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Stress and autophagy
Stress disrupts homeostasis, and although various processes in the brain quickly restore equilibrium following acute stres...
An energy blueprint of the human brain
Functional neuroimaging enables measurement of brain organization and dynamics, but it only indirectly measures the subcel...
Widespread brain–body integration during changes of arousal
Widespread brain–body integration during changes of arousal
Widespread, slow fluctuations in brain blood flow detected via functional MRI and neural activity are integrated with syst...
Social rank modulates methamphetamine-seeking in dominant and subordinate male rodents via distinct dopaminergic pathways
Social rank modulates methamphetamine-seeking in dominant and subordinate male rodents via distinct dopaminergic pathways
Social status has a profound impact on mental health and propensity towards drug addiction. However, the neural mechanisms...
MeCP2 and non-CG DNA methylation stabilize the expression of long genes that distinguish closely related neuron types
MeCP2 and non-CG DNA methylation stabilize the expression of long genes that distinguish closely related neuron types
The diversity of mammalian neurons is delineated by subtle gene expression differences that may require specialized mechan...
Bilateral integration in somatosensory cortex is controlled by behavioral relevance
Bilateral integration in somatosensory cortex is controlled by behavioral relevance
Sensory perception requires the processing of stimuli from both sides of the body. Yet, how neurons bind stimulus informat...
Activity-driven myelin sheath growth is mediated by mGluR5
Activity-driven myelin sheath growth is mediated by mGluR5
Myelination by oligodendrocytes in the central nervous system is influenced by neuronal activity, but the molecular mechan...
Aging and injury drive neuronal senescence in the dorsal root ganglia
Aging and injury drive neuronal senescence in the dorsal root ganglia
Aging negatively impacts central nervous system function; however, there is limited information about the cellular impact ...
Mapping out multiple sclerosis with spatial transcriptomics
Mapping out multiple sclerosis with spatial transcriptomics
In this issue, Alsema, Wijering, Miedema, Kotah et al. and Lerma-Martin, Badia-i-Mompel et al. demonstrate the ever-growin...
Cell type mapping reveals tissue niches and interactions in subcortical multiple sclerosis lesions
Cell type mapping reveals tissue niches and interactions in subcortical multiple sclerosis lesions
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. Inflammation is gradually compart...
Spatially resolved gene signatures of white matter lesion progression in multiple sclerosis
Spatially resolved gene signatures of white matter lesion progression in multiple sclerosis
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system characterized by myelin loss and progress...
Deep RNA sequencing of human dorsal root ganglion neurons reveals somatosensory mechanisms
Deep RNA sequencing of human dorsal root ganglion neurons reveals somatosensory mechanisms
We used single-soma deep RNA sequencing to generate a high-resolution atlas of human somatosensory dorsal root ganglion ne...
Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease
Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease
Astrocytes are crucial to brain homeostasis, yet their changes along the spatiotemporal progression of Alzheimer’s d...
TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model
TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model
Alzheimer’s disease is one of at least 26 diseases characterized by tau-positive accumulation in neurons, glia or bo...
Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices
Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices
Seizures are made up of the coordinated activity of networks of neurons, suggesting that control of neurons in the patholo...
Emergence of a brainstem somatosensory tonotopic map for substrate vibration
Emergence of a brainstem somatosensory tonotopic map for substrate vibration
Perceiving substrate-borne vibrations is a fundamental component of tactile perception. How location (somatotopy) and freq...
That’s a wrap
The myelination of newly formed neurons is facilitated by the differentiation of oligodendrocyte precursor cells (OPCs). O...
Astrocytes know when to feed neurons
Neurons require a constant supply of energy to function, some of which is supplied by astrocytes in the form of lactate. I...
Neutrophil–microglia interactions in AD
APOE4 is a strong risk factor for Alzheimer’s disease (AD) and, when expressed on ‘neurodegenerative microglia’ (MGnDs), i...
Glia move to the foreground
In this special issue of Nature Neuroscience, we shine a spotlight on glia. Research into glia has become one of the most ...
In conversation with Sonia Mayoral
In conversation with Sonia Mayoral
As part of our special issue focused on glia, Nature Neuroscience is having conversations with both established leaders in...
Neuronal activity stimulates a genetic program to rapidly generate synapses during development
Neuronal activity stimulates a genetic program to rapidly generate synapses during development
In Caenorhabditis elegans, loss of the transcription factors FOS-1 and EGL-43 — orthologs of human FOS and MECOM, re...
Author Correction: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
Author Correction: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
Axel RomingerPresent address: Department of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, SwitzerlandChai...
Publisher Correction: Nested compressed co-representations of multiple sequential experiences during sleep
Authors and AffiliationsDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USAKefei Liu, Jeremie Sibille &a...
Restoring sensation to prosthetics
Amputees often experience paresthesia and difficulties using prosthetic limbs because of impaired sensorimotor processing....
HDAC3 stokes microglia in stroke
Microglia play a complex role in the response to brain injury, with past work showing that these cells can both aid in the...
Pushing the bounds on dimensionality
Low-dimensional representations can capture structure in neural dynamics data, but it is unclear whether additional struct...
Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding
Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding
Learning and memory require activity-induced changes in dendritic translation, but which mRNAs are involved and how they a...
Widespread changes in alternative splicing in developing and adult mouse brain
Widespread changes in alternative splicing in developing and adult mouse brain
In the first comprehensive mRNA isoform atlas of the developing and adult mouse brain, we discover that region and age inf...
Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain
Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain
RNA isoforms influence cell identity and function. However, a comprehensive brain isoform map was lacking. We analyze sing...
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