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Hypoimmune stem cells and islets: hype or a true breakthrough in diabetes treatment?
Hypoimmune stem cells and islets: hype or a true breakthrough in diabetes treatment?
Immune-resistant pancreatic islets hold great promise for advancing diabetes cell therapy. Two key approaches, hypoimmunog...
RSL3 promotes PARP1 apoptotic functions by distinct mechanisms during ferroptosis
RSL3 promotes PARP1 apoptotic functions by distinct mechanisms during ferroptosis
The classical ferroptosis activator RSL3 targets enzymes with nucleophilic active sites, primarily acting on glutathione p...
Bridging pancreatic and hepatic development: overlapping genes and their role in diabetes
Bridging pancreatic and hepatic development: overlapping genes and their role in diabetes
Diabetes mellitus is a complex metabolic disorder characterized by hyperglycemia due to impaired insulin production, actio...
Endogenous cardiac catecholaminergic systems in cardiac development, physiology, and pathophysiology
Endogenous cardiac catecholaminergic systems in cardiac development, physiology, and pathophysiology
Catecholamines, canonically associated with the sympathetic nerves and the adrenal medulla, are also produced by neuropara...
LncRNA-like MMP14 RNA facilitates colorectal cancer metastasis by suppressing H3K27cr at the STARD13 promoter region
LncRNA-like MMP14 RNA facilitates colorectal cancer metastasis by suppressing H3K27cr at the STARD13 promoter region
MMP14 protein has been recognized to promote tumor metastasis through protease activity, yet drugs targeting the protein f...
Tumor-derived exosomal KPNA2 activates fibroblasts and interacts with KIFC1 to promote bladder cancer progression, a process inhibited by miR-26b-5p
Tumor-derived exosomal KPNA2 activates fibroblasts and interacts with KIFC1 to promote bladder cancer progression, a process inhibited by miR-26b-5p
Recent studies have illuminated the complexities of treating advanced bladder cancer (BCa), underscoring the importance of...
Human urine stem cells protect against cyclophosphamide-induced premature ovarian failure by inhibiting SLC1A4-mediated outflux of intracellular serine in ovarian granulosa cells
Human urine stem cells protect against cyclophosphamide-induced premature ovarian failure by inhibiting SLC1A4-mediated outflux of intracellular serine in ovarian granulosa cells
Cyclophosphamide (CTX) is the first-line medication for the treatment of breast cancer, although it potentially leads to s...
Exposure of A2E to blue light promotes ferroptosis in the retinal pigment epithelium
Exposure of A2E to blue light promotes ferroptosis in the retinal pigment epithelium
Age-dependent accumulation of lipofuscin in the retinal pigment epithelium (RPE) is closely related to the etiology of aut...
Regulating chemoresistance and cancer stemness: the CDH17-YAP pathway in distinct cellular states of lung cancer CTC clusters
Regulating chemoresistance and cancer stemness: the CDH17-YAP pathway in distinct cellular states of lung cancer CTC clusters
Drug resistance in metastatic lung cancer significantly contributes to patient mortality. This study explores the role of ...
Tetraspanin 3 promotes NSCLC cell proliferation via regulation of β1 integrin intracellular recycling
Tetraspanin 3 promotes NSCLC cell proliferation via regulation of β1 integrin intracellular recycling
The involvement of tetraspanins in cancer development has been widely implicated. In this study, the function and molecula...
The role and therapeutic potential of itaconate in lung disease
The role and therapeutic potential of itaconate in lung disease
Lung diseases triggered by endogenous or exogenous factors have become a major concern, with high morbidity and mortality ...
Endometrial regeneration cell-derived exosomes loaded with siSLAMF6 inhibit cardiac allograft rejection through the suppression of desialylation modification
Endometrial regeneration cell-derived exosomes loaded with siSLAMF6 inhibit cardiac allograft rejection through the suppression of desialylation modification
Acute transplant rejection is a major component of poor prognoses for organ transplantation. Owing to the multiple complex...
Caspase-8 in inflammatory diseases: a potential therapeutic target
Caspase-8 in inflammatory diseases: a potential therapeutic target
Caspase-8, a renowned cysteine-aspartic protease within its enzyme family, initially garnered attention for its regulatory...
Research progress of ankyrin repeat domain 1 protein: an updated review
Research progress of ankyrin repeat domain 1 protein: an updated review
Ankyrin repeat domain 1 (Ankrd1) is an acute response protein that belongs to the muscle ankyrin repeat protein (MARP) fam...
