Chan JF, Kok KH, Zhu Z, Chu H, To KK, Yuan S, Yuen KY (2020) Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect 9:221–236

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu F, Zhao S, Yu B, Chen YM, Wang W, Song ZG, Hu Y, Tao ZW, Tian JH, Pei YY, Yuan ML, Zhang YL, Dai FH, Liu Y, Wang QM, Zheng JJ, Xu L, Holmes EC, Zhang YZ (2020) A new coronavirus associated with human respiratory disease in China. Nature 579:265–269

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ruan YJ, Wei CL, Ee AL, Vega VB, Thoreau H, Su ST, Chia JM, Ng P, Chiu KP, Lim L, Zhang T, Peng CK, Lin EO, Lee NM, Yee SL, Ng LF, Chee RE, Stanton LW, Long PM, Liu ET (2003) Comparative full-length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection. Lancet 361:1779–1785

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rehman SU, Shafique L, Ihsan A, Liu Q (2020) Evolutionary Trajectory for the Emergence of Novel Coronavirus SARS-CoV-2. Pathogens 9:240

Article  PubMed  PubMed Central  Google Scholar 

Jarczak D, Nierhaus A (2022) Cytokine Storm-Definition, Causes, and Implications. Int J Mol Sci 23:11740

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun X, Wang T, Cai D, Hu Z, Chen J, Liao H, Zhi L, Wei H, Zhang Z, Qiu Y, Wang J, Wang A (2020) Cytokine storm intervention in the early stages of COVID-19 pneumonia. Cytokine Growth Factor Rev. 53:38–42. https://doi.org/10.1016/j.cytogfr.2020.04.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burnstock G, Campbell G, Satchell D, Smythe A (1970) Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut. Br J Pharmacol 40:668–688

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carvalho-Barbosa N, Zeidler JD, Savio LEB and Coutinho-Silva R (2023) Purinergic signaling in the battlefield of viral infections. Purinergic Signal. 10–09981

Dubyak GR and el-Moatassim C (1993) Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides. Am J Physiol. 265:C577-C606

Coutinho-Silva R, Savio LEB (2021) Purinergic signalling in host innate immune defence against intracellular pathogens. Biochem. Pharmacol. 187:114405. https://doi.org/10.1016/j.bcp.2021.114405

Article  CAS  PubMed  Google Scholar 

Dosch M, Gerber J, Jebbawi F, Beldi G (2018) Mechanisms of ATP Release by Inflammatory Cells. Int J Mol Sci 19:1222

Article  PubMed  PubMed Central  Google Scholar 

Morciano G, Sarti AC, Marchi S, Missiroli S, Falzoni S, Raffaghello L, Pistoia V, Giorgi C, Di VF, Pinton P (2017) Use of luciferase probes to measure ATP in living cells and animals. Nat Protoc 12:1542–1562

Article  CAS  PubMed  Google Scholar 

Faas MM, Sáez T and de VP (2017) Extracellular ATP and adenosine: The Yin and Yang in immune responses? Mol. Aspects Med. 55:9-19. https://doi.org/10.1016/j.mam.2017.01.002

Burnstock G, Verkhratsky A (2009) Evolutionary origins of the purinergic signalling system. Acta Physiol (Oxf) 195:415–447

Article  CAS  PubMed  Google Scholar 

Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC (2007) Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med 204:1257–1265

Article  CAS  PubMed  PubMed Central  Google Scholar 

Díaz-García E, García-Tovar S, Alfaro E, Zamarrón E, Mangas A, Galera R, Ruíz-Hernández JJ, Solé-Violán J, Rodríguez-Gallego C, Van-Den-Rym A, Pérez-de-Diego R, Nanwani-Nanwani K, López-Collazo E, García-Rio F, Cubillos-Zapata C (2022) Role of CD39 in COVID-19 Severity: Dysregulation of Purinergic Signaling and Thromboinflammation. Front Immunol 13:847894. https://doi.org/10.3389/fimmu.2022.847894. eCollection;%2022.:847894

Aeffner F, Woods PS, Davis IC (2015) Ecto-5’-nucleotidase CD73 modulates the innate immune response to influenza infection but is not required for development of influenza-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol 309:L1313–L1322

Article  CAS  PubMed  PubMed Central  Google Scholar 

He T, Brocca-Cofano E, Gillespie DG, Xu C, Stock JL, Ma D, Policicchio BB, Raehtz KD, Rinaldo CR, Apetrei C, Jackson EK, Macatangay BJ, Pandrea I (2015) Critical Role for the Adenosine Pathway in Controlling Simian Immunodeficiency Virus-Related Immune Activation and Inflammation in Gut Mucosal Tissues. J Virol 89:9616–9630

