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The Impact of Obesity on Pressure–Volume Relationship in Ambulatory Heart Failure
The Impact of Obesity on Pressure–Volume Relationship in Ambulatory Heart Failure
Assessment of volume status is essential in heart failure (HF) management, yet the relationship between cardiac filling pr...
Machine Learning-based Prediction of Temporal Velocity-Informatics (TVI) Variables for Accelerated Characterization of Intracranial Aneurysms’ Rupture Status
Machine Learning-based Prediction of Temporal Velocity-Informatics (TVI) Variables for Accelerated Characterization of Intracranial Aneurysms’ Rupture Status
Temporal velocity-informatics (TVI) is a novel technique utilizing spatial analysis of time-resolved 3D velocity fields to...
Preclinical Assessment of a Novel Polymer-Free Hybrid Drug Eluting Stent
Preclinical Assessment of a Novel Polymer-Free Hybrid Drug Eluting Stent
We aimed to evaluate a novel polymer-free hybrid drug eluting stent (DES) relative to benchmark devices and speci...
Roles of Long Non-Coding RNAs in the Pathogenesis of Cardiovascular Disorders: Challenges and Opportunities
Roles of Long Non-Coding RNAs in the Pathogenesis of Cardiovascular Disorders: Challenges and Opportunities
Cardiovascular disease (CVD) is a prominent contributor to global mortality rates, and its prevalence is consistently on t...
Reprogramming of Mitochondrial and Cellular Energy Metabolism in Fibroblasts and Cardiomyocytes: Mechanisms and Therapeutic Strategies in Cardiac Fibrosis
Reprogramming of Mitochondrial and Cellular Energy Metabolism in Fibroblasts and Cardiomyocytes: Mechanisms and Therapeutic Strategies in Cardiac Fibrosis
Cardiac fibrosis, marked by excessive extracellular matrix accumulation, is a key endpoint in various cardiac diseases and...
VEGFR1 as a Target for Cardiovascular Gene Therapy
VEGFR1 as a Target for Cardiovascular Gene Therapy
Vascular endothelial growth factor receptor 1 (VEGFR1) is a key regulator of endothelial function, angiogenesis, inflammat...
Advances in Acute Myocardial Infarction (AMI) Diagnostics: Classical Biomarkers, Emerging Tools, and the Rise of Non-Invasive Sampling
Advances in Acute Myocardial Infarction (AMI) Diagnostics: Classical Biomarkers, Emerging Tools, and the Rise of Non-Invasive Sampling
Acute myocardial infarction (AMI) remains a leading cause of mortality worldwide, highlighting the need for improved diagn...
Platelet Reactivity and Fibrin Clot-Strength as assessed by TEG in Patients with Atrial Fibrillation undergoing Percutaneous Coronary Intervention
Platelet Reactivity and Fibrin Clot-Strength as assessed by TEG in Patients with Atrial Fibrillation undergoing Percutaneous Coronary Intervention
Platelet reactivity (PR) in clopidogrel-treated patients undergoing percutaneous coronary syndrome (PCI) associat...
Diammonium Glycyrrhizinate Alleviated Myocardial Fibrosis Induced by Isoprenaline Via Modulation of STAT/Smad3 Pathway
Diammonium Glycyrrhizinate Alleviated Myocardial Fibrosis Induced by Isoprenaline Via Modulation of STAT/Smad3 Pathway
Myocardial fibrosis (MF) severely impairs the heart structure and function post-myocardial infarction. The study investiga...
Characterization of Neutrophil Extracellular Traps in Acute Myocardial Infarction: A Translational Study
Characterization of Neutrophil Extracellular Traps in Acute Myocardial Infarction: A Translational Study
Neutrophil extracellular traps (NETs) are implicated in thrombosis and inflammation during acute myocardial infarction (AM...
Long Non-coding RNA Based Therapy for Cardiovascular Disease
Long Non-coding RNA Based Therapy for Cardiovascular Disease
Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality worldwide, necessitating innovative thera...
The Use of the Medina Coronary Bifurcation Classification has Led to Confusion and Missing One Third of True Bifurcation Lesions. The Movahed Bifurcation Classification Should be the Preferred Classification as it Categorizes All True Bifurcation Lesions in One Simple Category B2 Lesions with Limitless Suffixes that Can be Added if Needed
The Use of the Medina Coronary Bifurcation Classification has Led to Confusion and Missing One Third of True Bifurcation Lesions. The Movahed Bifurcation Classification Should be the Preferred Classification as it Categorizes All True Bifurcation Lesions in One Simple Category B2 Lesions with Limitless Suffixes that Can be Added if Needed
Rahimi F, Löffelhardt N, Minners J, Breitbart P, Franke K, Hartikainen TS, Valina C, Mühlen CVZ, Nührenberg T, Kastrati A,...
Circulating as a Diagnostic Biomarker of Early Endothelial Dysfunction in Young Dyslipidemic Individuals
Circulating as a Diagnostic Biomarker of Early Endothelial Dysfunction in Young Dyslipidemic Individuals
Diagnostic potential of sialin in identifying endothelial dysfunction is explored. 50 CAD patients, 50 young (20–35&...
Cardioplegic Machine Perfusion of Hearts Donated after Circulatory Death
Cardioplegic Machine Perfusion of Hearts Donated after Circulatory Death
We compared the effects of ex-vivo machine perfusion (EVMP) of hearts donated after circulatory death (DCD) with the singl...
