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Pharmacological characterization of sex differences in the effects of dopaminergic drugs on effort-based decision making in rats
Pharmacological characterization of sex differences in the effects of dopaminergic drugs on effort-based decision making in rats
Motivational dysfunctions related to effort exertion are common in psychiatric disorders. Dopamine systems regulate exerti...
Ellagic Acid Reverses Alterations in the Expression of AMPA Receptor and Its Scaffolding Proteins in the Cerebral Cortex and Memory Decline in STZ-sporadic Alzheimer’ s Disease Mouse Model
Ellagic Acid Reverses Alterations in the Expression of AMPA Receptor and Its Scaffolding Proteins in the Cerebral Cortex and Memory Decline in STZ-sporadic Alzheimer’ s Disease Mouse Model
Alzheimer’s disease (AD), an age-dependent devastating neuropsychiatric disorder, is a leading cause of learning, me...
Acute nicotine administration reduces the efficacy of punishment in curbing remifentanil consumption in a seeking-taking chain schedule of reinforcement
Acute nicotine administration reduces the efficacy of punishment in curbing remifentanil consumption in a seeking-taking chain schedule of reinforcement
Nicotine dependence is highly comorbid with opioid use disorders (OUDs). The use of nicotine-containing products increases...
Acute ethanol disrupts conditioned inhibition in the male rat
Acute ethanol disrupts conditioned inhibition in the male rat
Alcohol can disrupt conditioned sexual inhibition (CSI) established by first-order conditioning in male rats. CSI can also...
Elucidating the molecular symphony: unweaving the transcriptional & epigenetic pathways underlying neuroplasticity in opioid dependence and withdrawal
Elucidating the molecular symphony: unweaving the transcriptional & epigenetic pathways underlying neuroplasticity in opioid dependence and withdrawal
The persistent use of opioids leads to profound changes in neuroplasticity of the brain, contributing to the emergence and...
Hypocretin-1 receptor antagonism improves inhibitory control during the Go/No-Go task in highly motivated, impulsive male mice
Hypocretin-1 receptor antagonism improves inhibitory control during the Go/No-Go task in highly motivated, impulsive male mice
Motivation and inhibitory control are dominantly regulated by the dopaminergic (DA) and noradrenergic (NA) systems, respec...
Choice of alcohol over a natural reward: an experimental study in light and heavy social drinkers
Choice of alcohol over a natural reward: an experimental study in light and heavy social drinkers
A core symptom of alcohol use disorder (AUD) is a progressively increased choice of alcohol over alternative rewards despi...
Oxytocin differentially modulates reward system responses to social and non-social incentives
Oxytocin differentially modulates reward system responses to social and non-social incentives
Oxytocin has been shown to modulate behavior related to processing of monetary incentives and to regulate social and repro...
Perceived changes in mental health and social engagement attributed to a single psychedelic experience in autistic adults: results from an online survey
Perceived changes in mental health and social engagement attributed to a single psychedelic experience in autistic adults: results from an online survey
Anecdotal reports suggest that psychedelic drugs can improve psychological wellbeing and social engagement in autistic peo...
Assessment of pharmacological effects and abuse potential of 5F-EDMB-PICA, CUMYL-PEGACLONE, and NM-2201 in mice
Assessment of pharmacological effects and abuse potential of 5F-EDMB-PICA, CUMYL-PEGACLONE, and NM-2201 in mice
The newly emerging synthetic cannabinoids (SCs) 5F-EDMB-PICA, CUMYL-PEGACLONE, and NM-2201 have been observed to produce e...
Dose-dependent effect of acute THC on extinction memory recall and fear renewal: a randomized, double-blind, placebo-controlled study
Dose-dependent effect of acute THC on extinction memory recall and fear renewal: a randomized, double-blind, placebo-controlled study
Prior work from our lab and others demonstrates that the endocannabinoid system is a promising avenue for improving fear m...
Aerobic exercise prevents and improves cognitive dysfunction caused by morphine withdrawal via regulating endogenous opioid peptides in the brain
Aerobic exercise prevents and improves cognitive dysfunction caused by morphine withdrawal via regulating endogenous opioid peptides in the brain
Morphine withdrawal leads to serious cognitive deficits in which dynorphins are directly involved. Recently, exercise has ...
Immediate effects of propofol on mood: a randomized comparison of two doses in a cohort with depression
Immediate effects of propofol on mood: a randomized comparison of two doses in a cohort with depression
The intravenous anesthetic propofol is known to induce positive mood effects during routine clinical use, suggesting it mi...
Exploring the efficacy of cholinergic agents for the treatment of psychostimulant use disorder: a systematic review
Exploring the efficacy of cholinergic agents for the treatment of psychostimulant use disorder: a systematic review
No drugs are currently validated to treat psychostimulant use disorder (PUD). Pathophysiological studies consistently high...
Glia dysfunction in schizophrenia: evidence of possible therapeutic effects of nervonic acid in a preclinical model
Glia dysfunction in schizophrenia: evidence of possible therapeutic effects of nervonic acid in a preclinical model
Neuroinflammation may inhibit oligodendrocyte and astrocyte differentiation, which causes demyelination and synaptic degen...
