SCI Abstract

search
+
Polymer-Based Antimicrobial Peptide Mimetics for Treating Multi-drug Resistant Infections: Therapy and Toxicity Evaluation
Polymer-Based Antimicrobial Peptide Mimetics for Treating Multi-drug Resistant Infections: Therapy and Toxicity Evaluation
By outsmarting antibiotics, the multidrug-resistant microbial strains, so-called ‘superbugs’ have rapidly evol...
Alleviation of LPS-induced Endothelial Injury due to GHRH Antagonist Treatment
Alleviation of LPS-induced Endothelial Injury due to GHRH Antagonist Treatment
GHRH is produced in the hypothalamus and affects various tissues beyond the pituitary, including the lungs.GHRH antagonist...
Structural Characterization of Disulfide-Linked p53-Derived Peptide Dimers
Structural Characterization of Disulfide-Linked p53-Derived Peptide Dimers
Disulfide bonds provide a convenient method for chemoselective alteration of peptide and protein structure and function. W...
De Novo Design and Characterization of Novel Antimicrobial Peptides, Lk3 and Lk4, Containing Repeating Unit
De Novo Design and Characterization of Novel Antimicrobial Peptides, Lk3 and Lk4, Containing Repeating Unit
Short cationic antimicrobial peptides (AMPs) have an excellent potential for treating various infections. This study focus...
AI-Driven Design of Cell-Penetrating Peptides for Therapeutic Biotechnology
AI-Driven Design of Cell-Penetrating Peptides for Therapeutic Biotechnology
Cell-penetrating peptides (CPPs) are short sequences of amino acids, typically ranging from 5 to 30 residues, known for th...
Thionin Production in Elicited Plant Cell Suspension and its Application as Antibacterial, Anticancer and Anti-Inflammatory Agent
Thionin Production in Elicited Plant Cell Suspension and its Application as Antibacterial, Anticancer and Anti-Inflammatory Agent
Antibiotic resistance poses a global health threat. It reduces the effectiveness of antibiotics against bacterial infectio...
Cobra Venom: From Envenomation Syndromes to Therapeutic Innovations
Cobra Venom: From Envenomation Syndromes to Therapeutic Innovations
Snakebite envenomation, classified as a neglected tropical disease, represents a significant global health threat, particu...
Sec-isoamyl Mercaptan (SIT), a Multi-faceted Disulfide Based Protecting Group for Cysteine Thiol
Sec-isoamyl Mercaptan (SIT), a Multi-faceted Disulfide Based Protecting Group for Cysteine Thiol
The successful synthesis of a peptide requires the synchronization of several processes, including the efficient execution...
Heterologous Production of Bacteriocin EMM1 from Pseudomonas Protegens and its Antimicrobial Activity against Multidrug-resistant Clinical Isolates
Heterologous Production of Bacteriocin EMM1 from Pseudomonas Protegens and its Antimicrobial Activity against Multidrug-resistant Clinical Isolates
Bacteria produce antimicrobial compounds to compete for nutrients and space in particular habitat. Bacteria of the genus P...
Host Defense Peptides: Exploiting an Innate Immune Component Against Infectious Diseases and Cancer
Host Defense Peptides: Exploiting an Innate Immune Component Against Infectious Diseases and Cancer
This review aims to elucidate the mechanisms employed by Host Defense Peptides (HDPs) in propagating their effector functi...
Morpholine Prevents the Formation of Aspartimide from β-allyl ester aspartic acid during Fmoc Cleavage in SPPS of Stapled Peptides
Morpholine Prevents the Formation of Aspartimide from β-allyl ester aspartic acid during Fmoc Cleavage in SPPS of Stapled Peptides
Despite significant advancements in peptide chemistry, the persistent occurrence of aspartimide formation during peptide s...
Adjuvant Potential of Lionfish Venom on LPS Activated Mammalian Macrophages
Adjuvant Potential of Lionfish Venom on LPS Activated Mammalian Macrophages
The lionfish, originally from the Indo-Pacific, has become established in the western Atlantic Ocean and the Caribbean Sea...
Investigating the Inhibitory Effect of Animal Antimicrobial Peptides on Gram-Positive and Gram-Negative Bacteria in Diabetic Foot Ulcers
Investigating the Inhibitory Effect of Animal Antimicrobial Peptides on Gram-Positive and Gram-Negative Bacteria in Diabetic Foot Ulcers
One of the problems of diabetic patients is the formation of ulcers in the lower areas, especially the legs, and the treat...
Conformational Flexibility and Net Charge are Key Determinants for the Antimicrobial Activity of Peptide Uy234 Against Multidrug-resistant Bacteria
Conformational Flexibility and Net Charge are Key Determinants for the Antimicrobial Activity of Peptide Uy234 Against Multidrug-resistant Bacteria
The antimicrobial activity of two peptides, Uy234 derived from the venom of the scorpion Urodacus yaschenkoi and a consens...
Insulin Prodrugs with Programmed Chemical Release of an Intramolecular Cross-Link
Insulin Prodrugs with Programmed Chemical Release of an Intramolecular Cross-Link
Basal insulin therapy is conventionally achieved by one of two broad medicinal approaches that entail either protracted ab...
Synthesis and Pharmacological Characterization of Adrenocorticotropic Hormone (ACTH 1–24) and C-Terminal Truncated Analogues Identifies the Minimal ACTH N-Terminal Fragment Required for Melanocorton-2 Receptor Activation
Synthesis and Pharmacological Characterization of Adrenocorticotropic Hormone (ACTH 1–24) and C-Terminal Truncated Analogues Identifies the Minimal ACTH N-Terminal Fragment Required for Melanocorton-2 Receptor Activation
The melanocortin system has been implicated in regulating various physiological pathways including skin and hair pigmentat...