Hypoxia Aggravates Myocardial Ischemia/Reperfusion Injury Through the Promotion of Ferroptosis via ACSL4 Lactylation
Hypoxia Aggravates Myocardial Ischemia/Reperfusion Injury Through the Promotion of Ferroptosis via ACSL4 Lactylation
Myocardial ischemia/reperfusion injury (MIRI) worsens ischemic damage, with ferroptosis as a key mediator of this iron-dep...
Network Medicine-Based Repurposing of Mesalazine for Atherosclerosis Treatment
Network Medicine-Based Repurposing of Mesalazine for Atherosclerosis Treatment
Atherosclerosis remains a leading cause of cardiovascular disease and mortality worldwide, despite advancements in statin ...
Endothelial Cell-Derived Extracellular Vesicles Allow to Differentiate Between Various Endotypes of INOCA: A Multicentre, Prospective, Cohort Study
Endothelial Cell-Derived Extracellular Vesicles Allow to Differentiate Between Various Endotypes of INOCA: A Multicentre, Prospective, Cohort Study
Ischemia and non-obstructive coronary artery disease (INOCA) might be due to coronary microvascular dysfunction (CMD), vas...
Prediction of Major Adverse Limb Events in Females with Peripheral Artery Disease using Blood-Based Biomarkers and Clinical Features
Prediction of Major Adverse Limb Events in Females with Peripheral Artery Disease using Blood-Based Biomarkers and Clinical Features
The objective of this study was to identify a female-specific prognostic biomarker for peripheral artery disease ...
Associations of Blood Lipid-Related Polygenic Scores, Lifestyle Factors and Their Combined Effects with Risk of Coronary Artery Disease in the UK Biobank Cohort
Associations of Blood Lipid-Related Polygenic Scores, Lifestyle Factors and Their Combined Effects with Risk of Coronary Artery Disease in the UK Biobank Cohort
Circulating lipids play a crucial role in the development of coronary artery disease (CAD). However, it is unclear whether...
NAT10 Modulates Atherosclerosis Progression Mediated by Macrophage Polarization Through Regulating ac4C Modification of TLR9
NAT10 Modulates Atherosclerosis Progression Mediated by Macrophage Polarization Through Regulating ac4C Modification of TLR9
Atherosclerosis (AS) is an inflammatory disease affected by macrophage polarization. N4-acetylcytosine (ac4C) modification...
Machine Learning Model for Risk Prediction of Prolonged Intensive Care Unit in Patients Receiving Intra-aortic Balloon Pump Therapy during Coronary Artery Bypass Graft Surgery
Machine Learning Model for Risk Prediction of Prolonged Intensive Care Unit in Patients Receiving Intra-aortic Balloon Pump Therapy during Coronary Artery Bypass Graft Surgery
This study aimed to construct machine learning models and predict prolonged intensive care units (ICU) stay in patients re...
Diagnostic Value and Short-Term Prognosis Assessment of Copeptin in Non-ST-Elevation Acute Coronary Syndrome
Diagnostic Value and Short-Term Prognosis Assessment of Copeptin in Non-ST-Elevation Acute Coronary Syndrome
This study explored the early diagnosis and prognostic value of copeptin in non-ST-segment elevation acute coronary syndro...
Bufalin Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Macrophage Pyroptosis via P62 Pathway
Bufalin Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Macrophage Pyroptosis via P62 Pathway
Bufalin, which is isolated from toad venom, exerts positive effects on hearts under pathological circumstance. We aimed to...
Long Non-Coding RNAs in Diabetic Cardiomyopathy: Potential Function as Biomarkers and Therapeutic Targets of Exercise Training
Long Non-Coding RNAs in Diabetic Cardiomyopathy: Potential Function as Biomarkers and Therapeutic Targets of Exercise Training
Recent studies emphasize the beneficial effects of exercise on diabetic cardiomyopathy (DCM), adding to the growing body o...
Development and Internal Validation of an AI-Enabled Cuff-less, Non-invasive Continuous Blood Pressure Monitor Across All Classes of Hypertension
Development and Internal Validation of an AI-Enabled Cuff-less, Non-invasive Continuous Blood Pressure Monitor Across All Classes of Hypertension
Non-invasive, continuous blood pressure monitoring technologies require additional validation beyond standard cuff-based m...
CRISPR-Cas9 Targeting PCSK9: A Promising Therapeutic Approach for Atherosclerosis
CRISPR-Cas9 Targeting PCSK9: A Promising Therapeutic Approach for Atherosclerosis
CRISPR-Cas9 gene editing technology, as an innovative biomedical tool, holds significant potential in the prevention and t...
p16INK4a Aggravated Sepsis-associated Cardiac Injury by Inhibiting the PI3K/AKT Pathway and Inducing Redox Imbalance
p16INK4a Aggravated Sepsis-associated Cardiac Injury by Inhibiting the PI3K/AKT Pathway and Inducing Redox Imbalance
Severe sepsis can promote myocardial injury and cardiac dysfunction, but role of p16 in sepsis-induced myocardial injury r...
Chitinase-3-like Protein 1 Reduces the Stability of Atherosclerotic Plaque via Impairing Macrophagic Efferocytosis
Chitinase-3-like Protein 1 Reduces the Stability of Atherosclerotic Plaque via Impairing Macrophagic Efferocytosis
CHI3L1 is strongly associated with atherosclerosis, but its role in macrophages remains unknown. In this study, we observe...
Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease
Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease
Phosphatidylinositol-3 kinases (PI3Ks) play a critical role in maintaining cardiovascular health and the development of ca...
Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise
Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise
HFpEF is a prevalent and complex type of heart failure. The concurrent presence of conditions such as obesity, hypertensio...
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