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Neohesperidin Improves Depressive-Like Behavior Induced by Chronic Unpredictable Mild Stress in Mice
Neohesperidin Improves Depressive-Like Behavior Induced by Chronic Unpredictable Mild Stress in Mice
Depression is a common and complex neuropsychiatric disorder affecting people of all ages worldwide, associated with high ...
Breaking Barriers in Huntington’s Disease Therapy: Focused Ultrasound for Targeted Drug Delivery
Breaking Barriers in Huntington’s Disease Therapy: Focused Ultrasound for Targeted Drug Delivery
Huntington’s disease (HD) is a progressive neurodegenerative disease resulting from a mutation in the huntingtin (HT...
PKR Inhibitor C16 Regulates HIV-gp120 Induced Neuronal Injury and Cognitive Impairment in Vivo and in Vitro Models
PKR Inhibitor C16 Regulates HIV-gp120 Induced Neuronal Injury and Cognitive Impairment in Vivo and in Vitro Models
To study the neuronal protective effect and its potential mechanism of C16 against gp120-induced cognitive impairment in v...
Regulation of Glutamate Transporter Type 1 by TSA and the Antiepileptic Mechanism of TSA
Regulation of Glutamate Transporter Type 1 by TSA and the Antiepileptic Mechanism of TSA
Epilepsy (EP) is a neurological disorder characterized by abnormal, sudden neuronal discharges. Seizures increase extracel...
Challenges of Investigating Compartmentalized Brain Energy Metabolism Using Nuclear Magnetic Resonance Spectroscopy in vivo
Challenges of Investigating Compartmentalized Brain Energy Metabolism Using Nuclear Magnetic Resonance Spectroscopy in vivo
Brain function requires continuous energy supply. Thus, unraveling brain metabolic regulation is critical not only for our...
Glycyrrhizic Acid Mitigates Haloperidol-Induced Neurotoxicity in SHSY-5Y Cells and Rats Via Activation of PI3k/Akt/Nrf2 Pathways
Glycyrrhizic Acid Mitigates Haloperidol-Induced Neurotoxicity in SHSY-5Y Cells and Rats Via Activation of PI3k/Akt/Nrf2 Pathways
Antipsychotic medications are used to treat a psychological condition called ‘Schizophrenia’. However, its lon...
Identification of a Subpopulation of Astrocyte Progenitor Cells in the Neonatal Subventricular Zone: Evidence that Migration is Regulated by Glutamate Signaling
Identification of a Subpopulation of Astrocyte Progenitor Cells in the Neonatal Subventricular Zone: Evidence that Migration is Regulated by Glutamate Signaling
In mice engineered to express enhanced green fluorescent protein (eGFP) under the control of the entire glutamate transpor...
α-Ketoisocaproic Acid Disrupts Mitochondrial Bioenergetics in the Brain of Neonate Rats: Molecular Modeling Studies of α-ketoglutarate Dehydrogenase Subunits Inhibition
α-Ketoisocaproic Acid Disrupts Mitochondrial Bioenergetics in the Brain of Neonate Rats: Molecular Modeling Studies of α-ketoglutarate Dehydrogenase Subunits Inhibition
Brain accumulation of the branched-chain α-keto acids α-ketoisocaproic acid (KIC), α-keto-β-methylvale...
Trehalose Inhibits ferroptosis Through Activating SIRT3/SOD2 Signaling Axis and Alleviates Brain Injury After Traumatic Brain Injury
Trehalose Inhibits ferroptosis Through Activating SIRT3/SOD2 Signaling Axis and Alleviates Brain Injury After Traumatic Brain Injury
Trehalose has neuroprotective effects in neurodegenerative diseases. This study aimed to explore the impact of trehalose o...
Blackcurrant (Ribes nigrum L.) and Its Association with Donepezil Restore Cognitive Impairment, Suppress Oxidative Stress and Pro-inflammatory Responses, and Improve Purinergic Signaling in a Scopolamine-Induced Amnesia Model in Mice
Blackcurrant (Ribes nigrum L.) and Its Association with Donepezil Restore Cognitive Impairment, Suppress Oxidative Stress and Pro-inflammatory Responses, and Improve Purinergic Signaling in a Scopolamine-Induced Amnesia Model in Mice
Purinergic signaling plays a major role in aging and neurodegenerative diseases, which are associated with memory decline....
