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Causal relationship between plasma metabolites and carpal tunnel syndrome risk: evidence from a mendelian randomization study
Causal relationship between plasma metabolites and carpal tunnel syndrome risk: evidence from a mendelian randomization study
BackgroundCarpal tunnel syndrome (CTS) is a common symptom of nerve compression and a leading cause of pain and hand dysfu...
Corrigendum: Deepening insights into cholinergic agents for intraocular pressure reduction: systems genetics, molecular modeling, and in vivo perspectives
Acknowledgements: We extend our gratitude to Kirk Hevener and Wei Li for providing access to the molecular modeling statio...
Navigating directed evolution efficiently: optimizing selection conditions and selection output analysis
Navigating directed evolution efficiently: optimizing selection conditions and selection output analysis
Directed evolution is a powerful tool that can bypass gaps in our understanding of the sequence-function relationship of p...
Corrigendum: Comprehensive analysis of the prognostic and immunological role of PAFAH1B in pan-cancer
Corrigendum: Comprehensive analysis of the prognostic and immunological role of PAFAH1B in pan-cancer
Corrigendum on: Yuan Y, Jiang X, Tang L, Wang J, Duan L. Comprehensive Analysis of the Prognostic and Immunological Role o...
Exploration of phytoconstituents of Medhya Rasayana herbs to identify potential inhibitors for cerebroside sulfotransferase through high-throughput screening
Exploration of phytoconstituents of Medhya Rasayana herbs to identify potential inhibitors for cerebroside sulfotransferase through high-throughput screening
Cerebroside sulfotransferase (CST) is a key enzyme in sulfatide biosynthesis and regulation of the myelin sheath in the ne...
How lactate affects immune strategies in lymphoma
How lactate affects immune strategies in lymphoma
Tumor cells undergo metabolic reprogramming through shared pathways, resulting in a hypoxic, acidic, and highly permeable ...
Editorial: Celebrating women’s contribution to protein folding, misfolding, and degradation in honor of Susan Lindquist (1949–2016)
David H. Koch Institute for Integrative Cancer Research, and a biology professor at MIT for the rest of her career.Susan L...
Profiling of the serum MiRNAome in pediatric egyptian patients with wilms tumor
Profiling of the serum MiRNAome in pediatric egyptian patients with wilms tumor
Wilms tumor (WT) is a pediatric kidney cancer associated with poor outcomes in patients with unfavorable histological feat...
Integrated analysis of abnormal metabolic homeostasis for decoding tumor microenvironment
Integrated analysis of abnormal metabolic homeostasis for decoding tumor microenvironment
In 2023 and 2024, Nature published a series of crucial roles of metabolic abnormalities in tumor occurrence, development, ...
Editorial: Bio-nanomaterials and systems for enhanced bioimaging in biomedical applications
This editorial provides an overview of the contributions to the Frontiers Research Topic "Bio-Nanomaterials and S...
Identification of potential bioactive phytochemicals for the inhibition of platelet-derived growth factor receptor β: a structure-based approach for cancer therapy
Identification of potential bioactive phytochemicals for the inhibition of platelet-derived growth factor receptor β: a structure-based approach for cancer therapy
Platelet-derived growth factor receptor beta (PDGFRβ) belongs to the receptor tyrosine kinase (RTK) protein family and is ...
Genome-wide identification and analysis of the HD-Zip transcription factor family in oats
1 IntroductionOats (Avena sativa L.) are an annual herbaceous plant of the oat genus (Avena) in the Poaceae family, and ar...
Crotonylation modification and its role in diseases
1 IntroductionPost-translational modifications (PTMs) of proteins significantly impact their biological functions, includi...
Anhydrous microwave synthesis as efficient method for obtaining model advanced glycation end-products
1 IntroductionAdvanced glycation end-products (AGEs) are products of the non-enzymatic reaction of proteins and reducing s...
Differential expression of ferroptosis-related proteins in urinary exosomes: potential indicators for monitoring acute gout attack
1 IntroductionGout is an inflammatory disease caused by high levels of uric acid in the blood, leading to various forms of...
