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Surface-Enhanced Raman Scattering to Improve the Sensitivity of the MTT Assay
Surface-Enhanced Raman Scattering to Improve the Sensitivity of the MTT Assay
Currently, empirical therapy regimens are often used in the treatment of infectious diseases that are not based on data on...
Unveiling Survival: Genetic Variability, Pathogenesis, and Antimicrobial Drug Resistance
Unveiling Survival: Genetic Variability, Pathogenesis, and Antimicrobial Drug Resistance
Despite nearly a century of therapy for gonococcal infection with a variety of antimicrobials, more than 80 million cases ...
Enzymes of ADP-Heptose Biosynthesis As Targets for the Creation of Broad-Spectrum Antibacterial Drugs
Enzymes of ADP-Heptose Biosynthesis As Targets for the Creation of Broad-Spectrum Antibacterial Drugs
Abstract—Solving the problem of multidrug resistance currently requires the development of nonstandard approaches, s...
Antibiotic Resistance Genes in Cattle Gut Microbiota: Influence of Housing Conditions
Antibiotic Resistance Genes in Cattle Gut Microbiota: Influence of Housing Conditions
Resistance to antimicrobial drugs is an urgent problem not only in public health, but also in animal husbandry. The widesp...
History of the Creation of a New Generation of Antibiotics of the Group of Polycyclic Glycopeptides
History of the Creation of a New Generation of Antibiotics of the Group of Polycyclic Glycopeptides
Increased resistance to polycyclic glycopeptide antibiotics has become a serious problem for chemotherapy of infections ca...
CpG Traffic Lights Are Involved in Active DNA Demethylation
CpG Traffic Lights Are Involved in Active DNA Demethylation
DNA methylation is one of the most important mechanisms closely involved in the epigenetic regulation of gene expression. ...
Unraveling Cancer Progression in Oral Squamous Cell Carcinoma through Regulatory Network Analysis; miRNA-Target Gene Interaction
Unraveling Cancer Progression in Oral Squamous Cell Carcinoma through Regulatory Network Analysis; miRNA-Target Gene Interaction
Dysregulation of microRNAs (miRs) plays an essential role in tumor progression of oral squamous cell carcinoma (OSCC) thro...
Cytotoxic Effects of the Combination of Pam3CSK4 with Carfilzomib, Ixazomib, and Venetoclax in Human Multiple Myeloma Cells
Cytotoxic Effects of the Combination of Pam3CSK4 with Carfilzomib, Ixazomib, and Venetoclax in Human Multiple Myeloma Cells
Proteasome inhibitors (PIs) are effective in the treatment of multiple myeloma (MM), which is a plasma cell malignancy. Di...
Mechanism of Oxidative Stress Inducing Pyroptosis by Activating the NLRP3/Caspase-1/GSDMD Pathway in Lens Epithelial Cells under High Glucose Environment
Mechanism of Oxidative Stress Inducing Pyroptosis by Activating the NLRP3/Caspase-1/GSDMD Pathway in Lens Epithelial Cells under High Glucose Environment
Diabetic patients face an increased risk of cataract development. This study investigates the molecular mechanism by which...
N-Acetylgalactosamine-Conjugated Antisense Oligonucleotides Designed as Inhibitors of ABCB1: Coping with Multidrug Resistance in Hepatocellular Carcinoma
N-Acetylgalactosamine-Conjugated Antisense Oligonucleotides Designed as Inhibitors of ABCB1: Coping with Multidrug Resistance in Hepatocellular Carcinoma
Cancer-multidrug resistance (MDR) is recognized as one of the barriers to the treatment of advanced hepatocellular carcino...
Synthesis and Antimicrobial Activity of Thiosulfinates and Allicin Analogues
Synthesis and Antimicrobial Activity of Thiosulfinates and Allicin Analogues
Diallyl thiosulfinate (allicin) effectively inhibits the growth of various microorganisms, including antibiotic-resistant ...
Antiglycation Activity of Isoindole Derivatives and Its Prediction Using Frontier Molecular Orbital Energies
Antiglycation Activity of Isoindole Derivatives and Its Prediction Using Frontier Molecular Orbital Energies
Abstract—The extracellular matrix (ECM) provides structural support and regulates cell activity. ECM dysfunction due...
Adapting Mouse Genome Editing Technique from Scratch Using Electroporation
Adapting Mouse Genome Editing Technique from Scratch Using Electroporation
Mouse genome modification requires costly equipment and highly skilled personnel to manipulate zygotes. A number of zygote...
Afamin Ameliorates Testosterone Propionate (TP)-Induced Oxidative Stress and Mitochondrial Damage in Human Ovarian Granulosa Tumor Cells (KGN) by Upregulating the Expression of SIRT1
Afamin Ameliorates Testosterone Propionate (TP)-Induced Oxidative Stress and Mitochondrial Damage in Human Ovarian Granulosa Tumor Cells (KGN) by Upregulating the Expression of SIRT1
Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. Considerable research...
Elucidating the Effects of Aromatic Mutations on the RNA Binding Efficacy of CELF2 Protein
Elucidating the Effects of Aromatic Mutations on the RNA Binding Efficacy of CELF2 Protein
RNA Recognition Motifs (RRMs) are the most common type of protein domain found in eukaryotic RNA-binding proteins (RBPs). ...