Nanoparticle Interactions with the Blood Brain Barrier: Insights from Drosophila and Implications for Human Astrocyte Targeted Therapies
Nanoparticle Interactions with the Blood Brain Barrier: Insights from Drosophila and Implications for Human Astrocyte Targeted Therapies
This review explores the intricate connections between Drosophila models and the human blood-brain barrier (BBB) with nano...
Exploring Ubiquitination in Spinal Cord Injury Therapy: Multifaceted Targets and Promising Strategies
Exploring Ubiquitination in Spinal Cord Injury Therapy: Multifaceted Targets and Promising Strategies
Spinal cord injury (SCI) is a severely debilitating neurological condition that often results in significant functional im...
Intermittent Fasting Improves Sevoflurane-Induced Cognitive Dysfunction in Rats Through SIRT1-Mediated Autophagy
Intermittent Fasting Improves Sevoflurane-Induced Cognitive Dysfunction in Rats Through SIRT1-Mediated Autophagy
Perioperative neurocognitive disorders (PND) is a common complication affecting the central nervous system, commonly induc...
FTO Suppresses Proliferation and Induces Apoptosis of T98G Glioblastoma Cells via N6-methyladenosine Modification of GSTO1
FTO Suppresses Proliferation and Induces Apoptosis of T98G Glioblastoma Cells via N6-methyladenosine Modification of GSTO1
Glioblastoma (GBM) is the most malignant type of glioma with a very poor prognosis. N6-methyladenosine (m6A) is well-docum...
Methionine Sulfoximine as a Tool for Studying Temporal Lobe Epilepsy: Initiator, Developer, Attenuator
Methionine Sulfoximine as a Tool for Studying Temporal Lobe Epilepsy: Initiator, Developer, Attenuator
Methionine sulfoximine (MSO) is a compound originally discovered as a byproduct of agene-based milled flour maturation. MS...
Correction to: β-Caryophyllene Liposomes Attenuate Neurovascular Unit Damage After Subarachnoid Hemorrhage in Rats
Correction to: β-Caryophyllene Liposomes Attenuate Neurovascular Unit Damage After Subarachnoid Hemorrhage in Rats
Cite this articleWang, F., Teng, Z., Liu, D. et al. Correction to: β-Caryophyllene Liposomes Attenuate Neurovascular Unit ...
Varenicline Attenuates Memory Impairment in Amyloid-Beta-Induced Rat Model of Alzheimer’s Disease
Varenicline Attenuates Memory Impairment in Amyloid-Beta-Induced Rat Model of Alzheimer’s Disease
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder characterized by cognitive decline. Despit...
The Regulation of Messenger RNAs and Biological Pathways by Long Non-Coding RNAs and Circular RNAs in Ischemic Stroke
The Regulation of Messenger RNAs and Biological Pathways by Long Non-Coding RNAs and Circular RNAs in Ischemic Stroke
Our aim was to evaluate the regulation of messenger RNAs (mRNAs) and biological pathways by long non-coding RNAs (lncRNAs)...
Role of Glial Cells and Receptors in Schizophrenia Pathogenesis
Role of Glial Cells and Receptors in Schizophrenia Pathogenesis
The specific pathogeneses of schizophrenia (SCZ) remain an enigma despite extensive research that has implicated both gene...
Circ_0001361/miR-490-5p/IGF2 Axis Regulates the Viability and Apoptosis of Neuroblastoma Cells
Circ_0001361/miR-490-5p/IGF2 Axis Regulates the Viability and Apoptosis of Neuroblastoma Cells
Background: Circular RNAs (circRNAs) are involved in the neuroblastoma (NB) development. Objectie: The study aimed to dete...
