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Mapping out multiple sclerosis with spatial transcriptomics
Mapping out multiple sclerosis with spatial transcriptomics
In this issue, Alsema, Wijering, Miedema, Kotah et al. and Lerma-Martin, Badia-i-Mompel et al. demonstrate the ever-growin...
Cell type mapping reveals tissue niches and interactions in subcortical multiple sclerosis lesions
Cell type mapping reveals tissue niches and interactions in subcortical multiple sclerosis lesions
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. Inflammation is gradually compart...
Spatially resolved gene signatures of white matter lesion progression in multiple sclerosis
Spatially resolved gene signatures of white matter lesion progression in multiple sclerosis
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system characterized by myelin loss and progress...
Deep RNA sequencing of human dorsal root ganglion neurons reveals somatosensory mechanisms
Deep RNA sequencing of human dorsal root ganglion neurons reveals somatosensory mechanisms
We used single-soma deep RNA sequencing to generate a high-resolution atlas of human somatosensory dorsal root ganglion ne...
Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease
Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease
Astrocytes are crucial to brain homeostasis, yet their changes along the spatiotemporal progression of Alzheimer’s d...
TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model
TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model
Alzheimer’s disease is one of at least 26 diseases characterized by tau-positive accumulation in neurons, glia or bo...
Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices
Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices
Seizures are made up of the coordinated activity of networks of neurons, suggesting that control of neurons in the patholo...
Emergence of a brainstem somatosensory tonotopic map for substrate vibration
Emergence of a brainstem somatosensory tonotopic map for substrate vibration
Perceiving substrate-borne vibrations is a fundamental component of tactile perception. How location (somatotopy) and freq...
That’s a wrap
The myelination of newly formed neurons is facilitated by the differentiation of oligodendrocyte precursor cells (OPCs). O...
Astrocytes know when to feed neurons
Neurons require a constant supply of energy to function, some of which is supplied by astrocytes in the form of lactate. I...
Neutrophil–microglia interactions in AD
APOE4 is a strong risk factor for Alzheimer’s disease (AD) and, when expressed on ‘neurodegenerative microglia’ (MGnDs), i...
Glia move to the foreground
In this special issue of Nature Neuroscience, we shine a spotlight on glia. Research into glia has become one of the most ...
In conversation with Sonia Mayoral
In conversation with Sonia Mayoral
As part of our special issue focused on glia, Nature Neuroscience is having conversations with both established leaders in...
Neuronal activity stimulates a genetic program to rapidly generate synapses during development
Neuronal activity stimulates a genetic program to rapidly generate synapses during development
In Caenorhabditis elegans, loss of the transcription factors FOS-1 and EGL-43 — orthologs of human FOS and MECOM, re...
Author Correction: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
Author Correction: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
Axel RomingerPresent address: Department of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, SwitzerlandChai...
Publisher Correction: Nested compressed co-representations of multiple sequential experiences during sleep
Authors and AffiliationsDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USAKefei Liu, Jeremie Sibille &a...
Restoring sensation to prosthetics
Amputees often experience paresthesia and difficulties using prosthetic limbs because of impaired sensorimotor processing....
HDAC3 stokes microglia in stroke
Microglia play a complex role in the response to brain injury, with past work showing that these cells can both aid in the...
Pushing the bounds on dimensionality
Low-dimensional representations can capture structure in neural dynamics data, but it is unclear whether additional struct...
Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding
Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding
Learning and memory require activity-induced changes in dendritic translation, but which mRNAs are involved and how they a...
Widespread changes in alternative splicing in developing and adult mouse brain
Widespread changes in alternative splicing in developing and adult mouse brain
In the first comprehensive mRNA isoform atlas of the developing and adult mouse brain, we discover that region and age inf...
Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain
Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain
RNA isoforms influence cell identity and function. However, a comprehensive brain isoform map was lacking. We analyze sing...
Advancing the neuroscience of human pregnancy
Advancing the neuroscience of human pregnancy
The study of the female brain during pregnancy and motherhood is gaining traction, and holds the potential to address the ...
Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration
Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration
In neurons, RNA granules are transported along the axon for local translation away from the soma. Recent studies indicate ...
In conversation with Ukpong Eyo
In conversation with Ukpong Eyo
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the f...
In conversation with Kelsey Martin
In conversation with Kelsey Martin
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the f...
Updating the striatal–pallidal wiring diagram
Updating the striatal–pallidal wiring diagram
The striatal and pallidal complexes are basal ganglia structures that orchestrate learning and execution of flexible behav...
Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension
Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension
Hypertension (HTN), a disease afflicting over one billion individuals worldwide, is a leading cause of cognitive impairmen...
Myelin and Alzheimer’s disease
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
How we promote data sharing
In 2022, we began a pilot to facilitate data sharing for manuscripts submitted to Nature Neuroscience. Here, we analyze it...
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