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Intranasal administration of temozolomide conjugated nanoparticles with transcranial magnetic stimulation improves the survival in glioblastoma xenograft models
Intranasal administration of temozolomide conjugated nanoparticles with transcranial magnetic stimulation improves the survival in glioblastoma xenograft models
Glioblastoma Multiforme (GBM) is the most common primary malignancy of the central nervous system with an average survival...
Microneedle loaded with luteolin-colostrum-derived exosomes: a dropless approach for treatment of glaucoma
Microneedle loaded with luteolin-colostrum-derived exosomes: a dropless approach for treatment of glaucoma
Glaucoma, a leading cause of irreversible blindness, is marked by elevated intraocular pressure (IOP) and retinal ganglion...
Microneedle patch-based transnasal delivery of naloxone
Microneedle patch-based transnasal delivery of naloxone
This study evaluates dissolving microneedle (MN) patches for naloxone (NAL) delivery via the transnasal route, addressing ...
Inhaled biologics for respiratory diseases: clinical potential and emerging technologies
Inhaled biologics for respiratory diseases: clinical potential and emerging technologies
The pulmonary route has gained significant attention as a drug delivery method, particularly for managing respiratory dise...
Encapsulation of the lipidated TLR7/8 agonist INI-4001 into ionic liposomes impacts H7 influenza antigen-specific immune responses
Encapsulation of the lipidated TLR7/8 agonist INI-4001 into ionic liposomes impacts H7 influenza antigen-specific immune responses
Toll-like receptors (TLRs) are the best characterized family of Pattern Recognition Receptor-targeting adjuvants. Activati...
Nasal inhalation of antiviral microparticulate powders to target early infection of upper airways
Nasal inhalation of antiviral microparticulate powders to target early infection of upper airways
During the COVID-19 pandemic, several compounds among which chloroquine diphosphate (CqP), have been repurposed as anti-SA...
Versatile and sensitive dual-detection HPLC method for rapid quantification of apomorphine hydrochloride: application to ex vivo percutaneous permeation and deposition studies utilising novel transdermal pressure-sensitive adhesive patches
Versatile and sensitive dual-detection HPLC method for rapid quantification of apomorphine hydrochloride: application to ex vivo percutaneous permeation and deposition studies utilising novel transdermal pressure-sensitive adhesive patches
Conventional delivery of apomorphine hydrochloride (APO) for management of ‘OFF’ periods in Parkinson’s ...
Advancing nanoparticle delivery studies: flow cytometry-based quantification of nanoparticle uptake and transfection in retinal tissue
Advancing nanoparticle delivery studies: flow cytometry-based quantification of nanoparticle uptake and transfection in retinal tissue
Millions of people worldwide suffer from vision impairments, significantly affecting their quality of life and mental heal...
A modeling framework for spring-driven autoinjectors with dual-chamber cartridges
A modeling framework for spring-driven autoinjectors with dual-chamber cartridges
Autoinjectors with dual-chamber cartridges (AIDCs) are single-use, self-administrable injection devices that facilitate au...
Intranasal delivery of engineered anti-SARS-CoV-2 extracellular vesicles therapeutically represses lung infection and inflammation
Intranasal delivery of engineered anti-SARS-CoV-2 extracellular vesicles therapeutically represses lung infection and inflammation
Extracellular vesicles (EVs) are amenable to genetic engineering in that EVs can be endowed with surface armaments that ca...
Innovate sodium alginate microneedle patches integrated with soft lidocaine invasomes: advanced strategies for oral ulcerative mucositis treatment via TNF-α/NF-κB pathways
Innovate sodium alginate microneedle patches integrated with soft lidocaine invasomes: advanced strategies for oral ulcerative mucositis treatment via TNF-α/NF-κB pathways
Oral ulcerative mucositis (OUM) is a common painful disease that affects oral functions, such as eating or speaking leadin...
Progress in topical nanoformulations against bacterial skin and soft tissue infections– current trends
Progress in topical nanoformulations against bacterial skin and soft tissue infections– current trends
The accelerating rate of antibiotic resistance has always been one of the leading causes of increased skin and soft tissue...
Emerging innovations in ophthalmic drug delivery for diabetic retinopathy: a translational perspective
Emerging innovations in ophthalmic drug delivery for diabetic retinopathy: a translational perspective
Diabetic retinopathy (DR) is a progressive microvascular complication of diabetes and a leading cause of vision impairment...
Development of simplified poly(β-aminoester)-zwitterion nanovehicles for controlled cancer cell transfection and enhanced gene delivery across a cell-based model of the blood-brain barrier
Development of simplified poly(β-aminoester)-zwitterion nanovehicles for controlled cancer cell transfection and enhanced gene delivery across a cell-based model of the blood-brain barrier
Although nucleotide-based therapeutics hold promise for a variety of diseases, their clinical application is limited becau...
