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Regulation of Hippocamposeptal Synaptic Transmission by GABABRs Is Altered in 5XFAD Mice in a Sex- and Age-Dependent Manner
Regulation of Hippocamposeptal Synaptic Transmission by GABABRs Is Altered in 5XFAD Mice in a Sex- and Age-Dependent Manner
Hippocamposeptal (HS) neurons send GABAergic projections from the hippocampus to the medial septum/diagonal band of Broca ...
Sedative Effects of Daidzin, Possibly Through the GABAA Receptor Interaction Pathway: In Vivo Approach with Molecular Dynamic Simulations
Sedative Effects of Daidzin, Possibly Through the GABAA Receptor Interaction Pathway: In Vivo Approach with Molecular Dynamic Simulations
The soy isoflavone daidzin (DZN) has been considered a hopeful bioactive compound having diverse biological activities, in...
REV-ERBα Mitigates Astrocyte Activation and Protects Dopaminergic Neurons from Damage
REV-ERBα Mitigates Astrocyte Activation and Protects Dopaminergic Neurons from Damage
Parkinson’s disease (PD) is characterized by astrocyte activation and disruptions in circadian rhythm. Within the as...
Sex-Specific ADNP/NAP (Davunetide) Regulation of Cocaine-Induced Plasticity
Sex-Specific ADNP/NAP (Davunetide) Regulation of Cocaine-Induced Plasticity
Cocaine use disorder (CUD) is a chronic neuropsychiatric disorder estimated to effect 1–3% of the population. Activi...
Involvement of CXCL10 rs4256246, CXCR4 rs2228014, CCR2 rs1799864 and CXCL16 rs2277680 in the Predisposition to Schizophrenia
Involvement of CXCL10 rs4256246, CXCR4 rs2228014, CCR2 rs1799864 and CXCL16 rs2277680 in the Predisposition to Schizophrenia
Chemokine ligands and their receptors have acquired less attention than pro- and anti-inflammatory cytokines in schizophre...
Identification and Validation of Endoplasmic Reticulum Stress-Related Gene in Traumatic Brain Injury
Identification and Validation of Endoplasmic Reticulum Stress-Related Gene in Traumatic Brain Injury
Endoplasmic reticulum stress (ERS) plays an essential role in the development of traumatic brain injury (TBI). We aimed to...
An early Transcriptomic Investigation in Adult Patients with Spinal Muscular Atrophy Under Treatment with Nusinersen
An early Transcriptomic Investigation in Adult Patients with Spinal Muscular Atrophy Under Treatment with Nusinersen
Spinal muscular atrophy (SMA) is a rare degenerative disorder with loss of motor neurons caused by mutations in the SMN1 g...
The Role of Thioredoxin System in Shank3 Mouse Model of Autism
The Role of Thioredoxin System in Shank3 Mouse Model of Autism
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by difficulties in social interactio...
Genomic Validation in the UK Biobank Cohort Suggests a Role of C8B and MFG-E8 in the Pathogenesis of Trigeminal Neuralgia
Genomic Validation in the UK Biobank Cohort Suggests a Role of C8B and MFG-E8 in the Pathogenesis of Trigeminal Neuralgia
Trigeminal neuralgia (TN) is a severe facial pain disease of uncertain pathophysiology and unclear genetic background. Alt...
Investigating the Genetic Association of 40 Biochemical Indicators with Parkinson’s Disease
Investigating the Genetic Association of 40 Biochemical Indicators with Parkinson’s Disease
The mechanisms of Parkinson’s disease (PD) are not fully understood, which hinders the development of effective ther...
Clinical and Molecular Profiles of a Cohort of Egyptian Patients with Collagen VI-Related Dystrophy
Clinical and Molecular Profiles of a Cohort of Egyptian Patients with Collagen VI-Related Dystrophy
Collagen VI-related dystrophies (COL6-RD) display a wide spectrum of disease severity and genetic variability ranging from...
Identification of Pathogenic Missense Mutations of NF1 Using Computational Approaches
Identification of Pathogenic Missense Mutations of NF1 Using Computational Approaches
Neurofibromatosis type 1 (NF1) is a prevalent autosomal dominant disorder caused by mutations in the NF1 gene, leading to ...
Exploring the hub Genes and Potential Mechanisms of Complement system-related Genes in Parkinson Disease: Based on Transcriptome Sequencing and Mendelian Randomization
Exploring the hub Genes and Potential Mechanisms of Complement system-related Genes in Parkinson Disease: Based on Transcriptome Sequencing and Mendelian Randomization
An accurate diagnosis of Parkinson’s disease (PD) remains challenging and the exact cause of the disease is unclean....
The Inhibition of Reactive Oxygen Species Modulator 1 Attenuates Sevoflurane-Induced Neural Injury via Reducing Apoptosis and Oxidative Stress
The Inhibition of Reactive Oxygen Species Modulator 1 Attenuates Sevoflurane-Induced Neural Injury via Reducing Apoptosis and Oxidative Stress
Sevoflurane causes neural injury by promoting apoptosis and oxidative stress. Reactive oxygen species modulator 1 (ROMO1) ...
Effects of Electroacupuncture at Varied Frequencies on Analgesia and Mechanisms in Sciatic Nerve Cuffing-Induced Neuropathic Pain Mice
Effects of Electroacupuncture at Varied Frequencies on Analgesia and Mechanisms in Sciatic Nerve Cuffing-Induced Neuropathic Pain Mice
Addressing the intricate challenge of chronic neuropathic pain has significant implications for the physical and psycholog...
Role of Senataxin in Amyotrophic Lateral Sclerosis
Role of Senataxin in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive, uncurable neurodegenerative disorder characterized by the degradatio...
