Al Ammar WA, Albeesh FH, Ibrahim LM, Algindan YY, Yamani LZ, Khattab RY (2021) Effect of omega-3 fatty acids and fish oil supplementation on multiple sclerosis: a systematic review. Nutr Neurosci 24:569–579. https://doi.org/10.1080/1028415X.2019.1659560

Article  PubMed  Google Scholar 

Auerbach M, DeLoughery TG, Tirnauer JS (2025) Iron deficiency in adults: a review. JAMA 333:1813–1823. https://doi.org/10.1001/jama.2025.0452

Article  PubMed  Google Scholar 

Ayton S, Barton D, Brew B, Brodtmann A, Clarnette R, Desmond P, Devos D, Ellis KA, Fazlollahi A, Fradette C, Goh AMY, Kalinowski P, Kyndt C, Lai R, Lim YY, Maruff P, O’Brien TJ, Rowe C, Salvado O, Schofield PW, Spino M, Tricta F, Wagen A, Williams R, Woodward M, Bush AI (2025) Deferiprone in Alzheimer disease: a randomized clinical trial. JAMA Neurol 82:11–18. https://doi.org/10.1001/jamaneurol.2024.3733

Article  PubMed  Google Scholar 

Bacchetta J, Zaritsky JJ, Sea JL, Chun RF, Lisse TS, Zavala K, Nayak A, Wesseling-Perry K, Westerman M, Hollis BW, Salusky IB, Hewison M (2014) Suppression of iron-regulatory hepcidin by vitamin D. J Am Soc Nephrol 25:564–572. https://doi.org/10.1681/ASN.2013040355

Article  PubMed  Google Scholar 

Barcellos LF, Sawcer S, Ramsay PP, Baranzini SE, Thomson G, Briggs F, Cree BC, Begovich AB, Villoslada P, Montalban X, Uccelli A, Savettieri G, Lincoln RR, DeLoa C, Haines JL, Pericak-Vance MA, Compston A, Hauser SL, Oksenberg JR (2006) Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis. Hum Mol Genet 15:2813–2824. https://doi.org/10.1093/hmg/ddl223

Article  PubMed  Google Scholar 

Barnett MH, Prineas JW (2004) Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion. Ann Neurol 55:458–468. https://doi.org/10.1002/ana.20016

Article  PubMed  Google Scholar 

Bjornevik K, Cortese M, Healy BC, Kuhle J, Mina MJ, Leng Y, Elledge SJ, Niebuhr DW, Scher AI, Munger KL, Ascherio A (2022) Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis. Science 375:296–301. https://doi.org/10.1126/science.abj8222

Article  PubMed  Google Scholar 

Bsteh G, Haschka D, Tymoszuk P, Berek K, Petzer V, Hegen H, Wurth S, Auer M, Zinganell A, Pauli FD, Deisenhammer F, Weiss G, Berger T (2019) Serum Hepcidin levels in multiple sclerosis. Mult Scler J Exp Transl Clin 5:2055217319885984. https://doi.org/10.1177/2055217319885984eCollection 2019 Oct-Dec

Article  PubMed  PubMed Central  Google Scholar 

Castellazzi M, Contini C, Tamborino C, Fasolo F, Roversi G, Seraceni S, Rizzo R, Baldi E, Tola MR, Bellini T, Granieri E, Fainardi E (2014) Epstein-Barr virus-specific intrathecal oligoclonal IgG production in relapsing-remitting multiple sclerosis is limited to a subset of patients and is composed of low-affinity antibodies. J Neuroinflammation 11:188. https://doi.org/10.1186/s12974-014-0188-1

Article  PubMed  PubMed Central  Google Scholar 

Chang R, Chu KA, Lin MC, Chu YH, Hung YM, Wei JC (2020) Newly diagnosed iron deficiency anemia and subsequent autoimmune disease: a matched cohort study in Taiwan. Curr Med Res Opin 36:985–992. https://doi.org/10.1080/03007995.2020.1748585

Article  PubMed  Google Scholar 

Chao CT, Lai CF, Huang JW (2012) Risk factors for herpes zoster reactivation in maintenance hemodialysis patients. Eur J Intern Med 23:711–715. https://doi.org/10.1016/j.ejim.2012.08.005

Article  PubMed  Google Scholar 

Chatterjee P, Mohammadi M, Goozee K, Shah TM, Sohrabi HR, Dias CB, Shen K, Asih PR, Dave P, Pedrini S, Ashton NJ, Hye A, Taddei K, Lovejoy DB, Zetterberg H, Blennow K, Martins RN (2020) Serum hepcidin levels in cognitively normal older adults with high neocortical amyloid-beta load. J Alzheimers Dis 76:291–301. https://doi.org/10.3233/JAD-200162

Article  PubMed  PubMed Central  Google Scholar 

Connor JR, Menzies SL (1996) Relationship of iron to oligodendrocytes and myelination. Glia 17:83–93. https://doi.org/10.1002/(SICI)1098-1136(199606)17:2/83::AID-GLIA1/3.0.CO;2-7

Davis W, van Rensburg SJ, Cronje FJ, Whati L, Fisher LR, van der Merwe L, Geiger D, Hassan MS, Matsha T, Erasmus RT, Kotze MJ (2014) The fat mass and obesity-associated FTO rs9939609 polymorphism is associated with elevated homocysteine levels in patients with multiple sclerosis screened for vascular risk factors. Metab Brain Dis 29:409–419. https://doi.org/10.1007/s11011-014-9486-7

