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Targeting anti-PAD4 autoantibodies in RA
Findings implicate anti-PAD4 antibodies in the pathogenesis of rheumatoid arthritis.
Arterial and venous thrombosis in systemic and monogenic vasculitis
Arterial and venous thrombosis in systemic and monogenic vasculitis
Systemic vasculitis, common forms of which include anti-neutrophil cytoplasmic antibody-associated small-vessel vasculitis...
Understanding rheumatic disease through continuous cell state analysis
Understanding rheumatic disease through continuous cell state analysis
Autoimmune rheumatic diseases are a heterogeneous group of conditions, including rheumatoid arthritis (RA) and systemic lu...
Region-specific, data-driven guidelines are needed for rheumatic diseases in LMICs
Separate guidelines are needed for the management and diagnosis of rheumatic diseases in low- and middle-income countries,...
The pathogenesis, clinical presentations and treatment of monogenic systemic vasculitis
The pathogenesis, clinical presentations and treatment of monogenic systemic vasculitis
Many monogenic autoinflammatory diseases, including DADA2 (deficiency of adenosine deaminase 2), HA20 (haploinsufficiency ...
Fibroblasts in immune responses, inflammatory diseases and therapeutic implications
Fibroblasts in immune responses, inflammatory diseases and therapeutic implications
Once regarded as passive bystander cells of the tissue stroma, fibroblasts have emerged as active orchestrators of tissue ...
How JAK inhibitors tip the prothrombotic balance in rheumatoid arthritis
The increased incidence of deep vein thromboses and pulmonary emboli has long been noted in rheumatoid arthritis and has b...
Insights into Lyme arthritis
Two complimentary studies provide a deeper understanding of Lyme disease and the associated chronic complications, such as...
Risk of uveitis in SpA is changing
Findings from an observational study suggest that the frequency of uveitis in patients with spondyloarthritis has declined...
Rheumatology in the digital health era: status quo and quo vadis?
Rheumatology in the digital health era: status quo and quo vadis?
Rheumatology faces a critical shortage of health-care professionals, exacerbated by an ageing patient population and escal...
Novel autoantigen in idiopathic lung disease
The presence of anti-IFI16 autoantibodies in patients with idiopathic interstitial pneumonia is linked to poor prognosis a...
Dupuytren contracture treatments compared
In an open-label clinical trial, collagenase injection was not noninferior to limited fasciectomy for the treatment of Dup...
The management of adult and paediatric uveitis for rheumatologists
The management of adult and paediatric uveitis for rheumatologists
Uveitis encompasses multiple different conditions that are all characterized by intra-ocular inflammation. Uveitis occurs ...
The essential roles of memory B cells in the pathogenesis of systemic lupus erythematosus
The essential roles of memory B cells in the pathogenesis of systemic lupus erythematosus
Emerging evidence indicates that memory B cells are dysfunctional in systemic lupus erythematosus (SLE). They are hyporesp...
Publisher Correction: Recent advances in the diagnosis and management of neuropsychiatric lupus
Authors and AffiliationsDivision of Rheumatology, Department of Medicine, Dalhousie University and Queen Elizabeth II Heal...
The emergence of SLE-causing UNC93B1 variants in 2024
During the past year, four studies have reported ten mutations in UNC93B1, which encodes the Toll-like receptor (TLR) chap...
Advancements and challenges in CAR T cell therapy in autoimmune diseases
Advancements and challenges in CAR T cell therapy in autoimmune diseases
Chimeric antigen receptor (CAR) T cells are highly effective at targeting and eliminating cells of the B cell lineage. CAR...
The past 25 years in paediatric rheumatology: insights from monogenic diseases
The past 25 years in paediatric rheumatology: insights from monogenic diseases
The past 25 years have seen major novel developments in the field of paediatric rheumatology. The concept of autoinflammat...
The role of obesity and adipose tissue dysfunction in osteoarthritis pain
The role of obesity and adipose tissue dysfunction in osteoarthritis pain
Obesity has a pivotal and multifaceted role in pain associated with osteoarthritis (OA), extending beyond the mechanistic ...
Behavioural therapy app for fibromyalgia
Cognitive behavioural therapy, including acceptance and commitment therapy (ACT), is recommended as part of a multimodal a...
Ion channels in osteoarthritis: emerging roles and potential targets
Ion channels in osteoarthritis: emerging roles and potential targets
Osteoarthritis (OA) is a highly prevalent joint disease that causes substantial disability, yet effective approaches to di...
PDZK1 downregulation linked to mitochondrial dysfunction in OA
PDZK1 downregulation linked to mitochondrial dysfunction in OA
The PDZ domain-containing scaffold protein PDZK1 is downregulated in osteoarthritic chondrocytes and is linked to mitochon...
Advancing equity in genomic medicine for rheumatology
Increasing diversity in genomic studies is essential to advance precision medicine and health equity in rheumatic diseases...
Macrophage-coated nanocarriers for gouty arthritis
Macrophage-coated nanocarriers for gouty arthritis
In a new study, researchers use M2 macrophage exosomes and membranes to disguise a tri-drug-carrying nanosystem that reduc...
Author Correction: International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative
National Institute for Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, ...
Author Correction: Proposals for the rheumatological use of JAK inhibitors
Authors and AffiliationsUniversity della Campania, Department of Precision Medicine, Naples, ItalyFrancesco CicciaUniversi...
Time for a new approach to drug development for rare systemic autoinflammatory diseases
Despite the transformative potential of treatments for systemic autoinflammatory diseases, these conditions remain underfu...
Author Correction: Therapeutic potential in rheumatic diseases of extracellular vesicles derived from mesenchymal stromal cells
Author notesThese authors contributed equally: Christian Jorgensen, Danièle Noël.Authors and AffiliationsIRMB, University ...
Benralizumab noninferior to mepolizumab for EGPA
In a head-to-head phase III trial of two drugs that target IL-5 or its receptor, benralizumab was noninferior to mepolizum...
Joint-specific memory, resident memory T cells and the rolling window of opportunity in arthritis
Joint-specific memory, resident memory T cells and the rolling window of opportunity in arthritis
In rheumatoid arthritis, juvenile idiopathic arthritis and other forms of inflammatory arthritis, the immune system target...
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