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Identification of STAT3 and MYC as critical ferroptosis-related biomarkers in septic cardiomyopathy: a bioinformatics and experimental study
Identification of STAT3 and MYC as critical ferroptosis-related biomarkers in septic cardiomyopathy: a bioinformatics and experimental study
Ferroptosis is the well-known mechanism of septic cardiomyopathy (SCM). Bioinformatics analysis was employed to identify f...
Hereditary non-spherocytic hemolytic anemia with GPI mutations successfully treated with allogeneic hematopoietic stem cell transplantation: a first report of two cases
Hereditary non-spherocytic hemolytic anemia with GPI mutations successfully treated with allogeneic hematopoietic stem cell transplantation: a first report of two cases
Glucose phosphate isomerase (GPI) deficiency caused by GPI gene mutations is a rare heterogenous condition that causes her...
Kat7 accelerates osteoarthritis disease progression through the TLR4/NF-κB signaling pathway
Kat7 accelerates osteoarthritis disease progression through the TLR4/NF-κB signaling pathway
Osteoarthritis (OA) is a common degenerative bone and joint disease with an unclear pathogenesis. Our study identified tha...
Macrophage co-culture promotes cell reprogramming and prevents ferroptosis in aging fibroblasts for neurodegeneration therapy
Macrophage co-culture promotes cell reprogramming and prevents ferroptosis in aging fibroblasts for neurodegeneration therapy
Ferroptosis, a form of programmed cell death associated with lipid peroxidation and iron dependency, plays a critical role...
CircRNA CDR1AS promotes cardiac ischemia–reperfusion injury in mice by triggering cardiomyocyte autosis
CircRNA CDR1AS promotes cardiac ischemia–reperfusion injury in mice by triggering cardiomyocyte autosis
Myocardial ischemia/reperfusion (IR) injury is a common adverse event in the clinical treatment of myocardial ischemic dis...
The role of lncRNA in the differentiation of adipose-derived stem cells: from functions to mechanism
The role of lncRNA in the differentiation of adipose-derived stem cells: from functions to mechanism
Adipose-derived stem cells (ADSCs) have become one of the best seed cells widely studied and concerned in tissue engineeri...
Deciphering metabolic shifts in Gaucher disease type 1: a multi-omics study
Deciphering metabolic shifts in Gaucher disease type 1: a multi-omics study
Gaucher disease (GD), an autosomal recessive lysosomal disorder, primarily affects the lysosomal enzyme β-glucocerebr...
Mesenchymal stem cell–derived extracellular vesicles in periodontal bone repair
Mesenchymal stem cell–derived extracellular vesicles in periodontal bone repair
Periodontitis is a chronic inflammatory disease that destroys tooth-supporting structures and poses significant public hea...
Rare variants in cardiomyopathy genes predispose to cardiac injury in severe COVID-19 patients of African or Hispanic ancestry
Rare variants in cardiomyopathy genes predispose to cardiac injury in severe COVID-19 patients of African or Hispanic ancestry
In one of the earliest reports from China during COVID-19, it was noted that over 20% of patients hospitalized with the di...
Drosophila modeling to identify causative genes and reveal the underlying molecular mechanisms for primary ovarian insufficiency
Drosophila modeling to identify causative genes and reveal the underlying molecular mechanisms for primary ovarian insufficiency
Primary ovarian insufficiency (POI) is a disease defined as a reduction in ovarian function under the age of 40 and repres...
Indole-3-Aldehyde alleviates lung inflammation in COPD through activating Aryl Hydrocarbon Receptor to inhibit HDACs/NF-κB/NLRP3 signaling pathways
Indole-3-Aldehyde alleviates lung inflammation in COPD through activating Aryl Hydrocarbon Receptor to inhibit HDACs/NF-κB/NLRP3 signaling pathways
Indole-3-aldehyde (I3A) is an intestinal microbial metabolite that regulates inflammation in various inflammatory diseases...
VSMC-specific TRPC1 deletion attenuates angiotensin II-induced hypertension and cardiovascular remodeling
VSMC-specific TRPC1 deletion attenuates angiotensin II-induced hypertension and cardiovascular remodeling
Transient receptor potential canonical 1 (TRPC1) channel, a Ca2+-permeable ion channel widely expressed in vasculature, ha...
Mediator kinase inhibition drives myometrial stem cell differentiation and the uterine fibroid phenotype through super-enhancer reprogramming
Mediator kinase inhibition drives myometrial stem cell differentiation and the uterine fibroid phenotype through super-enhancer reprogramming
Uterine fibroids (UFs) are the most common non-cutaneous tumors in women worldwide. UFs arise from genetic alterations in ...
Glucose enrichment reduces lifespan and promotes tau phosphorylation in human tau-expressing C. elegans, unaffected by O-β-GlcNAcylation induction
Glucose enrichment reduces lifespan and promotes tau phosphorylation in human tau-expressing C. elegans, unaffected by O-β-GlcNAcylation induction
Alzheimer’s disease (AD) is associated with the formation of tau-hyperphosphorylated neurofibrillary tangles (NFTs)....