Article  PubMed  Google Scholar 

DeLuca GC, Ramagopalan SV, Herrera BM, Dyment DA, Lincoln MR, Montpetit A, Pugliatti M, Barnardo MC, Risch NJ, Sadovnick AD, Chao M (2007) An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA- DRB1 locus. Proc Natl Acad Sci U S A 104:20896–20901. https://doi.org/10.1073/pnas.0707731105

Article  PubMed  PubMed Central  Google Scholar 

Demirag MD, Haznedaroglu S, Sancak B, Konca C, Gulbahar O, Ozturk MA, Goker B (2009) Circulating hepcidin in the crossroads of anemia and inflammation associated with rheumatoid arthritis. Intern Med 48:421–426. https://doi.org/10.2169/internalmedicine.48.1578

Article  PubMed  Google Scholar 

Disanto G, Sandve GK, Berlanga-Taylor AJ, Ragnedda G, Morahan JM, Watson CT, Giovannoni G, Ebers GC, Ramagopalan SV (2012) Vitamin d receptor binding, chromatin states and association with multiple sclerosis. Hum Mol Genet 21:3575–3586. https://doi.org/10.1093/hmg/dds189

Article  PubMed  PubMed Central  Google Scholar 

Disanto G, Pakpoor J, Morahan JM, Hall C, Meier UC, Giovannoni G, Ramagopalan SV (2013) Epstein-Barr virus, latitude and multiple sclerosis. Mult Scler 19:362–365. https://doi.org/10.1177/1352458512451942

Article  PubMed  Google Scholar 

Dolladille C, Chrétien B, Peyro-Saint-Paul L, Alexandre J, Dejardin O, Fedrizzi S, Defer G (2021) Association between disease-modifying therapies prescribed to persons with multiple sclerosis and cancer: a WHO pharmacovigilance database analysis. Neurotherapeutics 18:1657–1664. https://doi.org/10.1007/s13311-021-01073-y

Article  PubMed  PubMed Central  Google Scholar 

Dunlop E, Daly A, Mori TA, Langer-Gould A, Pereira G, Black LJ (2024) Plasma levels of polyunsaturated fatty acids and multiple sclerosis susceptibility in a US case-control study. Mult Scler Relat Disord 92:105920. https://doi.org/10.1016/j.msard.2024.105920

Article  PubMed  Google Scholar 

Duque X, Mendoza E, Morán S, Suárez-Arriaga MC, Morales-Sánchez A, Fontes-Lemus JI, Domínguez-Martínez DA, Fuentes-Pananá EM (2023) Epstein-Barr virus infection is associated with elevated hepcidin levels. Int J Mol Sci 24:1630. https://doi.org/10.3390/ijms24021630

Article  PubMed  PubMed Central  Google Scholar 

Elkady AM, Cobzas D, Sun H, Seres P, Blevins G, Wilman AH (2019) Five year iron changes in relapsing-remitting multiple sclerosis deep gray matter compared to healthy controls. Mult Scler Relat Disord 33:107–115. https://doi.org/10.1016/j.msard.2019.05.028

Article  PubMed  Google Scholar 

Ellidag Hy, Kurtulus F, Yaman A, Eren E, Yilmaz N, Aydin O, Bayindir A (2014) Serum iron metabolism markers including Hepcidin in multiple sclerosis patients. Neurochem J 8:226–230. https://doi.org/10.1134/S1819712414030040

Article  Google Scholar 

Fassl S, Leisser C, Huettenbrenner S, Maier S, Rosenberger G, Strasser S, Grusch M, Fuhrmann G, Leuhuber K, Polgar D, Stani J, Tichy B, Nowotny C, Krupitza G (2003) Transferrin ensures survival of ovarian carcinoma cells when apoptosis is induced by TNFalpha, FasL, TRAIL, or Myc. Oncogene 22:8343–8355. https://doi.org/10.1038/sj.onc.1207047

Article  PubMed  Google Scholar 

Fitzsimmons L, Kelly GL (2017) EBV and apoptosis: the viral master regulator of cell fate? Viruses 9(11):339. https://doi.org/10.3390/v9110339

Article  PubMed  PubMed Central  Google Scholar 

Frei K, Fredrikson S, Fontana A, Link H (1991) Interleukin-6 is elevated in plasma in multiple sclerosis. J Neuroimmunol 31:147–153. https://doi.org/10.1016/0165-5728(91)90020-8

Article  PubMed  Google Scholar 

Galesloot TE, Vermeulen SH, Geurts-Moespot AJ, Klaver SM, Kroot JJ, van Tienoven D, Wetzels JF, Kiemeney LA, Sweep FC, den Heijer M, Swinkels DW (2011) Serum hepcidin: reference ranges and biochemical correlates in the general population. Blood 117:e218–e225. https://doi.org/10.1182/blood-2011-02-337907

Article  PubMed  Google Scholar 

Galoppin M, Kari S, Soldati S, Pal A, Rival M, Engelhardt B, Astier A, Thouvenot E (2022) Full spectrum of vitamin D immunomodulation in multiple sclerosis: mechanisms and therapeutic implications. Brain Commun 4:fcac171. https://doi.org/10.1093/braincomms/fcac171

Article  PubMed  PubMed Central  Google Scholar 

Gemmati D, Zeri G, Orioli E, De Gaetano FE, Salvi F, Bartolomei I, D’Alfonso S, Dall’osso C, Leone MA, Singh AV, Asselta R, Zamboni P (2012) Polymorphisms in the genes coding for iron binding and transporting proteins are associated with disability, severity, and early progression in multiple sclerosis. BMC Med Genet 13:70. https://doi.org/10.1186/1471-2350-13-70

Article  PubMed  PubMed Central