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Endothelial Cell-Derived Extracellular Vesicles Allow to Differentiate Between Various Endotypes of INOCA: A Multicentre, Prospective, Cohort Study
Endothelial Cell-Derived Extracellular Vesicles Allow to Differentiate Between Various Endotypes of INOCA: A Multicentre, Prospective, Cohort Study
Ischemia and non-obstructive coronary artery disease (INOCA) might be due to coronary microvascular dysfunction (CMD), vas...
Prediction of Major Adverse Limb Events in Females with Peripheral Artery Disease using Blood-Based Biomarkers and Clinical Features
Prediction of Major Adverse Limb Events in Females with Peripheral Artery Disease using Blood-Based Biomarkers and Clinical Features
The objective of this study was to identify a female-specific prognostic biomarker for peripheral artery disease ...
Associations of Blood Lipid-Related Polygenic Scores, Lifestyle Factors and Their Combined Effects with Risk of Coronary Artery Disease in the UK Biobank Cohort
Associations of Blood Lipid-Related Polygenic Scores, Lifestyle Factors and Their Combined Effects with Risk of Coronary Artery Disease in the UK Biobank Cohort
Circulating lipids play a crucial role in the development of coronary artery disease (CAD). However, it is unclear whether...
NAT10 Modulates Atherosclerosis Progression Mediated by Macrophage Polarization Through Regulating ac4C Modification of TLR9
NAT10 Modulates Atherosclerosis Progression Mediated by Macrophage Polarization Through Regulating ac4C Modification of TLR9
Atherosclerosis (AS) is an inflammatory disease affected by macrophage polarization. N4-acetylcytosine (ac4C) modification...
Machine Learning Model for Risk Prediction of Prolonged Intensive Care Unit in Patients Receiving Intra-aortic Balloon Pump Therapy during Coronary Artery Bypass Graft Surgery
Machine Learning Model for Risk Prediction of Prolonged Intensive Care Unit in Patients Receiving Intra-aortic Balloon Pump Therapy during Coronary Artery Bypass Graft Surgery
This study aimed to construct machine learning models and predict prolonged intensive care units (ICU) stay in patients re...
Diagnostic Value and Short-Term Prognosis Assessment of Copeptin in Non-ST-Elevation Acute Coronary Syndrome
Diagnostic Value and Short-Term Prognosis Assessment of Copeptin in Non-ST-Elevation Acute Coronary Syndrome
This study explored the early diagnosis and prognostic value of copeptin in non-ST-segment elevation acute coronary syndro...
Bufalin Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Macrophage Pyroptosis via P62 Pathway
Bufalin Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Macrophage Pyroptosis via P62 Pathway
Bufalin, which is isolated from toad venom, exerts positive effects on hearts under pathological circumstance. We aimed to...
Long Non-Coding RNAs in Diabetic Cardiomyopathy: Potential Function as Biomarkers and Therapeutic Targets of Exercise Training
Long Non-Coding RNAs in Diabetic Cardiomyopathy: Potential Function as Biomarkers and Therapeutic Targets of Exercise Training
Recent studies emphasize the beneficial effects of exercise on diabetic cardiomyopathy (DCM), adding to the growing body o...
Development and Internal Validation of an AI-Enabled Cuff-less, Non-invasive Continuous Blood Pressure Monitor Across All Classes of Hypertension
Development and Internal Validation of an AI-Enabled Cuff-less, Non-invasive Continuous Blood Pressure Monitor Across All Classes of Hypertension
Non-invasive, continuous blood pressure monitoring technologies require additional validation beyond standard cuff-based m...
CRISPR-Cas9 Targeting PCSK9: A Promising Therapeutic Approach for Atherosclerosis
CRISPR-Cas9 Targeting PCSK9: A Promising Therapeutic Approach for Atherosclerosis
CRISPR-Cas9 gene editing technology, as an innovative biomedical tool, holds significant potential in the prevention and t...
p16INK4a Aggravated Sepsis-associated Cardiac Injury by Inhibiting the PI3K/AKT Pathway and Inducing Redox Imbalance
p16INK4a Aggravated Sepsis-associated Cardiac Injury by Inhibiting the PI3K/AKT Pathway and Inducing Redox Imbalance
Severe sepsis can promote myocardial injury and cardiac dysfunction, but role of p16 in sepsis-induced myocardial injury r...
Chitinase-3-like Protein 1 Reduces the Stability of Atherosclerotic Plaque via Impairing Macrophagic Efferocytosis
Chitinase-3-like Protein 1 Reduces the Stability of Atherosclerotic Plaque via Impairing Macrophagic Efferocytosis
CHI3L1 is strongly associated with atherosclerosis, but its role in macrophages remains unknown. In this study, we observe...
Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease
Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease
Phosphatidylinositol-3 kinases (PI3Ks) play a critical role in maintaining cardiovascular health and the development of ca...
Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise
Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise
HFpEF is a prevalent and complex type of heart failure. The concurrent presence of conditions such as obesity, hypertensio...
The link between ferroptosis and autophagy in myocardial ischemia/reperfusion injury: new directions for therapy
The link between ferroptosis and autophagy in myocardial ischemia/reperfusion injury: new directions for therapy
Myocardial ischemia/reperfusion (I/R)-induced cell death, such as autophagy and ferroptosis, is a major contributor to car...
H-FABP as a Biomarker in Transient Ischemic Attack
H-FABP as a Biomarker in Transient Ischemic Attack
The study investigates the utility of heart fatty-acid binding protein (H-FABP) in distinguishing TIA from mimics. Data fr...