Low Molecular Weight Peptides Derived from Iranian Scorpion (Odontobuthus bidentatus) Venom Induces Apoptosis in the Hepatocellular Carcinoma Cell Line (HepG2) in 3D Cell Culture
Low Molecular Weight Peptides Derived from Iranian Scorpion (Odontobuthus bidentatus) Venom Induces Apoptosis in the Hepatocellular Carcinoma Cell Line (HepG2) in 3D Cell Culture
Hepatocellular carcinoma (HCC) is a deadly form of liver cancer with limited treatment options. Natural compounds, such as...
Diastereomers of the Anticancer Peptide CIGB-300 with Altered β-Turn Structures
Diastereomers of the Anticancer Peptide CIGB-300 with Altered β-Turn Structures
The next-generation anti-tumor drug peptide CIGB-300, developed by the Center for Genetic Engineering and Biotechnology (C...
Antimicrobial Peptides (AMPs): New Perspectives on Their Function in Dermatological Diseases
Antimicrobial Peptides (AMPs): New Perspectives on Their Function in Dermatological Diseases
Antimicrobial peptides (AMPs) are small cationic or amphipathic molecules that are produced by both prokaryotic and eukary...
Fish Protein Hydrolysate Research Trends over the Last 5 Years and Future Research Predictions; a Bibliometric Analysis
Fish Protein Hydrolysate Research Trends over the Last 5 Years and Future Research Predictions; a Bibliometric Analysis
This bibliometric analysis delves into the latest research on protein hydrolysates from fish, examining its potential to c...
A Robust Strategy Against Multi-Resistant Pathogens in Oral Health: Harnessing the Potency of Antimicrobial Peptides in Nanofiber-Mediated Therapies
A Robust Strategy Against Multi-Resistant Pathogens in Oral Health: Harnessing the Potency of Antimicrobial Peptides in Nanofiber-Mediated Therapies
A robust strategy is imperative to counteract multi-resistant pathogens within the oral cavity and mitigate the occurrence...
ADPDB: A Comprehensive Knowledgebase of Manually Curated Peptides Against Dengue Virus
ADPDB: A Comprehensive Knowledgebase of Manually Curated Peptides Against Dengue Virus
Dengue, a significant mosquito-borne disease, presents a global health challenge with limited treatment options. Recently,...
Anticancer Peptide MCP-1 Induces Ferroptosis in Liver Cancer HCCLM3 Cells by Targeting FOXM1/ALOXE3 Signal Pathway
Anticancer Peptide MCP-1 Induces Ferroptosis in Liver Cancer HCCLM3 Cells by Targeting FOXM1/ALOXE3 Signal Pathway
FOXM1 is a crucial oncogenic transcription factor involved in almost all cancer hallmark pathways across all cancer types....
In Silico Discovery of LL13, a Shortened Pardaxin 6 Peptide Derivative with Anti-proliferative Activity
In Silico Discovery of LL13, a Shortened Pardaxin 6 Peptide Derivative with Anti-proliferative Activity
Liver cancer is a worldwide issue that also affects the Malaysian population. The occurrence is closely related to risk fa...
Molecular Basis of JZTX-III Inhibiting the Fast Inactivation of Voltage-Gated Sodium Channel Nav1.5
Molecular Basis of JZTX-III Inhibiting the Fast Inactivation of Voltage-Gated Sodium Channel Nav1.5
Prior research has established that Jingzhaotoxin-III (JZTX-III) can selectively target Nav1.5 channels. It achieves this ...
The Role and Development of Peptide Vaccines in Cervical Cancer Treatment
The Role and Development of Peptide Vaccines in Cervical Cancer Treatment
In recent years, as cancer immunotherapeutic approaches continue to be intensively investigated, therapeutic cancer vaccin...
Exploring the Potential of Designed Peptides Containing Lysine and Arginine Repeats against VIM-2 Metallo-Beta-Lactamases
Exploring the Potential of Designed Peptides Containing Lysine and Arginine Repeats against VIM-2 Metallo-Beta-Lactamases
The persistent development of bacterial resistance to β-lactam antibiotics presents a serious risk to public health w...
Stability of Multi-Peptide Vaccines in Conditions Enabling Accessibility in Limited Resource Settings
Stability of Multi-Peptide Vaccines in Conditions Enabling Accessibility in Limited Resource Settings
We have previously shown that lyophilized mixtures of six- and twelve-melanoma peptide vaccines retain stability, purity, ...
Exploring Therapeutic Potential: A Comprehensive Review of Antimicrobial Peptides in Oral Cancer Management
Exploring Therapeutic Potential: A Comprehensive Review of Antimicrobial Peptides in Oral Cancer Management
Antimicrobial peptides (AMPs) have garnered attention for their differential regulation in cancers like oral squamous cell...
Weissellicin LM85 Purified from Weissella confusa LM85 Effluxes Potassium Ions and Depletes Proton Motive Force in Escherichia coli ATCC 25922
Weissellicin LM85 Purified from Weissella confusa LM85 Effluxes Potassium Ions and Depletes Proton Motive Force in Escherichia coli ATCC 25922
Bacteriocins are membrane-acting peptides and generally kill closely related bacteria using pore formation. In this study,...
Load More
format_indent_increase