Rodriguez-Abreu D, Bordoni A, Zucca E (2007) Epidemiology of hematological malignancies. Ann Oncol 18 Suppl 1:i3–i8. https://doi.org/10.1093/annonc/mdl443
Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74(3):229–263. https://doi.org/10.3322/caac.21834
Bispo JAB, Pinheiro PS, Kobetz EK (2020) Epidemiology and etiology of leukemia and lymphoma. Cold Spring Harb Perspect Med 10(6):a034819. https://doi.org/10.1101/cshperspect.a034819
Lin K, Jia H, Cao M, Xu T, Chen Z, Song X et al (2023) Epidemiological characteristics of leukemia in China, 2005–2017: a log-linear regression and age-period-cohort analysis. BMC Public Health 23(1):1647. https://doi.org/10.1186/s12889-023-16226-1
Article PubMed PubMed Central Google Scholar
Abaza Y, McMahon C, Garcia JS (2024) Advancements and challenges in the treatment of AML. Am Soc Clin Oncol Educ Book 44(3):e438662. https://doi.org/10.1200/edbk_438662
Vultaggio-Poma V, Sarti AC, Di Virgilio F (2020) Extracellular ATP: a feasible target for cancer therapy. Cells 9(11):2496. https://doi.org/10.3390/cells9112496
Article PubMed PubMed Central CAS Google Scholar
Burnstock G (2007) Purine and pyrimidine receptors. Cell Mol Life Sci 64(12):1471–1483. https://doi.org/10.1007/s00018-007-6497-0
Sluyter R (2017) The P2X7 receptor. Adv Exp Med Biol 1051:17–53. https://doi.org/10.1007/5584_2017_59
Zhang GP, Liao JX, Liu YY, Zhu FQ, Huang HJ, Zhang WJ (2024) Ion channel P2X7 receptor in the progression of cancer. Front Oncol 13:1297775. https://doi.org/10.3389/fonc.2023.1297775
Article PubMed PubMed Central CAS Google Scholar
De Marchi E, Orioli E, Pegoraro A, Sangaletti S, Portararo P, Curti A et al (2019) The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment. Oncogene 38(19):3636–3650. https://doi.org/10.1038/s41388-019-0684-y
De Marchi E, Pegoraro A, Adinolfi E (2021) P2X7 receptor in hematological malignancies. Front Cell Dev Biol 9:645605. https://doi.org/10.3389/fcell.2021.645605
Article PubMed PubMed Central Google Scholar
Furini F, Giuliani AL, Parlati ME, Govoni M, Di Virgilio F, Bortoluzzi A (2019) P2X7 receptor expression in patients with serositis related to systemic lupus erythematosus. Front Pharmacol 10:435. https://doi.org/10.3389/fphar.2019.00435
Article PubMed PubMed Central CAS Google Scholar
Pegoraro A, Adinolfi E (2021) The ATP/P2X7 axis is a crucial regulator of leukemic initiating cells proliferation and homing and an emerging therapeutic target in acute myeloid leukemia. Purinergic Signal 17(3):319–321. https://doi.org/10.1007/s11302-021-09789-4
Buell GN, Talabot F, Gos A, Lorenz J, Lai E, Morris MA, Antonarakis SE (1998) Gene structure and chromosomal localization of the human P2X7 receptor. Receptors Channels 5(6):347–354
Di Virgilio F, Jiang LH, Roger S et al (2019) Structure, function and techniques of investigation of the P2X7 receptor (P2X7R) in mammalian cells. Methods Enzymol 629:115–150. https://doi.org/10.1016/bs.mie.2019.07.043
Roger S, Jelassi B, Couillin I, Pelegrin P, Besson P, Jiang LH (2015) Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives. Biochim Biophys Acta 1848(10 Pt B):2584–2602. https://doi.org/10.1016/j.bbamem.2014.10.029
Costa-Junior HM, Sarmento Vieira F, Coutinho-Silva R (2011) C terminus of the P2X7 receptor: treasure hunting. Purinergic Signal 7(1):7–19. https://doi.org/10.1007/s11302-011-9215-1
Liang X, Samways DSK, Cox J, Egan TM (2019) Ca2+ flux through splice variants of the ATP-gated ionotropic receptor P2X7 is regulated by its cytoplasmic N terminus. J Biol Chem 294(33):12521–12533. https://doi.org/10.1074/jbc.RA119.009666
Migita K, Oyabu K, Terada K (2023) Rectification of ATP-gated current of rat P2X2 and P2X7 receptors depends on the cytoplasmic N-terminus. Biochem Biophys Res Commun 688:149213. https://doi.org/10.1016/j.bbrc.2023.149213
Article PubMed CAS Google Scholar
Sluyter R, Stokes L (2011) Significance of P2X7 receptor variants to human health and disease. Recent Pat DNA Gene Seq 5(1):41–54. https://doi.org/10.2174/187221511794839219
Di Virgilio F, Dal Ben D, Sarti AC, Giuliani AL, Falzoni S (2017) The P2X7 receptor in infection and inflammation. Immunity 47(1):15–31. https://doi.org/10.1016/j.immuni.2017.06.020
