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TMEM16A Activation Inhibits Autophagy in Dorsal Root Ganglion Cells, Which is Associated with the p38 MAPK/mTOR Pathway
TMEM16A Activation Inhibits Autophagy in Dorsal Root Ganglion Cells, Which is Associated with the p38 MAPK/mTOR Pathway
Transmembrane member 16A (TMEM16A) exhibits a negative correlation with autophagy, though the underlying mechanism remains...
Identification of miRNA-TF Regulatory Pathways Related to Diseases from a Neuroendocrine-Immune Perspective
Identification of miRNA-TF Regulatory Pathways Related to Diseases from a Neuroendocrine-Immune Perspective
The neuroendocrine-immune (NEI) network is fundamental for maintaining body's homeostasis and health. While the roles ...
Exosomal MiRNA Therapy for Central Nervous System Injury Diseases
Exosomal MiRNA Therapy for Central Nervous System Injury Diseases
Central nervous system diseases include central nervous system injury diseases, neurodegenerative diseases, and other cond...
Exploring the Neuroprotective Effects of Rufinamide in a Streptozotocin-Induced Dementia Model
Exploring the Neuroprotective Effects of Rufinamide in a Streptozotocin-Induced Dementia Model
Due to the complex pathophysiology of AD (Alzheimer’s Disease), there are currently no effective clinical treatments...
Single-Cell RNA-Seq Reveals the Pseudo-temporal Dynamic Evolution Characteristics of ADSCs to Neuronal Differentiation
Single-Cell RNA-Seq Reveals the Pseudo-temporal Dynamic Evolution Characteristics of ADSCs to Neuronal Differentiation
Adipose-derived stromal cells (ADSCs) are commonly used in regenerative medicine, but the genetic features of their develo...
Application of Circulating Tumor DNA in the Auxiliary Diagnosis and Prognosis Prediction of Glioma
Application of Circulating Tumor DNA in the Auxiliary Diagnosis and Prognosis Prediction of Glioma
Glioma is the most common primary malignant brain tumor. Despite significant advances in the past decade in understanding ...
Molecular Signaling Pathways of Quercetin in Alzheimer’s Disease: A Promising Arena
Molecular Signaling Pathways of Quercetin in Alzheimer’s Disease: A Promising Arena
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by cognitive impairment and memory deficit. Ev...
Differences in Blood and Cerebrospinal Fluid Between Parkinson’s Disease and Related Diseases
Differences in Blood and Cerebrospinal Fluid Between Parkinson’s Disease and Related Diseases
It is difficult to distinguish Parkinson’s disease (PD) in the early stage from those of various disorders including...
A Focal Traumatic Injury to the Neonatal Rodent Spinal Cord Causes an Immediate and Massive Spreading Depolarization Sustained by Chloride Ions, with Transient Network Dysfunction
A Focal Traumatic Injury to the Neonatal Rodent Spinal Cord Causes an Immediate and Massive Spreading Depolarization Sustained by Chloride Ions, with Transient Network Dysfunction
In clinics, physical injuries to the spinal cord cause a temporary motor areflexia below lesion, known as spinal shock. Th...
Correction: Expression of CGRP in the Trigeminal Ganglion and Its Effect on the Polarization of Macrophages in Rats with Temporomandibular Arthritis
Correction: Expression of CGRP in the Trigeminal Ganglion and Its Effect on the Polarization of Macrophages in Rats with Temporomandibular Arthritis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Correction: Sevoflurane Induces Learning and Memory Impairment in Young Mice Through a Reduction in Neuronal Glucose Transporter 3
Correction: Sevoflurane Induces Learning and Memory Impairment in Young Mice Through a Reduction in Neuronal Glucose Transporter 3
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Genetically Predicted Leucine Level Mediates Association Between CD4/CD8br T Lymphocytes and Insomnia
Genetically Predicted Leucine Level Mediates Association Between CD4/CD8br T Lymphocytes and Insomnia
Immune and metabolic factors play an important role in the onset and development of insomnia. This study aimed to investig...
AMPA Receptors in Synaptic Plasticity, Memory Function, and Brain Diseases
AMPA Receptors in Synaptic Plasticity, Memory Function, and Brain Diseases
Tetrameric AMPA-type ionotropic glutamate receptors are primary transducers of fast excitatory synaptic transmission in th...
Correction: Docosahexaenoic Acid Alleviates Oxidative Stress-Based Apoptosis Via Improving Mitochondrial Dynamics in Early Brain Injury After Subarachnoid Hemorrhage
Correction: Docosahexaenoic Acid Alleviates Oxidative Stress-Based Apoptosis Via Improving Mitochondrial Dynamics in Early Brain Injury After Subarachnoid Hemorrhage
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Correction: Myosin IIA Regulated Tight Junction in Oxygen Glucose-Deprived Brain Endothelial Cells Via Activation of TLR4/PI3K/Akt/JNK1/2/14-3-3ε/NF-κB/MMP9 Signal Transduction Pathway
Correction: Myosin IIA Regulated Tight Junction in Oxygen Glucose-Deprived Brain Endothelial Cells Via Activation of TLR4/PI3K/Akt/JNK1/2/14-3-3ε/NF-κB/MMP9 Signal Transduction Pathway
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Differential Neuronal Activation of Nociceptive Pathways in Neuropathic Pain After Spinal Cord Injury
Differential Neuronal Activation of Nociceptive Pathways in Neuropathic Pain After Spinal Cord Injury
Neuropathic pain, a prevalent complication following spinal cord injury (SCI), severely impairs the life quality of patien...
