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A Journey between Neurons and Astrocytes: A Tribute to Giorgio Carmignoto
A Journey between Neurons and Astrocytes: A Tribute to Giorgio Carmignoto
The intimate relation between astrocytes and blood vessels was proposed by Camillo Golgi in 1870. Santiago Ramon y Cajal s...
Wnt7b Promotes Axon Differentiation and Extension by Regulating JNK-Mediated Cytoskeletal Dynamics
Wnt7b Promotes Axon Differentiation and Extension by Regulating JNK-Mediated Cytoskeletal Dynamics
Neuronal polarization and axon growth are critical processes underlying neuronal differentiation and maturation. Wnt prote...
Autophagy Modulation by Antidepressants: Mechanisms and Implications
Autophagy Modulation by Antidepressants: Mechanisms and Implications
Depression is a significant global health concern that extends beyond mere neurotransmitter imbalances, as the significanc...
Hindbrain Lactoprivic Regulation of Hypothalamic Third Ventricular Alpha-2 Tanycyte Metabolic Sensor Gene Expression in Hypoglycemic Male Versus Female Rats
Hindbrain Lactoprivic Regulation of Hypothalamic Third Ventricular Alpha-2 Tanycyte Metabolic Sensor Gene Expression in Hypoglycemic Male Versus Female Rats
Alpha-2 (α2-) tanycytes line the ventral wall of the third ventricle where they ostensibly engage in metabolic screen...
Dapagliflozin Ameliorates Doxorubicin-Induced Chemobrain and Cognitive Abnormalities in Rats: Modulation of AKT/GSK-3β and Wnt/β-Catenin Pathways
Dapagliflozin Ameliorates Doxorubicin-Induced Chemobrain and Cognitive Abnormalities in Rats: Modulation of AKT/GSK-3β and Wnt/β-Catenin Pathways
Cognitive impairments are frequently observed in cancer survivors who received chemotherapy based on doxorubicin (DOX), at...
Dual Targeting of TLR9 and cGAS-STING Pathways Attenuates Astrocyte Inflammatory Activation: Potential Implication in Multiple Sclerosis
Dual Targeting of TLR9 and cGAS-STING Pathways Attenuates Astrocyte Inflammatory Activation: Potential Implication in Multiple Sclerosis
This study aims to investigate the role of Toll-like receptor 9 (TLR9), a deoxyribose nucleic acid (DNA) sensor, in astroc...
Astrocyte Autophagy in Neurodegenerative Diseases: Current Progress in Mechanisms and Therapeutics
Astrocyte Autophagy in Neurodegenerative Diseases: Current Progress in Mechanisms and Therapeutics
Astrocytes, the most abundant and functionally diverse glial cell type in the brain, play a crucial role in maintaining ce...
Correction to: Ameliorative Role of Phosphodiesterase-5 (PDE-5) Inhibitor “Avanafil” Via Modulating cAMP & cGMP Pathway Against Alzheimer’s Disease
Correction to: Ameliorative Role of Phosphodiesterase-5 (PDE-5) Inhibitor “Avanafil” Via Modulating cAMP & cGMP Pathway Against Alzheimer’s Disease
Cite this articleTalib, M., Siddiqui, N., Tripathi, P.N. et al. Correction to: Ameliorative Role of Phosphodiesterase-5 (P...
The Role of Neuroglia in Cognitive Longevity
The Role of Neuroglia in Cognitive Longevity
The concept of the central nervous system (CNS) reserve emerged from the mismatch often observed between the extent of bra...
Astrocyte-Neuron Metabolic Synergies in Neurological Homeostasis and Disease
Astrocyte-Neuron Metabolic Synergies in Neurological Homeostasis and Disease
Metabolic synergy between astrocytes and neurons is key to maintaining normal brain function. As the main supporting cells...
Therapeutic Effect of Physical Activity in a Male Wistar Rat Model of Paraquat and Maneb-Induced Parkinson’s Disease
Therapeutic Effect of Physical Activity in a Male Wistar Rat Model of Paraquat and Maneb-Induced Parkinson’s Disease
Parkinson’s disease (PD) is characterized by impairments in motor control following the degeneration of dopamine-pro...