Ras-Related Protein Rab-7a Regulates Glucose Metabolism under Hypoxia by Interacting with Hypoxia-Inducible Factor 1-Alpha in HepG2 Cells
Ras-Related Protein Rab-7a Regulates Glucose Metabolism under Hypoxia by Interacting with Hypoxia-Inducible Factor 1-Alpha in HepG2 Cells
Ras-related protein Rab-7a (RAB7A) is a member of the RAS oncogene superfamily; it plays an important role in vesicle tran...
πDMD Simulation as a Strategy for Refinement of AlphaFold2 Modeled Fuzzy Protein Complexes Structures
πDMD Simulation as a Strategy for Refinement of AlphaFold2 Modeled Fuzzy Protein Complexes Structures
Disordered proteins are of great interest due to their structural features, as they do not have well-defined three-dimensi...
Improving the Efficiency and Safety of Human Gene Editing by Selection of Optimal Guide RNAs for SpCAS9 and CAS12A
Improving the Efficiency and Safety of Human Gene Editing by Selection of Optimal Guide RNAs for SpCAS9 and CAS12A
Advances in CRISPR/Cas-mediated genome editing have opened up treatment alternatives for many human diseases, including HI...
Ginkgo biloba Leaf Polysaccharide Induces Autophagy and Modulates the Expression of Apoptosis Markers in Hepatocellular Carcinoma Cells
Ginkgo biloba Leaf Polysaccharide Induces Autophagy and Modulates the Expression of Apoptosis Markers in Hepatocellular Carcinoma Cells
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and poses a severe threat to human health. Gink...
Human eRF1 Translation Regulation
Human eRF1 Translation Regulation
Eukaryotic translation release factor eRF1 is an important cellular protein that plays a key role in translation terminati...
Silencing of the S-Phase Kinase-Associated Protein 2 Gene (SKP2) Inhibits Proliferation and Migration of Hepatocellular Carcinoma Cells
Silencing of the S-Phase Kinase-Associated Protein 2 Gene (SKP2) Inhibits Proliferation and Migration of Hepatocellular Carcinoma Cells
SKP2 gene is an independent prognostic factor in some diseases and a potential oncogene. The molecular mechanism underlyin...
Triosephosphate Isomerase Inhibition by Resveratrol: A New Mechanism of Anti-Glycolysis in Breast Cancer
Triosephosphate Isomerase Inhibition by Resveratrol: A New Mechanism of Anti-Glycolysis in Breast Cancer
Breast cancer cells undergo a process of reprogramming their metabolism for rapid growth and proliferation. One of the mos...
New Epigenetic Markers of Age-Dependent Changes in the Cardiovascular System
New Epigenetic Markers of Age-Dependent Changes in the Cardiovascular System
Cardiovascular diseases remain a predominant global cause of mortality, with a noteworthy rise in the risk of morbidity wi...
Structure and Function of the Transglutaminase Cluster in the Basal Metazoan Halisarca dujardinii (Sponge)
Structure and Function of the Transglutaminase Cluster in the Basal Metazoan Halisarca dujardinii (Sponge)
Transglutaminases are enzymes that carry out post-translational modifications of proteins and participate in the regulatio...
Spatial Organization of Chromatin of the KLF5 Gene Promoter Region in Pancreatic Ductal Adenocarcinoma Cells
Spatial Organization of Chromatin of the KLF5 Gene Promoter Region in Pancreatic Ductal Adenocarcinoma Cells
Pancreatic Ductal AdenoCarcinoma (PDAC) is characterized by a poor prognosis and is poorly amenable to modern therapies. A...
GRIP1 is Involved in the Interaction of Vimentin Filaments with Focal Adhesions in Endothelial Cells
GRIP1 is Involved in the Interaction of Vimentin Filaments with Focal Adhesions in Endothelial Cells
Vimentin intermediate filaments are dynamic structures that are able to move in cytoplasm owing to activity of the motor p...
Multi-Omic Rejuvenation: A New Strategy for Lifespan Extension
Multi-Omic Rejuvenation: A New Strategy for Lifespan Extension
Various age-related disorders accumulate during aging, causing a decline in tissue and organ function, raising the risk of...
Inactivation of Type 3 Fimbriae Increases Adhesion of Klebsiella oxytoca to Lung Epithelial Cells
Inactivation of Type 3 Fimbriae Increases Adhesion of Klebsiella oxytoca to Lung Epithelial Cells
Klebsiella oxytoca is a causative agent of various community-acquired and nosocomial infections, including urinary tract i...
Point Mutations V546E and D547H of the RBM-B Motif Do Not Affect the Binding of PrimPol to RPA and DNA
Point Mutations V546E and D547H of the RBM-B Motif Do Not Affect the Binding of PrimPol to RPA and DNA
The human primase-polymerase PrimPol is a key participant of the mechanism of DNA synthesis restart during replication for...
Redox Status and Protein Glutathionylation in Binase-Treated HPV16-Positive SiHa Carcinoma Cells
Redox Status and Protein Glutathionylation in Binase-Treated HPV16-Positive SiHa Carcinoma Cells
Human papillomavirus type 16 (HPV16) belongs to viruses of the high-risk type and is associated by overexpression of E6 an...
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