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The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats
The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats
An increasing number of traditional Chinese medicine(TCM) have been confirmed to possess analgesic bioactivity. 701 Dieda ...
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y receptor in the primary somatosensory cortex
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y receptor in the primary somatosensory cortex
Increasing evidence indicated that purinergic signalling involved in electroacupuncture (EA)-induced analgesia. Whether pu...
Mechanosensitive release of ATP in the urinary bladder mucosa
Mechanosensitive release of ATP in the urinary bladder mucosa
The urinary bladder mucosa (urothelium and suburothelium/lamina propria) functions as a barrier between the content of the...
CD39 activities in the treated acupoints contributed to the analgesic mechanism of acupuncture on arthritis rats
CD39 activities in the treated acupoints contributed to the analgesic mechanism of acupuncture on arthritis rats
Our previous work had identified that at the acupuncture point (acupoint), acupuncture-induced ATP release was a pivotal e...
Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells
Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells
The P2X7 receptor, an ATP-gated ion channel which belongs to the P2X receptor family, plays critical roles in recognizing ...
The role of the P2X7 receptor in inactivated SARS-CoV-2-induced lung injury
The role of the P2X7 receptor in inactivated SARS-CoV-2-induced lung injury
Purinergic signaling plays a role in the pathophysiology of different viral infections. Recently, we showed that COVID-19 ...
Purinergic P2Y and P2Y receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk
Purinergic P2Y and P2Y receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk
Purines are important mediators of intercellular communication in the enteric nervous system (ENS) that participate in phy...
Extracellular ATP regulates phagocytic activity, mitochondrial respiration, and cytokine secretion of human astrocytic cells
Extracellular ATP regulates phagocytic activity, mitochondrial respiration, and cytokine secretion of human astrocytic cells
The two main glial cell types of the central nervous system (CNS), astrocytes and microglia, are responsible for neuroimmu...
A adenosine receptor-triggered intracellular calcium mobilization: Cell type-dependent involvement of G, G, G proteins and protein kinase C
A adenosine receptor-triggered intracellular calcium mobilization: Cell type-dependent involvement of G, G, G proteins and protein kinase C
Activation of PLCβ enzymes by Giβγ and Gαq/11 proteins is a common mechanism to trigger cytosolic Ca2+...
SCH58261 effectively prevents the reduction in excitability of striatal MSNs in mice following 20 h of sleep deprivation
SCH58261 effectively prevents the reduction in excitability of striatal MSNs in mice following 20 h of sleep deprivation
Adenosine, a sleep-associated neuromodulator, is crucial in various physiological and pathological processes. Previous stu...
Ligand-directed covalent labelling of adenosine receptors
Ligand-directed covalent labelling of adenosine receptors
Adenosine signalling pathways have a significant role in many physiological processes involving immune response, regulatio...
First evidence of Borelli, 1899 (Buthidae) venom altering purine metabolism in rat blood cells
First evidence of Borelli, 1899 (Buthidae) venom altering purine metabolism in rat blood cells
Purinergic signaling pathways play crucial roles in regulating hemostatic and inflammatory responses, both of which are im...
Combined oral contraceptives alter ectonucleotidase and adenosine deaminase activities in peripheral blood cells
Combined oral contraceptives alter ectonucleotidase and adenosine deaminase activities in peripheral blood cells
Hormonal contraceptives, one of the most widely used contraceptive methods, are associated with the development of thrombo...
Establishment and behavioural characterization of a novel constitutive P2X7 receptor knockout mouse line
Establishment and behavioural characterization of a novel constitutive P2X7 receptor knockout mouse line
The P2X7 receptor is an adenosine triphosphate (ATP)-gated ion channel expressed in different cell types of the brain. Pol...
The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain
The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain
Acupuncture is a traditional medicinal practice in China that has been increasingly recognized in other countries in recen...
Targeting adenosine A2A receptors for early intervention of retinopathy of prematurity
Targeting adenosine A2A receptors for early intervention of retinopathy of prematurity
Retinopathy of prematurity (ROP) continues to pose a significant threat to the vision of numerous children worldwide, prim...