Cholesterol-Lowering Treatment Suppresses Neuromuscular Transmission Via Presynaptic Mechanism at the Mouse Diaphragm Muscle
Cholesterol-Lowering Treatment Suppresses Neuromuscular Transmission Via Presynaptic Mechanism at the Mouse Diaphragm Muscle
Statins are widely prescribed and effective cholesterol-lowering drugs for the therapy of cerebrovascular and cardiovascul...
Silencing PVT1 Alleviates Sevoflurane Anesthesia-Induced Oxidative Stress and Cognitive Dysfunction by Regulating miR-486-5p
Silencing PVT1 Alleviates Sevoflurane Anesthesia-Induced Oxidative Stress and Cognitive Dysfunction by Regulating miR-486-5p
To investigate the role and mechanism of long non-coding RNA PVT1 in sevoflurane-induced oxidative stress and cognitive dy...
Special Collection of Neurochemical Research Volume 50, 2025 in Remembrance of Prof. Arne Schousboe
Special Collection of Neurochemical Research Volume 50, 2025 in Remembrance of Prof. Arne Schousboe
Surprisingly, I can remember Arne going back + 50 years. He often visited Abel Lajtha at the Research Institute for Neuroc...
Methylsulfonylmethane Mitigates Neurobehavioral Impairment, Oxidative Stress, Changes in Trace Elements and Clock Expression in Alcohol and Circadian-Disrupted C57BL/6J Mice Brain
Methylsulfonylmethane Mitigates Neurobehavioral Impairment, Oxidative Stress, Changes in Trace Elements and Clock Expression in Alcohol and Circadian-Disrupted C57BL/6J Mice Brain
Alcohol consumption can affect the brain due to an elevation in oxidative stress and inflammation. Alcoholism influences t...
Riboflavin (Vitamin B2) Accumulation Modulates Neuronal Cellular Homeostasis in Typical Brain Development and Cerebral Palsy
Riboflavin (Vitamin B2) Accumulation Modulates Neuronal Cellular Homeostasis in Typical Brain Development and Cerebral Palsy
The developing brain requires high energy demands and metabolic efforts to regulate oxidative stress and myelination. Earl...
Neohesperidin Improves Depressive-Like Behavior Induced by Chronic Unpredictable Mild Stress in Mice
Neohesperidin Improves Depressive-Like Behavior Induced by Chronic Unpredictable Mild Stress in Mice
Depression is a common and complex neuropsychiatric disorder affecting people of all ages worldwide, associated with high ...
Breaking Barriers in Huntington’s Disease Therapy: Focused Ultrasound for Targeted Drug Delivery
Breaking Barriers in Huntington’s Disease Therapy: Focused Ultrasound for Targeted Drug Delivery
Huntington’s disease (HD) is a progressive neurodegenerative disease resulting from a mutation in the huntingtin (HT...
PKR Inhibitor C16 Regulates HIV-gp120 Induced Neuronal Injury and Cognitive Impairment in Vivo and in Vitro Models
PKR Inhibitor C16 Regulates HIV-gp120 Induced Neuronal Injury and Cognitive Impairment in Vivo and in Vitro Models
To study the neuronal protective effect and its potential mechanism of C16 against gp120-induced cognitive impairment in v...
Regulation of Glutamate Transporter Type 1 by TSA and the Antiepileptic Mechanism of TSA
Regulation of Glutamate Transporter Type 1 by TSA and the Antiepileptic Mechanism of TSA
Epilepsy (EP) is a neurological disorder characterized by abnormal, sudden neuronal discharges. Seizures increase extracel...
Challenges of Investigating Compartmentalized Brain Energy Metabolism Using Nuclear Magnetic Resonance Spectroscopy in vivo
Challenges of Investigating Compartmentalized Brain Energy Metabolism Using Nuclear Magnetic Resonance Spectroscopy in vivo
Brain function requires continuous energy supply. Thus, unraveling brain metabolic regulation is critical not only for our...
