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Prolactin regulates body temperature in pregnancy
Prolactin regulates body temperature in pregnancy
Prolactin is known to have a wide range of functions during reproduction, from supporting lactation to initiating maternal...
The incretin effect — almost magical
The foundations for modern medical treatments for diabetes mellitus and obesity were laid more than 60 years ago by severa...
Amylin: emergent therapeutic opportunities in overweight, obesity and diabetes mellitus
Amylin: emergent therapeutic opportunities in overweight, obesity and diabetes mellitus
The identification of amylin as a glucoregulatory peptide hormone with roles in meal-ending satiation sparked a surge of e...
Liothyronine treatment for hypothyroidism — a patient’s view
Liothyronine treatment for hypothyroidism — a patient’s view
Despite its prevalence, treatment of hypothyroidism has long divided opinion in the research and clinical fields. Here, I ...
The inflammatory spark: how TNF rewrote the insulin resistance narrative
Long before the word ‘inflammation’ gained prominence in immunometabolic research, Gökhan S. Hotamışlıgil and his team wer...
The endocrine effects of leptin on energy metabolism
The second law of thermodynamics asserts that energy within a system must be conserved, and that changes arise from altera...
Endocrine-disrupting chemicals and female reproductive health: a growing concern
Endocrine-disrupting chemicals and female reproductive health: a growing concern
Female fertility and reproductive health depend on a series of developmental steps from embryogenesis through puberty, in ...
Hypoglycaemia exacerbates diabetic retinopathy via HIF accumulation
Hypoglycaemia exacerbates diabetic retinopathy via HIF accumulation
Tight glycaemic control (TGC) is known to reduce the risk and/or progression of diabetic retinopathy, a diabetes mellitus ...
Our future, we decide: five ways to reform the scientific publication process
Our future, we decide: five ways to reform the scientific publication process
Although science is becoming ever more complex, interdisciplinary and open, the scientific publication process has largely...
Looking back at the TEDDY study: lessons and future directions
Looking back at the TEDDY study: lessons and future directions
The goal of the TEDDY (The Environmental Determinants of Diabetes in the Young) study is to elucidate factors lea...
Intricacies and obscurities of non-shivering thermogenesis
Mammalian cellular machinery has evolved to function best at ~37 °C, making maintenance of core body temperature (at ~37 °...
Macrophages support pancreatic development
Macrophages support pancreatic development
Engineering pancreatic tissue transplants to treat diabetes mellitus will require knowledge of how different cell types re...
Highlights from the Joint Irish–UK Endocrine Meeting 2024
This October, the first joint meeting between the Irish Endocrine Society (IES) and the British Society for Endocrinology ...
IL-17 has a role in whole-body homeostasis
IL-17 has a role in whole-body homeostasis
The immune system is known to have a circadian rhythm; however, how circadian rhythms might affect immune homeostasis and ...
Autologous stem-cell derived islets — the ultimate frontier in diabetes mellitus?
Autologous stem-cell derived islets — the ultimate frontier in diabetes mellitus?
A patient with longstanding type 1 diabetes mellitus has achieved insulin independence for at least 1 ye...
Growth hormone-releasing hormone and its analogues in health and disease
Growth hormone-releasing hormone and its analogues in health and disease
Growth hormone-releasing hormone (GHRH) and its ability to stimulate the production and release of growth hormone from the...
CCN3 maintains bone density during lactation
CCN3 maintains bone density during lactation
In female individuals, oestradiol preserves bone mass. However, oestradiol levels drop during lactation, which is also a t...
The interactions between energy homeostasis and neurovascular plasticity
The interactions between energy homeostasis and neurovascular plasticity
Food intake and energy expenditure are sensed and processed by multiple brain centres to uphold energy homeostasis. Eviden...
Endocrine effects of heat exposure and relevance to climate change
Endocrine effects of heat exposure and relevance to climate change
Climate change is increasing both seasonal temperatures and the frequency and severity of heat extremes. As the endocrine ...
Combination therapy increases human β-cell mass in vivo
Combination therapy increases human β-cell mass in vivo
People with diabetes mellitus have substantially reduced numbers of pancreatic β-cells compared with healthy individuals. ...
Microbial hydrogen sulfide hampers L-cell GLP-1 production
Microbial hydrogen sulfide hampers L-cell GLP-1 production
The gut microbiota strongly influences digestive and metabolic health. A study recently published in Nature Metabolism rep...
Medically not yet explained symptoms in hypothyroidism
Medically not yet explained symptoms in hypothyroidism
Persistent symptoms are common in the general population and even more so in people with hypothyroidism. When symptoms are...
International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents
International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents
Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours that arise not only in adulthood but also in ...
Thyroid nodules: diagnosis and management
Thyroid nodules: diagnosis and management
Thyroid nodules, with a prevalence of almost 25% in the general population, are a common occurrence. Their prevalence vari...
The hypothalamic–pituitary–gonadal axis and the enigma of Alzheimer disease sex differences
The hypothalamic–pituitary–gonadal axis and the enigma of Alzheimer disease sex differences
Alzheimer disease has a sex bias: women are twice as likely as men to be affected. Studies have linked elevated follicle-s...
Reply to ‘Slowly progressive insulin dependent diabetes mellitus in type 1 diabetes endotype 2’
We are grateful to Tetsuro Kobayashi and Takashi Kadowaki for their correspondence on our Review (Red...
Slowly progressive insulin-dependent diabetes mellitus in type 1 diabetes endotype 2
We have read with great interest the Review by Maria J. Redondo and Noel G. Morgan (Redondo, M.J., Mo...
Protein tyrosine phosphatase 1B in metabolic diseases and drug development
Protein tyrosine phosphatase 1B in metabolic diseases and drug development
Protein tyrosine phosphatase 1B (PTP1B), a non-transmembrane phosphatase, has a major role in a variety of signal...
Metformin acts through appetite-suppressing metabolite: Lac-Phe
Metformin acts through appetite-suppressing metabolite: Lac-Phe
Metformin is a first-line medication for type 2 diabetes mellitus (T2DM) that acts to reduce blood levels of glucose, food...
Continuous glucose monitoring for the routine care of type 2 diabetes mellitus
Continuous glucose monitoring for the routine care of type 2 diabetes mellitus
Although continuous glucose monitoring (CGM) devices are now considered the standard of care for people with type 1 diabet...
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