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The potential of alphapinene as a therapeutic agent for maternal hypoxia-induced cognitive impairments: a study on HO-1 and Nrf2 gene expression in rats
The potential of alphapinene as a therapeutic agent for maternal hypoxia-induced cognitive impairments: a study on HO-1 and Nrf2 gene expression in rats
This research seeks to address the gap in past studies by examining the role of the Nrf2 (nuclear factor erythroid 2-relat...
The protective efficacy of omega-3 polyunsaturated fatty acids on oxidative stress, inflammation, neurotransmitter perturbations, and apoptosis induced by monosodium glutamate in the brain of male rats
The protective efficacy of omega-3 polyunsaturated fatty acids on oxidative stress, inflammation, neurotransmitter perturbations, and apoptosis induced by monosodium glutamate in the brain of male rats
Exaggerated neuronal excitation by glutamate is a well-known cause of excitotoxicity, a key factor in numerous neurodegene...
2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione protects against MPP+-induced neurotoxicity by ameliorating oxidative stress, apoptosis and autophagy in SH-SY5Y cells
2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione protects against MPP+-induced neurotoxicity by ameliorating oxidative stress, apoptosis and autophagy in SH-SY5Y cells
2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD) is a cyclohexanedione compound extracted from the roots of Averrho...
The effects of ursodeoxycholic acid on Parkinson’s disease, a mechanistic review of the recent evidence
The effects of ursodeoxycholic acid on Parkinson’s disease, a mechanistic review of the recent evidence
Introduction. Parkinson`s disease stands as the second-most widespread neurodegenerative disorder. Parkinson`s disease is ...
Brain interleukins and Alzheimer’s disease
Brain interleukins and Alzheimer’s disease
The central nervous system (CNS) is immune-privileged by several immuno-modulators as interleukins (ILs). ILs are cytokine...
TIPS and hepatic encephalopathy in patients with cirrhosis
TIPS and hepatic encephalopathy in patients with cirrhosis
Despite a better understanding in its prognosis and pathogenesis, hepatic encephalopathy (HE) remains one of the major com...
Altered gut microbiome and serum metabolome profiles associated with essential tremor
Altered gut microbiome and serum metabolome profiles associated with essential tremor
The genetic predisposition and environmental factors both trigger the complex neurological dyskinesia of essential tremor ...
Sodium butyrate ameliorates mitochondrial oxidative stress and alterations in membrane-bound enzyme activities in pentylenetetrazole-induced kindling rat model
Sodium butyrate ameliorates mitochondrial oxidative stress and alterations in membrane-bound enzyme activities in pentylenetetrazole-induced kindling rat model
Epilepsy is a chronic neurological disorder manifested through repeatedly recurrent unprovoked seizures. It is a debilitat...
Glutamate/GABA/glutamine ratios in intact and ischemia reperfusion challenged rat brain subregions, the effect of ischemic preconditioning
Glutamate/GABA/glutamine ratios in intact and ischemia reperfusion challenged rat brain subregions, the effect of ischemic preconditioning
The proper function of the brain is entirely dependent on intact neurotransmission, where glutamate (Glu) and γ-amino...
Gut microbiota-derived short chain fatty acids act as mediators of the gut-liver-brain axis
Gut microbiota-derived short chain fatty acids act as mediators of the gut-liver-brain axis
The gut microbiota plays a crucial role in the communication between the gut, liver, and brain through the production of s...
Unraveling the role of Nrf2 in dopaminergic neurons: a review of oxidative stress and mitochondrial dysfunction in Parkinson’s disease
Unraveling the role of Nrf2 in dopaminergic neurons: a review of oxidative stress and mitochondrial dysfunction in Parkinson’s disease
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an essential transcriptional factor, involved in the regulation of c...
A novel approach to metabolic profiling in case models of MECP2-related disorders
A novel approach to metabolic profiling in case models of MECP2-related disorders
Genetic abnormalities of the MECP2 gene cause several conditions grouped under the umbrella term of MECP2-related disorder...
ST3 beta-galactoside alpha-2,3-sialyltransferase 4 (St3gal4) deficiency reveals correlations among alkaline phosphatase activity, metabolic parameters, and fear-related behavior in mice
ST3 beta-galactoside alpha-2,3-sialyltransferase 4 (St3gal4) deficiency reveals correlations among alkaline phosphatase activity, metabolic parameters, and fear-related behavior in mice
ST3 beta-galactoside alpha-2,3-sialyltransferase 4 (ST3GAL4) is a sialyltransferase involved in the bios...
Lights and shadows of clozapine on the immune system in schizophrenia: a narrative literature review
Lights and shadows of clozapine on the immune system in schizophrenia: a narrative literature review
Schizophrenia is a chronic mental disorder and one of the main causes of disability in the world. Approximately 1% of the ...
α-asarone activates mitophagy to relieve diabetic encephalopathy via inhibiting apoptosis and oxidative stress
α-asarone activates mitophagy to relieve diabetic encephalopathy via inhibiting apoptosis and oxidative stress
Diabetic encephalopathy (DE) is a common complication of diabetes that may result in cognitive impairment. Currently, ther...
