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Chalcone-inspired indole, carbazole, and phenothiazine hybrids as potent aldose reductase inhibitors with selective anticancer potential: Rational design, synthesis, and multi-level characterization
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8-Amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives hybridized with antioxidants: new highly potent and selective human A2A adenosine receptor antagonists as useful agents against cerebral ischemia
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Chiral resolution of (R, S)-1-chloro-1-phenylethane by haloalkane dehalogenase DbjA in micro-aqueous phase
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Design, synthesis, and biological evaluation of Pseudolaric acid B derivatives as Ferroptosis inducers in Colon Cancer cells
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Kinsenoside derivatives mitigate acute liver injury in mice via MAPK pathway-mediated oxidative stress suppression
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Further insights into the multitarget anticancer activity of tetrahydrocarbazole-1-amine/5-arylidene-4-thiazolinone based hybrids
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Ultrasensitive chemiluminescent probe activated by NAG for real-time monitoring of AKI
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An SPR-based active ingredient recognition strategy for identifying PLK1-targeting withanolides as natural ferroptosis inducers
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Microalgae-derived potassium chlorophyllin as a photosensitizer in antimicrobial photodynamic therapy: From semi-synthesis to applications
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Rational discovery of novel tetrahydroisoquinoline-indole derivatives as potent P-glycoprotein inhibitor against multidrug resistance in MCF-7/ADR cell
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Roridin E and satratoxin H, macrocyclic trichothecene mycotoxins, induce endoplasmic reticulum stress-dependent apoptosis through ribosome interaction in B16 mouse melanoma cells
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Design and synthesis of ROCK2-selective inhibitors bearing 6-indazolamino-2-pyrrolidinylpyridine for the treatment of breast cancer metastasis
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A pomalidomide-based gefitinib PROTAC degrader effectively inhibits lung cancer progression in EGFR-TKIs-acquired resistant models by targeting EGFR degradation and ETFA-mediated ATP generation
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Discovery of pyrazolo[1,5-a]pyrimidines: Synthesis, in silico insights, and anticancer activity via novel CDK2/Tubulin dual inhibition approach
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Synthesis, antifungal activity, structure-activity relationship and mechanism of action of nicotinohydrazide derivatives
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Bufadienolides as bioorganic anticancer agents: Mechanistic insights into apoptosis, cell cycle arrest and signal pathway modulation
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Exploring therapeutic strategies for candidiasis: From current treatments to future perspectives
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Harnessing tyrosine kinase 2: Breakthroughs in autoimmune disease and cancer therapy
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The LSD1/HDAC dual-target inhibitor for cancer therapy: Challenge and opportunity
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Application of proteolysis targeting chimeric (PROTAC) technology in protein regulation and drug development
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Chemotherapeutic potential of radotinib against blood and solid tumors: A beacon of hope in drug repurposing
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Rational design and syntheses of naphthalimide-based fluorescent probes for targeted detection of diabetes biomarkers
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An overview of phenylsulfonylfuroxan-based nitric oxide donors for cancer treatment
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Current developments in PI3K-based anticancer agents: Designing strategies, biological activity, selectivity, structure-activity correlation, and docking insight
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Epidermal growth factor receptor mutations in breast Cancer: Therapeutic challenges and way forward
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Aldehyde dehydrogenases as drug targets for cancer: SAR and structural biology aspects for inhibitor design
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Beyond peptides: Unveiling the design strategies, structure activity correlations and protein-ligand interactions of small molecule inhibitors against PD-1/PD-L1
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Thiazole – A promising scaffold for antituberculosis agents and structure–activity relationships studies
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TDP1 represents a promising therapeutic target for overcoming tumor resistance to chemotherapeutic agents: progress and potential
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Targeting XPO1 for fighting relapsed/refractory diseases: The research progress of XPO1 inhibitors
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