Jensen EV, DeSombre ER. Estrogen-receptor interaction. Science. 1973;182(4108):126–34. https://doi.org/10.1126/science.182.4108.126.

Article  CAS  PubMed  Google Scholar 

Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA. Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci U S A. 1996;93(12):5925–30. https://doi.org/10.1073/pnas.93.12.5925.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsukahara S, Morishita M. Sexually dimorphic formation of the preoptic area and the bed nucleus of the stria terminalis by neuroestrogens. Front Neurosci. 2020;14:797. https://doi.org/10.3389/fnins.2020.00797.

Article  PubMed  PubMed Central  Google Scholar 

Wintermantel TM, Campbell RE, Porteous R, Bock D, Grone HJ, Todman MG, et al. Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility. Neuron. 2006;52(2):271–80. https://doi.org/10.1016/j.neuron.2006.07.023.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yeo SH, Herbison AE. Estrogen-negative feedback and estrous cyclicity are critically dependent upon estrogen receptor-alpha expression in the arcuate nucleus of adult female mice. Endocrinology. 2014;155(8):2986–95. https://doi.org/10.1210/en.2014-1128.

Article  CAS  PubMed  Google Scholar 

Geary N, Asarian L, Korach KS, Pfaff DW, Ogawa S. Deficits in E2-dependent control of feeding, weight gain, and cholecystokinin satiation in ER-alpha null mice. Endocrinology. 2001;142(11):4751–7. https://doi.org/10.1210/endo.142.11.8504.

Article  CAS  PubMed  Google Scholar 

Harris HA, Katzenellenbogen JA, Katzenellenbogen BS. Characterization of the biological roles of the estrogen receptors, ERalpha and ERbeta, in estrogen target tissues in vivo through the use of an ERalpha-selective ligand. Endocrinology. 2002;143(11):4172–7. https://doi.org/10.1210/en.2002-220403.

Article  CAS  PubMed  Google Scholar 

Ogawa S, Chester AE, Hewitt SC, Walker VR, Gustafsson JA, Smithies O, et al. Abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO). Proc Natl Acad Sci U S A. 2000;97(26):14737–41. https://doi.org/10.1073/pnas.250473597.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Trouillet AC, Ducroq S, Naule L, Capela D, Parmentier C, Radovick S, et al. Deletion of neural estrogen receptor alpha induces sex differential effects on reproductive behavior in mice. Commun Biol. 2022;5(1):383. https://doi.org/10.1038/s42003-022-03324-w.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krege JH, Hodgin JB, Couse JF, Enmark E, Warner M, Mahler JF, et al. Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc Natl Acad Sci U S A. 1998;95(26):15677–82. https://doi.org/10.1073/pnas.95.26.15677.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dombret C, Naule L, Trouillet AC, Parmentier C, Hardin-Pouzet H, Mhaouty-Kodja S. Effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice. Sci Rep. 2020;10(1):6242. https://doi.org/10.1038/s41598-020-63427-4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu F, Day M, Muniz LC, Bitran D, Arias R, Revilla-Sanchez R, et al. Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory. Nat Neurosci. 2008;11(3):334–43. https://doi.org/10.1038/nn2057.

Article  CAS  PubMed  Google Scholar 

Imwalle DB, Gustafsson JA, Rissman EF. Lack of functional estrogen receptor beta influences anxiety behavior and serotonin content in female mice. Physiol Behav. 2005;84(1):157–63. https://doi.org/10.1016/j.physbeh.2004.11.002.

Article  CAS  PubMed  Google Scholar 

Leite C, Madeira MD, Sa SI. Effects of sex steroids and estrogen receptor agonists on the expression of estrogen receptor alpha in the principal division of the bed nucleus of the stria terminalis of female rats. Brain Res. 2014;1582:99–106. https://doi.org/10.1016/j.brainres.2014.07.041.

Article  CAS  PubMed  Google Scholar 

Funabashi T, Kleopoulos SP, Brooks PJ, Kimura F, Pfaff DW, Shinohara K, et al. Changes in estrogenic regulation of estrogen receptor alpha mRNA and progesterone receptor mRNA in the female rat hypothalamus during aging: an in situ hybridization study. Neurosci Res. 2000;38(1):85–92. https://doi.org/10.1016/s0168-0102(00)00150-4.

Article  CAS  PubMed  Google Scholar 

Arteaga-Lopez PR, Dominguez R, Cerbon MA, Mendoza-Rodriguez CA, Cruz ME. Differential mRNA expression of alpha and beta estrogen receptor isoforms and GnRH in the left and right side of the preoptic and anterior hypothalamic area during the estrous cycle of the rat. Endocrine. 2003;21(3):251–60. https://doi.org/10.1385/ENDO:21:3:251.