Correction: Age-Dependent Regulation of Dendritic Spine Density and Protein Expression in Mir324 KO Mice
Correction: Age-Dependent Regulation of Dendritic Spine Density and Protein Expression in Mir324 KO Mice
University of Cincinnati Neuroscience Graduate Program, Cincinnati, OH, 45229, USAEmma V. Parkins, Sarah Yaser & Chris...
A Novel Truncating Mutation in PAX1 Gene Causes Otofaciocervical Syndrome Without Immunodeficiency
A Novel Truncating Mutation in PAX1 Gene Causes Otofaciocervical Syndrome Without Immunodeficiency
Otofaciocervical syndrome (OTFCS) is a rare genetic disorder of both autosomal recessive and autosomal dominant patterns o...
A Comprehensive Investigation of Risk Association Between the -786 T > C, + 884 G > A, VNTR, rs743506, rs3918226 of eNOS and Susceptibility of Migraine: A Updated Meta-Analysis Utilizing Trial Sequential Analysis
A Comprehensive Investigation of Risk Association Between the -786 T > C, + 884 G > A, VNTR, rs743506, rs3918226 of eNOS and Susceptibility of Migraine: A Updated Meta-Analysis Utilizing Trial Sequential Analysis
With a feature of complex pathogenic mechanisms, migraine is a well-known common neurovascular disorder. Multiple genes ar...
Effect of Proinflammatory S100A9 Protein on Migration and Proliferation of Microglial Cells
Effect of Proinflammatory S100A9 Protein on Migration and Proliferation of Microglial Cells
Alzheimer’s disease (AD) is a multifactorial disease affecting aging population worldwide. Neuroinflammation became ...
Hederagenin Upregulates PTPN1 Expression in Aβ-Stimulated Neuronal Cells, Exerting Anti-Oxidative Stress and Anti-Apoptotic Activities
Hederagenin Upregulates PTPN1 Expression in Aβ-Stimulated Neuronal Cells, Exerting Anti-Oxidative Stress and Anti-Apoptotic Activities
Alzheimer’s disease (AD) is a prevalently neurodegenerative disease characterized by neuronal damage which is associ...
IFN-γ Triggered IFITM2 Expression to Induce Malignant Phenotype in Elderly GBM
IFN-γ Triggered IFITM2 Expression to Induce Malignant Phenotype in Elderly GBM
Advanced age is an important risk factor for the worse clinical presentation of gliomas, especially glioblastoma (GBM). Th...
The Role of Cystathionine-β-Synthase, H2S, and miRNA-377 in Hypoxic-Ischemic Encephalopathy: Insights from Human and Animal Studies
The Role of Cystathionine-β-Synthase, H2S, and miRNA-377 in Hypoxic-Ischemic Encephalopathy: Insights from Human and Animal Studies
We aimed to investigate the mechanism underlying the roles of miRNA-377, Cystathionine-β-synthase (CBS), and hydrogen...
A Comprehensive Investigation into the Association Between Mthfr C677t, A1298c, and Ace I/D Variants and Risk of Migraine: an Updated Meta-Analysis of Genetic Association Studies with Trial Sequential Analysis and Meta-Regression
A Comprehensive Investigation into the Association Between Mthfr C677t, A1298c, and Ace I/D Variants and Risk of Migraine: an Updated Meta-Analysis of Genetic Association Studies with Trial Sequential Analysis and Meta-Regression
Many homeostatic genes are thought to play a role in the susceptibility to migraine, making it a highly complex neurovascu...
Nitric Oxide Synthase Inhibition Prevents Cell Proliferation in Glioblastoma
Nitric Oxide Synthase Inhibition Prevents Cell Proliferation in Glioblastoma
Glioblastoma multiforme (GBM) is a prevalent and aggressive primary brain tumor, presenting substantial treatment challeng...
Assessment of tRNAThr and tRNAGln Variants and Mitochondrial Functionality in Parkinson’s Disease (PD) Patients of Tamil Nadu Population
Assessment of tRNAThr and tRNAGln Variants and Mitochondrial Functionality in Parkinson’s Disease (PD) Patients of Tamil Nadu Population
Parkinson’s disease (PD) is speculated with genetic and environmental factors. At molecular level, the mitochondrial...
Investigation of LncRNA PVT1 and MiR-21-5p Expression as Promising Novel Biomarkers for Autism Spectrum Disorder
Investigation of LncRNA PVT1 and MiR-21-5p Expression as Promising Novel Biomarkers for Autism Spectrum Disorder
The characteristics of ncRNA in children with autism spectrum disorder (ASD) were observed to disclose a theoretical basis...
Age-Dependent Regulation of Dendritic Spine Density and Protein Expression in Mir324 KO Mice
Age-Dependent Regulation of Dendritic Spine Density and Protein Expression in Mir324 KO Mice
Dendritic spines are small, dynamic protrusions along the dendrite that comprise more than 90% of excitatory connections i...
Treadmill Exercise Improves Behavioral and Neurobiological Alterations in Restraint-Stressed Rats
Treadmill Exercise Improves Behavioral and Neurobiological Alterations in Restraint-Stressed Rats
Stress is a state that is known to impact an organism’s physiological and psychological balance as well as the morph...
A Novel Mutation in the MAP7D3 Gene in Two Siblings with Severe Intellectual Disability and Autistic Traits: Concurrent Assessment of BDNF Functional Polymorphism, X-Inactivation and Oxidative Stress to Explain Disease Severity
A Novel Mutation in the MAP7D3 Gene in Two Siblings with Severe Intellectual Disability and Autistic Traits: Concurrent Assessment of BDNF Functional Polymorphism, X-Inactivation and Oxidative Stress to Explain Disease Severity
Intellectual disabilities (ID) and autism spectrum disorders (ASD) are characterized by extreme genetic and phenotypic het...
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