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Role of macrophage ATP metabolism disorder in SiO‑induced pulmonary fibrosis: a review
Role of macrophage ATP metabolism disorder in SiO‑induced pulmonary fibrosis: a review
Silicosis, a chronic lung disease, results from prolonged inhalation of silica dust (SiO2) in occupational environments, a...
Depletion of P2X4 receptor alleviates prostate cancer bone metastasis through reduced cancer cell invasiveness and enhanced cell adhesion activities
Depletion of P2X4 receptor alleviates prostate cancer bone metastasis through reduced cancer cell invasiveness and enhanced cell adhesion activities
Prostate cancer (PCa) preferentially metastasizes to bone, which remains incurable and contributes significantly to mortal...
Acute effects of guanosine or inosine in a porcine model of hemorrhagic shock
Acute effects of guanosine or inosine in a porcine model of hemorrhagic shock
Hemorrhagic shock (HS) leads to systemic hypoperfusion, impaired tissue oxygenation, and multi-organ dysfunction, includin...
State of the art indicators for imaging purinergic dynamics in vitro and in vivo
State of the art indicators for imaging purinergic dynamics in vitro and in vivo
Purinergic neurotransmission, a dynamic signaling system using adenosine triphosphate (ATP), adenosine diphosphate (ADP), ...
Electroacupuncture alleviates capsaicin-induced rectal visceral pain in rats via inhibiting TRPV1 expression by blocking the P2X4R-activated p38 pathway
Electroacupuncture alleviates capsaicin-induced rectal visceral pain in rats via inhibiting TRPV1 expression by blocking the P2X4R-activated p38 pathway
Electroacupuncture (EA), as a combination of traditional acupuncture and modern electrotherapy, and has analgesic effects ...
The CALHM1 blocker CGP37157 increases seizure severity during status epilepticus in adult mice
The CALHM1 blocker CGP37157 increases seizure severity during status epilepticus in adult mice
Epilepsy is one of the most common chronic brain diseases affecting up to 70 million people worldwide. Major challenges of...
The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia
The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia
Endometriosis is a chronic gynecological condition characterized by endometrial tissue outside the uterine cavity. Recent ...
Therapeutic potential of P2X7 receptor in retinal diseases
Therapeutic potential of P2X7 receptor in retinal diseases
Retinal diseases affect the health of millions of people worldwide and activated P2X7 receptors (P2X7Rs) are associated wi...
Correction to: The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia
Correction to: The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia
Correction to: Purinergic SignallingUnfortunately, the original published version of ...
Adenosine receptors and acute kidney injury: perspectives for future therapy
Adenosine receptors and acute kidney injury: perspectives for future therapy
Adenosine is a key modulator in the pathophysiology of acute kidney injury (AKI), particularly through its influence on in...
Adenine at lower doses acts in the kidney as an aquaretic agent and prevents hyponatremia
Adenine at lower doses acts in the kidney as an aquaretic agent and prevents hyponatremia
We have previously reported that adenine at high doses interferes with the vasopressin signaling pathway, causes massive d...
The P2X7 receptor in leukemia: pathological mechanisms and therapeutic potential
The P2X7 receptor in leukemia: pathological mechanisms and therapeutic potential
The P2X7 receptor is a trimeric ion channel purinergic receptor. It plays a crucial part in the pathophysiology of cancers...
Breast cancer patients present pro-tumor biomarkers related to purinergic signaling and oxidative stress
Breast cancer patients present pro-tumor biomarkers related to purinergic signaling and oxidative stress
Breast cancer (BC) is a multifactorial disease characterized by cell cycle disorder and immune evasion. Studies reveal tha...
Blockage of P2X7 receptor activation attenuated bone loss in ligature-induced model of periodontitis in rats
Blockage of P2X7 receptor activation attenuated bone loss in ligature-induced model of periodontitis in rats
Periodontitis is a highly prevalent immunoinflammatory disease that compromises the supporting tissues of the teeth, espec...
