Potter LE, Burgess CR. The melanin-concentrating hormone system as a target for the treatment of sleep disorders. Front Neurosci. 2022;16:952275.
PubMed PubMed Central Google Scholar
Beekly BG, Rupp A, Burgess CR, Elias CF. Fast neurotransmitter identity of MCH neurons: do contents depend on context? Front Neuroendocrinol. 2023;70:101069.
CAS PubMed PubMed Central Google Scholar
Al-Massadi O, et al. Multifaceted actions of melanin-concentrating hormone on mammalian energy homeostasis. Nat Rev Endocrinol. 2021;17:745–55.
Concetti C, Burdakov D, Orexin/Hypocretin, Neurons MCH. Cognitive and motor roles beyond arousal. Front Neurosci. 2021;15:639313.
PubMed PubMed Central Google Scholar
Diniz GB, Bittencourt JC. The Melanin-Concentrating hormone (MCH) system: A Tale of two peptides. Front Neurosci. 2019;13:1280.
PubMed PubMed Central Google Scholar
Lee J, Raycraft L, Johnson AW. The dynamic regulation of appetitive behavior through lateral hypothalamic orexin and melanin concentrating hormone expressing cells. Physiol Behav. 2021;229:113234.
Jeon JY, et al. MCH-/- mice are resistant to aging-associated increases in body weight and insulin resistance. Diabetes. 2006;55:428–34.
Shimada M, Tritos NA, Lowell BB, Flier JS. Maratos-Flier, E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature. 1998;396:670–4.
Ludwig DS, et al. Melanin-concentrating hormone overexpression in Transgenic mice leads to obesity and insulin resistance. J Clin Invest. 2001;107:379–86.
CAS PubMed PubMed Central Google Scholar
Kokkotou E, et al. Mice with MCH ablation resist diet-induced obesity through strain-specific mechanisms. Am J Physiol Regul Integr Comp Physiol. 2005;289:R117–24.
Qu D, et al. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature. 1996;380:243–7.
Ludwig DS, et al. Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus. Am J Physiol. 1998;274:E627–33.
Noble EE, et al. Control of feeding behavior by cerebral ventricular volume transmission of Melanin-Concentrating hormone. Cell Metab. 2018;28:55–e687.
CAS PubMed PubMed Central Google Scholar
Mickelsen LE et al. Neurochemical Heterogeneity Among Lateral Hypothalamic Hypocretin/Orexin and Melanin-Concentrating Hormone Neurons Identified Through Single-Cell Gene Expression Analysis. eNeuro 4, ENEURO.0013-17.2017 (2017).
Whiddon BB, Palmiter RD. Ablation of neurons expressing melanin-concentrating hormone (MCH) in adult mice improves glucose tolerance independent of MCH signaling. J Neurosci Off J Soc Neurosci. 2013;33:2009–16.
Schneeberger M, et al. Functional analysis reveals differential effects of glutamate and MCH neuropeptide in MCH neurons. Mol Metab. 2018;13:83–9.
CAS PubMed PubMed Central Google Scholar
Sankhe AS, Bordeleau D, Alfonso DIM, Wittman G, Chee MJ. Loss of glutamatergic signalling from MCH neurons reduced anxiety-like behaviours in novel environments. J Neuroendocrinol. 2023;35:e13222.
Pham XT, et al. Glutamatergic signaling from melanin-concentrating hormone-producing neurons: A requirement for memory regulation, but not for metabolism control. PNAS Nexus. 2024;3:pgae275.
CAS PubMed PubMed Central Google Scholar
Naganuma F, Bandaru SS, Absi G, Chee MJ, Vetrivelan R. Melanin-concentrating hormone neurons promote rapid eye movement sleep independent of glutamate release. Brain Struct Funct. 2019;224:99–110.
