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Sexually dimorphic metabolic effects of a high fat diet on knee osteoarthritis in mice
Sexually dimorphic metabolic effects of a high fat diet on knee osteoarthritis in mice
Women have a higher risk of developing osteoarthritis (OA) than men, including with obesity. To better understand this dis...
Sex-dependent effects of chronic jet lag on circadian rhythm and metabolism in mice
Sex-dependent effects of chronic jet lag on circadian rhythm and metabolism in mice
The circadian clock integrates external environmental changes into the internal physiology of organisms. Perturbed circadi...
Sex differentially affects pro-inflammatory cell subsets in adipose tissue depots in a diet induced obesity model
Sex differentially affects pro-inflammatory cell subsets in adipose tissue depots in a diet induced obesity model
Obesity is a growing pandemic that increases the risk for cardiovascular diseases, type 2 diabetes, and particularly in wo...
Sex differences in mitochondrial gene expression during viral myocarditis
Sex differences in mitochondrial gene expression during viral myocarditis
Myocarditis is an inflammation of the heart muscle most often caused by viral infections. Sex differences in the immune re...
Attenuated sex-related DNA methylation differences in cancer highlight the magnitude bias mediating existing disparities
Attenuated sex-related DNA methylation differences in cancer highlight the magnitude bias mediating existing disparities
DNA methylation (DNAm) influences both sex differences and cancer development, yet the mechanisms connecting these factors...
Application and insights of targeted next-generation sequencing in a large cohort of 46,XY disorders of sex development in Chinese
Application and insights of targeted next-generation sequencing in a large cohort of 46,XY disorders of sex development in Chinese
46,XY disorders of sex development (46,XY DSD) are characterized by incomplete masculinization of genitalia with reduced a...
Fatty Liver Index (FLI) is the best score to predict MASLD with 50% lower cut-off value in women than in men
Fatty Liver Index (FLI) is the best score to predict MASLD with 50% lower cut-off value in women than in men
Metabolic dysfunction-associated steatotic liver disease (MASLD) is defined by the presence of hepatic steatosis, detected...
CGRP as a potential mediator for the sexually dimorphic responses to traumatic brain injury
CGRP as a potential mediator for the sexually dimorphic responses to traumatic brain injury
The outcomes of traumatic brain injury (TBI) exhibit variance contingent upon biological sex. Although female sex hormones...
Low testosterone levels relate to poorer cognitive function in women in an APOE-ε4-dependant manner
Low testosterone levels relate to poorer cognitive function in women in an APOE-ε4-dependant manner
Past research suggests that low testosterone levels relate to poorer cognitive function and higher Alzheimer’s disea...
Testosterone deficiency promotes arterial stiffening independent of sex chromosome complement
Testosterone deficiency promotes arterial stiffening independent of sex chromosome complement
Sex hormones and sex chromosomes play a vital role in cardiovascular disease. Testosterone plays a crucial role in menR...
Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell
Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell
The nucleus accumbens (NAc) is an important region in motivation and reward. Glutamatergic inputs from the infralimbic cor...
Sex bias in celiac disease: XWAS and monocyte eQTLs in women identify TMEM187 as a functional candidate gene
Sex bias in celiac disease: XWAS and monocyte eQTLs in women identify TMEM187 as a functional candidate gene
Celiac disease (CeD) is an immune-mediated disorder that develops in genetically predisposed individuals upon gluten consu...
Sex differences in type 2 diabetes: an opportunity for personalized medicine
Sex differences in type 2 diabetes: an opportunity for personalized medicine
Over the past several decades, substantial ground has been gained in understanding the biology of sex differences. With ne...
Sex and interspecies differences in ESR2-expressing cell distributions in mouse and rat brains
Sex and interspecies differences in ESR2-expressing cell distributions in mouse and rat brains
ESR2, a nuclear estrogen receptor also known as estrogen receptor β, is expressed in the brain and contributes to the...
Univariate and multivariate sex differences and similarities in gray matter volume within essential language-processing areas
Univariate and multivariate sex differences and similarities in gray matter volume within essential language-processing areas
Sex differences in language-related abilities have been reported. It is generally assumed that these differences stem from...
Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice
Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice
Metabolic dysfunction-associated steatotic liver disease (MASLD) is prevalent in Western countries, evolving into metaboli...
Sex differences in the rapid detection of neutral faces associated with emotional value
Sex differences in the rapid detection of neutral faces associated with emotional value
Rapid detection of faces with emotional meaning is essential for understanding the emotions of others, possibly promoting ...
Genetic hypogonadal mouse model reveals niche-specific influence of reproductive axis and sex on intestinal microbial communities
Genetic hypogonadal mouse model reveals niche-specific influence of reproductive axis and sex on intestinal microbial communities
The gut microbiome has been linked to many diseases with sex bias including autoimmune, metabolic, neurological, and repro...
Sex-differences in proteasome-dependent K48-polyubiquitin signaling in the amygdala are developmentally regulated in rats
Sex-differences in proteasome-dependent K48-polyubiquitin signaling in the amygdala are developmentally regulated in rats
Sex differences have been observed in several brain regions for the molecular mechanisms involved in baseline (resting) an...
Sex and age differences in social and cognitive function in offspring exposed to late gestational hypoxia
Sex and age differences in social and cognitive function in offspring exposed to late gestational hypoxia
Gestational sleep apnea is a hypoxic sleep disorder that affects 8–26% of pregnancies and increases the risk for cen...
Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice
Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice
Binge alcohol drinking is a risk factor linked to numerous disease states including alcohol use disorder (AUD). While men ...
Correction: Variability of temperature measurements recorded by a wearable device by biological sex
Correction: Variability of temperature measurements recorded by a wearable device by biological sex
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Regulatory mechanism of LncRNAs in gonadal differentiation of hermaphroditic fish, Monopterus albus
Regulatory mechanism of LncRNAs in gonadal differentiation of hermaphroditic fish, Monopterus albus
Monopterus albus is a hermaphroditic fish with sex reversal from ovaries to testes via the ovotestes in the process of gon...
Aromatase inhibition and ketamine in rats: sex-differences in antidepressant-like efficacy
Aromatase inhibition and ketamine in rats: sex-differences in antidepressant-like efficacy
Ketamine has been recently approved to treat resistant depression; however preclinical studies showed sex differences in i...
Sex-specific role of galectin-3 in aortic stenosis
Sex-specific role of galectin-3 in aortic stenosis
Aortic stenosis (AS) is characterized by inflammation, fibrosis, osteogenesis and angiogenesis. Men and women develop thes...
Spatial transcriptomics reveal basal sex differences in supraoptic nucleus gene expression of adult rats related to cell signaling and ribosomal pathways
Spatial transcriptomics reveal basal sex differences in supraoptic nucleus gene expression of adult rats related to cell signaling and ribosomal pathways
The supraoptic nucleus (SON) of the hypothalamus contains magnocellular neurosecretory cells that secrete the hormones vas...
Sex differences in the association between adipose insulin resistance and non-alcoholic fatty liver disease in Chinese adults
Sex differences in the association between adipose insulin resistance and non-alcoholic fatty liver disease in Chinese adults
Adipose insulin resistance (Adipo-IR) is associated with multiple metabolic diseases, including non-alcoholic fatty liver ...
Endothelin mediates sex-differences in acclimation to high salt diet in rats
Endothelin mediates sex-differences in acclimation to high salt diet in rats
Current understanding of sodium (Na+) handling is based on studies done primarily in males. Contrary to the gradual increa...
Two genetic variants in the SRD5A2 gene are found to be associated with sex differences in the disease characteristics of patients with chronic hepatitis B virus infection
Two genetic variants in the SRD5A2 gene are found to be associated with sex differences in the disease characteristics of patients with chronic hepatitis B virus infection
To examine the expression characteristics of single nucleotide polymorphisms (SNPs) in the SRD5A2 gene and investigate the...
Fetal sex differences in placental LCPUFA ether and plasmalogen phosphatidylethanolamine and phosphatidylcholine contents in pregnancies complicated by obesity
Fetal sex differences in placental LCPUFA ether and plasmalogen phosphatidylethanolamine and phosphatidylcholine contents in pregnancies complicated by obesity
We have previously reported that maternal obesity reduces placental transport capacity for lysophosphatidylcholine-docosah...
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