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Proliferative diabetic retinopathy subtypes defined by immune defense and endothelial mitochondrial dysfunction
Proliferative diabetic retinopathy subtypes defined by immune defense and endothelial mitochondrial dysfunction
Proliferative diabetic retinopathy (PDR) is a major complication of diabetes characterized by pathological angiogenesis in...
Vascular dementia: novel insights through multiscale mechanistic modeling
Vascular dementia: novel insights through multiscale mechanistic modeling
In a recent study published in Cell1 that combines cell-type-specific transc...
Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations
Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations
Protein folding is a fundamental process ensuring that polypeptide chains acquire the correct three-dimensional structures...
Peroxiredoxin 4 as a switch regulating PTEN/AKT axis in alveolar macrophages activation
Peroxiredoxin 4 as a switch regulating PTEN/AKT axis in alveolar macrophages activation
Phosphatase and tensin homolog (PTEN) is a critical inhibitor of the PI3K/AKT signaling pathway, yet its direct upstream r...
Gut-derived imidazole propionate promotes atherosclerosis through myeloid imidazoline-1 receptor signaling: new biomarker and therapeutic target
Gut-derived imidazole propionate promotes atherosclerosis through myeloid imidazoline-1 receptor signaling: new biomarker and therapeutic target
In a groundbreaking study published in Nature, Mastrangelo et al. identified...
Serotonin transporter: a potential new immune checkpoint for cytotoxic T cells
Serotonin transporter: a potential new immune checkpoint for cytotoxic T cells
In a recent publication in Cell, Yang and colleagues propose a novel role fo...
Redox regulation: mechanisms, biology and therapeutic targets in diseases
Redox regulation: mechanisms, biology and therapeutic targets in diseases
Redox signaling acts as a critical mediator in the dynamic interactions between organisms and their external environment, ...
Host FSTL1 defines the impact of stem cell therapy on liver fibrosis by potentiating the early recruitment of inflammatory macrophages
Host FSTL1 defines the impact of stem cell therapy on liver fibrosis by potentiating the early recruitment of inflammatory macrophages
Adult stem cell therapy holds great promise for treating decompensated liver cirrhosis on the basis of animal studies, des...
Epstein-Barr virus hijacks histone demethylase machinery to drive epithelial malignancy progression through KDM5B upregulation
Epstein-Barr virus hijacks histone demethylase machinery to drive epithelial malignancy progression through KDM5B upregulation
Epstein-Barr virus (EBV) is a significant epigenetic driver in the development of epithelial-origin nasopharyngeal carcino...
Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances
Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances
In the context of global ageing, the prevalence of neurodegenerative diseases and dementia, such as Alzheimer’s dise...
Landscape of small nucleic acid therapeutics: moving from the bench to the clinic as next-generation medicines
Landscape of small nucleic acid therapeutics: moving from the bench to the clinic as next-generation medicines
The ability of small nucleic acids to modulate gene expression via a range of processes has been widely explored. Compared...
Advances in the structures, mechanisms and targeting of molecular chaperones
Advances in the structures, mechanisms and targeting of molecular chaperones
Molecular chaperones, a class of complex client regulatory systems, play significant roles in the prevention of protein mi...
Thalidomide-based regimen shows promising efficacy in large granular lymphocytic leukemia: a multicenter phase II study
Thalidomide-based regimen shows promising efficacy in large granular lymphocytic leukemia: a multicenter phase II study
Large granular lymphocytic leukemia (LGLL) is characterized by the clonal proliferation of cytotoxic T lymphocytes or NK c...
Dietary protein sources, gut microbiome, and puberty timing in children: findings from a cohort study
Dietary protein sources, gut microbiome, and puberty timing in children: findings from a cohort study
Developing countries are in a critical term of nutritional transition, marked by a sharp increase in ...
Boosting liver regeneration: kinase inhibitor as a new tool to prevent liver failure
Boosting liver regeneration: kinase inhibitor as a new tool to prevent liver failure
In a recent manuscript in Cell, a first-in-class small molecule inhibitor of the kinase MKK4 (mitogen...
Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression
Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression
More than 90% of hepatocellular carcinoma (HCC) cases develop in the presence of fibrosis or cirrhosis, making the tumor m...
Cancer stem cells: advances in knowledge and implications for cancer therapy
Cancer stem cells: advances in knowledge and implications for cancer therapy
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-renewal and continuous prolifer...
Artificial intelligence meets body sense: task-driven neural networks reveal computational principles of the proprioceptive pathway
Artificial intelligence meets body sense: task-driven neural networks reveal computational principles of the proprioceptive pathway
In a recent study published in Cell, Marin Vargas and Bisi et al.1 present an innovative approach to ...
A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori
A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori
Helicobacter pylori (H. pylori) is currently recognized as the primary carcinogenic pathogen associated with gastric tumor...
Prosaposin hyperglycosylation: a novel tumor immune escape mechanism and implications for cancer immunotherapy
Prosaposin hyperglycosylation: a novel tumor immune escape mechanism and implications for cancer immunotherapy
In a recent article published in Science, Sharma et al. describes the essential role of saposins in c...
Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases
Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases
Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradica...
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encomp...
Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes
Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes
Mutations in the Contactin-associated protein-like 2 (CNTNAP2) gene are associated with autism spectrum disorder (ASD), an...
NF-κB in biology and targeted therapy: new insights and translational implications
NF-κB in biology and targeted therapy: new insights and translational implications
NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal ...
New clinical trial design in precision medicine: discovery, development and direction
New clinical trial design in precision medicine: discovery, development and direction
In the era of precision medicine, it has been increasingly recognized that individuals with a certain disease are complex ...
Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis
Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis
Temozolomide (TMZ) represents a standard-of-care chemotherapeutic agent in glioblastoma (GBM). However, the development of...
Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma
Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma
Natural killer T cell lymphoma (NKTCL) is highly aggressive, with advanced stage patients poorly responding to intensive c...
Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer
Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer
Despite the successful application of immune checkpoint therapy, no response or recurrence is typical in lung cancer. Canc...
Managing type 2 diabetes: targeting a microbial enzyme as a novel treatment option
Managing type 2 diabetes: targeting a microbial enzyme as a novel treatment option
In a recent Science article, Wang and colleagues showed that the dipeptidyl peptidase 4 (DPP4) enzyme...
IgE-Mast cell mediated allergy: a sensor of food quality
IgE-Mast cell mediated allergy: a sensor of food quality
In two recent studies published in Nature, Florsheim et al. and Plum et al. reported that allergic-sp...
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