Article  CAS  PubMed  Google Scholar 

Merchenthaler I, Lane MV, Numan S, Dellovade TL. Distribution of estrogen receptor alpha and beta in the mouse central nervous system: in vivo autoradiographic and immunocytochemical analyses. J Comp Neurol. 2004;473(2):270–91. https://doi.org/10.1002/cne.20128.

Article  CAS  PubMed  Google Scholar 

Mitra SW, Hoskin E, Yudkovitz J, Pear L, Wilkinson HA, Hayashi S, et al. Immunolocalization of estrogen receptor beta in the mouse brain: comparison with estrogen receptor alpha. Endocrinology. 2003;144(5):2055–67. https://doi.org/10.1210/en.2002-221069.

Article  CAS  PubMed  Google Scholar 

Zhang JQ, Cai WQ, Zhou DS, Su BY. Distribution and differences of estrogen receptor beta immunoreactivity in the brain of adult male and female rats. Brain Res. 2002;935(1–2):73–80. https://doi.org/10.1016/s0006-8993(02)02460-5.

Article  CAS  PubMed  Google Scholar 

Perez SE, Chen EY, Mufson EJ. Distribution of estrogen receptor alpha and beta immunoreactive profiles in the postnatal rat brain. Brain Res Dev Brain Res. 2003;145(1):117–39. https://doi.org/10.1016/s0165-3806(03)00223-2.

Article  CAS  PubMed  Google Scholar 

Shughrue PJ, Merchenthaler I. Distribution of estrogen receptor beta immunoreactivity in the rat central nervous system. J Comp Neurol. 2001;436(1):64–81.

Article  CAS  PubMed  Google Scholar 

Shughrue PJ, Lane MV, Merchenthaler I. Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system. J Comp Neurol. 1997;388(4):507–25. https://doi.org/10.1002/(sici)1096-9861(19971201)388:4%3c507::aid-cne1%3e3.0.co;2-6.

Article  CAS  PubMed  Google Scholar 

Kanaya M, Higo S, Ozawa H. Neurochemical characterization of neurons expressing estrogen receptor beta in the hypothalamic nuclei of rats using in situ hybridization and immunofluorescence. Int J Mol Sci. 2019;21:1. https://doi.org/10.3390/ijms21010115.

Article  CAS  Google Scholar 

Sagoshi S, Maejima S, Morishita M, Takenawa S, Otubo A, Takanami K, et al. Detection and characterization of estrogen receptor beta expression in the brain with newly developed transgenic mice. Neuroscience. 2020;438:182–97. https://doi.org/10.1016/j.neuroscience.2020.04.047.

Article  CAS  PubMed  Google Scholar 

Milner TA, Thompson LI, Wang G, Kievits JA, Martin E, Zhou P, et al. Distribution of estrogen receptor beta containing cells in the brains of bacterial artificial chromosome transgenic mice. Brain Res. 2010;1351:74–96. https://doi.org/10.1016/j.brainres.2010.06.038.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oyola MG, Thompson MK, Handa AZ, Handa RJ. Distribution and chemical composition of estrogen receptor beta neurons in the paraventricular nucleus of the female and male mouse hypothalamus. J Comp Neurol. 2017;525(17):3666–82. https://doi.org/10.1002/cne.24295.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andersson S, Sundberg M, Pristovsek N, Ibrahim A, Jonsson P, Katona B, et al. Insufficient antibody validation challenges oestrogen receptor beta research. Nat Commun. 2017;8:15840. https://doi.org/10.1038/ncomms15840.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ishii H, Otsuka M, Kanaya M, Higo S, Hattori Y, Ozawa H. Applicability of anti-human estrogen receptor beta antibody PPZ0506 for the immunodetection of rodent estrogen receptor beta proteins. Int J Mol Sci. 2019;20:24. https://doi.org/10.3390/ijms20246312.

Article  CAS  Google Scholar 

Hattori Y, Ishii H, Higo S, Otsuka M, Kanaya M, Matsumoto K, et al. Optimization of immunohistochemical detection of rat ESR2 proteins with well-validated monoclonal antibody PPZ0506. Mol Cell Endocrinol. 2021;523: 111145. https://doi.org/10.1016/j.mce.2020.111145.

Article  CAS  PubMed  Google Scholar 

Ozawa M, Hattori Y, Higo S, Otsuka M, Matsumoto K, Ozawa H, et al. Optimized mouse-on-mouse immunohistochemical detection of mouse ESR2 proteins with PPZ0506 monoclonal antibody. Acta Histochem Cytochem. 2022;55(5):159–68. https://doi.org/10.1267/ahc.22-00043.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Porteous R, Haden P, Hackwell ECR, Singline A, Herde MK, Desai R, et al. Reformulation of PULSAR for analysis of pulsatile lh secretion and a revised model of estrogen-negative feedback in mice. Endocrinology. 2021;162:11. https://doi.org/10.1210/endocr/bqab165.