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Synergistic combination of orally available safe-in-man pleconaril, AG7404, and mindeudesivir inhibits enterovirus infections in human cell and organoid cultures
Synergistic combination of orally available safe-in-man pleconaril, AG7404, and mindeudesivir inhibits enterovirus infections in human cell and organoid cultures
Enteroviruses can infect various human organs, causing diseases such as meningitis, the common cold, hand-foot-and-mouth d...
PARP12-mediated ADP-ribosylation contributes to breast cancer cell fate by regulating AKT activation and DNA-damage response
PARP12-mediated ADP-ribosylation contributes to breast cancer cell fate by regulating AKT activation and DNA-damage response
Breast cancer represents the primary cause of death of women under 65 in developed countries, due to the acquisition of mu...
CFAP65 is essential for C2a projection integrity in axonemes: implications for organ-specific ciliary dysfunction and infertility
CFAP65 is essential for C2a projection integrity in axonemes: implications for organ-specific ciliary dysfunction and infertility
Defects in motile cilia and flagella lead to motile ciliopathies, including primary ciliary dyskinesia (PCD), which manife...
Calcium-binding protein CALU-1 is essential for proper collagen formation in Caenorhabditis elegans
Calcium-binding protein CALU-1 is essential for proper collagen formation in Caenorhabditis elegans
Collagen, a major component of the extracellular matrix, is crucial for the structural integrity of the Caenorhabditis ele...
M6A -mediated lncRNA SCIRT stability promotes NSCLC progression through binding to SFPQ and activating the PI3K/Akt pathway
M6A -mediated lncRNA SCIRT stability promotes NSCLC progression through binding to SFPQ and activating the PI3K/Akt pathway
Non-small cell lung cancer (NSCLC) has emerged as one of the most prevalent malignancies worldwide. N6-methyladenosine (m6...
NFAT5 exacerbates β-cell ferroptosis by suppressing the transcription of PRDX2 in obese type 2 diabetes mellitus
NFAT5 exacerbates β-cell ferroptosis by suppressing the transcription of PRDX2 in obese type 2 diabetes mellitus
Pancreatic β-cell damage is a critical pathological mechanism in the progression of obese type 2 diabetes mellitus (T...
From smog to scarred hearts: unmasking the detrimental impact of air pollution on myocardial ischemia–reperfusion injury
From smog to scarred hearts: unmasking the detrimental impact of air pollution on myocardial ischemia–reperfusion injury
Air pollution is a global environmental health hazard associated with elevated cardiovascular morbidity and mortality. Eme...
Ebastine-mediated destabilization of E3 ligase MKRN1 protects against metabolic dysfunction-associated steatohepatitis
Ebastine-mediated destabilization of E3 ligase MKRN1 protects against metabolic dysfunction-associated steatohepatitis
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic condition encompassing metabolic dysfunction...
D-Serine disrupts Cbln1 and GluD1 interaction and affects Cbln1-dependent synaptic effects and nocifensive responses in the central amygdala
D-Serine disrupts Cbln1 and GluD1 interaction and affects Cbln1-dependent synaptic effects and nocifensive responses in the central amygdala
Ionotropic glutamate receptors (iGluRs) mediate fast excitatory neurotransmission in the nervous system. In addition to NM...
Innate and adaptive immunity in neurodegenerative disease
Innate and adaptive immunity in neurodegenerative disease
Neurodegenerative diseases (NDs) are a group of neurological disorders characterized by the progressive loss of s...
Dnajc5b contributes to male fertility by maintaining the mitochondrial functions and autophagic homeostasis during spermiogenesis
Dnajc5b contributes to male fertility by maintaining the mitochondrial functions and autophagic homeostasis during spermiogenesis
DnaJ heat shock protein family member C5 beta (DNAJC5B), also known as cysteine-string protein beta, exhibits a prominent ...
Measurement of serum 1,5-AG provides insights for diabetes management and the anti-viral immune response
Measurement of serum 1,5-AG provides insights for diabetes management and the anti-viral immune response
Achieving an in-range glycated haemoglobin (HbA1c) is essential for managing diabetes mellitus (DM). However, this paramet...
Ketogenic diet induces an inflammatory reactive astrocytes phenotype reducing glioma growth
Ketogenic diet induces an inflammatory reactive astrocytes phenotype reducing glioma growth
The use of a ketogenic diet (KD) in glioma is currently tested as an adjuvant treatment in standard chemotherapy regimens....
SLPI controls neutrophil migration abilities and impacts neutrophil skin infiltration in experimental psoriasis
SLPI controls neutrophil migration abilities and impacts neutrophil skin infiltration in experimental psoriasis
Skin infiltration by neutrophils is a hallmark of the chronic inflammatory skin disease psoriasis, yet the mechanisms unde...
