Doran SJ, Ritzel RM, Glaser EP, Henry RJ, Faden AI, Loane DJ. Sex differences in acute neuroinflammation after experimental traumatic brain injury are mediated by infiltrating myeloid cells. J Neurotrauma. 2019;36(7):1040–53.

Article  PubMed  PubMed Central  Google Scholar 

Gupte R, Brooks W, Vukas R, Pierce J, Harris J. Sex differences in traumatic brain injury: what we know and what we should know. J Neurotrauma. 2019;36(22):3063–91.

Article  PubMed  PubMed Central  Google Scholar 

Rubin TG, Lipton ML. Sex differences in animal models of traumatic brain injury. J Exp Neurosci. 2019;13:1179069519844020.

Article  PubMed  PubMed Central  Google Scholar 

Kövesdi E, Szabó-Meleg E, Abrahám IM. The role of estradiol in traumatic brain injury: mechanism and treatment potential. Int J Mol Sci. 2020;22(1):11.

Article  PubMed  PubMed Central  Google Scholar 

Khaleghi M, Rajizadeh MA, Bashiri H, Kohlmeier KA, Mohammadi F, Khaksari M, et al. Estrogen attenuates physical and psychological stress-induced cognitive impairments in ovariectomized rats. Brain Behav. 2021;11(5):e02139.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bramlett HM, Dietrich WD. Neuropathological protection after traumatic brain injury in intact female rats versus males or ovariectomized females. J Neurotrauma. 2001;18(9):891–900.

Article  CAS  PubMed  Google Scholar 

Bruce-Keller AJ, Dimayuga FO, Reed JL, Wang C, Angers R, Wilson ME, et al. Gender and estrogen manipulation do not affect traumatic brain injury in mice. J Neurotrauma. 2007;24(1):203–15.

Article  PubMed  Google Scholar 

Ma J, Huang S, Qin S, You C, Zeng Y. Progesterone for acute traumatic brain injury. Cochrane Database Syst Rev. 2016;12(12):CD008409.

PubMed  Google Scholar 

Wright DW, Kellermann AL, Hertzberg VS, Clark PL, Frankel M, Goldstein FC, et al. ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury. Ann Emerg Med. 2007;49(4):391–402. 402.e1–2.

Article  PubMed  Google Scholar 

Xiao G, Wei J, Yan W, Wang W, Lu Z. Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial. Crit Care. 2008;12(2):R61.

Article  PubMed  PubMed Central  Google Scholar 

Skolnick BE, Maas AI, Narayan RK, van der Hoop RG, MacAllister T, Ward JD, et al. A clinical trial of progesterone for severe traumatic brain injury. N Engl J Med. 2014;371(26):2467–76.

Article  PubMed  Google Scholar 

Wright DW, Yeatts SD, Silbergleit R, Palesch YY, Hertzberg VS, Frankel M, et al. Very early administration of progesterone for acute traumatic brain injury. N Engl J Med. 2014;371(26):2457–66.

Article  PubMed  PubMed Central  Google Scholar 

Borowicz KK, Piskorska B, Banach M, Czuczwar SJ. Neuroprotective actions of neurosteroids. Front Endocrinol (Lausanne). 2011;2:50.

Article  PubMed  Google Scholar 

Russell FA, King R, Smillie SJ, Kodji X, Brain SD. Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev. 2014;94(4):1099–142.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maddahi A, Warfvinge K, Holm A, Edvinsson JCA, Reducha PV, Kazantzi S, et al. Progesterone distribution in the trigeminal system and its role to modulate sensory neurotransmission: influence of sex. J Headache Pain. 2023;24(1):154.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thota C, Yallampalli C. Progesterone upregulates calcitonin gene-related peptide and adrenomedullin receptor components and cyclic adenosine 3’5’-monophosphate generation in Eker rat uterine smooth muscle cell line. Biol Reprod. 2005;72(2):416–22.