The impact of purine nucleosides on neuroplasticity in the adult brain
The impact of purine nucleosides on neuroplasticity in the adult brain
Neuroplasticity refers to the nervous system’s ability to adapt and reorganize its cell structures and neuronal netw...
Regulation of nerve-evoked contractions of the murine vas deferens
Regulation of nerve-evoked contractions of the murine vas deferens
Stimulation of sympathetic nerves in the vas deferens yields biphasic contractions consisting of a rapid transient compone...
Genetic and functional modulation by agonist MRS5698 and allosteric enhancer LUF6000 at the native A3 adenosine receptor in HL-60 cells
Genetic and functional modulation by agonist MRS5698 and allosteric enhancer LUF6000 at the native A3 adenosine receptor in HL-60 cells
The A3 adenosine receptor (AR) is an important inflammatory and immunological target. However, the underlying mechanisms a...
P2X7 receptors: a bibliometric review from 2002 to 2023
P2X7 receptors: a bibliometric review from 2002 to 2023
For many years, there has been ongoing research on the P2X7 receptor (P2X7R). A comprehensive, systematic, and objective e...
Novel synthesized ionizable lipid for LNP-mediated P2X7siRNA to inhibit migration and induce apoptosis of breast cancer cells
Novel synthesized ionizable lipid for LNP-mediated P2X7siRNA to inhibit migration and induce apoptosis of breast cancer cells
The development of ionizable lipid (IL) was necessary to enable the effective formulation of small interfering RNA (siRNA)...
Purinergic pathways and their clinical use in the treatment of acute myeloid leukemia
Purinergic pathways and their clinical use in the treatment of acute myeloid leukemia
Despite the use of various therapies such as hematopoietic stem cell transplantation and chimeric antigen receptor T cell ...
Implications of COVID-19 in Parkinson’s disease: the purinergic system in a therapeutic-target perspective to diminish neurodegeneration
Implications of COVID-19 in Parkinson’s disease: the purinergic system in a therapeutic-target perspective to diminish neurodegeneration
The pathophysiology of Parkinson’s disease (PD) is marked by degeneration of dopaminergic neurons in the substantia ...
Electroacupuncture regulates the P2X7R-NLRP3 inflammatory cascade to relieve decreased sensation on ocular surface of type 2 diabetic rats with dry eye
Electroacupuncture regulates the P2X7R-NLRP3 inflammatory cascade to relieve decreased sensation on ocular surface of type 2 diabetic rats with dry eye
Dry eye (DE) is a prevalent ocular surface disease in patients with type 2 diabetes (T2DM). However, current medications a...
The functional role of P2 purinergic receptors in the progression of gastric cancer
The functional role of P2 purinergic receptors in the progression of gastric cancer
Studies have confirmed that P2 purinergic receptors (P2X receptors and P2Y receptors) expressed in gastric cancer (GC) cel...
Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine
Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine
Berberine (BBR) is a Chinese herb with antioxidant and anti-inflammatory properties. In a previous study, we found that BB...
Cutaneous melanoma and purinergic modulation by phenolic compounds
Cutaneous melanoma and purinergic modulation by phenolic compounds
Cutaneous melanoma is a complex pathology that still has only treatments that lack efficiency and offer many adverse effec...
Machine learning-aided search for ligands of P2Y6 and other P2Y receptors
Machine learning-aided search for ligands of P2Y6 and other P2Y receptors
The P2Y6 receptor, activated by uridine diphosphate (UDP), is a target for antagonists in inflammatory, neurodegenerative,...
Deep learning structural insights into heterotrimeric alternatively spliced P2X7 receptors
Deep learning structural insights into heterotrimeric alternatively spliced P2X7 receptors
P2X7 receptors (P2X7Rs) are membrane-bound ATP-gated ion channels that are composed of three subunits. Different subunit s...
Purinergic signaling in the battlefield of viral infections
Purinergic signaling in the battlefield of viral infections
Purinergic signaling has been associated with immune defenses against pathogens such as bacteria, protozoa, fungi, and vir...
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