Benowitz NL, Henningfield JE (1994) Establishing a nicotine threshold for addiction. The implications for tobacco regulation. N Engl J Med 331:123–125
Article CAS PubMed Google Scholar
Bolin BL, Alcorn JL, Reynolds AR, Lile JA, Rush CR (2016) Human drug discrimination: a primer and methodological review. Exp Clin Psychopharmacol 24:214–228
Article PubMed PubMed Central Google Scholar
De Aquino JP, DeVito EE, Xie C, Meyerovich J, Parida S, Gueorguieva R, Sofuoglu M (2022a) Development of pulsed intravenous nicotine infusions as a model for inhaled nicotine in humans. Psychopharmacology 239:2809–2818
De Aquino JP, MacLean RR, Gueorguieva R, DeVito EE, Eid T, Sofuoglu M (2022b) Impact of delivery rate on the acute response to intravenous nicotine: a human laboratory study with implications for regulatory science. Addict Biol 27:e13161
DeVito EE, Herman AI, Waters AJ, Valentine GW, Sofuoglu M (2014) Subjective, physiological, and cognitive responses to intravenous nicotine: effects of sex and menstrual cycle phase. Neuropsychopharmacology 39:1431–1440
Article CAS PubMed PubMed Central Google Scholar
Donny EC, Denlinger RL, Tidey JW, Koopmeiners JS, Benowitz NL, Vandrey RG, Al’Absi M, Carmella SG, Cinciripini PM, Dermody SS (2015) Randomized trial of reduced-nicotine standards for cigarettes. N Engl J Med 373:1340–1349
Article CAS PubMed PubMed Central Google Scholar
Fischman MW (1989) Relationship between self-reported drug effects and their reinforcing effects: studies with stimulant. NIDA Res Monogr 92:211–230
Gottlieb S, Zeller M (2017) A nicotine-focused framework for public health. N Engl J Med 377:1111–1114
Hatsukami DK, Luo X, Jensen JA, al’Absi M, Allen SS, Carmella SG, Chen M, Cinciripini PM, Denlinger-Apte R, Drobes DJ (2018) Effect of immediate vs gradual reduction in nicotine content of cigarettes on biomarkers of smoke exposure: a randomized clinical trial. JAMA 320:880–891
Article CAS PubMed PubMed Central Google Scholar
Higgins ST, Tidey JW, Sigmon SC, Heil SH, Gaalema DE, Lee D, Hughes JR, Villanti AC, Bunn JY, Davis DR (2020) Changes in cigarette consumption with reduced nicotine content cigarettes among smokers with psychiatric conditions or socioeconomic disadvantage: 3 randomized clinical trials. JAMA Netw open 3:e2019311–e2019311
Article PubMed PubMed Central Google Scholar
Jensen KP, DeVito EE, Valentine G, Gueorguieva R, Sofuoglu M (2016) Intravenous nicotine self-administration in smokers: dose–response function and sex differences. Neuropsychopharmacology 41:2034–2040
Article CAS PubMed PubMed Central Google Scholar
MacLean RR, DeVito EE, Eid T, Parida S, Gueorguieva R, Sofuoglu M (2021a) Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers. Psychopharmacology 238:2083–2090
Article CAS PubMed PubMed Central Google Scholar
MacLean RR, Gueorguieva R, DeVito EE, Peltier MR, Parida S, Sofuoglu M (2021b) The effects of inhaled flavors on intravenous nicotine. Exp Clin Psychopharmacol 29:615–624
Article CAS PubMed Google Scholar
MacLean RR, Eid T, Parida S, Gueorguieva R, DeVito EE, Sofuoglu M (2023) Threshold for the pleasurable effects of nicotine are lower than its reinforcing effects during self-administration. Exp Clin Psychopharmacol 31:37–45
Article CAS PubMed Google Scholar
Morean ME, de Wit H, King AC, Sofuoglu M, Rueger SY, O’Malley SS (2013) The drug effects questionnaire: psychometric support across three drug types. Psychopharmacology 227:177–192
Article CAS PubMed Google Scholar
Perkins KA (2022) Acute nicotine reinforcement requires ability to discriminate the stimulus effects of nicotine. Exp Clin Psychopharmacol 30:253–268
Article CAS PubMed Google Scholar
Perkins KA, Kunkle N, Karelitz JL, Michael VC, Donny EC (2016) Threshold dose for discrimination of nicotine via cigarette smoking. Psychopharmacology 233:2309–2317
Article CAS PubMed PubMed Central Google Scholar
Perkins KA, Kunkle N, Karelitz JL (2017a) Threshold dose for behavioral discrimination of cigarette nicotine content in menthol vs. non-menthol smokers. Psychopharmacology 234:1255–1265
Article CAS PubMed Google Scholar
Perkins KA, Kunkle N, Karelitz JL, Perkins KA, Kunkle N, Karelitz JL (2017b) Preliminary test of cigarette nicotine discrimination threshold in non-dependent versus dependent smokers. Drug Alcohol Depend 175:36–41
Article CAS PubMed PubMed Central Google Scholar
Rose JE, Corrigall WA (1997) Nicotine self-administration in animals and humans: similarities and differences. Psychopharmacology 130:28–40
Article CAS PubMed Google Scholar
Rose JE, Behm FM, Westman EC, Coleman RE (1999) Arterial nicotine kinetics during cigarette smoking and intravenous nicotine administration: implications for addiction. Drug Alcohol Depend 56:99–107
Article CAS PubMed Google Scholar
Sofuoglu M, Lesage MG (2012) The reinforcement threshold for nicotine as a target for tobacco control. Drug Alcohol Depend 125:1–7
Article PubMed PubMed Central Google Scholar
St. Helen G, Nardone N, Addo N, Dempsey D, Havel C, Jacob P III, Benowitz N (2019) Differences in nicotine intake and effects from electronic and combustible cigarettes among dual users. Addiction 115:757–767
Stolerman IP, Childs E, Ford MM, Grant KA (2011) Role of training dose in drug discrimination: a review. Behav Pharmacol 22:415–429
Article PubMed PubMed Central Google Scholar
Valentine GW, DeVito EE, Jatlow PI, Gueorguieva R, Sofuoglu M (2018) Acute effects of inhaled menthol on the rewarding effects of intravenous nicotine in smokers. J Psychopharmacol 32:986–994
Article CAS PubMed PubMed Central Google Scholar
Wooters TE, Bevins RA, Bardo MT (2009) Neuropharmacology of the interoceptive stimulus properties of nicotine. Curr Drug Abuse Rev 2:243–255
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