Intrapericardial Administration to Achieve Localized and Targeted Treatment for Cardiac Disease
Intrapericardial Administration to Achieve Localized and Targeted Treatment for Cardiac Disease
Intrapericardial administration has been proposed as an alternative delivery route of pharmacological agents via the bilam...
Adult Cardiomyocyte-Derived Extracellular Vesicles: a Promising Therapy for Cardiac Fibrosis
Adult Cardiomyocyte-Derived Extracellular Vesicles: a Promising Therapy for Cardiac Fibrosis
Comment on: Prieto-Vila M, Yoshioka Y, Kuriyama N, Okamura A, Yamamoto Y, Muranaka A,...
An Updated Comprehensive Review of Existing Transcatheter Aortic Valve Replacement Access
An Updated Comprehensive Review of Existing Transcatheter Aortic Valve Replacement Access
For the past 20 years, transcatheter aortic valve replacement (TAVR) has been the treatment of choice for symptom...
AIM2 Deficiency Alleviates Cardiac Inflammation and Hypertrophy in HFD/STZ-Induced Diabetic Mice by Inhibiting the NLRC4/IRF1 Signaling Pathway
AIM2 Deficiency Alleviates Cardiac Inflammation and Hypertrophy in HFD/STZ-Induced Diabetic Mice by Inhibiting the NLRC4/IRF1 Signaling Pathway
Absent in melanoma 2(AIM2) exacerbates atherosclerosis by inflammasome assembly. However, AIM2-mediated inflammation in di...
Pearls and Pitfalls of Epicardial Echocardiography for Implantation of Impella CP Devices in Ovine Models
Pearls and Pitfalls of Epicardial Echocardiography for Implantation of Impella CP Devices in Ovine Models
The Impella CP is a percutaneously inserted temporary left ventricular assist device used in clinical practice and in tran...
Assessment of CMR Feature-Tracking Age- and Sex-Dependent Right Ventricular Strain in a Healthy Caucasian Cohort
Assessment of CMR Feature-Tracking Age- and Sex-Dependent Right Ventricular Strain in a Healthy Caucasian Cohort
Right ventricular (RV) strain offers crucial diagnostic insights in cardiovascular and pulmonary disorders. Nonetheless, t...
Dysfunctional HDL Diagnostic Metrics for Cardiovascular Disease Risk Stratification: Are we Ready to Implement in Clinics?
Dysfunctional HDL Diagnostic Metrics for Cardiovascular Disease Risk Stratification: Are we Ready to Implement in Clinics?
Epidemiological studies have revealed that patients with higher levels of high-density lipoprotein cholesterol (HDL-C) wer...
Leukocyte Extracellular Vesicles Predict Progression of Systolic Dysfunction in Heart Failure with Mildly Reduced Ejection Fraction (LYCHEE) – A Prospective, Multicentre Cohort Study
Leukocyte Extracellular Vesicles Predict Progression of Systolic Dysfunction in Heart Failure with Mildly Reduced Ejection Fraction (LYCHEE) – A Prospective, Multicentre Cohort Study
Risk stratification in heart failure with mildly-reduced ejection fraction (HFmrEF) remains challenging. We evaluated the ...
Hemodynamic Analysis in Aortic Dilatation after Arterial Switch Operation for Patients with Transposition of Great Arteries Using Computational Fluid Dynamics
Hemodynamic Analysis in Aortic Dilatation after Arterial Switch Operation for Patients with Transposition of Great Arteries Using Computational Fluid Dynamics
After an arterial switch operation for complete transposition of the great arteries, neo-aortic root dilatation occurs, wi...
CNDP2: An Enzyme Linking Metabolism and Cardiovascular Diseases?
CNDP2: An Enzyme Linking Metabolism and Cardiovascular Diseases?
The heart requires a substantial amount of energy to function, utilising various substrates including lipids, glucose and ...
Past Trends and Future Directions of Cardiac Regenerative Medicine – A Systematic Analysis of Clinical Trial Registries
Past Trends and Future Directions of Cardiac Regenerative Medicine – A Systematic Analysis of Clinical Trial Registries
Cell therapy, gene therapy, and tissue engineering have been explored as potential strategies to repair or regenerate dama...
4D-Flow MRI and Vector Ultrasound in the In-Vitro Evaluation of Surgical Aortic Heart Valves – a Pilot Study
4D-Flow MRI and Vector Ultrasound in the In-Vitro Evaluation of Surgical Aortic Heart Valves – a Pilot Study
Introduction: The aim of this study was the initial investigation of 4D-Flow MRI and Vector Ultrasound as novel imaging te...
Induction of Controllable Vortical Flow in a Dual-Stenosis Aorta Model: A Replication of Disordered Eddies Flow in Aneurysms
Induction of Controllable Vortical Flow in a Dual-Stenosis Aorta Model: A Replication of Disordered Eddies Flow in Aneurysms
This paper presents a two-stenosis aorta model mimicking vortical flow in vascular aneurysms. More specifically, we propos...
Circulating Extracellular Vesicles from Heart Failure Patients Inhibit Human Cardiomyocyte Activities
Circulating Extracellular Vesicles from Heart Failure Patients Inhibit Human Cardiomyocyte Activities
Extracellular vesicles (EVs) have been implicated in cardiac remodeling during heart failure (HF). However, the role of ci...
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