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The impact of aerobic exercise dose based on ACSM recommendations on patients with Parkinson’s disease: a systematic review and meta-analysis of randomized controlled trials
The impact of aerobic exercise dose based on ACSM recommendations on patients with Parkinson’s disease: a systematic review and meta-analysis of randomized controlled trials
BackgroundTo explore the effects of different dose of aerobic exercise on motor function, balance, mobility, and quality o...
MRI radiomics combined with machine learning for diagnosing mild cognitive impairment: a focus on the cerebellar gray and white matter
MRI radiomics combined with machine learning for diagnosing mild cognitive impairment: a focus on the cerebellar gray and white matter
ObjectiveMild Cognitive Impairment (MCI) is a recognized precursor to Alzheimer’s Disease (AD), presenting a significant r...
Disparities in structural brain imaging in older adults from rural communities in Southern Nevada
Disparities in structural brain imaging in older adults from rural communities in Southern Nevada
IntroductionIdentifying the associations between rural-living or neighborhood disadvantage and neurobiology may clarify ru...
Cognitive prehabilitation for older adults undergoing elective surgery: a systematic review and narrative synthesis
Cognitive prehabilitation for older adults undergoing elective surgery: a systematic review and narrative synthesis
BackgroundPerioperative cognitive maintenance and protection in older adults is an important patient safety imperative. In...
Association of trimethylamine oxide and its precursors with cognitive impairment: a systematic review and meta-analysis
Association of trimethylamine oxide and its precursors with cognitive impairment: a systematic review and meta-analysis
ObjectivesThe role of trimethylamine oxide (TMAO) in patients with cognitive impairment remains controversial. This study ...
A bibliometric analysis of cerebral small vessel disease
A bibliometric analysis of cerebral small vessel disease
BackgroundCerebral small vessel disease (CSVD) is a significant contributor to both stroke and dementia. While numerous st...
A review of proposed mechanisms for neurodegenerative disease
A review of proposed mechanisms for neurodegenerative disease
Neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis (ALS) affect millions and ...
Grip strength and depressive symptoms in Chinese middle-aged and older adults: the mediating effects of cognitive function
Grip strength and depressive symptoms in Chinese middle-aged and older adults: the mediating effects of cognitive function
ObjectiveThis study investigates the associations and mediating pathways between grip strength, cognitive function, and de...
Implicit memory reduced selectively for negative words with aging
Implicit memory reduced selectively for negative words with aging
BackgroundDisproportionally better memory for positive versus negative information (mnemonic positivity effect, MPE) in ol...
Neural effects of multisensory dance training in Parkinson’s disease: evidence from a longitudinal neuroimaging single case study
Neural effects of multisensory dance training in Parkinson’s disease: evidence from a longitudinal neuroimaging single case study
Dance is associated with beneficial outcomes in motor and non-motor domains in Parkinson’s disease (PD) and regular partic...
Machine learning models for diagnosing Alzheimer’s disease using brain cortical complexity
Machine learning models for diagnosing Alzheimer’s disease using brain cortical complexity
ObjectiveThis study aimed to develop and validate machine learning models (MLMs) to diagnose Alzheimer’s disease (AD) usin...
Emerging role of microglia in inter-cellular transmission of α-synuclein in Parkinson’s disease
Emerging role of microglia in inter-cellular transmission of α-synuclein in Parkinson’s disease
Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide, significantly prejudicing the heal...
Sources of perceived social support and cognitive function among older adults: a longitudinal study in rural China
Sources of perceived social support and cognitive function among older adults: a longitudinal study in rural China
BackgroundStudies have shown the positive impact of perceived social support on cognitive function among older adults in r...
Identification of key proteins in early-onset Alzheimer’s disease based on WGCNA
Identification of key proteins in early-onset Alzheimer’s disease based on WGCNA
IntroductionEarly-onset Alzheimer’s disease (EOAD) is sporadic, highly heterogeneous, and its underlying pathogenic mechan...
Genetically stratified Parkinson’s disease with freezing of gait is related to specific pattern of cognitive impairment and non-motor dominant endophenotype
Genetically stratified Parkinson’s disease with freezing of gait is related to specific pattern of cognitive impairment and non-motor dominant endophenotype
BackgroundFreezing of gait (FOG) is an important milestone in the individual disease trajectory of people with Parkinson’s...
