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Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development
Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development
Materials and methodsPatients and normal volunteersThis study was approved by the Biomedical Ethics Committee of Anhui Med...
New WHO ACPA standard enables standardisation among anti-CCP2 assays, but not other ACPA assays using different antigens
New WHO ACPA standard enables standardisation among anti-CCP2 assays, but not other ACPA assays using different antigens
Antibodies to citrullinated protein/peptide (ACPA) are established biomarkers for diagnosis and classification of rheumato...
Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis
Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis
IntroductionRheumatoid arthritis (RA) is a chronic inflammatory joint disease that affects up to 1% of the population.1 Th...
SerpinA3N limits cartilage destruction in osteoarthritis by inhibiting macrophage-derived leucocyte elastase
SerpinA3N limits cartilage destruction in osteoarthritis by inhibiting macrophage-derived leucocyte elastase
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Rheumatoid arthritis patients harbour aberrant enteric bacteriophages with autoimmunity-provoking potential: a paired sibling study
Rheumatoid arthritis patients harbour aberrant enteric bacteriophages with autoimmunity-provoking potential: a paired sibling study
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Multiorgan involvement and circulating IgG1 predict hypocomplementaemia in IgG4-related disease
Multiorgan involvement and circulating IgG1 predict hypocomplementaemia in IgG4-related disease
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EULAR/PReS recommendations for the diagnosis and management of Stills disease, comprising systemic juvenile idiopathic arthritis and adult-onset Stills disease
EULAR/PReS recommendations for the diagnosis and management of Stills disease, comprising systemic juvenile idiopathic arthritis and adult-onset Stills disease
Overarching principles OP A: sJIA and AOSD are the same disease, that should be designated by the same unique name, Still...
Development of international consensus on a standardised image acquisition protocol for diagnostic evaluation of the sacroiliac joints by MRI: an ASAS-SPARTAN collaboration
Development of international consensus on a standardised image acquisition protocol for diagnostic evaluation of the sacroiliac joints by MRI: an ASAS-SPARTAN collaboration
IntroductionFor several decades, MRI has been used to investigate the early diagnosis of inflammatory sacroiliitis.1 2 How...
Clinical information on imaging referrals for suspected or known axial spondyloarthritis: recommendations from the Assessment of Spondyloarthritis International Society (ASAS)
Clinical information on imaging referrals for suspected or known axial spondyloarthritis: recommendations from the Assessment of Spondyloarthritis International Society (ASAS)
IntroductionImaging plays a pivotal role in the diagnosis and ongoing management of axial spondyloarthritis (axSpA), a con...
Early identification of rheumatoid arthritis: does it induce treatment-related cost savings?
Early identification of rheumatoid arthritis: does it induce treatment-related cost savings?
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Paul Hunter Plotz (1937-2024): renaissance rheumatologist, human rights advocate and mensch
Paul Hunter Plotz (1937-2024): renaissance rheumatologist, human rights advocate and mensch
Paul Hunter Plotz, MD, a Scientist Emeritus in the National Institute of Arthritis and Musculoskeletal and Skin Diseases (...
Helicobacter pylori upregulates PAD4 expression via stabilising HIF-1{alpha} to exacerbate rheumatoid arthritis
Helicobacter pylori upregulates PAD4 expression via stabilising HIF-1{alpha} to exacerbate rheumatoid arthritis
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDS H. pylori infection promotes synovial cell proliferation and infla...
Association of rheumatoid factor, anti-citrullinated protein antibodies and shared epitope with clinical response to initial treatment in patients with early rheumatoid arthritis: data from a randomised controlled trial
Association of rheumatoid factor, anti-citrullinated protein antibodies and shared epitope with clinical response to initial treatment in patients with early rheumatoid arthritis: data from a randomised controlled trial
WHAT IS ALREADY KNOWN ON THIS TOPICRheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) serology are impo...
Shift in perspective: autoimmunity protecting against rheumatoid arthritis
Shift in perspective: autoimmunity protecting against rheumatoid arthritis
A hallmark of rheumatoid arthritis (RA) is the increased levels of autoantibodies preceding the onset and contributing to ...
Comorbidity clusters in patients with rheumatoid arthritis identify a patient phenotype with a favourable prognosis
Comorbidity clusters in patients with rheumatoid arthritis identify a patient phenotype with a favourable prognosis
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EPO promotes the progression of rheumatoid arthritis by inducing desialylation via increasing the expression of neuraminidase 3
EPO promotes the progression of rheumatoid arthritis by inducing desialylation via increasing the expression of neuraminidase 3
WHAT IS ALREADY KNOWN ON THIS TOPICAnaemia occurs in 30%–70% of patients with rheumatoid arthritis (RA), which leads to th...