Organochlorine Pesticides and Epigenetic Alterations in Brain Cancer
Organochlorine Pesticides and Epigenetic Alterations in Brain Cancer
Epigenetic alterations have emerged as critical factors in the pathogenesis of brain cancer, particularly gliomas. This ar...
Neutrophil Extracellular Traps Regulate Surgical Brain Injury by Activating the cGAS-STING Pathway
Neutrophil Extracellular Traps Regulate Surgical Brain Injury by Activating the cGAS-STING Pathway
Surgical brain injury (SBI), induced by neurosurgical procedures or instruments, has not attracted adequate attention. The...
Correction: Inhibition of mTOR Alleviates Early Brain Injury After Subarachnoid Hemorrhage Via Relieving Excessive Mitochondrial Fission
Correction: Inhibition of mTOR Alleviates Early Brain Injury After Subarachnoid Hemorrhage Via Relieving Excessive Mitochondrial Fission
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Correction: Relevance of Thymic Stromal Lymphopoietin on the Pathogenesis of Glioblastoma: Role of the Neutrophil
Correction: Relevance of Thymic Stromal Lymphopoietin on the Pathogenesis of Glioblastoma: Role of the Neutrophil
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Inhibition of UHRF1 Improves Motor Function in Mice with Spinal Cord Injury
Inhibition of UHRF1 Improves Motor Function in Mice with Spinal Cord Injury
Spinal-cord injury (SCI) is a severe condition that can lead to limb paralysis and motor dysfunction, and its pathogenesis...
Correction: GPR18 Agonist Resolvin D2 Reduces Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage by Multiple Protective Mechanisms
Correction: GPR18 Agonist Resolvin D2 Reduces Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage by Multiple Protective Mechanisms
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Association of Cadherin-Related Family Member 1 with Traumatic Brain Injury
Association of Cadherin-Related Family Member 1 with Traumatic Brain Injury
The cadherin family plays a pivotal role in orchestrating synapse formation in the central nervous system. Cadherin-relate...
Enhanced Spine Stability and Survival Lead to Increases in Dendritic Spine Density as an Early Response to Local Alpha-Synuclein Overexpression in Mouse Prefrontal Cortex
Enhanced Spine Stability and Survival Lead to Increases in Dendritic Spine Density as an Early Response to Local Alpha-Synuclein Overexpression in Mouse Prefrontal Cortex
Lewy Body Dementias (LBD), including Parkinson’s disease dementia and Dementia with Lewy Bodies, are characterized b...
The Efficacy of Different Material Scaffold-Guided Cell Transplantation in the Treatment of Spinal Cord Injury in Rats: A Systematic Review and Network Meta-analysis
The Efficacy of Different Material Scaffold-Guided Cell Transplantation in the Treatment of Spinal Cord Injury in Rats: A Systematic Review and Network Meta-analysis
Cell transplantation is a promising treatment option for spinal cord injury (SCI). However, there is no consensus on the c...
Stem Cell-Derived Exosomal MicroRNAs as Novel Potential Approach for Multiple Sclerosis Treatment
Stem Cell-Derived Exosomal MicroRNAs as Novel Potential Approach for Multiple Sclerosis Treatment
Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) characterized by inflammation and dem...
Correction: CKLF1 Aggravates Focal Cerebral Ischemia Injury at Early Stage Partly by Modulating Microglia/Macrophage Toward M1 Polarization Through CCR4
Correction: CKLF1 Aggravates Focal Cerebral Ischemia Injury at Early Stage Partly by Modulating Microglia/Macrophage Toward M1 Polarization Through CCR4
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
The Role of Beta2-Microglobulin in Central Nervous System Disease
The Role of Beta2-Microglobulin in Central Nervous System Disease
Central nervous system (CNS) disorders represent the leading cause of disability and the second leading cause of death wor...
A Pharmacogenomics-Based In Silico Investigation of Opioid Prescribing in Post-operative Spine Pain Management and Personalized Therapy
A Pharmacogenomics-Based In Silico Investigation of Opioid Prescribing in Post-operative Spine Pain Management and Personalized Therapy
Considering the variability in individual responses to opioids and the growing concerns about opioid addiction, prescribin...
Astrocyte-Specific Inhibition of the Primary Cilium Suppresses C3 Expression in Reactive Astrocyte
Astrocyte-Specific Inhibition of the Primary Cilium Suppresses C3 Expression in Reactive Astrocyte
C3-positive reactive astrocytes play a neurotoxic role in various neurodegenerative diseases. However, the mechanisms cont...
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