Louet J-F, LeMay C, Mauvais-Jarvis F. Antidiabetic actions of estrogen: insight from human and genetic mouse models. Curr Atheroscler Rep. 2004;6:180–5.
Tramunt B, et al. Sex differences in metabolic regulation and diabetes susceptibility. Diabetologia. 2020;63:453–61.
Varlamov O, Bethea CL, Roberts CT. Sex-specific differences in lipid and glucose metabolism. Front Endocrinol. 2014;5:241.
Ibáñez L, Valls C, Ong K, Dunger DB, de Zegher F. Metformin therapy during puberty delays menarche, prolongs pubertal growth, and augments adult height: a randomized study in low-birth-weight girls with early-normal onset of puberty. J Clin Endocrinol Metab. 2006;91:2068–73.
Dunger DB, Ahmed ML, Ong KK. Effects of obesity on growth and puberty. Best Pr Res Clin Endocrinol Metab. 2005;19:375–90.
Frisch RE, Revelle R. Height and weight at menarche and a hypothesis of critical body weights and adolescent events. Science. 1970;169:397–9.
Anderson GM, et al. Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work. Nat Rev Endocrinol. 2024;20:111–23.
Rasouli MA, Dumesic DA, Singhal V. Male infertility and obesity. Curr Opin Endocrinol Diabetes Obes. 2024;31:203–9.
Broughton DE, Moley KH. Obesity and female infertility: potential mediators of obesity’s impact. Fertil Steril. 2017;107:840–7.
Elias CF, Purohit D. Leptin signaling and circuits in puberty and fertility. Cell Mol Life Sci. 2013;70:841–62.
Sciarra F, et al. Disruption of circadian rhythms: A crucial factor in the etiology of infertility. Int J Mol Sci. 2020;21:3943.
CAS PubMed PubMed Central Google Scholar
Mahoney MM. Shift work, jet lag, and female reproduction. Int. J. Endocrinol. 2010;813764: 2010.
Stocker LJ, Macklon NS, Cheong YC, Bewley SJ. Influence of shift work on early reproductive outcomes: a systematic review and meta-analysis. Obstet Gynecol. 2014;124:99–110.
Williams WP, Kriegsfeld LJ. Circadian control of neuroendocrine circuits regulating female reproductive function. Front Endocrinol. 2012;3:60.
Kong D, et al. Glucose stimulation of hypothalamic MCH neurons involves KATP channels, is modulated by UCP2, and regulates peripheral glucose homeostasis. Cell Metab. 2010;12:545–52.
Cain-Hom C et al. Efficient mapping of transgene integration sites and local structural changes in Cre transgenic mice using targeted locus amplification. Nucleic Acids Res. 2017;45:e62
Dubose AJ, et al. Use of microarray hybrid capture and next-generation sequencing to identify the anatomy of a transgene. Nucleic Acids Res. 2013;41:e70.
CAS PubMed PubMed Central Google Scholar
Goodwin LO, et al. Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis. Genome Res. 2019;29:494–505.
CAS PubMed PubMed Central Google Scholar
Krivega I, Dean A. Enhancer and promoter interactions-long distance calls. Curr Opin Genet Dev. 2012;22:79–85.
Dean A. On a chromosome Far, Far away: LCRs and gene expression. Trends Genet TIG. 2006;22:38–45.
Gegenhuber B, Tollkuhn J. Epigenetic mechanisms of brain sexual differentiation. Cold Spring Harb Perspect Biol. 2022;14:a039099.
CAS PubMed PubMed Central Google Scholar
Andrawus M, Sharvit L, Atzmon G. Epigenetics and pregnancy: conditional snapshot or rolling event. Int J Mol Sci. 2022;23:12698.
CAS PubMed PubMed Central Google Scholar
Sang Q, Ray PF, Wang L. Understanding the genetics of human infertility. Science. 2023;380:158–63.
Sakali A-K, et al. Environmental factors affecting female fertility. Endocrine. 2024;86:58–69.
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