Curcumin alleviates arsenic trioxide-induced neural damage in the murine striatal region
Curcumin alleviates arsenic trioxide-induced neural damage in the murine striatal region
Arsenic-induced neurotoxicity, with dose-dependent effects, is well-documented in rodents. Curcumin (CUR), a cost-effectiv...
Ferulic acid ameliorates bisphenol A (BPA)-induced Alzheimer’s disease-like pathology through Akt-ERK crosstalk pathway in male rats
Ferulic acid ameliorates bisphenol A (BPA)-induced Alzheimer’s disease-like pathology through Akt-ERK crosstalk pathway in male rats
This study investigated the neuroprotective effect of ferulic acid (FA) against bisphenol A (BPA) induced Alzheimer’...
Preeclampsia as a possible risk factor for memory impairment, anxiety- and depressive-like behavior in offspring
Preeclampsia as a possible risk factor for memory impairment, anxiety- and depressive-like behavior in offspring
Preeclampsia is a condition that can affect the health in offspring at adult life. The effect on several systems has been ...
Long-term disruption of tissue levels of glutamate and glutamatergic neurotransmission neuromodulators, taurine and kynurenic acid induced by amphetamine
Long-term disruption of tissue levels of glutamate and glutamatergic neurotransmission neuromodulators, taurine and kynurenic acid induced by amphetamine
Chronic amphetamine (AMPH) use leading to addiction results in adaptive changes within the central nervous system that per...
Chronic REM sleep deprivation leads to manic- and OCD-related behaviors, and decreases hippocampal BDNF expression in female rats
Chronic REM sleep deprivation leads to manic- and OCD-related behaviors, and decreases hippocampal BDNF expression in female rats
Rapid-eye movement (REM) sleep deprivation (SD) can induce manic-like behaviors in rodents. On the other hand, lithium, as...
Synergistic use of deep TMS therapy with IV ketamine infusions for major depressive disorder: a pilot study
Synergistic use of deep TMS therapy with IV ketamine infusions for major depressive disorder: a pilot study
Major Depressive Disorder (MDD) is a pervasive psychiatric condition effecting approximately 21 million adults in the U.S....
Pharmacologic profile of ITI-333: a novel molecule for treatment of substance use disorders
Pharmacologic profile of ITI-333: a novel molecule for treatment of substance use disorders
Medications are urgently needed to treat symptoms of drug withdrawal and mitigate dysphoria and psychiatric comorbidities ...
Unraveling psilocybin’s therapeutic potential: behavioral and neuroplasticity insights in Wistar-Kyoto and Wistar male rat models of treatment-resistant depression
Unraveling psilocybin’s therapeutic potential: behavioral and neuroplasticity insights in Wistar-Kyoto and Wistar male rat models of treatment-resistant depression
Our study aimed to unravel the unknown mechanisms behind the exceptional efficacy of Psilocybin (PSI) in treating treatmen...
Reinforcing effects of fentanyl analogs found in illicit drug markets
Reinforcing effects of fentanyl analogs found in illicit drug markets
The potent synthetic opioid fentanyl, and its analogs, continue to drive opioid-related overdoses. Although the pharmacolo...
Pulsed nicotine infusions as a model for smoking: validating a tool to explore nicotine thresholds in humans
Pulsed nicotine infusions as a model for smoking: validating a tool to explore nicotine thresholds in humans
No previous studies examined the discriminative stimulus effects of intravenous (IV) nicotine in humans. To evaluate a pul...
Update on cannabis in human sexuality
Update on cannabis in human sexuality
Sexuality is a central aspect of being human that encompasses many facets. Cannabis, a widely used psychoactive substance,...
Heterogeneity in choice models of addiction: the role of context
Heterogeneity in choice models of addiction: the role of context
Theories of addiction guide scientific progress, funding priorities, and policy development and ultimately shape how peopl...
Efficacy of probiotic supplements in improving the symptoms of psychosis, anxiety, insomnia, and anorexia due to amphetamine and methamphetamine use: a randomized clinical trial
Efficacy of probiotic supplements in improving the symptoms of psychosis, anxiety, insomnia, and anorexia due to amphetamine and methamphetamine use: a randomized clinical trial
Changes in the density and diversity of gut microbiota in chronic use of methamphetamine have been mentioned as contributo...
Stimulus mediation, specificity and impact of menthol in rats trained to discriminate puffs of nicotine e-cigarette aerosol from nicotine-free aerosol
Stimulus mediation, specificity and impact of menthol in rats trained to discriminate puffs of nicotine e-cigarette aerosol from nicotine-free aerosol
It is unclear if e-cigarettes have reduced abuse liability relative to traditional cigarettes, especially when considering...
Light Cannabis Use and the Adolescent Brain: An 8-years Longitudinal Assessment of Mental Health, Cognition, and Reward Processing
Light Cannabis Use and the Adolescent Brain: An 8-years Longitudinal Assessment of Mental Health, Cognition, and Reward Processing
For decades, cannabis has been the most widely used illicit substance in the world, particularly among youth. Research sug...
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