Chang, M. H. & Nigrovic, P. A. Antibody-dependent and -independent mechanisms of inflammatory arthritis. JCI Insight 4, https://doi.org/10.1172/jci.insight.125278 (2019).

Gravallese, E. M. & Firestein, G. S. Rheumatoid arthritis — common origins, divergent mechanisms. N. Engl. J. Med. 388, 529–542 (2023).

CAS  PubMed  Google Scholar 

Roberts, W. N., Daltroy, L. H. & Anderson, R. J. Stability of normal joint findings in persistent classic rheumatoid arthritis. Arthritis Rheum. 31, 267–271 (1988).

CAS  PubMed  Google Scholar 

Chang, M. H. et al. Joint-specific memory and sustained risk for new joint accumulation in autoimmune arthritis. Arthritis Rheumatol. 74, 1851–1858 (2022).

PubMed  PubMed Central  Google Scholar 

Chang, M. H. et al. Arthritis flares mediated by tissue-resident memory T cells in the joint. Cell Rep. 37, 109902 (2021).

CAS  PubMed  PubMed Central  Google Scholar 

Heckert, S. L. et al. Joint inflammation tends to recur in the same joints during the rheumatoid arthritis disease course. Ann. Rheum. Dis. 81, 169–174 (2022).

PubMed  Google Scholar 

Heckert, S. L. et al. Patterns of clinical joint inflammation in juvenile idiopathic arthritis. RMD Open 9, e002941 (2023).

PubMed  PubMed Central  Google Scholar 

Gebhardt, T., Palendira, U., Tscharke, D. C. & Bedoui, S. Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance. Immunol. Rev. 283, 54–76 (2018).

CAS  PubMed  Google Scholar 

Szabo, P. A., Miron, M. & Farber, D. L. Location, location, location: tissue resident memory T cells in mice and humans. Sci. Immunol. 4, eaas9673 (2019).

CAS  PubMed  PubMed Central  Google Scholar 

Boniface, K. et al. Vitiligo skin is imprinted with resident memory CD8 T cells expressing CXCR3. J. Invest. Dermatol. 138, 355–364 (2018).

CAS  PubMed  Google Scholar 

Richmond, J. M. et al. Resident memory and recirculating memory T cells cooperate to maintain disease in a mouse model of vitiligo. J. Invest. Dermatol. 139, 769–778 (2019).

CAS  PubMed  Google Scholar 

Boyman, O. et al. Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-α. J. Exp. Med. 199, 731–736 (2004).

CAS  PubMed  PubMed Central  Google Scholar 

Samat, A. A. K., van der Geest, J., Vastert, S. J., van Loosdregt, J. & van Wijk, F. Tissue-resident memory T cells in chronic inflammation-local cells with systemic effects? Cells 10, 409 (2021).

CAS  PubMed  PubMed Central  Google Scholar 

Fonseca, R. et al. Developmental plasticity allows outside-in immune responses by resident memory T cells. Nat. Immunol. 21, 412–421 (2020).

CAS  PubMed  PubMed Central  Google Scholar 

Wijeyesinghe, S. et al. Expansible residence decentralizes immune homeostasis. Nature 592, 457–462 (2021).

CAS  PubMed  Google Scholar 

Mueller, S. N. & Mackay, L. K. Tissue-resident memory T cells: local specialists in immune defence. Nat. Rev. Immunol. 16, 79–89 (2016).

CAS  PubMed  Google Scholar 

Heeg, M. & Goldrath, A. W. Insights into phenotypic and functional CD8+ TRM heterogeneity. Immunol. Rev. 316, 8–22 (2023).

CAS  PubMed  Google Scholar 

Kumar, B. V. et al. Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites. Cell Rep. 20, 2921–2934 (2017).

CAS  PubMed  PubMed Central  Google Scholar 

Crowl, J. T. et al. Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments. Nat. Immunol. 23, 1121–1131 (2022).

CAS  PubMed  PubMed Central  Google Scholar 

Mackay, L. K. et al. Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes. Science 352, 459–463 (2016).

CAS  PubMed  Google Scholar 

Poon, M. M. L. et al. Tissue adaptation and clonal segregation of human memory T cells in barrier sites. Nat. Immunol. 24, 309–319 (2023).

CAS  PubMed  PubMed Central  Google Scholar 

Christo, S. N. et al. Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity. Nat. Immunol. 22, 1140–1151 (2021).

CAS  PubMed  Google Scholar 

Lin, Y. H. et al. Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes. Immunity 56, 207–223.e8 (2023).

CAS  PubMed  Google Scholar 

Schenkel, J. M. et al. IL-15-independent maintenance of tissue-resident and boosted effector memory CD8 T cells. J. Immunol. 196, 3920–3926 (2016).