The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats
The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats
An increasing number of traditional Chinese medicine(TCM) have been confirmed to possess analgesic bioactivity. 701 Dieda ...
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y receptor in the primary somatosensory cortex
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y receptor in the primary somatosensory cortex
Increasing evidence indicated that purinergic signalling involved in electroacupuncture (EA)-induced analgesia. Whether pu...
Mechanosensitive release of ATP in the urinary bladder mucosa
Mechanosensitive release of ATP in the urinary bladder mucosa
The urinary bladder mucosa (urothelium and suburothelium/lamina propria) functions as a barrier between the content of the...
CD39 activities in the treated acupoints contributed to the analgesic mechanism of acupuncture on arthritis rats
CD39 activities in the treated acupoints contributed to the analgesic mechanism of acupuncture on arthritis rats
Our previous work had identified that at the acupuncture point (acupoint), acupuncture-induced ATP release was a pivotal e...
Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells
Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells
The P2X7 receptor, an ATP-gated ion channel which belongs to the P2X receptor family, plays critical roles in recognizing ...
The role of the P2X7 receptor in inactivated SARS-CoV-2-induced lung injury
The role of the P2X7 receptor in inactivated SARS-CoV-2-induced lung injury
Purinergic signaling plays a role in the pathophysiology of different viral infections. Recently, we showed that COVID-19 ...
Purinergic P2Y and P2Y receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk
Purinergic P2Y and P2Y receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk
Purines are important mediators of intercellular communication in the enteric nervous system (ENS) that participate in phy...
Extracellular ATP regulates phagocytic activity, mitochondrial respiration, and cytokine secretion of human astrocytic cells
Extracellular ATP regulates phagocytic activity, mitochondrial respiration, and cytokine secretion of human astrocytic cells
The two main glial cell types of the central nervous system (CNS), astrocytes and microglia, are responsible for neuroimmu...
A adenosine receptor-triggered intracellular calcium mobilization: Cell type-dependent involvement of G, G, G proteins and protein kinase C
A adenosine receptor-triggered intracellular calcium mobilization: Cell type-dependent involvement of G, G, G proteins and protein kinase C
Activation of PLCβ enzymes by Giβγ and Gαq/11 proteins is a common mechanism to trigger cytosolic Ca2+...
SCH58261 effectively prevents the reduction in excitability of striatal MSNs in mice following 20 h of sleep deprivation
SCH58261 effectively prevents the reduction in excitability of striatal MSNs in mice following 20 h of sleep deprivation
Adenosine, a sleep-associated neuromodulator, is crucial in various physiological and pathological processes. Previous stu...
Ligand-directed covalent labelling of adenosine receptors
Ligand-directed covalent labelling of adenosine receptors
Adenosine signalling pathways have a significant role in many physiological processes involving immune response, regulatio...
First evidence of Borelli, 1899 (Buthidae) venom altering purine metabolism in rat blood cells
First evidence of Borelli, 1899 (Buthidae) venom altering purine metabolism in rat blood cells
Purinergic signaling pathways play crucial roles in regulating hemostatic and inflammatory responses, both of which are im...
Combined oral contraceptives alter ectonucleotidase and adenosine deaminase activities in peripheral blood cells
Combined oral contraceptives alter ectonucleotidase and adenosine deaminase activities in peripheral blood cells
Hormonal contraceptives, one of the most widely used contraceptive methods, are associated with the development of thrombo...
Establishment and behavioural characterization of a novel constitutive P2X7 receptor knockout mouse line
Establishment and behavioural characterization of a novel constitutive P2X7 receptor knockout mouse line
The P2X7 receptor is an adenosine triphosphate (ATP)-gated ion channel expressed in different cell types of the brain. Pol...
The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain
The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain
Acupuncture is a traditional medicinal practice in China that has been increasingly recognized in other countries in recen...
Targeting adenosine A2A receptors for early intervention of retinopathy of prematurity
Targeting adenosine A2A receptors for early intervention of retinopathy of prematurity
Retinopathy of prematurity (ROP) continues to pose a significant threat to the vision of numerous children worldwide, prim...
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