Association of frailty and serum neurofilament light chain levels: the mediating role of estimated glomerular filtration rate
Association of frailty and serum neurofilament light chain levels: the mediating role of estimated glomerular filtration rate
BackgroundBoth frailty and elevated serum neurofilament light chain (sNfL) levels are linked to cognitive impairment. Howe...
Diffusion and functional MRI reveal microstructural and network connectivity impairment in adult-onset neuronal intranuclear inclusion disease
Diffusion and functional MRI reveal microstructural and network connectivity impairment in adult-onset neuronal intranuclear inclusion disease
ObjectivesNeuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder lacking reliable neuroimagin...
Editorial: Model organisms in neuroinflammation and neuropathy: Drosophila melanogaster
neuroinflammation contributes to the pathogenesis of neurological disorders including Alzheimer's disease, Parkins...
Machine learning-based personalized composite score dissects risk and protective factors for cognitive and motor function in older participants
Machine learning-based personalized composite score dissects risk and protective factors for cognitive and motor function in older participants
IntroductionWith age, sensory, cognitive, and motor abilities decline, and the risk for neurodegenerative disorders increa...
Time trends in Alzheimer’s disease mortality attributable to metabolic risks and smoking in China from 1990 to 2019: an age-period-cohort analysis
Time trends in Alzheimer’s disease mortality attributable to metabolic risks and smoking in China from 1990 to 2019: an age-period-cohort analysis
BackgroundWith the increase in the aging population worldwide, Alzheimer’s disease has become a rapidly increasing public ...
Online awareness is associated with superior performance on assessments of functional cognition
Online awareness is associated with superior performance on assessments of functional cognition
BackgroundIntact awareness facilitates an individual’s adoption of strategies to support community living skills. However,...
A nomogram for individualized prediction of mild cognitive impairment in patients with subjective cognitive decline during physical examinations: a cross-sectional study
A nomogram for individualized prediction of mild cognitive impairment in patients with subjective cognitive decline during physical examinations: a cross-sectional study
Background and objectivesTo develop a nomogram for mild cognitive impairment (MCI) in patients with subjective cognitive d...
Exploring the association of physical activity on cognitive function in older adults from observational and genetic insights: a combined NHANES and Mendelian randomization study
Exploring the association of physical activity on cognitive function in older adults from observational and genetic insights: a combined NHANES and Mendelian randomization study
BackgroundCognitive function (CF) deterioration is a pressing concern in geriatric research. This study aimed to explore t...
The emerging role of brain neuroinflammatory responses in Alzheimer’s disease
The emerging role of brain neuroinflammatory responses in Alzheimer’s disease
As the most common cause of dementia, Alzheimer’s disease (AD) is characterized by neurodegeneration and synaptic loss wit...
Corrigendum: Glutamatergic and GABAergic neurons in the preoptic area of the hypothalamus play key roles in menopausal hot flashes
Corrigendum: Glutamatergic and GABAergic neurons in the preoptic area of the hypothalamus play key roles in menopausal hot flashes
In the published article, there was an error in Figure 3 as published. The wrong slide of microscopy was provided for OV...
ACOT7, a candidate and novel serum biomarker of Alzheimer’s disease
ACOT7, a candidate and novel serum biomarker of Alzheimer’s disease
Alzheimer’s disease (AD) is the most common fatal neurodegenerative disease among the elderly worldwide, characterized by ...
Emerging perspectives on precision therapy for Parkinson’s disease: multidimensional evidence leading to a new breakthrough in personalized medicine
Emerging perspectives on precision therapy for Parkinson’s disease: multidimensional evidence leading to a new breakthrough in personalized medicine
PD is a prevalent and progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Genes pla...
A glimpse into the future: revealing the key factors for survival in cognitively impaired patients
A glimpse into the future: revealing the key factors for survival in cognitively impaired patients
BackgroundDrawing on prospective data from the National Health and Nutrition Examination Survey (NHANES), our goal was to ...
Bidirectional two-sample Mendelian randomization analysis identifies causal associations between oxidative stress and Parkinson’s disease
Bidirectional two-sample Mendelian randomization analysis identifies causal associations between oxidative stress and Parkinson’s disease
BackgroundObservational studies have shown that oxidative stress (OS) is associated with Parkinson’s disease (PD). However...
Examining the influence of self-care practices on brain activity in healthy older adults
Examining the influence of self-care practices on brain activity in healthy older adults
IntroductionStudies on the aging brain often occur in active settings, but comparatively few investigate brain activity in...
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