CAS  PubMed  Google Scholar 

FitzPatrick, M. E. B. et al. Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets. Cell Rep. 34, 108661 (2021).

CAS  PubMed  PubMed Central  Google Scholar 

Milner, J. J. et al. Heterogenous populations of tissue-resident CD8+ T cells are generated in response to infection and malignancy. Immunity 52, 808–824.e7 (2020).

CAS  PubMed  PubMed Central  Google Scholar 

Frizzell, H. et al. Organ-specific isoform selection of fatty acid-binding proteins in tissue-resident lymphocytes. Sci. Immunol. 5, https://doi.org/10.1126/sciimmunol.aay9283 (2020).

Pan, Y. et al. Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature 543, 252–256 (2017).

CAS  PubMed  PubMed Central  Google Scholar 

Howie, D., Ten Bokum, A., Necula, A. S., Cobbold, S. P. & Waldmann, H. The role of lipid metabolism in T lymphocyte differentiation and survival. Front. Immunol. 8, 1949 (2017).

PubMed  Google Scholar 

Jin, R. et al. Role of FABP5 in T cell lipid metabolism and function in the tumor microenvironment. Cancers 15, https://doi.org/10.3390/cancers15030657 (2023).

Steinert, E. M. et al. Quantifying memory CD8 T cells reveals regionalization of immunosurveillance. Cell 161, 737–749 (2015).

CAS  PubMed  PubMed Central  Google Scholar 

Jung, J. et al. Synovial fluid CD69+CD8+ T cells with tissue-resident phenotype mediate perforin-dependent citrullination in rheumatoid arthritis. Clin. Transl. Immunol. 9, e1140 (2020).

CAS  Google Scholar 

Guggino, G., Rizzo, A., Mauro, D., Macaluso, F. & Ciccia, F. Gut-derived CD8+ tissue-resident memory T cells are expanded in the peripheral blood and synovia of SpA patients. Ann. Rheum. Dis. 80, e174 (2021).

PubMed  Google Scholar 

Horai, R. et al. Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice. J. Exp. Med. 191, 313–320 (2000).

CAS  PubMed  PubMed Central  Google Scholar 

Zhang, F. et al. Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry. Nat. Immunol. 20, 928–942 (2019).

PubMed  PubMed Central  Google Scholar 

Jonsson, A. H. et al. Granzyme K+ CD8 T cells form a core population in inflamed human tissue. Sci. Transl. Med. 14, eabo0686 (2022).

CAS  PubMed  PubMed Central  Google Scholar 

Petrelli, A. et al. PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation. J. Clin. Invest. 128, 4669–4681 (2018).

PubMed  PubMed Central  Google Scholar 

Vanni, A. et al. Clonally expanded PD-1-expressing T cells are enriched in synovial fluid of juvenile idiopathic arthritis patients. Eur. J. Immunol. 53, e2250162 (2023).

PubMed  Google Scholar 

Maschmeyer, P. et al. Antigen-driven PD-1+ TOX+ BHLHE40+ and PD-1+ TOX+ EOMES+ T lymphocytes regulate juvenile idiopathic arthritis in situ. Eur. J. Immunol. 51, 915–929 (2021).

CAS  PubMed  Google Scholar 

Steel, K. J. A. et al. Polyfunctional, proinflammatory, tissue-resident memory phenotype and function of synovial interleukin-17A+CD8+ T cells in psoriatic arthritis. Arthritis Rheumatol. 72, 435–447 (2020).

CAS  PubMed  PubMed Central  Google Scholar 

Povoleri, G. A. M. et al. Psoriatic and rheumatoid arthritis joints differ in the composition of CD8+ tissue-resident memory T cell subsets. Cell Rep. 42, 112514 (2023).

CAS  PubMed  PubMed Central  Google Scholar 

Penkava, F. et al. Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis. Nat. Commun. 11, 4767 (2020).

CAS  PubMed  PubMed Central  Google Scholar 

Qaiyum, Z., Gracey, E., Yao, Y. & Inman, R. D. Integrin and transcriptomic profiles identify a distinctive synovial CD8+ T cell subpopulation in spondyloarthritis. Ann. Rheum. Dis. 78, 1566–1575 (2019).

CAS  PubMed  Google Scholar 

Sasson, S. C., Gordon, C. L., Christo, S. N., Klenerman, P. & Mackay, L. K. Local heroes or villains: tissue-resident memory T cells in human health and disease. Cell Mol. Immunol. 17, 113–122 (2020).

CAS  PubMed  PubMed Central  Google Scholar 

Arazi, A. et al. The immune cell landscape in kidneys of patients with lupus nephritis. Nat. Immunol. 20, 902–914 (2019).

CAS  PubMed  PubMed Central