Role of CYLD in brain physiology and pathology
Role of CYLD in brain physiology and pathology
A common hallmark of several neuropsychiatric conditions is an altered protein homeostasis. In this context, ubiquitinatio...
Role of endosomal RANKL–LGR4 signaling during osteoclast differentiation
Role of endosomal RANKL–LGR4 signaling during osteoclast differentiation
Leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4, also known as GPR48) is a membrane receptor that negati...
Evaluation of circulating glypican 4 as a novel biomarker in disease – A comprehensive review
Evaluation of circulating glypican 4 as a novel biomarker in disease – A comprehensive review
Glypican 4 (GPC4), a member of the cell surface heparan sulfate proteoglycan family, plays a crucial role in regulating va...
Lipidomic insights on abdominal aortic aneurysm and peripheral arterial disease
Lipidomic insights on abdominal aortic aneurysm and peripheral arterial disease
Abdominal aortic aneurysm (AAA) and peripheral arterial disease (PAD) are two cardiovascular diseases associated with cons...
Extragustatory bitter taste receptors in head and neck health and disease
Extragustatory bitter taste receptors in head and neck health and disease
Taste receptors, first described for their gustatory functions within the oral cavity and oropharynx, are now known to be ...
Endoplasmic reticulum stress induces hepatic steatosis through interaction between PPARα and FoxO6 in vivo and in vitro
Endoplasmic reticulum stress induces hepatic steatosis through interaction between PPARα and FoxO6 in vivo and in vitro
Endoplasmic reticulum (ER) stress is a major cause of hepatic steatosis through increasing de novo lipogenesis. Forkhead b...
Current treatment of Psoriasis triggered by Cytokine Storm and future immunomodulation strategies
Current treatment of Psoriasis triggered by Cytokine Storm and future immunomodulation strategies
Psoriasis is a chronic condition caused by an inflammation mediated mainly by cytokines and T cells. In COVID-19, the same...
TRAP1 modulates mitochondrial biogenesis via PGC-1α/TFAM signalling pathway in colorectal cancer cells
TRAP1 modulates mitochondrial biogenesis via PGC-1α/TFAM signalling pathway in colorectal cancer cells
Metabolic rewiring promotes cancer cell adaptation to a hostile microenvironment, representing a hallmark of cancer. This ...
WNT2B high‑expressed fibroblasts induce the fibrosis of IBD by promoting NK cells secreting IL-33
WNT2B high‑expressed fibroblasts induce the fibrosis of IBD by promoting NK cells secreting IL-33
Fibrosis is an important pathological change in inflammatory bowel disease (IBD), but the mechanism has yet to be elucidat...
Oral pyrophosphate protects Abcc6-/- mice against vascular calcification induced by chronic kidney disease
Oral pyrophosphate protects Abcc6-/- mice against vascular calcification induced by chronic kidney disease
One of the hallmarks of chronic kidney disease (CKD) is the development of vascular calcification. Inorganic pyrophosphate...
New insights into the mechanisms and therapeutic strategies of chondrocyte autophagy in osteoarthritis
New insights into the mechanisms and therapeutic strategies of chondrocyte autophagy in osteoarthritis
Osteoarthritis (OA) is a chronic joint disease with an unclear cause characterized by secondary osteophytes and degenerati...
β-Adrenergic blockade attenuates adverse adipose tissue responses after burn
β-Adrenergic blockade attenuates adverse adipose tissue responses after burn
Severe burn injuries are defined by a prolonged hypermetabolic response characterized by increases in resting energy expen...
New CRISPR/Cas9-based Fgfr2C361Y/+ mouse model of Crouzon syndrome exhibits skull and behavioral abnormalities
New CRISPR/Cas9-based Fgfr2C361Y/+ mouse model of Crouzon syndrome exhibits skull and behavioral abnormalities
Crouzon syndrome (CS), a syndromic craniosynostosis, is a craniofacial developmental deformity caused by mutations in fibr...
Emerging technologies in regenerative medicine: The future of wound care and therapy
Emerging technologies in regenerative medicine: The future of wound care and therapy
Wound healing, an intricate biological process, comprises orderly phases of simple biological processed including hemostas...
Umbelliferone alleviates impaired wound healing and skin barrier dysfunction in high glucose-exposed dermal fibroblasts and diabetic skins
Umbelliferone alleviates impaired wound healing and skin barrier dysfunction in high glucose-exposed dermal fibroblasts and diabetic skins
Skin wound healing is a complex process involving various cellular and molecular events. However, chronic wounds, particul...
Hypoxia drives estrogen receptor β-mediated cell growth via transcription activation in non-small cell lung cancer
Hypoxia drives estrogen receptor β-mediated cell growth via transcription activation in non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is a highly malignant tumor with a poor prognosis. Hypoxia conditions affect multiple c...
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