Crystallographic insights into lipid-membrane protein interactions in microbial rhodopsins
IntroductionLipid-membrane protein (MP) interactions are known to predetermine the MP structure. The alteration of the lip...
Dynamics simulations of hypoxia inducible factor-1 regulatory network in cancer using formal verification techniques
1 IntroductionCancer cell growth is a fundamental biological process characterized by cell proliferation, and an increase ...
AKK-derived outer membrane vesicles alleviate indomethacin-induced mucin secretion reduction in LS174T cells by inhibiting endoplasmic reticulum stress
1 IntroductionExtracellular vesicles (EVs) are lipid bilayer-enclosed structures that carry a variety of biomolecules, inc...
Proteomics analysis of extracellular vesicles for biomarkers of autism spectrum disorder
1 IntroductionAutism spectrum disorder (ASD) is a complex neurodevelopmental condition, characterized by stereotyped repet...
Esophageal adenocarcinoma models: a closer look
1 IntroductionEsophageal cancer (EC) is the tenth most common cancer worldwide and the sixth leading cause of cancer death...
Gelatin-based nanoparticles and antibiotics: a new therapeutic approach for osteomyelitis?
Gelatin-based nanoparticles and antibiotics: a new therapeutic approach for osteomyelitis?
The result of infection of bone with microorganisms is osteomyelitis and septic arthritis. Methicillin-resistant Staphyloc...
Expression of calpastatin hcast 3-25 and activity of the calpain/calpastatin system in human glioblastoma stem cells: possible involvement of hcast 3-25 in cell differentiation
Expression of calpastatin hcast 3-25 and activity of the calpain/calpastatin system in human glioblastoma stem cells: possible involvement of hcast 3-25 in cell differentiation
Glioblastoma (GBM) is the most malignant brain tumor, characterized by cell heterogeneity comprising stem cells (GSCs) res...
Candidate proteins interacting with cytoskeleton in cells from the basal airway epithelium in vitro
Candidate proteins interacting with cytoskeleton in cells from the basal airway epithelium in vitro
Introduction: The cytoskeleton consists of actin, microtubules, septins, and intermediate filaments and, in most cells, is...
AlphaFold2 in biomedical research: facilitating the development of diagnostic strategies for disease
AlphaFold2 in biomedical research: facilitating the development of diagnostic strategies for disease
Proteins, as the primary executors of physiological activity, serve as a key factor in disease diagnosis and treatment. Re...
Retraction: Identification of an immunologic signature of lung adenocarcinomas based on genome-wide immune expression profiles
The journal retracts the 11 January 2021 article cited above.Following publication, concerns were raised regarding the int...
Role of 14-3-3 protein family in the pathobiology of EBV in immortalized B cells and Alzheimer’s disease
Role of 14-3-3 protein family in the pathobiology of EBV in immortalized B cells and Alzheimer’s disease
Background and AimsSeveral studies have revealed that Epstein-Barr virus (EBV) infection raised the likelihood of developi...
Application of bio-layer interferometry for the analysis of ribosome-protein interactions
Application of bio-layer interferometry for the analysis of ribosome-protein interactions
The ribosome, a ribonucleoprotein complex, performs the function of protein translation. While ribosomal RNA catalyzes pol...
Innovative tree-based method for sampling molecular conformations: exploring the ATP-binding cassette subfamily D member 1 (ABCD1) transporter as a case study
Innovative tree-based method for sampling molecular conformations: exploring the ATP-binding cassette subfamily D member 1 (ABCD1) transporter as a case study
We introduce a novel tree-based method for visualizing molecular conformation sampling. Our method offers enhanced precisi...
Editorial: Mitochondrial bioenergetics and metabolism: implication for human health and disease
Mitochondria are the central metabolic hubs in eucaryotic cells playing a central role in fundamental energy transformatio...
Molecular dynamic simulation reveals the inhibiting impact of Rhein on wild-type and P29S-mutated Rac1
Molecular dynamic simulation reveals the inhibiting impact of Rhein on wild-type and P29S-mutated Rac1
Ras-related C3 botulinum toxin substrate 1 (Rac1) is a small GTPase belonging to the Rho family. It acts as a binary molec...
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