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Fishing for covalent peptides
Fishing for covalent peptides
Electrophilic phage display has emerged as a powerful platform for discovering high-affinity or covalent peptide ligands. ...
Chemically programmable condensates for gene regulation
Chemically programmable condensates for gene regulation
We developed a ligand-responsive solid-state condensate platform for on-demand spatiotemporal control of gene expression i...
Chemical Decoding of Spatial Biology
Chemical Decoding of Spatial Biology
The spatial organization of biomolecules helps orchestrate a range of biological processes; however, links between spatial...
Biosurfactant biosynthesis by Alcanivorax borkumensis and its role in oil biodegradation
Biosurfactant biosynthesis by Alcanivorax borkumensis and its role in oil biodegradation
The marine bacterium Alcanivorax borkumensis degrades alkanes derived from phytoplankton, natural hydrocarbon seeps and oi...
Enzymatic combinatorial synthesis of E-64 and related cysteine protease inhibitors
Enzymatic combinatorial synthesis of E-64 and related cysteine protease inhibitors
E-64 is an irreversible cysteine protease inhibitor prominently used in chemical biology and drug discovery. Here we uncov...
Small-molecule dissolution of stress granules by redox modulation benefits ALS models
Small-molecule dissolution of stress granules by redox modulation benefits ALS models
Neurodegenerative diseases, such as amyotrophic lateral sclerosis, are often associated with mutations in stress granule p...
Direct nitrogen–nitrogen bond formation by an enzyme from the negamycin biosynthetic pathway
Direct nitrogen–nitrogen bond formation by an enzyme from the negamycin biosynthetic pathway
Negamcyin, a decades-old antibiotic, is a promising lead compound for the development of drugs for treatment of Gram-negat...
Development of an allosteric adhesion GPCR nanobody with therapeutic potential
Development of an allosteric adhesion GPCR nanobody with therapeutic potential
Allosteric modulation of receptor responses to endogenous agonists has therapeutic value, maintaining ligand profiles, red...
Evading resistance at the double
Evading resistance at the double
Synthesis and characterization of new macrolones — fusions of two antibiotic classes with distinct bacterial targets...
A multiplex single-cell RNA-Seq pharmacotranscriptomics pipeline for drug discovery
A multiplex single-cell RNA-Seq pharmacotranscriptomics pipeline for drug discovery
The gene-regulatory dynamics governing drug responses in cancer are yet to be fully understood. Here, we report a pipeline...
Carbonic anhydrase inhibition ameliorates tau toxicity via enhanced tau secretion
Carbonic anhydrase inhibition ameliorates tau toxicity via enhanced tau secretion
Tauopathies are neurodegenerative diseases that manifest with intracellular accumulation and aggregation of tau protein. T...
Engineering a xylose fermenting yeast for lignocellulosic ethanol production
Engineering a xylose fermenting yeast for lignocellulosic ethanol production
Lignocellulosic ethanol is produced by yeast fermentation of lignocellulosic hydrolysates generated by chemical pretreatme...
Author Correction: Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis
Yu ImaiPresent address: Department of Biomolecular Innovation, Institute for Biomedical Sciences, Shinshu University, Naga...
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway
These authors contributed equally: Jie Shi, Shangying Wang.Department of Bioengineering, University of California, Berkele...
Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT
Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT
The post-translational modification of intracellular proteins through O-linked β-N-acetylglucosamine (O-GlcNAc) is a ...
Open-ended molecular recording of sequential cellular events into DNA
Open-ended molecular recording of sequential cellular events into DNA
Genetically encoded DNA recorders noninvasively convert transient biological events into durable mutations in a cell’...
Stress it up
AKT is a serine/threonine kinase that is essential for cellular metabolism and proliferation and is overactive in cancer c...
Reeling in microorganisms
The metabolic engineering of microorganisms is an attractive platform for bioremediation and the industrial production of ...
The death gaze of MEDUSA
The death gaze of MEDUSA
Chemogenetic profiling can reveal genetic determinants that coordinate phenotypic responses to therapeutics, along with pr...
Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression
Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression
Telomere dysfunction is intricately linked to the aging process and stands out as a prominent cancer hallmark. Here we dem...
Engineering APOBEC3A deaminase for highly accurate and efficient base editing
Engineering APOBEC3A deaminase for highly accurate and efficient base editing
Cytosine base editors (CBEs) are effective tools for introducing C-to-T base conversions, but their clinical applications ...
LPS gets a fresh trim
LPS gets a fresh trim
Detection of intracellular lipolysaccharide (LPS) activates an immune response initiated by the non-canonical inflammasome...
Peptide vaccines get an OS update
Peptide vaccines get an OS update
Peptide vaccines use antigenic peptide fragments to induce an immune response but are problematic because of the short hal...
Bringing chemistry to medicine to redefine the undruggable
Bringing chemistry to medicine to redefine the undruggable
Chemical approaches, such as those that leverage induced proximity, targeted degradation, synthetic gene regulators or pro...
Biocatalytic cyclization of small macrolactams by a penicillin-binding protein-type thioesterase
Biocatalytic cyclization of small macrolactams by a penicillin-binding protein-type thioesterase
Macrocyclic peptides represent promising scaffolds for chemical tools and potential therapeutics. Synthetic methods for pe...
Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM
Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM
Compact Cas9 nucleases hold great promise for therapeutic applications. Although several compact Cas9 nucleases have been ...
In search of chemical rationales
In search of chemical rationales
Small molecules and drugs are not homogenously distributed across cells, and are instead enriched in distinct subcellular ...
Author Correction: An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity
Authors and AffiliationsDepartment of Chemistry, The University of Chicago, Chicago, IL, USATong Wu, Chang Liu, Siyuan Zou...
Characterizing the metabolomes of phase-separated condensates
Characterizing the metabolomes of phase-separated condensates
Cells contain compartments composed of phase-separated protein condensates. We find that these condensates have a unique c...
Medicine from modified mRNA
Medicine from modified mRNA
As the COVID-19 pandemic rapidly spread around the world, the scientific community desperately searched for therapeutic in...
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