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E3 ligase MIB1 regulates STAT1/P21 signaling via regulation of FGFR1 in colorectal cancer
E3 ligase MIB1 regulates STAT1/P21 signaling via regulation of FGFR1 in colorectal cancer
Mind bomb 1 (MIB1) is an E3 ubiquitin ligase that promotes the polyubiquitination-mediated degradation of NOTCH ligands an...
RepID depletion enhances TWS119-induced erythropoiesis through chromatin reprogramming and transcription factor recruitment
RepID depletion enhances TWS119-induced erythropoiesis through chromatin reprogramming and transcription factor recruitment
Erythrocytes, derived from hematopoietic stem cells, are essential for oxygen transport, ensuring survival in all vertebra...
Exploring the role of alternative splicing in the pathogenesis of Sjögren’s syndrome: identification of novel isoforms associated with salivary gland immune infiltration
Exploring the role of alternative splicing in the pathogenesis of Sjögren’s syndrome: identification of novel isoforms associated with salivary gland immune infiltration
Sjögren's syndrome (SS) is an autoimmune disorder affecting exocrine glands, causing dry mouth and eyes, with no ...
Molecular cloning, expression analysis, and functional characterization of Intelectin-1 from Chinese giant salamanders ()
Molecular cloning, expression analysis, and functional characterization of Intelectin-1 from Chinese giant salamanders ()
Intelectin (ITLN) plays a pivotal role in innate immunity, inflammatory responses, and tumor progression. However, its phy...
Backtracking identification techniques for predicting unclear bacterial taxonomy at species level: molecular diagnosis-based bacterial classification
Backtracking identification techniques for predicting unclear bacterial taxonomy at species level: molecular diagnosis-based bacterial classification
Bacterial 16S rRNA genes are widely used to classify bacterial communities within interesting environments (e.g., plants, ...
Whole transcriptome profiling of cardiac injury: insights from a neonatal mouse sepsis model
Whole transcriptome profiling of cardiac injury: insights from a neonatal mouse sepsis model
Neonatal sepsis is characterized by an excessive immune response, often leading to multiple organ failure, including cardi...
Alternative splicing of CHI3L1 regulates protein secretion through conformational changes
Alternative splicing of CHI3L1 regulates protein secretion through conformational changes
Alternative splicing (AS) plays a crucial role in regulating protein function through the generation of structurally disti...
Whole exome sequencing of 80 cases of sporadic mitral valve prolapse reveals novel disease-associated genes and variants in a Southern Chinese population
Whole exome sequencing of 80 cases of sporadic mitral valve prolapse reveals novel disease-associated genes and variants in a Southern Chinese population
Mitral valve prolapse (MVP) is a common valvular disorder with a complex genetic basis. While familial MVP-related genes h...
Ectopic expression of and induces green tissue formation in non-green organs of
Ectopic expression of and induces green tissue formation in non-green organs of
A dominant mutant, green root-dominant (grt-D), which exhibits a green-root phenotype, was identified using the GAL4-UAS a...
RNA-binding protein expression based machine learning model predicts metastasis and treatment outcome of testicular cancer
RNA-binding protein expression based machine learning model predicts metastasis and treatment outcome of testicular cancer
RNA-binding proteins (RBPs) are key regulators of cellular transcription and are associated with the occurrence and develo...
Gene expression profile in ulcerative colitis patients: , , , genes as potential biomarkers
Gene expression profile in ulcerative colitis patients: , , , genes as potential biomarkers
Ulcerative colitis (UC) is a complex, chronic inflammatory disease that primarily impacts the colon mucosa. One of the key...
Genome-wide identification of NAC transcription factors in and their expression dynamics during leaf aging
Genome-wide identification of NAC transcription factors in and their expression dynamics during leaf aging
The NAC family (consisting of NAM, ATAF1/2, and CUC2) represents a crucial plant-specific transcription factor family, con...
Transcriptomic analysis revealed that short-day treatment of seedlings promotes flowering in maize ( L.)
Transcriptomic analysis revealed that short-day treatment of seedlings promotes flowering in maize ( L.)
In this study, blockage of transition from vegetative to reproductive growth was observed in short-day maize (Zea mays L.)...
The GPR4 antagonist NE 52-QQ57 prevents ox-LDL-induced cellular senescence by promoting the expression of SIRT1
The GPR4 antagonist NE 52-QQ57 prevents ox-LDL-induced cellular senescence by promoting the expression of SIRT1
Cell senescence-associated endothelia dysfunction is a vital point in the pathological progression of atherosclerosis (AS)...
RalB promotes lymph node metastasis in tongue squamous cell carcinoma
RalB promotes lymph node metastasis in tongue squamous cell carcinoma
Lymph nodes metastasis is the main metastasis mode of tongue squamous cell carcinoma (TSCC). Ras related GTP binding prote...