Enhanced secretion of the amyotrophic lateral sclerosis ALS-associated misfolded TDP-43 mediated by the ER-ubiquitin specific peptidase USP19
Enhanced secretion of the amyotrophic lateral sclerosis ALS-associated misfolded TDP-43 mediated by the ER-ubiquitin specific peptidase USP19
Proteinopathies, such as amyotrophic lateral sclerosis (ALS), are marked by the accumulation of misfolded proteins that di...
Antiviral strategies against influenza virus: an update on approved and innovative therapeutic approaches
Antiviral strategies against influenza virus: an update on approved and innovative therapeutic approaches
Influenza viruses still represent a great concern for Public Health by causing yearly seasonal epidemics and occasionally ...
The immune sensitivity caused by DUSP11, an RNA 5′-end maturation phosphatase, is adjusted by a human non-coding RNA, nc886
The immune sensitivity caused by DUSP11, an RNA 5′-end maturation phosphatase, is adjusted by a human non-coding RNA, nc886
All cellular transcripts initially have a tri-phosphate (PPP) group at the 5′-end, recognized as a pathogen-associat...
Apache is a neuronal player in autophagy required for retrograde axonal transport of autophagosomes
Apache is a neuronal player in autophagy required for retrograde axonal transport of autophagosomes
Neurons are dependent on efficient quality control mechanisms to maintain cellular homeostasis and function due to their p...
Stabilization of RRBP1 mRNA via an m6A-dependent manner in prostate cancer constitutes a therapeutic vulnerability amenable to small-peptide inhibition of METTL3
Stabilization of RRBP1 mRNA via an m6A-dependent manner in prostate cancer constitutes a therapeutic vulnerability amenable to small-peptide inhibition of METTL3
Mounting evidence has implicated the RNA m6A methylation catalyzed by METTL3 in a wide range of physiological and patholog...
Mechanisms for assembly of the nucleoplasmic reticulum
Mechanisms for assembly of the nucleoplasmic reticulum
The nuclear envelope consists of an outer membrane connected to the endoplasmic reticulum, an inner membrane facing the nu...
Mutations in fibronectin dysregulate chondrogenesis in skeletal dysplasia
Mutations in fibronectin dysregulate chondrogenesis in skeletal dysplasia
Fibronectin (FN) is an extracellular matrix glycoprotein essential for the development and function of major vertebrate or...
NPRL2 promotes TRIM16-mediated ubiquitination degradation of Galectin-3 to prevent CD8+T lymphocyte cuproptosis in glioma
NPRL2 promotes TRIM16-mediated ubiquitination degradation of Galectin-3 to prevent CD8+T lymphocyte cuproptosis in glioma
Our previous study found that tumor suppressor nitrogen permease regulator like-2(NPRL2) is frequently downregulated in gl...
The role of immune cells settled in the bone marrow on adult hematopoietic stem cells
The role of immune cells settled in the bone marrow on adult hematopoietic stem cells
Certain immune cells, including neutrophils, macrophages, dendritic cells, B cells, Breg cells, CD4+ T cells, CD8+ T cells...
Virus neutralization assays for human respiratory syncytial virus using airway organoids
Virus neutralization assays for human respiratory syncytial virus using airway organoids
Neutralizing antibodies are considered a correlate of protection against severe human respiratory syncytial virus (HRSV) d...
Glycine-induced activation of GPR158 increases the intrinsic excitability of medium spiny neurons in the nucleus accumbens
Glycine-induced activation of GPR158 increases the intrinsic excitability of medium spiny neurons in the nucleus accumbens
It has been recently established that GPR158, a class C orphan G protein-coupled receptor, serves as a metabotropic glycin...
Uncovering the role of TET2-mediated ENPEP activation in trophoblast cell fate determination
Uncovering the role of TET2-mediated ENPEP activation in trophoblast cell fate determination
Early trophoblast differentiation is crucial for embryo implantation, placentation and fetal development. Dynamic changes ...
Unveiling the crucial role of betaine: modulation of GABA homeostasis via SLC6A1 transporter (GAT1)
Unveiling the crucial role of betaine: modulation of GABA homeostasis via SLC6A1 transporter (GAT1)
Betaine is an endogenous osmolyte that exhibits therapeutic potential by mitigating various neurological disorders. Howeve...
Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants
Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants
Acid-sensing ion channels (ASICs) are trimeric proton-gated cation channels that play a role in neurotransmission and pain...
Targeting ubiquitination machinery in cystic fibrosis: Where do we stand?
Targeting ubiquitination machinery in cystic fibrosis: Where do we stand?
Cystic Fibrosis (CF) is a genetic disease caused by mutations in CFTR gene expressing the anion selective channel CFTR loc...
Hidden secrets of the cancer genome: unlocking the impact of non-coding mutations in gene regulatory elements
Hidden secrets of the cancer genome: unlocking the impact of non-coding mutations in gene regulatory elements
Discoveries in the field of genomics have revealed that non-coding genomic regions are not merely "junk DNA", bu...
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