Article  CAS  PubMed  Google Scholar 

Gangula PRR, Chauhan M, Reed L, Yallampalli C. Age-related changes in dorsal root ganglia, circulating and vascular calcitonin gene-related peptide (CGRP) concentrations in female rats: effect of female sex steroid hormones. Neurosci Lett. 2009;454(2):118–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Averitt DL, Hornung RS, Murphy AZ. Role of Sex Hormones on Pain. In: Oxford Research Encyclopedia of Neuroscience. 2019 [cited 2024 Apr 15]. https://oxfordre.com/neuroscience/display/10.1093/acrefore/9780190264086.001.0001/acrefore-9780190264086-e-247.

Avona A, Mason BN, Burgos-Vega C, Hovhannisyan AH, Belugin SN, Mecklenburg J, et al. Meningeal CGRP-prolactin interaction evokes female-specific migraine behavior. Ann Neurol. 2021;89(6):1129–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rubio-Beltrán E, Labastida-Ramírez A. Sex Hormones and CGRP. In: Maassen van den Brink A, MacGregor EA, editors. Gender and Migraine. Cham: Springer International Publishing; 2019 [cited 2024 Apr 15]. pp. 89–100. https://doi.org/10.1007/978-3-030-02988-3_7.

Chen LX, Zhang WF, Wang M, Jia PF. Relationship of calcitonin gene-related peptide with disease progression and prognosis of patients with severe traumatic brain injury. Neural Regen Res. 2018;13(10):1782–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Holland JP, Sydserff SG, Taylor WA, Bell BA. Calcitonin gene-related peptide reduces brain injury in a rat model of focal cerebral ischemia. Stroke. 1994;25(10):2055–8. discussion 2058–2059.

Article  CAS  PubMed  Google Scholar 

Shah KA, White TG, Powell K, Woo HH, Narayan RK, Li C. Trigeminal nerve stimulation improves cerebral macrocirculation and microcirculation after subarachnoid hemorrhage: an exploratory study. Neurosurgery. 2022;90(4):485–94.

Article  PubMed  Google Scholar 

Tian XH, Wang ZG, Meng H, Wang YH, Feng W, Wei F, et al. Tat peptide-decorated gelatin-siloxane nanoparticles for delivery of CGRP transgene in treatment of cerebral vasospasm. Int J Nanomed. 2013;8:865–76.

Article  Google Scholar 

Yang SI, Yuan Y, Jiao S, Luo QI, Yu J. Calcitonin gene-related peptide protects rats from cerebral ischemia/reperfusion injury via a mechanism of action in the MAPK pathway. Biomed Rep. 2016;4(6):699–703.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhai L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, et al. Endogenous calcitonin gene-related peptide suppresses ischemic brain injuries and progression of cognitive decline. J Hypertens. 2018;36(4):876–91.

Article  CAS  PubMed  Google Scholar 

Cai H, Xu X, Liu Z, Wang Q, Feng G, Li Y, et al. The effects of calcitonin gene-related peptide on bFGF and AQP4 expression after focal cerebral ischemia reperfusion in rats. Pharmazie. 2010;65(4):274–8.

CAS  PubMed  Google Scholar 

Li C, White TG, Shah KA, Chaung W, Powell K, Wang P, et al. Percutaneous trigeminal nerve stimulation induces cerebral vasodilation in a dose-dependent manner. Neurosurgery. 2021;88(6):E529–36.

Article  PubMed  PubMed Central  Google Scholar 

Amara SG, Jonas V, Rosenfeld MG, Ong ES, Evans RM. Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature. 1982;298(5871):240–4.

Article  CAS  PubMed  Google Scholar 

Wimalawansa SJ. Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology, and therapeutic potentials. Endocr Rev. 1996;17(5):533–85.

Article  CAS  PubMed  Google Scholar 

Zaidi M, Moonga BS, Bevis PJ, Bascal ZA, Breimer LH. The calcitonin gene peptides: biology and clinical relevance. Crit Rev Clin Lab Sci. 1990;28(2):109–74.

Article  CAS  PubMed  Google Scholar 

Labastida-Ramírez A, Rubio-Beltrán E, Villalón CM, MaassenVanDenBrink A. Gender aspects of CGRP in migraine. Cephalalgia. 2019;39(3):435–44.

Article  PubMed