Childhood obesity: The threatening apprentice of the adiposity empire

Jebeile H, Kelly AS, O’Malley G, Baur LA. Obesity in children and adolescents: epidemiology, causes, assessment, and management. Lancet Diabetes Endocrinol. 2022;8587(22):1–16.

Google Scholar 

Lister NB, Baur LA, Felix JF, Hill AJ, Marcus C, Reinehr T, et al. Child and adolescent obesity. Nat Rev Dis Primers. 2023;9(1):24.

PubMed  Google Scholar 

Pulgarón ER. Childhood obesity: a review of increased risk for physical and psychological comorbidities. Clin Ther. 2013;35(1):A18-32.

PubMed  PubMed Central  Google Scholar 

Faienza MF, Wang DQH, Frühbeck G, Garruti G, Portincasa P. The dangerous link between childhood and adulthood predictors of obesity and metabolic syndrome. Intern Emerg Med. 2016;11(2):175–82.

PubMed  Google Scholar 

McPhee PG, Singh S, Morrison KM. Childhood obesity and cardiovascular disease risk: Working toward solutions. Can J Cardiol. 2020;36(9):1352–61.

PubMed  Google Scholar 

Littleton SH, Berkowitz RI, Grant SFA. Genetic determinants of childhood obesity. Mol Diagn Ther. 2020;24(6):653–63.

PubMed  PubMed Central  Google Scholar 

Grummer-Strawn LM, Reinold C, Krebs NF, Centers for Disease Control and Prevention (CDC). Use of World Health Organization and CDC growth charts for children aged 0–59 months in the United States. MMWR Recomm Rep. 2010;59(RR-9):1–15.

PubMed  Google Scholar 

World Health Organization. Weight for length/height charts. 1993. Available from: https://www.who.int/tools/child-growth-standards/standards/weight-for-length-height. Accessed 13 Oct 2024.

World Health Organization. Obesity and overweight. 2021. p. 5. Available from: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. Accessed 13 Oct 2024.

Kelly AS, Barlow SE, Rao G, Inge TH, Hayman LL, Steinberger J, et al. Severe obesity in children and adolescents: Identification, associated health risks, and treatment approaches: a scientific statement from the American Heart Association. Circulation. 2013;128(15):1689–712.

PubMed  Google Scholar 

Deepesh K, Welch BS, Rehman A. Pathophysiology of obesity. Treasure Island (FL): StatPearls Publishing. 2022.

Xu J, Kitada M, Ogura Y, Koya D. Relationship between autophagy and metabolic syndrome characteristics in the pathogenesis of atherosclerosis. Front Cell Dev Biol. 2021;9:641852.

PubMed  PubMed Central  Google Scholar 

Latorre J, Lluch A, Ortega FJ, Gavaldà-Navarro A, Comas F, Morón-Ros S, et al. Adipose tissue knockdown of lysozyme reduces local inflammation and improves adipogenesis in high-fat diet-fed mice. Pharmacol Res. 2021;166:105486.

CAS  PubMed  Google Scholar 

Yeo GSH, Chao DHM, Siegert AM, Koerperich ZM, Ericson MD, Simonds SE, et al. The melanocortin pathway and energy homeostasis: From discovery to obesity therapy. Mol Metab. 2021;48:101206.

CAS  PubMed  PubMed Central  Google Scholar 

Kaur Y, de Souza RJ, Gibson WT, Meyre D. A systematic review of genetic syndromes with obesity. Obes Rev. 2017;18(6):603–34.

CAS  PubMed  Google Scholar 

Poitou C, Mosbah H, Clément K. Mechanisms in endocrinology: update on treatments for patients with genetic obesity. Eur J Endocrinol. 2020;183(5):R149–66.

CAS  PubMed  Google Scholar 

Czajkowski P, Adamska-Patruno E, Bauer W, Fiedorczuk J, Krasowska U, Moroz M, et al. The impact of FTO genetic variants on obesity and its metabolic consequences is dependent on daily macronutrient intake. Nutrients. 2020;12(11):3255.

CAS  PubMed  PubMed Central  Google Scholar 

Koochakpour G, Esfandiar Z, Hosseini-Esfahani F, Mirmiran P, Daneshpour MS, Sedaghati-Khayat B, et al. Evaluating the interaction of common FTO genetic variants, added sugar, and trans-fatty acid intakes in altering obesity phenotypes. Nutr Metab Cardiovasc Dis. 2019;29(5):474–80.

CAS  PubMed  Google Scholar 

Busebee B, Ghusn W, Cifuentes L, Acosta A. Obesity: a review of pathophysiology and classification. Mayo Clin Proc. 2023;98(12):1842–57.

PubMed  Google Scholar 

Cummings DE, Overduin J. Gastrointestinal regulation of food intake. J Clin Invest. 2007;117(1):13–23.

CAS  PubMed  PubMed Central  Google Scholar 

Brüning JC, Fenselau H. Integrative neurocircuits that control metabolism and food intake. Science. 2023;381(6665):eabl7398.

PubMed  Google Scholar 

Hill JO, Wyatt HR, Reed GW, Peters JC. Obesity and the environment: where do we go from here? Science. 2003;299(5608):853–5.

