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Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss
Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss
The autonomic nervous system regulates pancreatic function. Islet capillaries are essential for the extension of axonal pr...
Impact of tyrosine kinase inhibitors on glucose control and insulin regulation in chronic myeloid leukemia patients
Impact of tyrosine kinase inhibitors on glucose control and insulin regulation in chronic myeloid leukemia patients
Treatment with tyrosine kinase inhibitors (TKIs), especially nilotinib, often results in hyperglycemia, which may further ...
A reduction of skeletal muscle DHA content does not result in impaired whole-body glucose tolerance or skeletal muscle basal insulin signaling in healthy mice
A reduction of skeletal muscle DHA content does not result in impaired whole-body glucose tolerance or skeletal muscle basal insulin signaling in healthy mice
Delta-6 desaturase (D6D), encoded by the Fads2 gene, catalyzes the first step in the conversion of alpha-linolenic acid to...
A physiologic increase in brain glucagon action alters the hepatic gluconeogenic glycogenolytic ratio but not glucagon's overall effect on glucose production
A physiologic increase in brain glucagon action alters the hepatic gluconeogenic glycogenolytic ratio but not glucagon's overall effect on glucose production
It has been proposed that brain glucagon action inhibits glucagon stimulated hepatic glucose production (HGP), which may e...
The role of preproglucagon peptides in regulating β-cell morphology and responses to streptozotocin-induced diabetes
The role of preproglucagon peptides in regulating β-cell morphology and responses to streptozotocin-induced diabetes
Insulin secretion from β-cells is tightly regulated by local signaling from preproglucagon (Gcg) products from neighboring...
Deletion of GABAB receptors from Kiss1 cells affects glucose homeostasis without altering reproduction in male mice.
Deletion of GABAB receptors from Kiss1 cells affects glucose homeostasis without altering reproduction in male mice.
Kisspeptin and gamma amino butyric acid (GABA), synthesized in the central nervous system, are critical for reproduction. ...
Ketone monoester ingestion increases postexercise serum erythropoietin concentrations in healthy men
Ketone monoester ingestion increases postexercise serum erythropoietin concentrations in healthy men
To our knowledge, this study was the first to assess the effects of ketone monoester ingestion on erythropoietin concentra...
PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice
PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice
Interplay between endoplasmic reticulum stress and inflammation contributes to cardiovascular disease progression. The stu...
Investigating dual inhibition of ACC and CD36 for the treatment of non-alcoholic fatty liver disease in mice
Investigating dual inhibition of ACC and CD36 for the treatment of non-alcoholic fatty liver disease in mice
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Dysregulation in hepatic lip...
Inhibition of the endocannabinoid system reverses obese phenotype in aged mice and partly restores skeletal muscle function
Inhibition of the endocannabinoid system reverses obese phenotype in aged mice and partly restores skeletal muscle function
Sarcopenia, the age-related loss of skeletal muscle mass is associated with lipid accumulation and anabolic resistance; ph...
Fibroblast Growth Factor 21 as a Potential Master Regulator in Metabolic Disorders
Fibroblast Growth Factor 21 as a Potential Master Regulator in Metabolic Disorders
Fibroblast growth factor 21 (FGF21) is an endocrine hormone that controls key metabolic processes and induces the synthesi...
Maternal obesity damages the median eminence blood-brain barrier structure and function in the progeny: The beneficial impact of cross-fostering by lean mothers
Maternal obesity damages the median eminence blood-brain barrier structure and function in the progeny: The beneficial impact of cross-fostering by lean mothers
Maternal obesity is an important risk factor for obesity, cardiovascular, and metabolic diseases in the offspring. Studies...
High-resolution analysis of the cytosolic Ca2+ events in β cell collectives in situ
High-resolution analysis of the cytosolic Ca2+ events in β cell collectives in situ
Physiological glucose or ryanodine stimulation of β cell collectives generates a large number of [Ca2+]c events, which can...
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