Wallace, I. J. et al. Knee osteoarthritis has doubled in prevalence since the mid-20th century. Proc. Natl Acad. Sci. USA 114, 9332–9336 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hunter, D. J. & Bierma-Zeinstra, S. Osteoarthritis. Lancet 393, 1745–1759 (2019).

Article  CAS  PubMed  Google Scholar 

Safiri, S. et al. Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017. Ann. Rheum. Dis. 79, 819–828 (2020).

Article  PubMed  Google Scholar 

Blüher, M. Obesity: global epidemiology and pathogenesis. Nat. Rev. Endocrinol. 15, 288–298 (2019).

Article  PubMed  Google Scholar 

González-Muniesa, P. et al. Obesity. Nat. Rev. Dis. Prim. 3, 17034 (2017).

Article  PubMed  Google Scholar 

The GBD 2015 Obesity Collaborators. Health effects of overweight and obesity in 195 countries over 25 years. N. Engl. J. Med. 377, 13–27 (2017).

Article  Google Scholar 

Berenbaum, F., Wallace, I. J., Lieberman, D. E. & Felson, D. T. Modern-day environmental factors in the pathogenesis of osteoarthritis. Nat. Rev. Rheumatol. 14, 674–681 (2018).

Article  PubMed  Google Scholar 

Zheng, H. & Chen, C. Body mass index and risk of knee osteoarthritis: systematic review and meta-analysis of prospective studies. BMJ Open 5, e007568 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Reyes, C. et al. Association between overweight and obesity and risk of clinically diagnosed knee, hip, and hand osteoarthritis: a population-based cohort study: overweight/obesity and the risk of developing OA. Arthritis Rheumatol. 68, 1869–1875 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Yusuf, E. et al. Association between weight or body mass index and hand osteoarthritis: a systematic review. Ann. Rheum. Dis. 69, 761–765 (2010).

Article  PubMed  Google Scholar 

Visser, A. et al. Adiposity and hand osteoarthritis: the Netherlands Epidemiology of Obesity study. Arthritis Res. Ther. 16, R19 (2014).

Article  PubMed  PubMed Central  Google Scholar 

Collins, K. H. et al. Adipose tissue is a critical regulator of osteoarthritis. Proc. Natl Acad. Sci. USA 118, e2021096118 (2021).

Article  CAS  PubMed  Google Scholar 

Kahn, C. R., Wang, G. & Lee, K. Y. Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome. J. Clin. Invest. 129, 3990–4000 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Kawai, T., Autieri, M. V. & Scalia, R. Adipose tissue inflammation and metabolic dysfunction in obesity. Am. J. Physiol. Cell Physiol. 320, C375–C391 (2021).

Article  CAS  PubMed  Google Scholar 

Malfait, A.-M. & Schnitzer, T. J. Towards a mechanism-based approach to pain management in osteoarthritis. Nat. Rev. Rheumatol. 9, 654–664 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gossec, L. et al. The role of pain and functional impairment in the decision to recommend total joint replacement in hip and knee osteoarthritis: an international cross-sectional study of 1909 patients. Report of the OARSI-OMERACT Task Force on total joint replacement. Osteoarthr. Cartil. 19, 147–154 (2011).

Article  CAS  Google Scholar 

Neogi, T. The epidemiology and impact of pain in osteoarthritis. Osteoarthr. Cartil. 21, 1145–1153 (2013).

Article  CAS  Google Scholar 

Losina, E., Song, S., Bensen, G. P. & Katz, J. N. Opioid use among medicare beneficiaries with knee osteoarthritis: prevalence and correlates of chronic use. Arthritis Care Res. 75, 876–884 (2023).

Article  Google Scholar 

Eitner, A., Hofmann, G. O. & Schaible, H.-G. Mechanisms of osteoarthritic pain. studies in humans and experimental models. Front. Mol. Neurosci. 10, 349 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Jinks, C., Jordan, K. P., Blagojevic, M. & Croft, P. Predictors of onset and progression of knee pain in adults living in the community. A prospective study. Rheumatology 47, 368–374 (2007).

Article  Google Scholar 

Chin, S.-H., Huang, W.-L., Akter, S. & Binks, M. Obesity and pain: a systematic review. Int. J. Obes. 44, 969–979 (2020).

Article  Google Scholar 

Wluka, A. E., Lombard, C. B. & Cicuttini, F. M. Tackling obesity in knee osteoarthritis. Nat. Rev. Rheumatol. 9, 225–235 (2013).

Article  PubMed  Google Scholar 

Murphy, L. et al. Lifetime risk of symptomatic knee osteoarthritis. Arthritis Rheum. 59, 1207–1213 (2008).

Article  PubMed  PubMed Central  Google Scholar 

Raud, B. et al. Level of obesity is directly associated with the clinical and functional consequences of knee osteoarthritis. Sci. Rep. 10, 3601 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Emery, C. F., Finkel, D. & Dahl Aslan, A. K. Bidirectional associations between body mass and bodily pain among middle-aged and older adults. Pain 163, 2061–2067 (2022).

Article  PubMed  Google Scholar 

Collins, A. T. et al. Obesity alters the in vivo mechanical response and biochemical properties of cartilage as measured by MRI. Arthritis Res. Ther. 20, 232 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Robbins, S. M. et al. Association of pain with frequency and magnitude of knee loading in knee osteoarthritis. Arthritis Care Res. 63, 991–997 (2011).

Article  Google Scholar 

Chen, L. et al. Pathogenesis and clinical management of obesity-related knee osteoarthritis: impact of mechanical loading. J. Orthop. Transl. 24, 66–75 (2020).

CAS  Google Scholar 

Beckwée, D. et al. The influence of joint loading on bone marrow lesions in the knee: a systematic review with meta-analysis. Am. J. Sports Med. 43, 3093–3107 (2015).

Article  PubMed  Google Scholar 

Aso, K., Shahtaheri, S. M., McWilliams, D. F. & Walsh, D. A. Association of subchondral bone marrow lesion localization with weight-bearing pain in people with knee osteoarthritis: data from the Osteoarthritis Initiative. Arthritis Res. Ther. 23, 35 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Felson, D. T., Goggins, J., Niu, J., Zhang, Y. & Hunter, D. J. The effect of body weight on progression of knee osteoarthritis is dependent on alignment. Arthritis Rheum. 50, 3904–3909 (2004).

Article  PubMed  Google Scholar 

Lo, G. H., Harvey, W. F. & McAlindon, T. E. Associations of varus thrust and alignment with pain in knee osteoarthritis. Arthritis Rheum. 64, 2252–2259 (2012).

Article  PubMed  PubMed Central  Google Scholar 

Mohamed, N. S. et al. The rise of obesity among total knee arthroplasty patients. J. Knee Surg. 35, 001–006 (2022).

Article  Google Scholar 

Weiss, E. Knee osteoarthritis, body mass index and pain: data from the Osteoarthritis Initiative. Rheumatology 53, 2095–2099 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cimmino, M. A. et al. Body mass and osteoarthritic pain: results from a study in general practice. Clin. Exp. Rheumatol. 31, 843–849 (2013).

PubMed  Google Scholar