CAS  PubMed  Google Scholar 

Zapata JK, Catalán V, Rodríguez A, Ramírez B, Silva C, Escalada J, et al. Resting energy expenditure is not altered in children and adolescents with obesity. Effect of age and gender and association with serum Leptin levels. Nutrients. 2021;13(4):1216.

CAS  PubMed  PubMed Central  Google Scholar 

Carneiro IP, Elliott SA, Siervo M, Padwal R, Bertoli S, Battezzati A, et al. Is obesity associated with altered energy expenditure? Adv Nutr. 2016;7:476–87.

CAS  PubMed  PubMed Central  Google Scholar 

Westerterp KR. Doubly labelled water assessment of energy expenditure: principle, practice, and promise. Eur J Appl Physiol. 2017;117:1277–85.

CAS  PubMed  PubMed Central  Google Scholar 

Delsoglio M, Achamrah N, Berger MM, Pichard C. Indirect calorimetry in clinical practice. J Clin Med. 2019;8(9):1387.

CAS  PubMed  PubMed Central  Google Scholar 

Unamuno X, Gómez-Ambrosi J, Rodríguez A, Becerril S, Frühbeck G, Catalán V. Adipokine dysregulation and adipose tissue inflammation in human obesity. Eur J Clin Invest. 2018;48(9):e12997.

PubMed  Google Scholar 

Frühbeck G. A heliocentric view of leptin. Proc Nutr Soc. 2001;60(3):301–18.

PubMed  Google Scholar 

Frühbeck G, Gómez-Ambrosi J, Salvador J. Leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes. FASEB J. 2001;15(2):333–40.

PubMed  Google Scholar 

Muruzábal FJ, Frühbeck G, Gómez-Ambrosi J, Archanco M, Burrell MA. Immunocytochemical detection of leptin in non-mammalian vertebrate stomach. Gen Comp Endocrinol. 2002;128(2):149–52.

PubMed  Google Scholar 

Gómez-Ambrosi J, Salvador J, Páramo JA, Orbe J, de Irala J, Diez-Caballero A, et al. Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors. Clin Biochem. 2002;35(4):315–20.

PubMed  Google Scholar 

Caminiti C, Armeno M, Mazza CS. Waist-to-height ratio as a marker of low-grade inflammation in obese children and adolescents. J Pediatr Endocrinol Metab. 2016;29(5):543–51.

CAS  PubMed  Google Scholar 

Singer K, Eng DS, Lumeng CN, Gebremariam A, Lee JM. The relationship between body fat mass percentiles and inflammation in children. Obesity. 2014;22(6):1332–6.

CAS  PubMed  Google Scholar 

Stroescu RF, Mǎrginean O, Bizerea T, Gafencu M, Voicu A, Doroş G. Adiponectin, leptin and high sensitivity C-reactive protein values in obese children - Important markers for metabolic syndrome? J Pediatr Endocrinol Metab. 2019;32(1):27–31.

CAS  PubMed  Google Scholar 

Seo YG, Lim H, Kim Y, Ju YS, Lee HJ, Jang HB, et al. The effect of a multidisciplinary lifestyle intervention on obesity status, body composition, physical fitness, and cardiometabolic risk markers in children and adolescents with obesity. Nutrients. 2019;11(1):1–16.

Google Scholar 

Weihrauch-Blüher S, Schwarz P, Klusmann JH. Childhood obesity: increased risk for cardiometabolic disease and cancer in adulthood. Metabolism. 2019;92:147–52.

PubMed  Google Scholar 

Mamun AA, Mannan M, Doi SAR. Gestational weight gain in relation to offspring obesity over the life course: a systematic review and bias-adjusted meta-analysis. Obes Rev. 2014;15(4):338–47.

CAS  PubMed  Google Scholar 

Drozdz D, Alvarez-Pitti J, Wójcik M, Borghi C, Gabbianelli R, Mazur A, et al. Obesity and cardiometabolic risk factors: from childhood to adulthood. Nutrients. 2021;13(11):1–20.

Google Scholar 

Geserick M, Vogel M, Gausche R, Lipek T, Spielau U, Keller E, et al. Acceleration of BMI in early childhood and risk of sustained obesity. N Engl J Med. 2018;379(14):1303–12.

PubMed  Google Scholar 

Zhang X, Liu J, Ni Y, Yi C, Fang Y, Ning Q, et al. Global prevalence of overweight and obesity in children and adolescents: a systematic review and meta-analysis. JAMA Pediatr. 2024;178(8):800–13.

PubMed  PubMed Central  Google Scholar 

Colmenarejo G. Machine learning models to predict childhood and adolescent obesity: a review. Nutrients. 2020;12(8):1–31.

Google Scholar 

Lara-Castor L, Micha R, Cudhea F, Miller V, Shi P, Zhang J, et al. Intake of sugar sweetened beverages among children and adolescents in 185 countries between 1990 and 2018: population based study. BMJ. 2024;386:e079234.

PubMed  PubMed Central  Google Scholar 

Caprio S, Santoro N, Weiss R. Childhood obesity and the associated rise in cardiometabolic complications. Nat Metab. 2020;2(3):223–32.

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