Puigserver, P. et al. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829–839 (1998).
Article CAS PubMed Google Scholar
Wu, Z. et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98, 115–124 (1999).
Article CAS PubMed Google Scholar
Lehman, J. J. et al. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J. Clin. Invest. 106, 847–856 (2000).
Article CAS PubMed PubMed Central Google Scholar
Wu, H. et al. Regulation of mitochondrial biogenesis in skeletal muscle by CaMK. Science 296, 349–352 (2002).
Article ADS CAS PubMed Google Scholar
Patten, I. S. et al. PGC-1 coactivators in the cardiovascular system. Trends Endocrinol. Metab. 23, 90–97 (2012).
Article CAS PubMed Google Scholar
Rius-Perez, S. et al. Impairment of PGC-1 Alpha Up-Regulation Enhances Nitrosative Stress in the Liver during Acute Pancreatitis in Obese Mice. Antioxidants (Basel). 9, 887 (2020).
De Vitto, H. et al. The PGC-1/ERR network and its role in precision oncology. NPJ Precis. Oncol. 3, 9 (2019).
Article PubMed PubMed Central Google Scholar
Yin, Z. et al. MiR-30c/PGC-1beta protects against diabetic cardiomyopathy via PPARalpha. Cardiovasc. Diabetol. 18, 7 (2019).
Article PubMed PubMed Central Google Scholar
Piccinin, E. et al. PGC-1s in the Spotlight with Parkinson’s Disease. Int J Mol Sci. 22, 3487 (2021).
Thirupathi, A. et al. Multi-regulatory network of ROS: the interconnection of ROS, PGC-1 alpha, and AMPK-SIRT1. Exerc. J. Physiol. Biochem. 73, 487–494 (2017).
Summermatter, S. et al. PGC-1alpha and exercise in the control of body weight. Int. J. Obes. (Lond.). 36, 1428–1435 (2012).
Article CAS PubMed Google Scholar
Suntar, I. et al. Natural products, PGC-1 alpha, and Duchenne muscular dystrophy. Acta Pharm. Sin. B. 10, 734–745 (2020).
Article CAS PubMed PubMed Central Google Scholar
Puigserver, P. et al. Activation of PPARgamma coactivator-1 through transcription factor docking. Science 286, 1368–1371 (1999).
Article CAS PubMed Google Scholar
Herzig, S. et al. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 413, 179–183 (2001).
Article ADS CAS PubMed Google Scholar
Vega, R. B. et al. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol. Cell Biol. 20, 1868–1876 (2000).
Article CAS PubMed PubMed Central Google Scholar
Lin, J. et al. Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta), a novel PGC-1-related transcription coactivator associated with host cell factor. J. Biol. Chem. 277, 1645–1648 (2002).
Article CAS PubMed Google Scholar
Andersson, U. et al. Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells. Mol. Cell Biol. 21, 3738–3749 (2001).
Article CAS PubMed PubMed Central Google Scholar
Miura, S. et al. Isoform-specific increases in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to beta2-adrenergic receptor activation and exercise. Endocrinology 149, 4527–4533 (2008).
Article CAS PubMed Google Scholar
Zhang, L. N. et al. Novel small-molecule PGC-1alpha transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes 62, 1297–1307 (2013).
Article CAS PubMed PubMed Central Google Scholar
Kressler, D. et al. The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha. J. Biol. Chem. 277, 13918–13925 (2002).
Article CAS PubMed Google Scholar
Handschin, C. et al. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr. Rev. 27, 728–735 (2006).
Article CAS PubMed Google Scholar
He, X. et al. Peri-implantation lethality in mice lacking the PGC-1-related coactivator protein. Dev. Dyn. 241, 975–983 (2012).
Article CAS PubMed Google Scholar
Monsalve, M. et al. Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1. Mol. Cell. 6, 307–316 (2000).
Article CAS PubMed Google Scholar
van Der Houven Van Oordt, W. et al. Role of SR protein modular domains in alternative splicing specificity in vivo. Nucleic Acids Res. 28, 4822–4831 (2000).
Article PubMed PubMed Central Google Scholar
Puigserver, P. et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 423, 550–555 (2003).
Article ADS CAS PubMed Google Scholar
Cunningham, J. T. et al. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature 450, 736–740 (2007).
Article ADS CAS PubMed Google Scholar
Scarpulla, R. C. Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol. Rev. 88, 611–638 (2008).
Article CAS PubMed Google Scholar
Haemmerle, G. et al. ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-alpha and PGC-1. Nat. Med. 17, 1076–1085 (2011).
Article CAS PubMed PubMed Central Google Scholar
Muzio, G. et al. Peroxisome Proliferator-Activated Receptors (PPARs) and Oxidative Stress in Physiological Conditions and in Cancer. Antioxidants (Basel). 10, 1734 (2021).
Vernier, M. et al. Estrogen-related receptors are targetable ROS sensors. Genes Dev. 34, 544–559 (2020).
Article CAS PubMed PubMed Central Google Scholar
Ziegler, A. K. et al. An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise. Sci. Rep. 9, 12069 (2019).
Article ADS CAS PubMed PubMed Central Google Scholar
Jager, S. et al. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc. Natl Acad. Sci. Usa. 104, 12017–12022 (2007).
Article ADS PubMed PubMed Central Google Scholar
Gerhart-Hines, Z. et al. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J. 26, 1913–1923 (2007).
Article CAS PubMed PubMed Central Google Scholar
Teyssier, C. et al. Activation of nuclear receptor coactivator PGC-1alpha by arginine methylation. Genes Dev. 19, 1466–1473 (2005).
Article CAS PubMed PubMed Central Google Scholar
De Rasmo, D. et al. cAMP/Ca2+ response element-binding protein plays a central role in the biogenesis of respiratory chain proteins in mammalian cells. IUBMB Life. 62, 447–452 (2010).
Ishii, K. A. et al. Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nat. Med. 15, 259–266 (2009).
Article CAS PubMed Google Scholar
Conkright, M. D. et al. TORCs: transducers of regulated CREB activity. Mol. Cell. 12, 413–423 (2003).
Article CAS PubMed Google Scholar
Wu, Z. et al. Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells. Proc. Natl Acad. Sci. USA. 103, 14379–14384 (2006).
Article ADS CAS PubMed PubMed Central Google Scholar
Nogueiras, R. et al. Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol. Rev. 92, 1479–1514 (2012).
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