WTAP/IGF2BP3-mediated GBE1 expression accelerates the proliferation and enhances stemness in pancreatic cancer cells via upregulating c-Myc
WTAP/IGF2BP3-mediated GBE1 expression accelerates the proliferation and enhances stemness in pancreatic cancer cells via upregulating c-Myc
Pancreatic cancer (PC) is one of the most malignant cancers with highly aggressiveness and poor prognosis. N6-methyladenos...
The marine-derived HIF-1α inhibitor, Yardenone 2, reduces prostate cancer cell proliferation by targeting HIF-1 target genes
The marine-derived HIF-1α inhibitor, Yardenone 2, reduces prostate cancer cell proliferation by targeting HIF-1 target genes
Prostate cancer (PCa) ranks as the second most prevalent cancer in men, with advanced stages posing significant treatment ...
Epigenetic control of skeletal muscle atrophy
Epigenetic control of skeletal muscle atrophy
Skeletal muscular atrophy is a complex disease involving a large number of gene expression regulatory networks and various...
New mechanistic understanding of osteoclast differentiation and bone resorption mediated by P2X7 receptors and PI3K-Akt-GSK3β signaling
New mechanistic understanding of osteoclast differentiation and bone resorption mediated by P2X7 receptors and PI3K-Akt-GSK3β signaling
Osteoporosis is a global health issue characterized by decreased bone mass and microstructural degradation, leading to an ...
Emerging role of glutathione peroxidase 4 in myeloid cell lineage development and acute myeloid leukemia
Emerging role of glutathione peroxidase 4 in myeloid cell lineage development and acute myeloid leukemia
Phospholipid Hydroperoxide Gluthatione Peroxidase also called Glutathione Peroxidase 4 is one of the 25 described human se...
Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury
Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury
Acute kidney injury (AKI) is a common clinical disorder with complex etiology and poor prognosis, and currently lacks spec...
Curriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review
Curriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review
RNA-binding proteins (RBPs) are kinds of proteins with either singular or multiple RNA-binding domains (RBDs), and they ca...
Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development
Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development
Gut microbiota regulates various aspects of human physiology by producing metabolites, metabolizing enzymes, and toxins. M...
A multiplex RPA-CRISPR/Cas12a-based POCT technique and its application in human papillomavirus (HPV) typing assay
A multiplex RPA-CRISPR/Cas12a-based POCT technique and its application in human papillomavirus (HPV) typing assay
Persistent infection with high-risk human papillomavirus (HR-HPV) is the primary and initiating factor for cervical cancer...
The micro-743a-3p–GSTM1 pathway is an endogenous protective mechanism against alcohol-related liver disease in mice
The micro-743a-3p–GSTM1 pathway is an endogenous protective mechanism against alcohol-related liver disease in mice
Epidemiological evidence suggests that the phenotype of glutathione S-transferase mu 1 (GSTM1), a hepatic high-expressed p...
Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice
Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice
Acute respiratory distress syndrome (ARDS) is a disease with high mortality and morbidity. Regulator of G protein signalin...
METTL3/YTHDC1-medicated m6A modification of circRNA3634 regulates the proliferation and differentiation of antler chondrocytes by miR-124486-5-MAPK1 axis
METTL3/YTHDC1-medicated m6A modification of circRNA3634 regulates the proliferation and differentiation of antler chondrocytes by miR-124486-5-MAPK1 axis
The deer antler, a remarkable mammalian appendage, has a growth rate surpassing that of any other known osseous organ. Eme...
Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer’s disease
Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer’s disease
Alzheimer’s disease (AD) is a chronic illness marked by increasing cognitive decline and nervous system deterioratio...
Metabolite itaconate in host immunoregulation and defense
Metabolite itaconate in host immunoregulation and defense
Metabolic states greatly influence functioning and differentiation of immune cells. Regulating the metabolism of immune ce...
Global research trends in CRISPR-related technologies associated with extracellular vesicles from 2015 to 2022: a bibliometric, dynamic, and visualized study
Global research trends in CRISPR-related technologies associated with extracellular vesicles from 2015 to 2022: a bibliometric, dynamic, and visualized study
This study aims to explore the emerging trends, dynamic development, and research hotspots of clustered regularly interspa...
Synthetic CRISPR/dCas9-KRAB system driven by specific PSA promoter suppresses malignant biological behavior of prostate cancer cells through negative feedback inhibition of PSA expression
Synthetic CRISPR/dCas9-KRAB system driven by specific PSA promoter suppresses malignant biological behavior of prostate cancer cells through negative feedback inhibition of PSA expression
PSA is a type of proto-oncogene that is specifically and highly expressed in embryonic and prostate cancer cells, but not ...
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