease: direct and indirect endocrine connections
The prostate gland is an endocrine-sensitive organ responding to multiple stimuli. Its development and function are regula...
Sheer drop ahead: reviewing sarcopenia outcomes in elderly patients undergoing bariatric surgery
Sheer drop ahead: reviewing sarcopenia outcomes in elderly patients undergoing bariatric surgery
The global prevalence of obesity among elderly patients continues to rise. Despite the availability of new antiobesity med...
Growth hormone-releasing hormone receptor (GHRH-R) and its signaling
Growth hormone-releasing hormone receptor (GHRH-R) and its signaling
The hypothalamic polypeptide growth hormone-releasing hormone (GHRH) stimulates the secretion of growth hormone (GH) from ...
Rathke’s cleft cyst: From history to molecular genetics
Rathke’s cleft cyst: From history to molecular genetics
A Rathke’s cleft cyst (RCC) is a remnant of the embryologic Rathke’s pouch and a common pituitary lesion. A tr...
Are strategies to increase muscle mass and strength as effective in people with type 2 diabetes?
Are strategies to increase muscle mass and strength as effective in people with type 2 diabetes?
People with type 2 diabetes (T2D) have a 2–3-time higher risk of developing sarcopenia, a musculoskeletal disease ma...
Melatonin administration on bone properties of animals under hypoestrogenism: A systematic review
Melatonin administration on bone properties of animals under hypoestrogenism: A systematic review
Purpose: Hypoestrogenism is associated with loss of bone mass and strength. Melatonin has become a strategy due to its act...
Skeletal muscle atrophy and dysfunction in obesity and type-2 diabetes mellitus: Myocellular mechanisms involved
Skeletal muscle atrophy and dysfunction in obesity and type-2 diabetes mellitus: Myocellular mechanisms involved
Obesity and type-2 diabetes mellitus (T2DM) are interrelated metabolic disorders primarily driven by overnutrition and phy...
Cancer screening in patients with acromegaly: a plea for a personalized approach and international registries
Cancer screening in patients with acromegaly: a plea for a personalized approach and international registries
Acromegaly is a rare condition, and often diagnosis is delayed by several years, for most patients. Acromegaly is characte...
Mention to Prof. Andrew V. Schally
Mention to Prof. Andrew V. Schally
1.1 GHRH: The first 50 yearsHalf a century has passed since the discovery of growth hormone-releasing hormone (GHRH), a gr...
Insulin icodec: A novel once-weekly formulation for the treatment of type 1 and type 2 diabetes mellitus
Insulin icodec: A novel once-weekly formulation for the treatment of type 1 and type 2 diabetes mellitus
Insulin icodec is a novel once-weekly basal insulin analog subcutaneous injection seeking approval by the United States Fo...
Incretins and SGLT-2 inhibitors in diabetic patients with neuroendocrine tumors: current updates and future directions
Incretins and SGLT-2 inhibitors in diabetic patients with neuroendocrine tumors: current updates and future directions
Neuroendocrine tumors (NET) are frequently associated with glycemic disorders, such as prediabetes or diabetes, which may ...
Ectopic GHRH production: revisiting a rare cause of acromegaly
Ectopic GHRH production: revisiting a rare cause of acromegaly
Growth Hormone-Releasing Hormone (GHRH) is a hypothalamic hormone that stimulates GH secretion by the anterior pituitary g...
Childhood obesity: The threatening apprentice of the adiposity empire
Childhood obesity: The threatening apprentice of the adiposity empire
Childhood obesity is a global health problem, with its prevalence having tripled since 1975. The increase in its prevalenc...
The science of bioelectrical impedance-derived phase angle: insights from body composition in youth
The science of bioelectrical impedance-derived phase angle: insights from body composition in youth
Despite bioelectrical impedance analysis (BIA)-derived phase angle (PhA) being recognized as a global marker of health, re...
Surgical outcomes of partial adrenalectomy for pheochromocytoma: A systematic review and meta-analysis
Surgical outcomes of partial adrenalectomy for pheochromocytoma: A systematic review and meta-analysis
The purpose of our study was to evaluate the efficacy and safety of partial adrenalectomy (PA) in the management ...
Effectiveness and safety of continuous subcutaneous hydrocortisone infusion in managing adrenocortical insufficiency in adult patients: a systematic review
Effectiveness and safety of continuous subcutaneous hydrocortisone infusion in managing adrenocortical insufficiency in adult patients: a systematic review
Oral hormone replacement therapy has been and continues to be the cornerstone of adrenocortical insufficiency management. ...
Continuous glucose monitoring in patients with inherited metabolic disorders at risk for Hypoglycemia and Nutritional implications
Continuous glucose monitoring in patients with inherited metabolic disorders at risk for Hypoglycemia and Nutritional implications
Managing Inherited Metabolic Disorders (IMDs) at risk for hypoglycemia, such as Glycogen Storage Diseases (GSDs), Heredita...
Iron homeostasis and insulin sensitivity: unraveling the complex interactions
Iron homeostasis and insulin sensitivity: unraveling the complex interactions
Diabetes has arisen as a noteworthy global health issue, marked by escalating incidence and mortality rates. Insulin, cruc...
Primary hyperparathyroidism: from guidelines to outpatient clinic
Primary hyperparathyroidism: from guidelines to outpatient clinic
Primary hyperparathyroidism (PHPT) is a common endocrine disease characterized by hypercalcemia due to inappropriately hig...
Growth hormone – releasing hormone in the immune system
Growth hormone – releasing hormone in the immune system
GHRH is a neuropeptide associated with a diverse variety of activities in human physiology and immune responses. The prese...
Clinical research progress on β-cell dysfunction in T2DM development in the Chinese population
Clinical research progress on β-cell dysfunction in T2DM development in the Chinese population
The prevalence of type-2 diabetes mellitus (T2DM) has increased over 10-fold in the past 40 years in China, which now has ...
The molecular basis of hypoprolactinaemia
The molecular basis of hypoprolactinaemia
Hypoprolactinaemia is an endocrinopathy which is typically encountered as part of a combined pituitary hormone deficiency ...
A novel approach for the treatment of AML, through GHRH antagonism: MIA-602
A novel approach for the treatment of AML, through GHRH antagonism: MIA-602
Acute myeloid leukemia (AML) is the most aggressive and prevalent form of leukemia in adults. The gold-standard interventi...
Growth hormone-releasing hormone and cancer
Growth hormone-releasing hormone and cancer
The hypothalamic hormone growth hormone-releasing hormone (GHRH), in addition to promoting the synthesis and release of gr...
Meal replacements on obesity and leptin: a systematic review and meta-analysis
Meal replacements on obesity and leptin: a systematic review and meta-analysis
The global prevalence of obesity and overweight is a significant concern in the field of public health. Numerous intervent...
GHRH and its analogues in central nervous system diseases
GHRH and its analogues in central nervous system diseases
Growth hormone-releasing hormone (GHRH) is primarily produced by the hypothalamus and stimulates the release of growth hor...
Prolactin: structure, receptors, and functions
Prolactin: structure, receptors, and functions
Prolactin (PRL) is a 23-kDa protein synthesized and secreted by lactotroph cells of the anterior pituitary gland but also ...
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