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Expression patterns of circRFX3 and miR-587 in colorectal cancer patients
Circular RNAs (circRNAs) are non-coding, single-stranded RNAs considered by their closed-loop structures. Research has est...
HIV-1 reverse transcriptase subtyping revealed CRF35-AD as a current subtype in the northeast of Iran
Previously, the sequence of the HIV-1 reverse transcriptase gene was analyzed to identify mutations associated with drug r...
Comprehensive computational analysis of deleterious nsSNPs in PTEN gene for structural and functional insights
Single nucleotide polymorphisms (SNPs) are pivotal in understanding the genetic basis of complex disorders. Among them, no...
Gene co-expression network analysis reveals relationship between leukocyte fraction and genomic instability in dedifferentiated liposarcoma
Dedifferentiated Liposarcoma (DDLPS) is one of the common subtypes of liposarcoma that is considered a highly malignant ca...
Breast cancer susceptibility is associated with Cyclin D1 single nucleotide polymorphisms in Iran: A case-control study
Breast cancer (BC) is the main cause of cancer-related death in women worldwide. We evaluated the association between the ...
The importance of TP53 status in cancer therapy: The example of chronic lymphocytic leukemia
The TP53 gene encodes the tumor suppressor protein p53, which plays a critical role in genomic stability and cell cycle re...
Dysregulated LINC01133 expression in laryngeal carcinoma: Prognostic implications and predicted ceRNA interactome
Long non-coding RNAs (lncRNAs) have recently emerged as critical regulators of oncogenic or tumor-suppressive pathways in ...
Non-spike protein inhibition of SARS-CoV-2 by natural products through the key mediator protein ORF8
The recent pernicious COVID-19 pandemic is caused by SARS-CoV-2. While most therapeutic strategies have focused on the vir...
Dysregulated genes in HIGK-treated F. nucleatum and their possible association with HNSCC
The present study aims to identify the differentially expressed genes in HIGK treated with Fusobacterium nucleatum (Fn) an...
Prediction the functional impacts of highly deleterious non-synonymous variants of TSGA10 gene
Testis specific gene antigen 10 (TSGA10) is a protein which has roles in spermatogenesis and cancers so that deletion or m...
Isolation and characterization of thermotolerant hydrocarbon degrading bacteria which sustained the activity at extreme salinity and high osmotic conditions
The bioremediation method is considered an economical and environmentally friendly strategy for the remediation of oil-con...
Expressing red fluorescent protein on the surface of Escherichia coli using C-terminal domain of autotransporters
The Type V secretion system, or “autotransporter”, is a secretion system that enables bacteria to directly export proteins...
IL13 gene polymorphisms among Sudanese patients with bronchial asthma: a case-control study
Genetic polymorphisms in interleukin-13 (IL13) gene have been associated with asthma susceptibility in different ethniciti...
A CRISPR-HITI strategy approach to improve CHO cell viability by modifying the 3'UTR of Caspase 8 Associated Protein 2
Chinese Hamster Ovary (CHO) cells are essential in biopharmaceutical manufacturing.  Scientists use CRISPR to enhance prod...
Evaluation of several strategies for controlling canker plant disease caused by Pseudomonas syringae
Pseudomonas syringae is a gram-negative bacterium that causes a diversity of diseases in numerous plants. Strategies to in...
A comprehensive in silico analysis of mutation spectrum of maple syrup urine disease (MSUD) genes in Iranian population
Maple syrup urine disease (MSUD) represents an infrequent metabolic disease precipitated by an insufficiency of the enzyma...
In silico analysis for SARS-CoV-2 detection in the context of genetic variability of the Algerian omicron variant
The risk to public health conferred by the Omicron variant is still not completely clear, although its numerous gene mutat...
Comparison of inflammatory molecular mechanisms between osteoarthritis and rheumatoid arthritis via gene microarrays
Osteoarthritis (OA) and rheumatoid arthritis (RA) treatment requires exact arthritis type diagnosis. We compared inflammat...
Down-regulation of key regulatory factors in sphingosine-1-phosphate (S1P) pathway in human lung fibroblasts transfected with selected microRNAs
Sphingosine 1 phosphate (S1P) is involved in the pathogenesis of asthma by stimulation of the alpha-smooth muscle actin (S...
The hepatoprotective effects of sitagliptin against cyclophosphamide-induced hepatotoxicity in rat
Hepatotoxicity is a serious side effects of cyclophosphamide. Thus, the present research investigates the protective prope...
In-silico comparison of fungal and bacterial asparaginase enzymes
L-asparaginase is a commercial enzyme with a wide variety of applications. Asparaginase is known as an anti-cancer agent t...
Clinical profile of FTL3-ITD mutation in West Algerian population with acute myeloid leukemia
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the abnormal and ra...
The effects of NLRP3 rs10754558 and rs4612666 polymorphisms on preeclampsia susceptibility, onset, and severity: a case-control study and in silico analysis
Preeclampsia (PE) is one of the serious complications of pregnancy and its exact etiology is unknown. Inflammasomes are mu...
Genome-wide mining and characterization of MATE transporters in Coriandrum sativum L.
Multidrug and Toxic Compound Extrusion (MATE) proteins are responsible for the transport of a wide range of metabolites ou...
Comparison of Mir122 expression in children with biliary atresia and healthy group
Biliary atresia (BA) is the primary cause of neonatal jaundice with various pathological mechanisms. Many BA patients may ...
Effects of silymarin as adjuvant drug on serum levels of CTRP3, anti-cyclic citrullinated peptide (CCP), and high-sensitivity C-reactive protein (hs-CRP) in rheumatoid arthritis patients
Silymarin is known for its anti-inflammatory and antioxidant properties. We investigated these effects on serum levels of ...
Natural compounds solasonine and alisol B23-acetate target GLI3 signaling to block oncogenesis in MED12-altered breast cancer
Breast cancer remains to be the second leading cause of cancer deaths worldwide thereby highlighting the critical need to ...
A survey of resistance mutations to reverse transcriptase inhibitors (RTIs) among HIV-1 patients in northeast of Iran
The use of a combination of three-drug regimen has improved HIV-1 infected patients' life span and quality; however t...
Valproic acid and/or rapamycin preconditioning protects hair follicle stem cells from oxygen glucose serum deprivation-induced oxidative injury via activating Nrf2 pathway
Among leading causes of the ischemic stroke pathogenesis, oxidative stress strongly declines rate of stem cell engraftment...
The effects of thymidylate synthase 3'UTR genotype on methylation of tumor-specific genes promoter in 22 colorectal cancer patients from southern Iran
To investigate the effects of thymidylate synthase (TS) 3'UTR genotype on promotor methylation of tumor-related genes...
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