Proinflammatory phenotype of B10 and B10pro cells elicited by TNF-{alpha} in rheumatoid arthritis
Proinflammatory phenotype of B10 and B10pro cells elicited by TNF-{alpha} in rheumatoid arthritis
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Can rheumatologists unequivocally diagnose axial spondyloarthritis in patients with chronic back pain of less than 2 years duration? Primary outcome of the 2-year SPondyloArthritis Caught Early (SPACE) cohort
Can rheumatologists unequivocally diagnose axial spondyloarthritis in patients with chronic back pain of less than 2 years duration? Primary outcome of the 2-year SPondyloArthritis Caught Early (SPACE) cohort
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Single-cell profiling reveals kidney CD163+ dendritic cell participation in human lupus nephritis
Single-cell profiling reveals kidney CD163+ dendritic cell participation in human lupus nephritis
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Deep immunophenotyping reveals that autoimmune and autoinflammatory disorders are spread along two immunological axes capturing disease inflammation levels and types
Deep immunophenotyping reveals that autoimmune and autoinflammatory disorders are spread along two immunological axes capturing disease inflammation levels and types
IntroductionAutoimmune diseases (AD) and autoinflammatory diseases (AIF) are pathological conditions arising from the imba...
Comparison of the effect of treatment with NSAIDs added to anti-TNF therapy versus anti-TNF therapy alone on the progression of structural damage in the spine over 2 years in patients with radiographic axial spondyloarthritis from the randomised-controlled CONSUL trial
Comparison of the effect of treatment with NSAIDs added to anti-TNF therapy versus anti-TNF therapy alone on the progression of structural damage in the spine over 2 years in patients with radiographic axial spondyloarthritis from the randomised-controlled CONSUL trial
WHAT IS ALREADY KNOWN ON THIS TOPICContinuous intake of celecoxib over 2 years was associated with retardation of radiogra...
Vasculitis that did not read the books
Vasculitis that did not read the books
A 29-year-old woman presented to our rheumatology clinic with a 6-month history of cough, dysphonia, dyspnoea and weight l...
Associations of residential greenness with bone mineral density and osteoporosis: the modifying effect of genetic susceptibility
Associations of residential greenness with bone mineral density and osteoporosis: the modifying effect of genetic susceptibility
WHAT IS ALREADY KNOWN ON THIS TOPICOsteoporosis is a complex disease caused by both genetic and environmental factors.The ...
Immunomodulators and risk for breakthrough COVID-19 after third SARS-CoV-2 mRNA vaccine among patients with rheumatoid arthritis: a cohort study
Immunomodulators and risk for breakthrough COVID-19 after third SARS-CoV-2 mRNA vaccine among patients with rheumatoid arthritis: a cohort study
The US Centers for Disease Control and Prevention (CDC) recommends three SARS-CoV-2 messenger ribonucleic acid (mRNA) vacc...
Validation of the definition of rheumatoid arthritis flare based on SDAI and CDAI in clinical practice in two French independent cohorts
Validation of the definition of rheumatoid arthritis flare based on SDAI and CDAI in clinical practice in two French independent cohorts
New definitions for flares in rheumatoid arthritis (RA) based on the Simplified and Clinical Disease Activity Indices (SDA...
Correction: Lupus low disease activity state attainment in the phase 3 TULIP trials of anifrolumab in active systemic lupus erythematosus
Correction: Lupus low disease activity state attainment in the phase 3 TULIP trials of anifrolumab in active systemic lupus erythematosus
Morand EF, Abreu G, Furie RA, et al. Lupus low disease activity state attainment in the phase 3 TULIP trials of anifroluma...
Gender imbalance in expert panels of recommendations in rheumatology
Gender imbalance in expert panels of recommendations in rheumatology
Gender imbalance is a major source of inequity in the society. Inequality is an enduring topic also in medical research, a...
Directed differentiation of human pluripotent stem cells into articular cartilage reveals effects caused by absence of WISP3, the gene responsible for progressive pseudorheumatoid arthropathy of childhood
Directed differentiation of human pluripotent stem cells into articular cartilage reveals effects caused by absence of WISP3, the gene responsible for progressive pseudorheumatoid arthropathy of childhood
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Is colchicine prophylaxis required with start-low go-slow allopurinol dose escalation in gout? A non-inferiority randomised double-blind placebo-controlled trial
Is colchicine prophylaxis required with start-low go-slow allopurinol dose escalation in gout? A non-inferiority randomised double-blind placebo-controlled trial
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Disease activity drives transcriptomic heterogeneity in early untreated rheumatoid synovitis
Disease activity drives transcriptomic heterogeneity in early untreated rheumatoid synovitis
IntroductionSynovitis is the clinical hallmark of rheumatoid arthritis (RA), and the analysis of synovial tissue from affe...
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