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Clusterin-mediated polarization of M2 macrophages: a mechanism of temozolomide resistance in glioblastoma stem cells
Clusterin-mediated polarization of M2 macrophages: a mechanism of temozolomide resistance in glioblastoma stem cells
Glioblastoma remains one of the most lethal malignancies, largely due to its resistance to standard chemotherapy such as t...
Exosomes derived from a mesenchymal-like endometrial regenerative cells ameliorate renal ischemia reperfusion injury through delivery of CD73
Exosomes derived from a mesenchymal-like endometrial regenerative cells ameliorate renal ischemia reperfusion injury through delivery of CD73
Renal ischemia reperfusion (I/R) injury is a major contributor to graft dysfunction and inflammation leading to graft loss...
LincRNA-ASAO promotes dental pulp repair through interacting with PTBP1 to increase ALPL alternative splicing
LincRNA-ASAO promotes dental pulp repair through interacting with PTBP1 to increase ALPL alternative splicing
Alternative splicing not only expands the genetic encoding of genes but also determines cellular activities. This study ai...
Emerging role and function of Hippo-YAP/TAZ signaling pathway in musculoskeletal disorders
Emerging role and function of Hippo-YAP/TAZ signaling pathway in musculoskeletal disorders
Hippo pathway is an evolutionarily conservative key pathway that regulates organ size and tissue regeneration by regulatin...
Concurrent hypoxia and apoptosis imparts immune programming potential in mesenchymal stem cells: Lesson from acute graft-versus-host-disease model
Concurrent hypoxia and apoptosis imparts immune programming potential in mesenchymal stem cells: Lesson from acute graft-versus-host-disease model
Mesenchymal stem cells (MSCs) have emerged as promising candidates for immune modulation in various diseases that are asso...
Identification of CD141+vasculogenic precursor cells from human bone marrow and their endothelial engagement in the arteriogenesis by co-transplantation with mesenchymal stem cells
Identification of CD141+vasculogenic precursor cells from human bone marrow and their endothelial engagement in the arteriogenesis by co-transplantation with mesenchymal stem cells
Critical limb ischemia (CLI) is a condition characterized by insufficient blood flow to the lower limbs, resulting in seve...
Dental stem cell dynamics in periodontal ligament regeneration: from mechanism to application
Dental stem cell dynamics in periodontal ligament regeneration: from mechanism to application
Periodontitis, a globally prevalent chronic inflammatory disease is characterized by the progressive degradation of tooth-...
Mesenchymal stem cells-derived extracellular vesicles ameliorate lupus nephritis by regulating T and B cell responses
Mesenchymal stem cells-derived extracellular vesicles ameliorate lupus nephritis by regulating T and B cell responses
Human umbilical cord mesenchymal stem cells-derived extracellular vesicles (hUCMSC-EVs) have potent immunomodulatory prope...
Efficacy of using adipose-derived stem cells and PRP on regeneration of 40 -mm long sciatic nerve defect bridged by polyglycolic-polypropylene mesh in canine model
Efficacy of using adipose-derived stem cells and PRP on regeneration of 40 -mm long sciatic nerve defect bridged by polyglycolic-polypropylene mesh in canine model
Sciatic nerve repair becomes a focus of research in neurological aspect to restore the normal physical ability of the anim...
Human umbilical cord mesenchymal stem cell-based gene therapy for hemophilia B using scAAV-DJ/8-LP1-hFIXco transduction
Human umbilical cord mesenchymal stem cell-based gene therapy for hemophilia B using scAAV-DJ/8-LP1-hFIXco transduction
Hemophilia B is an X-linked bleeding disorder caused by a mutation in the gene responsible for encoding coagulation factor...
Epicardial EMT and cardiac repair: an update
Epicardial EMT and cardiac repair: an update
Epicardial epithelial-to-mesenchymal transition (EMT) plays a pivotal role in both heart development and injury response a...
Genome-scale CRISPR-Cas9 screening in stem cells: theories, applications and challenges
Genome-scale CRISPR-Cas9 screening in stem cells: theories, applications and challenges
Due to the rapid development of stem cell technology, there have been tremendous advances in molecular biological and path...
Bioprinting of human pluripotent stem cell derived corneal endothelial cells with hydrazone crosslinked hyaluronic acid bioink
Bioprinting of human pluripotent stem cell derived corneal endothelial cells with hydrazone crosslinked hyaluronic acid bioink
Human corneal endothelial cells lack regenerative capacity through cell division in vivo. Consequently, in the case of tra...
Transplanted human photoreceptors transfer cytoplasmic material but not to the recipient mouse retina
Transplanted human photoreceptors transfer cytoplasmic material but not to the recipient mouse retina
The discovery of material transfer between transplanted and host mouse photoreceptors has expanded the possibilities for u...