Glycyrrhizic Acid Mitigates Haloperidol-Induced Neurotoxicity in SHSY-5Y Cells and Rats Via Activation of PI3k/Akt/Nrf2 Pathways
Glycyrrhizic Acid Mitigates Haloperidol-Induced Neurotoxicity in SHSY-5Y Cells and Rats Via Activation of PI3k/Akt/Nrf2 Pathways
Antipsychotic medications are used to treat a psychological condition called ‘Schizophrenia’. However, its lon...
Identification of a Subpopulation of Astrocyte Progenitor Cells in the Neonatal Subventricular Zone: Evidence that Migration is Regulated by Glutamate Signaling
Identification of a Subpopulation of Astrocyte Progenitor Cells in the Neonatal Subventricular Zone: Evidence that Migration is Regulated by Glutamate Signaling
In mice engineered to express enhanced green fluorescent protein (eGFP) under the control of the entire glutamate transpor...
α-Ketoisocaproic Acid Disrupts Mitochondrial Bioenergetics in the Brain of Neonate Rats: Molecular Modeling Studies of α-ketoglutarate Dehydrogenase Subunits Inhibition
α-Ketoisocaproic Acid Disrupts Mitochondrial Bioenergetics in the Brain of Neonate Rats: Molecular Modeling Studies of α-ketoglutarate Dehydrogenase Subunits Inhibition
Brain accumulation of the branched-chain α-keto acids α-ketoisocaproic acid (KIC), α-keto-β-methylvale...
Trehalose Inhibits ferroptosis Through Activating SIRT3/SOD2 Signaling Axis and Alleviates Brain Injury After Traumatic Brain Injury
Trehalose Inhibits ferroptosis Through Activating SIRT3/SOD2 Signaling Axis and Alleviates Brain Injury After Traumatic Brain Injury
Trehalose has neuroprotective effects in neurodegenerative diseases. This study aimed to explore the impact of trehalose o...
Blackcurrant (Ribes nigrum L.) and Its Association with Donepezil Restore Cognitive Impairment, Suppress Oxidative Stress and Pro-inflammatory Responses, and Improve Purinergic Signaling in a Scopolamine-Induced Amnesia Model in Mice
Blackcurrant (Ribes nigrum L.) and Its Association with Donepezil Restore Cognitive Impairment, Suppress Oxidative Stress and Pro-inflammatory Responses, and Improve Purinergic Signaling in a Scopolamine-Induced Amnesia Model in Mice
Purinergic signaling plays a major role in aging and neurodegenerative diseases, which are associated with memory decline....
Nanoparticle Interactions with the Blood Brain Barrier: Insights from Drosophila and Implications for Human Astrocyte Targeted Therapies
Nanoparticle Interactions with the Blood Brain Barrier: Insights from Drosophila and Implications for Human Astrocyte Targeted Therapies
This review explores the intricate connections between Drosophila models and the human blood-brain barrier (BBB) with nano...
Exploring Ubiquitination in Spinal Cord Injury Therapy: Multifaceted Targets and Promising Strategies
Exploring Ubiquitination in Spinal Cord Injury Therapy: Multifaceted Targets and Promising Strategies
Spinal cord injury (SCI) is a severely debilitating neurological condition that often results in significant functional im...
Intermittent Fasting Improves Sevoflurane-Induced Cognitive Dysfunction in Rats Through SIRT1-Mediated Autophagy
Intermittent Fasting Improves Sevoflurane-Induced Cognitive Dysfunction in Rats Through SIRT1-Mediated Autophagy
Perioperative neurocognitive disorders (PND) is a common complication affecting the central nervous system, commonly induc...
FTO Suppresses Proliferation and Induces Apoptosis of T98G Glioblastoma Cells via N6-methyladenosine Modification of GSTO1
FTO Suppresses Proliferation and Induces Apoptosis of T98G Glioblastoma Cells via N6-methyladenosine Modification of GSTO1
Glioblastoma (GBM) is the most malignant type of glioma with a very poor prognosis. N6-methyladenosine (m6A) is well-docum...
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