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Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss
The autonomic nervous system regulates pancreatic function. Islet capillaries are essential for the extension of axonal pr...
American Journal Of Physiology-endocrinology And Metabolism
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Impact of tyrosine kinase inhibitors on glucose control and insulin regulation in chronic myeloid leukemia patients
Treatment with tyrosine kinase inhibitors (TKIs), especially nilotinib, often results in hyperglycemia, which may further ...
American Journal Of Physiology-endocrinology And Metabolism
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A reduction of skeletal muscle DHA content does not result in impaired whole-body glucose tolerance or skeletal muscle basal insulin signaling in healthy mice
Delta-6 desaturase (D6D), encoded by the Fads2 gene, catalyzes the first step in the conversion of alpha-linolenic acid to...
American Journal Of Physiology-endocrinology And Metabolism
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A physiologic increase in brain glucagon action alters the hepatic gluconeogenic glycogenolytic ratio but not glucagon's overall effect on glucose production
It has been proposed that brain glucagon action inhibits glucagon stimulated hepatic glucose production (HGP), which may e...
American Journal Of Physiology-endocrinology And Metabolism
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The role of preproglucagon peptides in regulating β-cell morphology and responses to streptozotocin-induced diabetes
Insulin secretion from β-cells is tightly regulated by local signaling from preproglucagon (Gcg) products from neighboring...
American Journal Of Physiology-endocrinology And Metabolism
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Deletion of GABAB receptors from Kiss1 cells affects glucose homeostasis without altering reproduction in male mice.
Kisspeptin and gamma amino butyric acid (GABA), synthesized in the central nervous system, are critical for reproduction. ...
American Journal Of Physiology-endocrinology And Metabolism
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