Cytoprotective role of human dental pulp stem cell-conditioned medium in chemotherapy-induced alopecia
Cytoprotective role of human dental pulp stem cell-conditioned medium in chemotherapy-induced alopecia
Chemotherapy-induced alopecia (CIA) is a distressing adverse effect of chemotherapy, with an estimated incidence of 65% an...
iMSC-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva
iMSC-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease caused by a gain-of-function mutation in ACVR1, whic...
Neural cell engraftment therapy for sporadic Creutzfeldt-Jakob disease restores neuroelectrophysiological parameters in a cerebral organoid model
Neural cell engraftment therapy for sporadic Creutzfeldt-Jakob disease restores neuroelectrophysiological parameters in a cerebral organoid model
Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, is a fatal neurodegenerative disease with ...
CRX haploinsufficiency compromises photoreceptor precursor translocation and differentiation in human retinal organoids
CRX haploinsufficiency compromises photoreceptor precursor translocation and differentiation in human retinal organoids
The CRX-associated autosomal dominant retinopathies suggest a possible pathogenic mechanism of gene haploinsufficiency. Ho...
Emerging role of mesenchymal stromal cells in gynecologic cancer therapy
Emerging role of mesenchymal stromal cells in gynecologic cancer therapy
Mesenchymal stromal cells (MSCs) show considerable promise in regenerative medicine with superior anti-fibrotic, immunomod...
Gene editing and cardiac disease modelling for the interpretation of genetic variants of uncertain significance in congenital heart disease
Gene editing and cardiac disease modelling for the interpretation of genetic variants of uncertain significance in congenital heart disease
Genomic sequencing in congenital heart disease (CHD) patients often discovers novel genetic variants, which are classified...
The effect of TLR3 priming conditions on MSC immunosuppressive properties
The effect of TLR3 priming conditions on MSC immunosuppressive properties
Mesenchymal stromal cells (MSCs) have regenerative and immunomodulatory properties, making them suitable for cell therapy....
Induced pluripotent stem cells modulate the Wnt pathway in the bleomycin-induced model of idiopathic pulmonary fibrosis
Induced pluripotent stem cells modulate the Wnt pathway in the bleomycin-induced model of idiopathic pulmonary fibrosis
The Wnt signaling pathway has been implicated in the pathogenesis of fibrotic disorders and malignancies. Hence, we aimed ...
Deciphering the role of extrachromosomal circular DNA in adipose stem cells from old and young donors
Deciphering the role of extrachromosomal circular DNA in adipose stem cells from old and young donors
The functional impairment of adipose stem cells (ASCs) during aging limits their clinical transformation. Studies have sho...
Oxidative stress regulation and related metabolic pathways in epithelial–mesenchymal transition of breast cancer stem cells
Oxidative stress regulation and related metabolic pathways in epithelial–mesenchymal transition of breast cancer stem cells
Epithelial–mesenchymal transition (EMT) is a cell remodeling process in which epithelial cells undergo a reversible ...
Adipose-derived mesenchymal stem cells cultured in serum-free medium attenuate acute contrast-induced nephropathy by exerting anti-apoptotic effects
Adipose-derived mesenchymal stem cells cultured in serum-free medium attenuate acute contrast-induced nephropathy by exerting anti-apoptotic effects
Contrast-induced nephropathy (CIN) is a major clinical problem associated with acute kidney injury during hospitalization....
Correction: Mesenchymal stem cell-secreted prostaglandin E2 ameliorates acute liver failure via attenuation of cell death and regulation of macrophage polarization
Correction: Mesenchymal stem cell-secreted prostaglandin E2 ameliorates acute liver failure via attenuation of cell death and regulation of macrophage polarization
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Application of patient-derived induced pluripotent stem cells and organoids in inherited retinal diseases
Application of patient-derived induced pluripotent stem cells and organoids in inherited retinal diseases
Inherited retinal diseases (IRDs) can induce severe sight-threatening retinal degeneration and impose a considerable econo...
Disclosing the molecular profile of the human amniotic mesenchymal stromal cell secretome by filter-aided sample preparation proteomic characterization
Disclosing the molecular profile of the human amniotic mesenchymal stromal cell secretome by filter-aided sample preparation proteomic characterization
The secretome of mesenchymal stromal cells isolated from the amniotic membrane (hAMSCs) has been extensively studied for i...
HIF-1α promotes kidney organoid vascularization and applications in disease modeling
HIF-1α promotes kidney organoid vascularization and applications in disease modeling
Kidney organoids derived from human pluripotent stem cells (HiPSCs) hold huge applications for drug screening, disease mod...
The influence of inflammation on the characteristics of adipose-derived mesenchymal stem cells (ADMSCs) and tissue repair capability in a hepatic injury mouse model
The influence of inflammation on the characteristics of adipose-derived mesenchymal stem cells (ADMSCs) and tissue repair capability in a hepatic injury mouse model
Mesenchymal stem cells (MSCs) are adult stem cells with self-renewal and multi-directional differentiation potential and p...
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