Perillic acid disrupts the specification of germ layers by upregulating the FGF/MAPK pathway
Perillic acid disrupts the specification of germ layers by upregulating the FGF/MAPK pathway
Xenopus embryo is an ideal model for teratogenesis assays to assess the effects of any compounds on the cellular processes...
Hippocampal MCT4 as a key regulator in excessive exercise-induced cognitive impairment: involvement of neuroinflammation
Hippocampal MCT4 as a key regulator in excessive exercise-induced cognitive impairment: involvement of neuroinflammation
As human life expectancy increases, maintaining a healthy lifestyle has become crucial. However, excessive exercise (EE) c...
De novo somatic mosaicisms of and in patients with Charcot-Marie-Tooth disease
De novo somatic mosaicisms of and in patients with Charcot-Marie-Tooth disease
Somatic mosaicism is caused by a postzygotic de novo mutation. It is a very rare genetic event, and mosaic cases have been...
Comparison of unique Dong Tao chickens from Vietnam and Thailand: genetic background and differences for resource management
Comparison of unique Dong Tao chickens from Vietnam and Thailand: genetic background and differences for resource management
Rare Dong Tao (DT) chickens are a unique and highly productive poultry breed introduced from Vietnam to Thailand ~&#...
Clinical report and genetic analysis of a Chinese family with retinitis pigmentosa 79 caused by a novel loss-of-function HK1 variant
Clinical report and genetic analysis of a Chinese family with retinitis pigmentosa 79 caused by a novel loss-of-function HK1 variant
Retinitis pigmentosa (RP) is a genetically heterogeneous disease. RP 79 has been associated with heterozygous variants of ...
Units containing telomeric repeats are prevalent in subtelomeric regions of a Mesorhabditis isolate collected from the Republic of Korea
Units containing telomeric repeats are prevalent in subtelomeric regions of a Mesorhabditis isolate collected from the Republic of Korea
Mesorhabditis is known for its somatic genome being only a small portion of the germline genome due to programmed DNA elim...
Weighted gene co-expression network analysis and identification of ginsenoside biosynthesis candidate genes for ginseng adventitious roots under MeJA treatment
Weighted gene co-expression network analysis and identification of ginsenoside biosynthesis candidate genes for ginseng adventitious roots under MeJA treatment
Ginseng (Panax ginseng) is an herb with a long history and a wide range of applications. Ginsenoside is one of the most re...
Integrated analysis of single-cell RNA-seq and bulk RNA-seq revealed key genes for bone metastasis and chemoresistance in prostate cancer
Integrated analysis of single-cell RNA-seq and bulk RNA-seq revealed key genes for bone metastasis and chemoresistance in prostate cancer
Prostate cancer (PCa) is a serious malignancy. The main causes of PCa aggravation and death are unexplained resistance to ...
GVAF: generalized, flexible filtering software for annotated variant files
GVAF: generalized, flexible filtering software for annotated variant files
In the rapidly advancing field of genomics, many tools have been developed to interpret genetic variants using next-genera...
Genome-wide identification and expression profiling of the Wnt gene family in three abalone species
Genome-wide identification and expression profiling of the Wnt gene family in three abalone species
The Wnt gene family plays pivotal roles in a variety of biological processes including cell proliferation and differentiat...
Genetic diversity and structure of Persicaria amphibia (Polygonaceae) in South Korea using genotyping by sequencing
Genetic diversity and structure of Persicaria amphibia (Polygonaceae) in South Korea using genotyping by sequencing
Persicaria amphibia, a member of the Polygonaceae family, exists both aquatic and terrestrial forms. It is native to North...
Machine learning identification of NK cell immune characteristics in hepatocellular carcinoma based on single-cell sequencing and bulk RNA sequencing
Machine learning identification of NK cell immune characteristics in hepatocellular carcinoma based on single-cell sequencing and bulk RNA sequencing
Hepatocellular carcinoma (HCC) is a highly malignant tumor; however, its immune microenvironment and mechanisms remain elu...
Transcriptome analysis of tilapia streptococcus agalactiae in response to baicalin
Transcriptome analysis of tilapia streptococcus agalactiae in response to baicalin
Streptococcus agalactiae (S. agalactiae) is a highly pathogenic bacterial pathogen in aquatic animals. Our previous study ...
A novel CLRN2 variant: expanding the mutation spectrum and its critical role in isolated hearing impairment
A novel CLRN2 variant: expanding the mutation spectrum and its critical role in isolated hearing impairment
Biallelic variants in the CLRN2 gene have been reported to cause autosomal recessive profound hearing impairment in humans...
A novel frameshift TBX4 variant in a family with ischio-coxo-podo-patellar syndrome and variable severity
A novel frameshift TBX4 variant in a family with ischio-coxo-podo-patellar syndrome and variable severity
Congenital anomalies of the knee are a spectrum of rare disorders with wide clinical and genetic variability, which are ma...
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