Wiley JS, Sluyter R, Gu BJ, Stokes L, Fuller SJ (2011) The human P2X7 receptor and its role in innate immunity. Tissue Antigens 78(5):321–332. https://doi.org/10.1111/j.1399-0039.2011.01780.x
Surprenant A, Rassendren F, Kawashima E, North RA, Buell G (1996) The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). Science 272(5262):735–738. https://doi.org/10.1126/science.272.5262.735
Zhang XJ, Zheng GG, Ma XT et al (2004) Expression of P2X7 in human hematopoietic cell lines and leukemia patients. Leuk Res 28(12):1313–1322. https://doi.org/10.1016/j.leukres.2004.04.001
Orioli E, De Marchi E, Giuliani AL, Adinolfi E (2017) P2X7 receptor orchestrates multiple signalling pathways triggering inflammation, autophagy and metabolic/trophic responses. Curr Med Chem 24(21):2261–2275. https://doi.org/10.2174/0929867324666170303161659
Guerra Martinez C (2019) P2X7 receptor in cardiovascular disease: the heart side. Clin Exp Pharmacol Physiol 46(6):513–526. https://doi.org/10.1111/1440-1681.13079
Article PubMed CAS Google Scholar
Lara R, Adinolfi E, Harwood CA, Philpott M, Barden JA, Di Virgilio F, McNulty S (2020) P2X7 in cancer: from molecular mechanisms to therapeutics. Front Pharmacol 11:793. https://doi.org/10.3389/fphar.2020.00793
Article PubMed PubMed Central CAS Google Scholar
Jiang LH, Caseley EA, Muench SP, Roger S (2021) Structural basis for the functional properties of the P2X7 receptor for extracellular ATP. Purinergic Signal 17(3):331–344. https://doi.org/10.1007/s11302-021-09790-x
Article PubMed PubMed Central CAS Google Scholar
Hu SQ, Hu JL, Zou FL, Liu JP, Luo HL, Hu DX et al (2022) P2X7 receptor in inflammation and pain. Brain Res Bull 187:199–209. https://doi.org/10.1016/j.brainresbull.2022.07.006
Article PubMed CAS Google Scholar
Zheng H, Liu Q, Zhou S, Luo H, Zhang W (2024) Role and therapeutic targets of P2X7 receptors in neurodegenerative diseases. Front Immunol 15:1345625. https://doi.org/10.3389/fimmu.2024.1345625
Article PubMed PubMed Central CAS Google Scholar
Adinolfi E, Giuliani AL, De Marchi E, Pegoraro A, Orioli E, Di Virgilio F (2018) The P2X7 receptor: a main player in inflammation. Biochem Pharmacol 151:234–244. https://doi.org/10.1016/j.bcp.2017.12.021
Article PubMed CAS Google Scholar
El Idrissi IG, Podlewska S, Abate C, Bojarski AJ, Lacivita E, Leopoldo M (2024) Structure-activity relationships and therapeutic potential of purinergic P2X7 receptor antagonists. Curr Med Chem 31(11):1361–1403. https://doi.org/10.2174/0929867330666230403094538
Barberà-Cremades M, Gómez AI, Baroja-Mazo A, Martínez-Alarcón L, Martínez CM, de Torre-Minguela C, Pelegrín P (2017) P2X7 receptor induces tumor necrosis factor-α converting enzyme activation and release to boost TNF-α production. Front Immunol 8:862. https://doi.org/10.3389/fimmu.2017.00862
Article PubMed PubMed Central CAS Google Scholar
Zou YT, Li JY, Chai JY, Hu YS, Zhang WJ, Zhang Q (2024) The impact of the P2X7 receptor on the tumor immune microenvironment and its effects on tumor progression. Biochem Biophys Res Commun 707:149513. https://doi.org/10.1016/j.bbrc.2024.149513
Article PubMed CAS Google Scholar
Nuñez-Ríos JD, Reyna-Jeldes M, Mata-Martínez E, Campos-Contreras ADR, Lazcano-Sánchez I Lazcano-Sánchez I et al (2024) Extracellular ATP/P2X7 receptor, a regulatory axis of migration in ovarian carcinoma-derived cells. PLos One 19(6):e0304062. https://doi.org/10.1371/journal.pone.0304062
Janho Dit Hreich S, Hofman P, Vouret-Craviari V (2023) The role of IL-18 in P2RX7-mediated antitumor immunity. Int J Mol Sci 24(11):9235. https://doi.org/10.3390/ijms24119235
Adinolfi E, Raffaghello L, Giuliani AL, Cavazzini L, Capece M, Chiozzi P et al (2012) Expression of P2X7 receptor increases in vivo tumor growth. Cancer Res 72(12):2957–2969. https://doi.org/10.1158/0008-5472.Can-11-1947
Article PubMed CAS Google Scholar
Adinolfi E, De Marchi E, Orioli E, Pegoraro A, Di Virgilio F (2019) Role of the P2X7 receptor in tumor-associated inflammation. Curr Opin Pharmacol 47:59–64. https://doi.org/10.1016/j.coph.2019.02.012
Comments (0)