Unlocking NAC’s potential ATF4 and m6A dynamics in rescuing cognitive impairments in PTSD
Unlocking NAC’s potential ATF4 and m6A dynamics in rescuing cognitive impairments in PTSD
In this study, we investigated the therapeutic potential of N-acetylcysteine (NAC) in a mouse model of post-traumatic stre...
Neuroprotective effects of L-carnitine towards oxidative stress and inflammatory processes: a review of its importance as a therapeutic drug in some disorders
Neuroprotective effects of L-carnitine towards oxidative stress and inflammatory processes: a review of its importance as a therapeutic drug in some disorders
L-carnitine (LC) is a natural compound crucial for transporting long-chain fatty acids into mitochondria for ATP productio...
Untargeted metabolomics unveils critical metabolic signatures in novel phenotypes of acute ischemic stroke
Untargeted metabolomics unveils critical metabolic signatures in novel phenotypes of acute ischemic stroke
This study aimed to identify metabolic footprints associated with distinct phenotypes of acute ischemic stroke (AIS) using...
Bulk-RNA and single-nuclei RNA seq analyses reveal the role of lactate metabolism-related genes in Alzheimer’s disease
Bulk-RNA and single-nuclei RNA seq analyses reveal the role of lactate metabolism-related genes in Alzheimer’s disease
Dysfunctional lactate metabolism in the brain has been implicated in neuroinflammation, Aβ deposition, and cell distu...
Morin attenuated the global cerebral ischemia via antioxidant, anti-inflammatory, and antiapoptotic mechanisms in rats
Morin attenuated the global cerebral ischemia via antioxidant, anti-inflammatory, and antiapoptotic mechanisms in rats
Global cerebral ischemia is one of the major causes of memory and cognitive impairment. Hyperactivation of acetylcholine e...
Exercise-produced irisin effects on brain-related pathological conditions
Exercise-produced irisin effects on brain-related pathological conditions
Exercise increases peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α) expression, which in...
Integrative analysis reveals key lysosomal genes as potential therapeutic targets in Alzheimer’s disease
Integrative analysis reveals key lysosomal genes as potential therapeutic targets in Alzheimer’s disease
Alzheimer's disease (AD) is a neurodegenerative disorder with early autophagy deficits. Our study probed the role of l...
Treatment response of venlafaxine induced alterations of gut microbiota and metabolites in a mouse model of depression
Treatment response of venlafaxine induced alterations of gut microbiota and metabolites in a mouse model of depression
Antidepressants remain the first-line treatment for depression. However, the factors influencing medication response are s...
Peganum harmala L. seed extract attenuates anxiety and depression in rats by reducing neuroinflammation and restoring the BDNF/TrkB signaling pathway and monoamines after exposure to chronic unpredictable mild stress
Peganum harmala L. seed extract attenuates anxiety and depression in rats by reducing neuroinflammation and restoring the BDNF/TrkB signaling pathway and monoamines after exposure to chronic unpredictable mild stress
Depression is a mental disorder characterised by persistent low mood, anhedonia and cognitive impairment that affects an e...
Neurological recovery in rats with portocaval anastomosis-induced hepatic encephalopathy treated with leuprolide acetate, a GnRH agonist
Neurological recovery in rats with portocaval anastomosis-induced hepatic encephalopathy treated with leuprolide acetate, a GnRH agonist
Hepatic encephalopathy (HE) is a neuropsychiatric complication of acute liver failure or chronic liver injury. Liver dysfu...
Role of peripheral inflammation in minimal hepatic encephalopathy
Role of peripheral inflammation in minimal hepatic encephalopathy
Many patients with liver cirrhosis show minimal hepatic encephalopathy (MHE) with mild cognitive impairment (MCI) and moto...
Genomic, epigenomic and transcriptomic landscape of glioblastoma
Genomic, epigenomic and transcriptomic landscape of glioblastoma
The mostly aggressive and extremely malignant type of central nervous system is Glioblastoma (GBM), which is characterized...
Advances and challenges in serine in the central nervous system: physicochemistry, physiology, and pharmacology
Advances and challenges in serine in the central nervous system: physicochemistry, physiology, and pharmacology
Neurological disorders are the primary cause of human disability and mortality globally, however, current medications slig...
Involvement of oncomiRs miR-23, miR-24, and miR-27 in the regulation of alternative polyadenylation in glioblastoma via CFIm25 cleavage factor
Involvement of oncomiRs miR-23, miR-24, and miR-27 in the regulation of alternative polyadenylation in glioblastoma via CFIm25 cleavage factor
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with a poor prognosis. The cleavage factor Im 25 (CFIm25)...
Infection, inflammation and hepatic encephalopathy from a clinical perspective
Infection, inflammation and hepatic encephalopathy from a clinical perspective
Hepatic encephalopathy (HE) is a syndrome that is associated with both acute and chronic liver injury. It manifests as a w...
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