Thermoresponsive nanoparticles for targeted and controlled delivery of doxorubicin in triple negative breast cancer: a 2D and 3D in vitro evaluation
Thermoresponsive nanoparticles for targeted and controlled delivery of doxorubicin in triple negative breast cancer: a 2D and 3D in vitro evaluation
Controlled release of chemotherapeutic drugs is a key factor in cancer therapy. In this regard, temperature triggered rele...
Sunitinib-eluting thin films for Inhibition of corneal neovascularization
Sunitinib-eluting thin films for Inhibition of corneal neovascularization
Corneal disease is a leading cause of blindness globally, and is commonly associated with corneal neovascularization, whic...
Intranasal delivery route for neurodegenerative diseases: recent insights and future directions
Intranasal delivery route for neurodegenerative diseases: recent insights and future directions
Neurodegenerative diseases are increasingly significant causes of mortality and morbidity worldwide, particularly among th...
Development of Ra-labeled polymeric nanocarriers with variable administration routes for alpha-therapy of colorectal cancer
Development of Ra-labeled polymeric nanocarriers with variable administration routes for alpha-therapy of colorectal cancer
Alpha-therapy for hard-to-treat oncological diseases such as colorectal cancer has drawn significant attention. However, t...
Engineering mannose-functionalized nanostructured lipid carriers by sequential design using hybrid artificial intelligence tools
Engineering mannose-functionalized nanostructured lipid carriers by sequential design using hybrid artificial intelligence tools
Nanostructured lipid carriers (NLCs) hold significant promise as drug delivery systems (DDS) owing to their small size and...
Plant-derived exosome-like nanoparticles for microRNA delivery in cancer treatment
Plant-derived exosome-like nanoparticles for microRNA delivery in cancer treatment
Plant-derived exosome-like nanoparticles (PELNs) are natural nanocarriers and effective delivery systems for plant microRN...
Microneedle patch with pure drug tips for delivery of liraglutide: pharmacokinetics in rats and minipigs
Microneedle patch with pure drug tips for delivery of liraglutide: pharmacokinetics in rats and minipigs
Transdermal delivery of peptide drugs is almost impossible with conventional penetration enhancers because of epidermal ba...
Cyclodextrins and their potential applications for delivering vitamins, iron, and iodine for improving micronutrient status
Cyclodextrins and their potential applications for delivering vitamins, iron, and iodine for improving micronutrient status
Cyclodextrins (CDs) have been investigated as potential biopolymeric carriers that can form inclusion complexes with numer...
Manufacturing and characterisation of 3D-printed sustained-release Timolol implants for glaucoma treatment
Manufacturing and characterisation of 3D-printed sustained-release Timolol implants for glaucoma treatment
Timolol maleate (TML) is a beta-blocker drug that is commonly used to lower the intraocular pressure in glaucoma. This stu...
Imiquimod nanocrystal-loaded dissolving microneedles prepared by DLP printing
Imiquimod nanocrystal-loaded dissolving microneedles prepared by DLP printing
The utilization of 3D printing– digital light processing (DLP) technique, for the direct fabrication of microneedles...
Anti-lung cancer synergy of low-dose doxorubicin and PD-L1 blocker co-delivered via mild photothermia-responsive black phosphorus
Anti-lung cancer synergy of low-dose doxorubicin and PD-L1 blocker co-delivered via mild photothermia-responsive black phosphorus
We have previously identified a latent interaction mechanism between non-small cell lung cancer cells (NSCLCC) and their a...
Wheat germ agglutinin modified mixed micelles overcome the dual barrier of mucus/enterocytes for effective oral absorption of shikonin and gefitinib
Wheat germ agglutinin modified mixed micelles overcome the dual barrier of mucus/enterocytes for effective oral absorption of shikonin and gefitinib
The combination of shikonin (SKN) and gefitinib (GFB) can reverse the drug resistance of lung cancer cells by affecting en...
Influence of physico-chemical properties of two lipoxin emulsion-loaded hydrogels on pre-polarized macrophages: a comparative analysis
Influence of physico-chemical properties of two lipoxin emulsion-loaded hydrogels on pre-polarized macrophages: a comparative analysis
Inflammation, a crucial defense mechanism, must be rigorously regulated to prevent the onset of chronic inflammation and s...
Quercetin loaded polymeric dissolving microarray patches: fabrication, characterisation and evaluation
Quercetin loaded polymeric dissolving microarray patches: fabrication, characterisation and evaluation
Quercetin, a natural compound, shows promising potential in wound healing by reducing fibrosis, limiting scar formation, a...
Resveratrol nanocrystals based dissolving microneedles with highly efficient for rheumatoid arthritis
Resveratrol nanocrystals based dissolving microneedles with highly efficient for rheumatoid arthritis
Rheumatoid arthritis (RA) is a common immune disease characterized mainly by erosive arthritis with extensive clinical seq...
Advancements in nanoscale delivery systems: optimizing intermolecular interactions for superior drug encapsulation and precision release
Advancements in nanoscale delivery systems: optimizing intermolecular interactions for superior drug encapsulation and precision release
Nanoscale preparations, such as nanoparticles, micelles, and liposomes, are increasingly recognized in pharmaceutical tech...
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