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hanley PJ, Musset B, Renigunta V, Limberg SH, Dalpke AH, Sus R, Heeg KM, Preisig-Müller R, Daut J (2004) Extracellular ATP induces oscillations of intracellular Ca2+ and membrane potential and promotes transcription of IL-6 in macrophages. Proc Natl Acad Sci U S A 101:9479–9484

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu W, Albalawi F, Beckel JM, Lim JC, Laties AM, Mitchell CH (2017) The P2X7 receptor links mechanical strain to cytokine IL-6 up-regulation and release in neurons and astrocytes. J Neurochem 141:436–448

Article  CAS  PubMed  PubMed Central  Google Scholar 

Savio LEB, Leite-Aguiar R, Alves VS, Coutinho-Silva R, Wyse ATS (2021) Purinergic signaling in the modulation of redox biology. Redox Biol. 47:102137. https://doi.org/10.1016/j.redox.2021.102137

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Z, Jin N, Narasaraju T, Chen J, McFarland LR, Scott M, Liu L (2004) Identification of two novel markers for alveolar epithelial type I and II cells. Biochem Biophys Res Commun 319:774–780

Article  CAS  PubMed  Google Scholar 

Olotu C, Kiefmann M, Ronneburg C, Lehmensiek F, Cuvenhaus A, Meidl V, Goetz AE, Kiefmann R (2020) Analysis of purine receptor expression and functionality in alveolar epithelial cells. Purinergic Signal 16:213–229

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sluyter R (2017) The P2X7 Receptor. Adv Exp Med Biol 1051:17–53. https://doi.org/10.1007/5584_2017_59.:17-53

Article  CAS  PubMed  Google Scholar 

Kaczmarek-Hajek K, Zhang J, Kopp R, Grosche A, Rissiek B, Saul A, Bruzzone S, Engel T, Jooss T, Krautloher A, Schuster S, Magnus T, Stadelmann C, Sirko S, Koch-Nolte F, Eulenburg V, Nicke A (2018) Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody. Elife 7:e36217. https://doi.org/10.7554/eLife.36217.:e36217

Article  PubMed  PubMed Central  Google Scholar 

Feng W, Yang X, Wang L, Wang R, Yang F, Wang H, Liu X, Ren Q, Zhang Y, Zhu X, Zheng G (2021) P2X7 promotes the progression of MLL-AF9 induced acute myeloid leukemia by upregulation of Pbx3. Haematologica 106:1278–1289

Article  CAS  PubMed  Google Scholar 

Song E, Bartley CM, Chow RD, Ngo TT, Jiang R, Zamecnik CR, Dandekar R, Loudermilk RP, Dai Y, Liu F, Sunshine S, Liu J, Wu W, Hawes IA, Alvarenga BD, Huynh T, McAlpine L, Rahman NT, Geng B, Chiarella J, Goldman-Israelow B, Vogels CBF, Grubaugh ND, Casanovas-Massana A, Phinney BS, Salemi M, Alexander JR, Gallego JA, Lencz T, Walsh H, Wapniarski AE, Mohanty S, Lucas C, Klein J, Mao T, Oh J, Ring A, Spudich S, Ko AI, Kleinstein SH, Pak J, DeRisi JL, Iwasaki A, Pleasure SJ, Wilson MR, Farhadian SF (2021) Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms. Cell Rep Med 2:100288

Article  PubMed  PubMed Central  Google Scholar 

Middleton EA, He XY, Denorme F, Campbell RA, Ng D, Salvatore SP, Mostyka M, Baxter-Stoltzfus A, Borczuk AC, Loda M, Cody MJ, Manne BK, Portier I, Harris ES, Petrey AC, Beswick EJ, Caulin AF, Iovino A, Abegglen LM, Weyrich AS, Rondina MT, Egeblad M, Schiffman JD, Yost CC (2020) Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome. Blood 136:1169–1179

Article  CAS  PubMed  Google Scholar 

Di Virgilio F, Dal Ben D, Sarti AC, Giuliani AL, Falzoni S (2017) The P2X7 Receptor in Infection and Inflammation. Immunity 47:15–31

Article  PubMed  Google Scholar 

He WT, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang ZH, Zhong CQ, Han J (2015) Gasdermin D is an executor of pyroptosis and required for interleukin-1Î2 secretion. Cell Res 25:1285–1298