Spontaneous Calcium Transients Recorded from Striatal Astrocytes in a Preclinical Model of Autism
Spontaneous Calcium Transients Recorded from Striatal Astrocytes in a Preclinical Model of Autism
Autism spectrum disorder (ASD) is known as a group of neurodevelopmental conditions including stereotyped and repetitive b...
Epigenetic Mechanisms of Aluminum-Induced Neurotoxicity and Alzheimer’s Disease: A Focus on Non-Coding RNAs
Epigenetic Mechanisms of Aluminum-Induced Neurotoxicity and Alzheimer’s Disease: A Focus on Non-Coding RNAs
Aluminum (Al) is known to induce neurotoxic effects, potentially contributing to Alzheimer’s disease (AD) pathogenes...
Correction to: Histone Deacetylase Inhibitor RGFP109 Overcomes Temozolomide Resistance by Blocking NF-κB-Dependent Transcription in Glioblastoma Cell Lines
Correction to: Histone Deacetylase Inhibitor RGFP109 Overcomes Temozolomide Resistance by Blocking NF-κB-Dependent Transcription in Glioblastoma Cell Lines
Brain Center, Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, Shenzhen Second People’s Hospital, The ...
Wnt Signaling Modulators Exhibit Neuroprotective Effects via Combating Astrogliosis and Balancing Synaptic Density at Early and Late Stage Temporal Lobe Epilepsy
Wnt Signaling Modulators Exhibit Neuroprotective Effects via Combating Astrogliosis and Balancing Synaptic Density at Early and Late Stage Temporal Lobe Epilepsy
Temporal Lobe Epilepsy (TLE) is a severe neurological condition characterized by recurrent seizures that often do not resp...
Brief Pup Separation in Lactation Confers Stress Resistance with Increased Prolactin and Adult Hippocampal Neurogenesis in Postpartum C57BL/6J Dams
Brief Pup Separation in Lactation Confers Stress Resistance with Increased Prolactin and Adult Hippocampal Neurogenesis in Postpartum C57BL/6J Dams
Prolactin (PRL) assumes a pivotal role during the postpartum phase, particularly within the hippocampus—a region den...
Age- and Sex-Associated Wnt Signaling Dysregulation is Exacerbated from the Early Stages of Neuropathology in an Alzheimer’s Disease Model
Age- and Sex-Associated Wnt Signaling Dysregulation is Exacerbated from the Early Stages of Neuropathology in an Alzheimer’s Disease Model
Emerging studies suggest that Wnt signaling is dysregulated in the brains of AD patients, suggesting that this pathway may...
Changes in Noradrenergic Synthesis and Dopamine Beta-Hydroxylase Activity in Response to Oxidative Stress after Iron-induced Brain Injury
Changes in Noradrenergic Synthesis and Dopamine Beta-Hydroxylase Activity in Response to Oxidative Stress after Iron-induced Brain Injury
Noradrenaline (NA) levels are altered during the first hours and several days after cortical injury. NA modulates motor fu...
Therapeutic Options of Crystallin Mu and Protein Disulfide Isomerase A3 for Cuprizone-Induced Demyelination in Mouse Hippocampus
Therapeutic Options of Crystallin Mu and Protein Disulfide Isomerase A3 for Cuprizone-Induced Demyelination in Mouse Hippocampus
This study investigates the changes in hippocampal proteomic profiles during demyelination and remyelination using the cup...
The Involvement of the Ventral Tegmental Area in the Electroacupuncture Alleviation of Anxiety-Like Behaviors Induced by Chronic Restraint Stress in Mice
The Involvement of the Ventral Tegmental Area in the Electroacupuncture Alleviation of Anxiety-Like Behaviors Induced by Chronic Restraint Stress in Mice
Emotional stress is a significant environmental risk factor for various mental health disabilities, such as anxiety. Elect...
Characterization of a Fatty Acid Amide Hydrolase (FAAH) in Hirudo Verbana
Characterization of a Fatty Acid Amide Hydrolase (FAAH) in Hirudo Verbana
The endocannabinoid system plays a critical role in modulating both peripheral and central nervous system function. Despit...
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