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Clinical characteristics and prognostic analysis of patients with type 2 diabetic kidney disease and non-diabetic kidney disease
1 BackgroundThe prevalence of diabetes has increased significantly over the past few decades. Diabetic kidney disease (DKD...
Construction and validation of novel nomograms based on the log odds of positive lymph nodes to predict the prognosis of papillary thyroid cancer: a retrospective cohort study
IntroductionPapillary thyroid cancer (PTC) is the most common thyroid malignancy, accounting for approximately 85% of case...
A feasibility double-blind trial of levothyroxine vs. levothyroxine-liothyronine in postsurgical hypothyroidism
IntroductionThe treatment of hypothyroidism is based on the substitution of synthetic T4, levothyroxine (LT4), for the los...
Obesity indices and diabetes risk among hypertensive patients: insights from the China Multi-Ethnicity Cohort study
1 IntroductionDiabetes mellitus, specifically type 2 diabetes (T2DM), is more than just a global health issue; it serves a...
Editorial: Women in bone research
Editorial: Women in Bone ResearchMonica De Mattei1*, Katherine A Staines2*, Michaela Tencerova3* 1 Department of Medical S...
Associations between cardiometabolic index with kidney stones: evidence from NHANES 2007-2018
1 IntroductionKidney stones are a prevalent urological ailment defined by the formation of crystalline deposits in the kid...
Editorial: Diagnostic, prognostic and treatment efficacy power of biomarkers of aging for frailty, age-related diseases and multimorbidity
papers have been previously demonstrated to be formally associated with age, so it is possible that some of them maintain ...
Update on the pathogenesis of endometriosis-related infertility based on contemporary evidence
1 IntroductionEndometriosis is an estrogen-dependent disease characterized by the implantation of endometrial glands and e...
Impact of dual residual risk of cholesterol and inflammation on adult male sex hormones: a cross-sectional study from NHANES
1 IntroductionTestosterone is a hormone that plays a key role in the development and maintenance of male reproductive tiss...
Comparison of microwave ablation and parathyroidectomy for treating severe secondary hyperparathyroidism
1 IntroductionSecondary hyperparathyroidism (SHPT) is a common complication of chronic renal insufficiency. Patients with ...
Hypothalamic GABAergic neurons: their roles in health and metabolic diseases
1 IntroductionThe hypothalamus is a crucial brain region for regulating metabolic homeostasis and energy balance, orchestr...
Unraveling the complexity of skeletal dysplasias in the national health system
IntroductionBone tissue is a large compartment of the human body that implicates a tightly regulated process for developin...
Wnt/β-catenin pathway activation is associated with glucocorticoid secretion in adrenocortical carcinoma, but not directly with immune cell infiltration
IntroductionAdrenocortical carcinoma (ACC) is a rare and aggressive malignancy with an incidence of 0.6-2 inhabitants per ...
The potential key genes within focal adhesion that regulate mesenchymal stem cells osteogenesis or adipogenesis in microgravity related disuse osteoporosis: an integrated analysis
1 IntroductionOsteoporosis is a global systemic bone metabolic disease that currently affects over 200 million people. It ...
Post translational modification regulation of transcription factors governing pancreatic β-cell identity and functional mass
IntroductionDiabetes is a growing public health concern that affects an estimated 537 million individuals worldwide (1), a...
Crosstalk of TGF-β and somatostatin signaling in adenocarcinoma and neuroendocrine tumors of the pancreas: a brief review
1 IntroductionThe vast majority of pancreas cancers (95%) are pancreatic ductal adenocarcinomas (PDAC). Thus, PDAC (and al...
Editorial: Oxytocin and metabolic dysregulation: from pathophysiology to pharmacotherapy
The many decades of searching for effective pharmacotherapies to combat obesity have brought mixed results. The excitement...
Methylation of the telomerase gene promoter region in umbilical cord blood of patients with gestational diabetes mellitus is associated with decreased telomerase expression levels and shortened telomere length
BackgroundGestational diabetes mellitus (GDM) is the most common metabolic imbalance during pregnancy and has a profound i...
Improvement of irritable bowel syndrome with glucagon like peptide-1 receptor agonists: a systematic review and meta-analysis
IntroductionIrritable bowel syndrome (IBS) is a prevalent and debilitating gastrointestinal condition characterized by rec...
The inflection point: α-Klotho levels and the risk of all-cause mortality
IntroductionIn 1997, Kuro-o (1) and his research group demonstrated that the deletion of the Klotho gene resulted in accel...
Estradiol-to-follicle ratio on human chorionic gonadotropin day is a novel predictor of gestational diabetes mellitus in women receiving fresh embryo transfer
Estradiol-to-follicle ratio on human chorionic gonadotropin day is a novel predictor of gestational diabetes mellitus in women receiving fresh embryo transfer
AimsTo assess the predictive value of estradiol (E2) related parameters on the incidence of gestational diabetes mellitus ...
A mobile health application use among diabetes mellitus patients: a systematic review and meta-analysis
A mobile health application use among diabetes mellitus patients: a systematic review and meta-analysis
BackgroundMobile health technologies are increasingly acknowledged as a cost-effective and convenient means of delivering ...
Evidence of apoptosis as an early event leading to cyclophosphamide-induced primordial follicle depletion in a prepubertal mouse model
Evidence of apoptosis as an early event leading to cyclophosphamide-induced primordial follicle depletion in a prepubertal mouse model
IntroductionThe mechanisms leading to ovarian primordial follicle depletion following gonadotoxic chemotherapy with cyclop...
Obesity-related renal dysfunction: gender-specific influence of visceral adiposity and early impact of metabolic and bariatric surgery
Obesity-related renal dysfunction: gender-specific influence of visceral adiposity and early impact of metabolic and bariatric surgery
IntroductionRenal dysfunction is a recognized complication of obesity with an incompletely characterized pathophysiology. ...
Investigating factors influencing overweight and obesity among adult households in Ethiopia: a multilevel ordered analysis of 2016 EDHS data
Investigating factors influencing overweight and obesity among adult households in Ethiopia: a multilevel ordered analysis of 2016 EDHS data
BackgroundIn both high- and low-income countries, including Ethiopia, overweight and obesity have emerged as public health...
Exploration of physical activity, sedentary behavior and insulin level among short sleepers
Exploration of physical activity, sedentary behavior and insulin level among short sleepers
BackgroundSufficient physical activity and sleep duration are essential for overall health. While one-third of the US popu...
Tracing links between micronutrients and type 2 diabetes risk: the singular role of selenium
Tracing links between micronutrients and type 2 diabetes risk: the singular role of selenium
BackgroundType 2 diabetes (T2D) is a growing global health concern. While micronutrients are crucial for physiological fun...
The role of p53 in male infertility
The role of p53 in male infertility
The tumor suppressor p53 is a transcription factor involved in a variety of crucial cellular functions, including cell cyc...
Targeting AMP-activated protein kinase in sepsis
Targeting AMP-activated protein kinase in sepsis
Sepsis is a global health challenge marked by limited clinical options and high mortality rates. AMP-activated protein kin...
The associations of the triglyceride-glucose index and its combination with blood pressure on cardiovascular and all-cause mortality in hypertension: a national study
The associations of the triglyceride-glucose index and its combination with blood pressure on cardiovascular and all-cause mortality in hypertension: a national study
The triglyceride-glucose (TyG) index, a reliable surrogate biomarker of insulin resistance (IR), is highlighted recently a...
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